HK1138602A1 - Sequence based engineering and optimization of single chain antibodies - Google Patents
Sequence based engineering and optimization of single chain antibodiesInfo
- Publication number
- HK1138602A1 HK1138602A1 HK10103877.0A HK10103877A HK1138602A1 HK 1138602 A1 HK1138602 A1 HK 1138602A1 HK 10103877 A HK10103877 A HK 10103877A HK 1138602 A1 HK1138602 A1 HK 1138602A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- optimization
- single chain
- chain antibodies
- sequence based
- based engineering
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90636507P | 2007-03-12 | 2007-03-12 | |
PCT/EP2008/001958 WO2008110348A1 (en) | 2007-03-12 | 2008-03-12 | Sequence based engineering and optimization of single chain antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1138602A1 true HK1138602A1 (en) | 2010-08-27 |
Family
ID=39586970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10103877.0A HK1138602A1 (en) | 2007-03-12 | 2010-04-21 | Sequence based engineering and optimization of single chain antibodies |
Country Status (12)
Country | Link |
---|---|
US (2) | US8280711B2 (he) |
EP (2) | EP3202786A3 (he) |
JP (1) | JP5622397B2 (he) |
CN (2) | CN101668771B (he) |
AU (1) | AU2008226067B2 (he) |
CA (1) | CA2680564C (he) |
HK (1) | HK1138602A1 (he) |
IL (1) | IL200710A (he) |
IN (1) | IN2009DN05758A (he) |
NZ (1) | NZ579594A (he) |
RU (2) | RU2009137582A (he) |
WO (1) | WO2008110348A1 (he) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101668771B (zh) | 2007-03-12 | 2013-08-21 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 单链抗体的基于序列的工程改造和最优化 |
SI2158315T1 (sl) | 2007-06-25 | 2016-05-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Postopki za spreminjanje protiteles in spremenjena protitelesa z izboljšanimi funkcionalnimi lastnostmi |
KR101530723B1 (ko) * | 2007-06-25 | 2015-06-22 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화 |
PL2307455T3 (pl) | 2008-06-25 | 2017-09-29 | Esbatech, An Alcon Biomedical Research Unit Llc | Optymalizacja rozpuszczalności cząsteczek immunowiążących |
EP3216803B1 (en) | 2008-06-25 | 2020-03-11 | Novartis Ag | Stable and soluble antibodies inhibiting vegf |
JP6100463B2 (ja) | 2008-06-25 | 2017-03-22 | エスバテック − ア ノバルティス カンパニー エルエルシー | TNFαを阻害する安定かつ可溶性の抗体 |
CN102164958A (zh) | 2008-06-25 | 2011-08-24 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
US8399625B1 (en) | 2009-06-25 | 2013-03-19 | ESBATech, an Alcon Biomedical Research Unit, LLC | Acceptor framework for CDR grafting |
AU2010321832B2 (en) | 2009-11-20 | 2014-08-14 | Amgen Inc. | Anti-Orai1 antigen binding proteins and uses thereof |
CN103339145A (zh) | 2010-09-22 | 2013-10-02 | 安姆根有限公司 | 运载体免疫球蛋白及其用途 |
AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
GB201310859D0 (en) * | 2013-06-18 | 2013-07-31 | Cambridge Entpr Ltd | Rational method for solubilising proteins |
JP6580570B2 (ja) * | 2013-09-06 | 2019-09-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗体安定性を向上させるための方法 |
AU2015318008B2 (en) | 2014-09-15 | 2021-05-20 | Amgen Inc. | Bi-specific anti-CGRP receptor/PAC1 receptor antigen binding proteins and uses thereof |
MA42821A (fr) | 2015-09-15 | 2018-07-25 | Amgen Inc | Protéines de liaison à l'antigène tétraspécifiques et bispécifiques tétravalentes et utilisations de celles-ci |
US10822408B2 (en) | 2015-12-15 | 2020-11-03 | Amgen Inc. | PACAP antibodies and uses thereof |
CA3043528A1 (en) | 2016-11-14 | 2018-05-17 | Amgen Inc. | Bispecific or biparatopic antigen binding proteins and uses thereof |
JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
TWI831762B (zh) | 2018-01-12 | 2024-02-11 | 美商安進公司 | Pac1抗體及其用途 |
WO2019233984A1 (en) * | 2018-06-08 | 2019-12-12 | Ventana Medical Systems, Inc. | Universal or normalized antibody frameworks for improved functionality and manufacturability |
TW202110877A (zh) | 2019-05-30 | 2021-03-16 | 美商安進公司 | 工程改造鉸鏈區以驅動抗體二聚化 |
CA3143524A1 (en) | 2019-06-28 | 2020-12-30 | Amgen Inc. | Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins |
AU2020380379A1 (en) | 2019-11-08 | 2022-05-26 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-IgG molecules |
WO2021102049A1 (en) | 2019-11-19 | 2021-05-27 | Amgen Inc. | Novel multispecific antibody format |
IL293640A (he) | 2019-12-20 | 2022-08-01 | Amgen Inc | מבני נוגדן רב-ספציפיים מיועדי-מזותלין אנטגוניסטיים ל-cd40 לטיפול בגידולים מוצקים |
EP4200338A1 (en) | 2020-08-20 | 2023-06-28 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
JP2023544769A (ja) | 2020-10-07 | 2023-10-25 | アムジエン・インコーポレーテツド | 多重特異性抗体の構築のためのビルディングブロックの合理的選択 |
WO2022103773A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Novel linkers of multispecific antigen binding domains |
CN116848136A (zh) | 2021-02-12 | 2023-10-03 | 勃林格殷格翰国际有限公司 | 补体c3抗原结合蛋白 |
WO2022190007A1 (en) | 2021-03-09 | 2022-09-15 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries |
MX2023010541A (es) | 2021-03-09 | 2023-11-24 | Cdr Life Ag | Proteinas de union al antigeno del peptido del mhc mage-a4. |
JP2024515301A (ja) | 2021-04-20 | 2024-04-08 | アムジエン・インコーポレーテツド | 多重特異性及び一価のigg分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布 |
CA3240046A1 (en) | 2021-12-14 | 2023-06-22 | Cdr-Life Ag | Dual mhc-targeting t cell engager |
WO2024056758A1 (en) | 2022-09-14 | 2024-03-21 | Cdr-Life Ag | Mage-a4 peptide dual t cell engagers |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
DK0669836T3 (da) * | 1992-11-13 | 1996-10-14 | Idec Pharma Corp | Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
WO1994025591A1 (en) * | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
US6740734B1 (en) * | 1994-01-14 | 2004-05-25 | Biovitrum Ab | Bacterial receptor structures |
CA2243459C (en) * | 1996-02-09 | 2002-09-17 | Basf Aktiengesellschaft | Human antibodies that bind human tnf.alpha. |
CN1062312C (zh) * | 1996-11-29 | 2001-02-21 | 中国科学院微生物研究所 | 抗ⅳ型胶原酶单链抗体 |
US6884879B1 (en) * | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
EP0985039B1 (en) * | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
NZ528199A (en) * | 1998-08-11 | 2005-06-24 | Idec Pharma Corp | Combination therapies for B-cell lyphomas comprising administration of anti-CD20 antibody |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
EP1140239B1 (en) | 1998-12-14 | 2004-07-14 | Osteotech, Inc., | Bone graft made of bone particles |
CN1232039A (zh) * | 1999-04-02 | 1999-10-20 | 中国人民解放军海军总医院 | 一种基因工程双特异抗体及其应用 |
SE9901379D0 (sv) | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
US6602977B1 (en) * | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
ES2225269T3 (es) * | 1999-12-28 | 2005-03-16 | Esbatech Ag | Intracuerpos con esqueleto definido que es estable en un ambiente reductor y aplicaciones de los mismos. |
BR0015875A (pt) | 2000-05-10 | 2003-06-24 | Mayo Foundation | Anticorpos igm humano com a capacidade de induzir remielinização, e usos diagnósticos e terapêutico dos mesmos, particularmente no sistema nervoso central |
US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
AU2002256371B2 (en) | 2001-04-26 | 2008-01-10 | Amgen Mountain View Inc. | Combinatorial libraries of monomer domains |
CA2453662A1 (en) * | 2001-07-19 | 2003-01-30 | Stefan Ewert | Modification of human variable domains |
CN103739706B (zh) * | 2002-05-22 | 2015-11-18 | 艾斯巴技术-诺华有限责任公司 | 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法 |
WO2005005604A2 (en) * | 2003-06-30 | 2005-01-20 | Centocor, Inc. | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
WO2005051998A2 (en) | 2003-11-28 | 2005-06-09 | Astrazeneca Ab | Antibodies binding to a c-terminal fragment of apolipoprotein e |
US8039588B2 (en) | 2004-05-21 | 2011-10-18 | The Uab Research Foundation | Variable lymphocyte receptors |
GB0416651D0 (en) | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
JP5113523B2 (ja) * | 2004-10-13 | 2013-01-09 | アブリンクス ナームローゼ フェンノートシャップ | アミロイド−βに対するナノ抗体及びアルツハイマー病のような神経変性疾患の治療のためのナノ抗体TMを含むポリペプチド |
US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
WO2006131013A2 (en) | 2005-06-07 | 2006-12-14 | Esbatech Ag | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα |
EP3366702B1 (en) | 2005-12-13 | 2023-08-09 | Eli Lilly And Company | Anti-il-17 antibodies |
ES2820837T3 (es) | 2006-07-10 | 2021-04-22 | Esbatech Alcon Biomed Res Unit | Anticuerpos scFv que pasan las capas epitelial y/o endotelial |
CN101668771B (zh) | 2007-03-12 | 2013-08-21 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 单链抗体的基于序列的工程改造和最优化 |
SI2158315T1 (sl) * | 2007-06-25 | 2016-05-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Postopki za spreminjanje protiteles in spremenjena protitelesa z izboljšanimi funkcionalnimi lastnostmi |
KR101530723B1 (ko) * | 2007-06-25 | 2015-06-22 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화 |
-
2008
- 2008-03-12 CN CN2008800079463A patent/CN101668771B/zh active Active
- 2008-03-12 RU RU2009137582/10A patent/RU2009137582A/ru unknown
- 2008-03-12 IN IN5758DEN2009 patent/IN2009DN05758A/en unknown
- 2008-03-12 EP EP17159837.8A patent/EP3202786A3/en not_active Withdrawn
- 2008-03-12 CN CN201310170015.8A patent/CN103275216B/zh active Active
- 2008-03-12 WO PCT/EP2008/001958 patent/WO2008110348A1/en active Application Filing
- 2008-03-12 EP EP08716464A patent/EP2118138A1/en not_active Withdrawn
- 2008-03-12 NZ NZ579594A patent/NZ579594A/en not_active IP Right Cessation
- 2008-03-12 US US12/530,756 patent/US8280711B2/en active Active
- 2008-03-12 CA CA2680564A patent/CA2680564C/en not_active Expired - Fee Related
- 2008-03-12 AU AU2008226067A patent/AU2008226067B2/en not_active Ceased
- 2008-03-12 JP JP2009553071A patent/JP5622397B2/ja active Active
-
2009
- 2009-09-03 IL IL200710A patent/IL200710A/he active IP Right Grant
-
2010
- 2010-04-21 HK HK10103877.0A patent/HK1138602A1/xx unknown
-
2012
- 2012-08-23 US US13/592,885 patent/US9938336B2/en active Active
-
2014
- 2014-07-03 RU RU2014127308A patent/RU2014127308A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101668771A (zh) | 2010-03-10 |
AU2008226067A1 (en) | 2008-09-18 |
IL200710A (he) | 2014-07-31 |
EP2118138A1 (en) | 2009-11-18 |
NZ579594A (en) | 2012-03-30 |
CN103275216A (zh) | 2013-09-04 |
JP5622397B2 (ja) | 2014-11-12 |
WO2008110348A1 (en) | 2008-09-18 |
IL200710A0 (en) | 2010-05-17 |
CN101668771B (zh) | 2013-08-21 |
US8280711B2 (en) | 2012-10-02 |
CA2680564C (en) | 2018-05-01 |
RU2009137582A (ru) | 2011-04-20 |
AU2008226067B2 (en) | 2012-11-08 |
CA2680564A1 (en) | 2008-09-18 |
IN2009DN05758A (he) | 2015-07-24 |
EP3202786A2 (en) | 2017-08-09 |
CN103275216B (zh) | 2015-05-06 |
US20100137150A1 (en) | 2010-06-03 |
EP3202786A3 (en) | 2017-10-11 |
JP2010523077A (ja) | 2010-07-15 |
RU2014127308A (ru) | 2016-02-10 |
US20130053259A1 (en) | 2013-02-28 |
US9938336B2 (en) | 2018-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1137035A1 (en) | Sequence based engineering and optimization of single chain antibodies | |
HK1138602A1 (en) | Sequence based engineering and optimization of single chain antibodies | |
IL248723B (he) | נוגדנים ספציפיים כנגד קומפלקס bcr ושיטות להשתמש בהם | |
HRP20160684T1 (hr) | Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću | |
EP1999470A4 (en) | IDENTIFICATION AND GENETIC MODIFICATION OF ANTIBODIES WITH HEAVY CHAINS OF VARIANTS AND METHODS OF USE THEREOF | |
ZA201106118B (en) | Anti-vegf antibody compositions and methods | |
ZA200900395B (en) | Antibodies directed to +-Vß6 and uses thereof | |
HK1194395A1 (zh) | 抗體及其製備和使用方法 | |
HK1138329A1 (zh) | 包含抗體代理輕鏈序列的構建和文庫 | |
IL192419A0 (en) | Anti-ephb4 antibodies and methods using same | |
HK1142341A1 (en) | Anti-hepcidin antibodies and uses thereof | |
IL197937A0 (en) | Antibodies to lymphotoxin-alpha | |
IL231891A0 (he) | נוגדנים אנטי–2ephriinb ושיטות לשימוש בהם | |
ZA200806053B (en) | Anti-EphB4 antibodies and methods using same | |
ZA200902346B (en) | Antibodies to lymphotoxin-alpha | |
PL384339A1 (pl) | Wyprażacz łańcuchowy | |
HUP0600762A2 (en) | Delaying chain |