HK1137810A1 - Method and apparatus for imaging target components in a biological sample using permanent magnets - Google Patents
Method and apparatus for imaging target components in a biological sample using permanent magnetsInfo
- Publication number
- HK1137810A1 HK1137810A1 HK10102561.3A HK10102561A HK1137810A1 HK 1137810 A1 HK1137810 A1 HK 1137810A1 HK 10102561 A HK10102561 A HK 10102561A HK 1137810 A1 HK1137810 A1 HK 1137810A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cells
- target
- sample
- target cells
- permanent magnet
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title abstract 3
- 239000012472 biological sample Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 7
- 210000001124 body fluid Anatomy 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000004163 cytometry Methods 0.000 abstract 1
- 239000004205 dimethyl polysiloxane Substances 0.000 abstract 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 238000010191 image analysis Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000006249 magnetic particle Substances 0.000 abstract 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 abstract 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 abstract 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract 1
- 239000012488 sample solution Substances 0.000 abstract 1
- 229920002379 silicone rubber Polymers 0.000 abstract 1
- 239000004945 silicone rubber Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/031,807 US7828968B2 (en) | 2007-08-30 | 2008-02-15 | Method and apparatus for imaging target components in a biological sample using permanent magnets |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1137810A1 true HK1137810A1 (en) | 2010-08-06 |
Family
ID=40506419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10102561.3A HK1137810A1 (en) | 2008-02-15 | 2010-03-11 | Method and apparatus for imaging target components in a biological sample using permanent magnets |
Country Status (7)
Country | Link |
---|---|
US (2) | US7828968B2 (ja) |
EP (1) | EP2090889B1 (ja) |
JP (1) | JP5507092B2 (ja) |
CN (1) | CN101533012B (ja) |
AT (1) | ATE540316T1 (ja) |
ES (1) | ES2377178T3 (ja) |
HK (1) | HK1137810A1 (ja) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003069421A2 (en) * | 2002-02-14 | 2003-08-21 | Immunivest Corporation | Methods and algorithms for cell enumeration in a low-cost cytometer |
US8189899B2 (en) * | 2004-07-30 | 2012-05-29 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
US8110101B2 (en) * | 2007-08-30 | 2012-02-07 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
US7828968B2 (en) * | 2007-08-30 | 2010-11-09 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
US8710836B2 (en) | 2008-12-10 | 2014-04-29 | Nanomr, Inc. | NMR, instrumentation, and flow meter/controller continuously detecting MR signals, from continuously flowing sample material |
US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US9428547B2 (en) | 2010-04-21 | 2016-08-30 | Dna Electronics, Inc. | Compositions for isolating a target analyte from a heterogeneous sample |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
BR112013024148B1 (pt) * | 2011-04-27 | 2022-01-25 | Becton, Dickinson And Company | Dispositivo, método e sistema para separar partes marcadas magneticamente em uma amostra, método de separar partes marcadas magneticamente em uma amostra |
CN103492081B (zh) * | 2011-04-29 | 2017-05-31 | 贝克顿·迪金森公司 | 流体管线式粒子固定和收集系统以及其使用方法 |
WO2014070235A1 (en) | 2012-10-29 | 2014-05-08 | Mbio Diagnostics, Inc. | Biological particle identification system, cartridge and associated methods |
WO2014097991A1 (ja) * | 2012-12-18 | 2014-06-26 | コニカミノルタ株式会社 | 希少細胞検出装置、希少細胞検出方法、希少細胞観察システム、および細胞展開用デバイス |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
DE102013200927A1 (de) * | 2013-01-22 | 2014-07-24 | Siemens Aktiengesellschaft | Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen |
US20150233932A1 (en) * | 2013-02-19 | 2015-08-20 | Ching-Ping Tseng | Methods, Systems, and Compositions for Enrichment of Rare Cells |
WO2015058103A1 (en) * | 2013-10-18 | 2015-04-23 | The Regents Of The University Of California | Method and device for detecting molecules or particles using fractionalized volumes |
US10564100B1 (en) * | 2018-10-12 | 2020-02-18 | SageMedic Corporation | Analysis of viable and nonviable cells |
CN111795919B (zh) * | 2020-05-25 | 2024-03-26 | 中国人民解放军陆军军医大学第二附属医院 | 一种骨髓细胞形态学自动检测系统及其工作方法 |
EP3922991A1 (en) * | 2020-06-10 | 2021-12-15 | PreOmics GmbH | Dispersion using a moving magnet |
CN114002195A (zh) * | 2021-10-22 | 2022-02-01 | 中国科学院广州生物医药与健康研究院 | 一种辅助悬浮细胞成像的系统及其使用方法和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4166768A (en) * | 1977-11-14 | 1979-09-04 | Monsanto Company | Continuous cell culture system |
US4498785A (en) * | 1982-06-09 | 1985-02-12 | Techne Corporation | Floating magnetic stirrer for culture medium |
US4465377A (en) * | 1983-06-07 | 1984-08-14 | Techne Corporation | Magnetic stirrer apparatus with guided, floating stirrer |
US5374531A (en) * | 1993-03-22 | 1994-12-20 | Zynaxis, Inc. | Immunoassay for determination of cells |
IL123210A0 (en) * | 1998-02-06 | 1998-09-24 | Gombinsky Moshe | A device and system for the collection of magnetic particles |
AU760560B2 (en) | 1998-02-12 | 2003-05-15 | Board Of Regents, The University Of Texas System | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
US20010018192A1 (en) | 1998-02-12 | 2001-08-30 | Terstappen Leon W.M.M. | Labeled cells for use as an internal functional control in rare cell detection assays |
JP4121708B2 (ja) * | 1998-10-13 | 2008-07-23 | ガンブロ ルンデイア アクチーボラグ | 生体適合性ポリマーフィルム |
US6551843B1 (en) | 1999-01-29 | 2003-04-22 | Immunivest Corporation | Methods for enhancing binding interactions between members of specific binding pairs |
US6623982B1 (en) | 1999-07-12 | 2003-09-23 | Immunivest Corporation | Increased separation efficiency via controlled aggregation of magnetic nanoparticles |
JP3766064B2 (ja) | 2001-02-12 | 2006-04-12 | イムニベスト・コーポレイション | 光学分析用の標本試料を収容するためのカートリッジ |
BR0207290A (pt) | 2001-02-16 | 2005-06-07 | Immunivest Corp | Método para analisar um paciente quanto à presença de uma malignidade, célula maligna isolada das células cultivadas, vacina de tumor, molécula associada com diátese de tumor alterada, métodos para determinar alterações em moléculas associadas com diátese de tumor como um meio para predizer a eficácia da terapia, como um meio para analisar dosagem apropriada para terapia, como um meio para monitorar eficácia da terapia, como um meio para analisar progressão de câncer, para realizar uma biópsia de corpo inteiro em um paciente, e para identificar alterações em uma célula de tumor circulante relativamente a células presentes numa massa de tumor in situ, e, kit de teste para analisar uma amostra de paciente quanto à presença de uma célula maligna não-hematopoiética |
KR20040053115A (ko) | 2001-08-23 | 2004-06-23 | 이뮤니베스트 코포레이션 | 분석용 세포 및 생물학적 시험편의 안정화 |
WO2003069421A2 (en) | 2002-02-14 | 2003-08-21 | Immunivest Corporation | Methods and algorithms for cell enumeration in a low-cost cytometer |
US7011794B2 (en) | 2002-11-25 | 2006-03-14 | Immunivest Corporation | Upon a cartridge for containing a specimen sample for optical analysis |
WO2006102233A2 (en) | 2005-03-18 | 2006-09-28 | Immunivest Corporation | Method and apparatus for imaging target components in a biological sample using permanent magnets |
US7777885B2 (en) * | 2005-08-17 | 2010-08-17 | Veridex, Llc | Diagnostic imaging device for the analysis of circulating rare cells |
CN200945454Y (zh) * | 2006-06-16 | 2007-09-12 | 复旦大学 | 一种便携式磁性分离笔 |
US7828968B2 (en) * | 2007-08-30 | 2010-11-09 | Veridex, Llc | Method and apparatus for imaging target components in a biological sample using permanent magnets |
-
2008
- 2008-02-15 US US12/031,807 patent/US7828968B2/en active Active
-
2009
- 2009-02-13 EP EP09250366A patent/EP2090889B1/en not_active Not-in-force
- 2009-02-13 CN CN200910130777.9A patent/CN101533012B/zh not_active Expired - Fee Related
- 2009-02-13 ES ES09250366T patent/ES2377178T3/es active Active
- 2009-02-13 JP JP2009032033A patent/JP5507092B2/ja active Active
- 2009-02-13 AT AT09250366T patent/ATE540316T1/de active
-
2010
- 2010-03-11 HK HK10102561.3A patent/HK1137810A1/xx not_active IP Right Cessation
- 2010-09-23 US US12/888,562 patent/US20110014686A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101533012B (zh) | 2013-12-25 |
EP2090889A1 (en) | 2009-08-19 |
US20110014686A1 (en) | 2011-01-20 |
JP2009192539A (ja) | 2009-08-27 |
CN101533012A (zh) | 2009-09-16 |
ATE540316T1 (de) | 2012-01-15 |
ES2377178T3 (es) | 2012-03-23 |
US20090061477A1 (en) | 2009-03-05 |
JP5507092B2 (ja) | 2014-05-28 |
US7828968B2 (en) | 2010-11-09 |
EP2090889B1 (en) | 2012-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200208 |