HK1134519A1 - Method for manufacturing a recombinant polyclonal protein - Google Patents

Method for manufacturing a recombinant polyclonal protein

Info

Publication number
HK1134519A1
HK1134519A1 HK10102454.3A HK10102454A HK1134519A1 HK 1134519 A1 HK1134519 A1 HK 1134519A1 HK 10102454 A HK10102454 A HK 10102454A HK 1134519 A1 HK1134519 A1 HK 1134519A1
Authority
HK
Hong Kong
Prior art keywords
collection
cells
manufacturing
recombinant polyclonal
polyclonal protein
Prior art date
Application number
HK10102454.3A
Other languages
English (en)
Inventor
Lars Soegaard Nielsen
Dietmar Weilguny
Anne Bondgaard Tolstrup
Finn Wiburg
Christian Mueller
Original Assignee
Symphogen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphogen As filed Critical Symphogen As
Publication of HK1134519A1 publication Critical patent/HK1134519A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Non-Volatile Memory (AREA)
HK10102454.3A 2007-05-25 2010-03-09 Method for manufacturing a recombinant polyclonal protein HK1134519A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200700764 2007-05-25
US92470807P 2007-05-29 2007-05-29
DKPA200701292 2007-09-07
US96000207P 2007-09-11 2007-09-11
PCT/DK2008/050116 WO2008145133A2 (en) 2007-05-25 2008-05-21 Method for manufacturing a recombinant polyclonal protein

Publications (1)

Publication Number Publication Date
HK1134519A1 true HK1134519A1 (en) 2010-04-30

Family

ID=39739965

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10102454.3A HK1134519A1 (en) 2007-05-25 2010-03-09 Method for manufacturing a recombinant polyclonal protein

Country Status (23)

Country Link
US (1) US7910332B2 (hr)
EP (1) EP2152872B1 (hr)
JP (2) JP5941616B2 (hr)
KR (1) KR101555658B1 (hr)
CN (1) CN101688204B (hr)
AT (1) ATE481483T1 (hr)
AU (1) AU2008255383B2 (hr)
BR (1) BRPI0812091A2 (hr)
CA (1) CA2683800C (hr)
CY (1) CY1110939T1 (hr)
DE (1) DE602008002593D1 (hr)
DK (1) DK2152872T3 (hr)
HK (1) HK1134519A1 (hr)
HR (1) HRP20100640T1 (hr)
IL (1) IL201395A (hr)
MX (1) MX2009012526A (hr)
NZ (1) NZ581316A (hr)
PL (1) PL2152872T3 (hr)
PT (1) PT2152872E (hr)
SI (1) SI2152872T1 (hr)
TW (1) TW200902548A (hr)
WO (1) WO2008145133A2 (hr)
ZA (1) ZA200908021B (hr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2512647C (en) 2003-01-07 2013-10-08 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
MX2009008908A (es) * 2007-03-01 2009-08-28 Symphogen As Metodo para clonacion de anticuerpos analogos.
NZ581316A (en) * 2007-05-25 2012-02-24 Symphogen As Method for manufacturing a recombinant polyclonal protein
MX2010002044A (es) * 2007-09-07 2010-03-18 Symphogen As Metodos para produccion recombinante de anticuerpos anti-virus sincitial respiratorio (anti-rsv).
NZ586957A (en) * 2008-02-01 2014-03-28 Chromocell Corp Cell lines and methods for making and using them
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
JP2011518790A (ja) * 2008-04-23 2011-06-30 シムフォゲン・アクティーゼルスカブ ポリクローナルタンパク質を製造する方法
EP2297331B1 (en) * 2008-05-28 2015-03-25 Bayer HealthCare, LLC Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells
RU2011111725A (ru) * 2008-08-29 2012-10-10 Симфоген А/С (Dk) Способ клонирования антител птиц
WO2010089387A1 (en) 2009-02-09 2010-08-12 Morphosys Ag Production of oligoclonal mixtures of immunoglobulins in single cells
EP2635604B1 (en) 2010-11-01 2016-11-30 Symphogen A/S Pan-her antibody composition
EP2640743B1 (en) 2010-11-16 2016-10-05 Excelimmune, Inc. Methods for producing recombinant proteins
CN102558353A (zh) * 2011-12-09 2012-07-11 上海应用技术学院 一种大肠杆菌NrfA基因表达蛋白多克隆抗体及其制备方法
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
JP6325527B2 (ja) 2012-05-02 2018-05-16 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ ヒト化ｐａｎ−ｈｅｒ抗体組成物
JP2016514091A (ja) 2013-02-08 2016-05-19 ミスフォールディング ダイアグノスティクス， インコーポレイテッド トランスサイレチン抗体およびその使用
AU2015316522B2 (en) 2014-09-16 2021-01-21 Symphogen A/S Anti-met antibodies and compositions
US20170044608A1 (en) * 2015-07-17 2017-02-16 Allele Biotechnology & Pharmaceuticals, Inc. Methods of selecting antibodies and antibody fragments
KR20180096793A (ko) * 2016-01-14 2018-08-29 안톤 바우어 생산 세포주를 제조하는 방법
WO2018073393A2 (en) 2016-10-19 2018-04-26 Cellectis Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
EP4116328A1 (en) 2017-04-05 2023-01-11 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Combination therapies targeting pd-1, tim-3, and lag-3
EP3810649A1 (en) 2018-06-22 2021-04-28 Genmab A/S Method for producing a controlled mixture of two or more different antibodies
CA3118692A1 (en) 2018-11-06 2020-05-14 Alsatech, Inc. Cell-based gene therapy for neurodegenerative diseases
CN109988751A (zh) * 2019-01-15 2019-07-09 济宁学院 一种用于制备抗egfr全人源化单克隆抗体的细胞株构建方法
EP3962941A4 (en) * 2019-04-30 2023-05-10 Gigagen, Inc. RECOMBINANT POLYCLONAL PROTEINS AND METHODS OF USE THEREOF
KR20220069052A (ko) * 2019-09-27 2022-05-26 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 클론 세포주의 생산 안정성을 예측하는 방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016074A1 (en) 1990-04-19 1991-10-31 Medimmune, Inc. Administration of monoclonal antibodies against respiratory viruses
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
EP1293564A4 (en) * 2000-06-08 2005-08-17 Mitsubishi Pharma Corp EXPRESSION VECTOR FOR SCREENING CELLS HIGH EXPRESSION OF RECOMBINANT PROTEINS, TRANSFORMING HIGH EXPRESSION OF A RECOMBINANT PROTEIN AND USE THEREOF
US6849259B2 (en) * 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy
NZ537277A (en) * 2002-07-18 2008-04-30 Crucell Holland Bv Recombinant production of mixtures of antibodies
WO2004029284A2 (en) * 2002-09-30 2004-04-08 Protein Design Labs, Inc. Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes
CN100383244C (zh) * 2003-01-07 2008-04-23 西福根有限公司 用于生产重组多克隆蛋白质的方法
US20060275766A1 (en) * 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins
CA2512647C (en) * 2003-01-07 2013-10-08 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
MX2007000644A (es) * 2004-07-20 2007-03-28 Symphogen As Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion.
NZ552264A (en) * 2004-07-20 2010-03-26 Symphogen As A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
AU2006322445B2 (en) 2005-12-05 2011-05-12 Symphogen A/S Anti-orthopoxvirus recombinant polyclonal antibody
JP2009528828A (ja) 2006-03-06 2009-08-13 シムフォゲン・アクティーゼルスカブ 消化器多核体ウイルス感染症の治療のための組み換えポリクローナル抗体
NZ581316A (en) * 2007-05-25 2012-02-24 Symphogen As Method for manufacturing a recombinant polyclonal protein

Also Published As

Publication number Publication date
US7910332B2 (en) 2011-03-22
NZ581316A (en) 2012-02-24
IL201395A0 (en) 2011-08-01
IL201395A (en) 2015-09-24
DE602008002593D1 (de) 2010-10-28
CY1110939T1 (el) 2015-06-10
US20090111142A1 (en) 2009-04-30
JP2011504721A (ja) 2011-02-17
PT2152872E (pt) 2010-11-17
HRP20100640T1 (hr) 2010-12-31
DK2152872T3 (da) 2010-12-06
CN101688204A (zh) 2010-03-31
MX2009012526A (es) 2009-12-09
TW200902548A (en) 2009-01-16
CA2683800A1 (en) 2008-12-04
KR101555658B1 (ko) 2015-09-24
EP2152872B1 (en) 2010-09-15
EP2152872A2 (en) 2010-02-17
AU2008255383B2 (en) 2012-11-01
CN101688204B (zh) 2013-07-03
WO2008145133A2 (en) 2008-12-04
KR20100017923A (ko) 2010-02-16
CA2683800C (en) 2015-03-17
ZA200908021B (en) 2010-11-24
SI2152872T1 (sl) 2011-01-31
JP2015037411A (ja) 2015-02-26
ATE481483T1 (de) 2010-10-15
AU2008255383A1 (en) 2008-12-04
BRPI0812091A2 (pt) 2014-10-14
WO2008145133A3 (en) 2009-02-05
JP5941616B2 (ja) 2016-06-29
PL2152872T3 (pl) 2011-03-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140521