HK1124068A1 - 2-arylindole derivatives as mpges-1 inhibitors - Google Patents

2-arylindole derivatives as mpges-1 inhibitors

Info

Publication number
HK1124068A1
HK1124068A1 HK09104184.9A HK09104184A HK1124068A1 HK 1124068 A1 HK1124068 A1 HK 1124068A1 HK 09104184 A HK09104184 A HK 09104184A HK 1124068 A1 HK1124068 A1 HK 1124068A1
Authority
HK
Hong Kong
Prior art keywords
mpges
inhibitors
arylindole derivatives
arylindole
derivatives
Prior art date
Application number
HK09104184.9A
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Barbara Garofalo
Guido Furlotti
Caterina Maugeri
Rosella Ombrato
Isabella Coletta
Lorenzo Polenzani
Giorgina Mangano
Beatrice Garrone
Angelo Guglielmotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of HK1124068A1 publication Critical patent/HK1124068A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK09104184.9A 2006-07-14 2009-05-06 2-arylindole derivatives as mpges-1 inhibitors HK1124068A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001368A ITMI20061368A1 (it) 2006-07-14 2006-07-14 Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
PCT/EP2007/055901 WO2008006663A1 (fr) 2006-07-14 2007-06-14 Dérivés de 2-arylindole utilisés comme inhibiteurs de npges-i

Publications (1)

Publication Number Publication Date
HK1124068A1 true HK1124068A1 (en) 2009-08-07

Family

ID=37895798

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09104184.9A HK1124068A1 (en) 2006-07-14 2009-05-06 2-arylindole derivatives as mpges-1 inhibitors

Country Status (22)

Country Link
US (1) US8017644B2 (fr)
EP (1) EP2049480B1 (fr)
JP (1) JP5302191B2 (fr)
KR (2) KR101440015B1 (fr)
CN (1) CN101490000B (fr)
AR (1) AR061973A1 (fr)
AU (1) AU2007271865B2 (fr)
BR (1) BRPI0712889A8 (fr)
CA (1) CA2655750C (fr)
DK (1) DK2049480T3 (fr)
EA (1) EA015689B1 (fr)
ES (1) ES2441594T3 (fr)
GE (1) GEP20115166B (fr)
HK (1) HK1124068A1 (fr)
IL (1) IL196000A (fr)
IT (1) ITMI20061368A1 (fr)
MX (1) MX2009000492A (fr)
PL (1) PL2049480T3 (fr)
PT (1) PT2049480E (fr)
SI (1) SI2049480T1 (fr)
UA (1) UA96759C2 (fr)
WO (1) WO2008006663A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078711A1 (fr) * 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Dérivés (aza)indole substitués en position 5, compositions pharmaceutiques, composés intermédiaires et procédé de préparation
TW201100398A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted indolo-pyridinone compounds
WO2011077313A1 (fr) 2009-12-22 2011-06-30 Pfizer Inc. Pipéridinecarboxamides en tant qu'inhibiteurs de mpges - 1
BR112014003496B1 (pt) 2011-08-18 2022-02-22 Nippon Shinyaku Co., Ltd Derivado heterocíclico, usos do mesmo e composição farmacêutica
WO2013038308A1 (fr) * 2011-09-15 2013-03-21 Glenmark Pharmaceuticals S.A. Composés à base d'hétéroaryle bicyclique substitué capables d'inhiber mpges-1
MX368504B (es) * 2014-04-14 2019-10-04 Shanghai hengrui pharmaceutical co ltd Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos.
JPWO2016021706A1 (ja) * 2014-08-08 2017-05-25 カズマパートナーズ株式会社 縮合複素環化合物
MA54133B1 (fr) 2018-03-08 2022-01-31 Incyte Corp Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
JP7337260B2 (ja) * 2019-08-26 2023-09-01 クッジェ ファーマ カンパニー，リミテッド インドールカルボキサミド誘導体及びそれを含む薬剤学的組成物
WO2021231474A1 (fr) * 2020-05-12 2021-11-18 Pmv Pharmaceuticals, Inc. Méthodes et composés pour la restauration de la fonction du p53 mutant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270426A1 (en) * 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
CN101328135A (zh) * 2003-02-07 2008-12-24 小野药品工业株式会社 羧酸化合物
BRPI0414130B8 (pt) * 2003-09-03 2021-05-25 Askat Inc compostos de fenilamida ou piridilamida, seu uso e composições farmacêuticas que os compreendem.
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
SI2049480T1 (sl) 2014-02-28
UA96759C2 (en) 2011-12-12
IL196000A0 (en) 2009-09-01
CA2655750A1 (fr) 2008-01-17
JP5302191B2 (ja) 2013-10-02
US20090186922A1 (en) 2009-07-23
US8017644B2 (en) 2011-09-13
DK2049480T3 (da) 2014-01-20
GEP20115166B (en) 2011-02-25
PL2049480T3 (pl) 2014-03-31
AR061973A1 (es) 2008-08-10
AU2007271865B2 (en) 2013-02-21
KR101440015B1 (ko) 2014-09-12
KR20140091569A (ko) 2014-07-21
EA200970124A1 (ru) 2009-06-30
BRPI0712889A2 (pt) 2012-10-09
EA015689B1 (ru) 2011-10-31
CA2655750C (fr) 2014-09-09
KR20090054962A (ko) 2009-06-01
AU2007271865A1 (en) 2008-01-17
MX2009000492A (es) 2009-01-27
PT2049480E (pt) 2013-12-16
EP2049480B1 (fr) 2013-10-30
IL196000A (en) 2013-10-31
ES2441594T3 (es) 2014-02-05
JP2009543766A (ja) 2009-12-10
EP2049480A1 (fr) 2009-04-22
CN101490000A (zh) 2009-07-22
CN101490000B (zh) 2012-10-03
ITMI20061368A1 (it) 2008-01-15
BRPI0712889A8 (pt) 2018-01-02
WO2008006663A1 (fr) 2008-01-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180614