HK1123296A1 - Pyrazine derivatives and use as pi3k inhibitors - Google Patents
Pyrazine derivatives and use as pi3k inhibitorsInfo
- Publication number
- HK1123296A1 HK1123296A1 HK09101033.8A HK09101033A HK1123296A1 HK 1123296 A1 HK1123296 A1 HK 1123296A1 HK 09101033 A HK09101033 A HK 09101033A HK 1123296 A1 HK1123296 A1 HK 1123296A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pi3k inhibitors
- pyrazine derivatives
- pyrazine
- derivatives
- pi3k
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71187305P | 2005-08-26 | 2005-08-26 | |
EP05107838 | 2005-08-26 | ||
PCT/EP2006/065688 WO2007023186A1 (en) | 2005-08-26 | 2006-08-25 | Pyrazine derivatives and use as pi3k inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1123296A1 true HK1123296A1 (en) | 2009-06-12 |
Family
ID=35276409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09101033.8A HK1123296A1 (en) | 2005-08-26 | 2009-02-05 | Pyrazine derivatives and use as pi3k inhibitors |
Country Status (18)
Country | Link |
---|---|
US (3) | US8071597B2 (he) |
EP (2) | EP1917252B1 (he) |
JP (1) | JP5226513B2 (he) |
KR (1) | KR20080049767A (he) |
CN (1) | CN101296909B (he) |
AU (1) | AU2006283846B2 (he) |
BR (1) | BRPI0615233A2 (he) |
CA (1) | CA2618479C (he) |
EA (1) | EA015937B1 (he) |
EC (1) | ECSP088215A (he) |
ES (1) | ES2456000T3 (he) |
HK (1) | HK1123296A1 (he) |
IL (1) | IL189737A (he) |
MX (1) | MX2008002723A (he) |
NZ (1) | NZ565749A (he) |
UA (1) | UA100358C2 (he) |
WO (1) | WO2007023186A1 (he) |
ZA (1) | ZA200801822B (he) |
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EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
AU2007284562B2 (en) | 2006-08-16 | 2013-05-02 | Exelixis, Inc. | Using PI3K and MEK modulators in treatments of cancer |
US8614215B2 (en) * | 2007-02-22 | 2013-12-24 | Merck Serono Sa | Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks) |
ES2446417T3 (es) | 2007-03-23 | 2014-03-07 | Amgen Inc. | Derivados de quinolina o quinoxalina sustituidos en 3 y su uso como inhibidores de fosfatidilinositol 3-cinasa (PI3K) |
WO2008127594A2 (en) * | 2007-04-11 | 2008-10-23 | Exelixis, Inc. | Combination therapies comprising quinoxaline inhibitors of pi3k-alpha for use in the treatment of cancer |
WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
CA2706436A1 (en) | 2007-11-20 | 2009-09-03 | 3M Innovative Properties Company | Environmental sampling articles and methods |
WO2009082667A1 (en) | 2007-12-21 | 2009-07-02 | 3M Innovative Properties Company | Microbiological systems and methods of fluid sample analysis |
WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
JP5687903B2 (ja) * | 2008-11-10 | 2015-03-25 | 協和発酵キリン株式会社 | キヌレニン産生抑制剤 |
US20120121515A1 (en) | 2009-03-13 | 2012-05-17 | Lenny Dang | Methods and compositions for cell-proliferation-related disorders |
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PL2427441T3 (pl) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Aktywatory PKM2 do stosowania w leczeniu raka |
ES2632954T3 (es) | 2009-06-29 | 2017-09-18 | Agios Pharmaceuticals, Inc. | Derivados de quinolina-8-sulfonamida que tienen una actividad anticancerosa |
PL2448581T3 (pl) | 2009-06-29 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Kompozycje terapeutyczne i odnośne sposoby ich stosowania |
US9649331B2 (en) * | 2009-08-27 | 2017-05-16 | Ara Medical Llc | Sprayable polymers as adhesion barriers |
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EP2519821B1 (en) | 2009-12-30 | 2016-11-30 | 3M Innovative Properties Company | Microbial detection article |
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TWI535442B (zh) | 2010-05-10 | 2016-06-01 | Kyowa Hakko Kirin Co Ltd | A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine |
CN102311396B (zh) | 2010-07-05 | 2015-01-07 | 暨南大学 | 一种吡嗪类衍生物和其制备方法及在制药中的应用 |
CN103270027A (zh) * | 2010-10-20 | 2013-08-28 | 默克雪兰诺日内瓦有限公司 | 制备取代的n-(3-氨基-喹喔啉-2-基)-磺酰胺和它们的中间体n-(3-氯-喹喔啉-2-基)-磺酰胺的方法 |
DE102010048800A1 (de) * | 2010-10-20 | 2012-05-10 | Merck Patent Gmbh | Chinoxalinderivate |
DE102010049595A1 (de) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | Chinazolinderivate |
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EP2518071A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Imidazopyridine derivatives as PI3K inhibitors |
EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
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JP2006137723A (ja) * | 2004-11-15 | 2006-06-01 | Kyowa Hakko Kogyo Co Ltd | スルホンアミド誘導体 |
RU2453540C2 (ru) * | 2005-04-21 | 2012-06-20 | Лаборатуар Сероно С.А. | 2,3-замещенные пиразинсульфонамиды в качестве ингибиторов crth2 |
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EP2351745A1 (en) | 2011-08-03 |
CN101296909B (zh) | 2011-10-12 |
EP1917252A1 (en) | 2008-05-07 |
EA200800668A1 (ru) | 2008-08-29 |
CA2618479C (en) | 2014-12-30 |
KR20080049767A (ko) | 2008-06-04 |
US20110319410A1 (en) | 2011-12-29 |
EA015937B1 (ru) | 2011-12-30 |
JP2009506015A (ja) | 2009-02-12 |
ES2456000T3 (es) | 2014-04-21 |
US20090082356A1 (en) | 2009-03-26 |
ECSP088215A (es) | 2008-03-26 |
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US20110312960A1 (en) | 2011-12-22 |
US8877757B2 (en) | 2014-11-04 |
IL189737A (he) | 2015-02-26 |
UA100358C2 (xx) | 2012-12-25 |
CN101296909A (zh) | 2008-10-29 |
US8071597B2 (en) | 2011-12-06 |
JP5226513B2 (ja) | 2013-07-03 |
NZ565749A (en) | 2010-12-24 |
MX2008002723A (es) | 2008-03-26 |
BRPI0615233A2 (pt) | 2011-05-10 |
IL189737A0 (en) | 2008-08-07 |
AU2006283846B2 (en) | 2012-04-05 |
EP1917252B1 (en) | 2014-01-01 |
CA2618479A1 (en) | 2007-03-01 |
WO2007023186A1 (en) | 2007-03-01 |
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