HK1122839A1 - Phage display using contranslational translocation of fusion polypeptides - Google Patents

Phage display using contranslational translocation of fusion polypeptides

Info

Publication number
HK1122839A1
HK1122839A1 HK08113901.3A HK08113901A HK1122839A1 HK 1122839 A1 HK1122839 A1 HK 1122839A1 HK 08113901 A HK08113901 A HK 08113901A HK 1122839 A1 HK1122839 A1 HK 1122839A1
Authority
HK
Hong Kong
Prior art keywords
phage
translocation
polypeptides
phage display
contranslational
Prior art date
Application number
HK08113901.3A
Other languages
English (en)
Inventor
Daniel Steiner
Patrik Forrer
Michael T Stumpp
Andreas Plueckthun
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Publication of HK1122839A1 publication Critical patent/HK1122839A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
HK08113901.3A 2005-07-08 2008-12-23 Phage display using contranslational translocation of fusion polypeptides HK1122839A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106236 2005-07-08
PCT/EP2006/063729 WO2007006665A1 (en) 2005-07-08 2006-06-30 Phage display using cotranslational translocation of fusion polypeptides

Publications (1)

Publication Number Publication Date
HK1122839A1 true HK1122839A1 (en) 2009-05-29

Family

ID=35063135

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08113901.3A HK1122839A1 (en) 2005-07-08 2008-12-23 Phage display using contranslational translocation of fusion polypeptides

Country Status (21)

Country Link
US (2) US8846577B2 (de)
EP (1) EP1902131B1 (de)
JP (1) JP5042218B2 (de)
KR (1) KR101268939B1 (de)
CN (1) CN101213299B (de)
AT (1) ATE448305T1 (de)
AU (1) AU2006268780B2 (de)
BR (1) BRPI0613593A2 (de)
CA (1) CA2614512C (de)
DE (1) DE602006010386D1 (de)
DK (1) DK1902131T3 (de)
ES (1) ES2335136T3 (de)
HK (1) HK1122839A1 (de)
IL (1) IL188518A (de)
MX (1) MX2008000345A (de)
NO (1) NO20080665L (de)
NZ (1) NZ564695A (de)
PL (1) PL1902131T3 (de)
RU (1) RU2412249C2 (de)
WO (1) WO2007006665A1 (de)
ZA (1) ZA200710687B (de)

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US8901076B2 (en) 2008-11-03 2014-12-02 Molecular Partner AG Binding proteins inhibiting the VEGF-A receptor interaction
GB0917647D0 (en) * 2009-10-08 2009-11-25 Glaxosmithkline Biolog Sa Expression system
MX2012005168A (es) * 2009-11-05 2012-06-08 Genentech Inc Metodos y composicion para secrecion de polipeptidos heterologos.
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
CN103459415B (zh) 2010-11-26 2021-04-09 分子组合公司 设计的与血清白蛋白结合的重复蛋白
ES2717657T3 (es) 2011-02-15 2019-06-24 Immunogen Inc Métodos para la preparación de conjugados
TW201302779A (zh) * 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗
KR20140039203A (ko) 2011-04-29 2014-04-01 얀센 바이오테크 인코포레이티드 Il4/il13 결합 반복 단백질 및 용도
BR112013032928A2 (pt) 2011-06-21 2017-01-24 Immunogen Inc "derivados de maitansinoide com ligante de peptídeo e conjugados dos mesmos, composição farmacêutica que os compreende e uso dos mesmos"
CN104508129A (zh) 2012-06-28 2015-04-08 分子伴侣公司 设计的与血小板衍生生长因子结合的锚蛋白重复序列蛋白
US9956341B2 (en) 2012-07-03 2018-05-01 Milestone Scientific, Inc. Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces
EP2887965A1 (de) 2012-08-22 2015-07-01 ImmunoGen, Inc. Zytotoxische benzodiazepin-derivate
EP2738180A1 (de) 2012-11-30 2014-06-04 Molecular Partners AG Bindeproteine mit mindestens zwei Bindedomänen gegen HER2
JP6423804B2 (ja) 2013-02-28 2018-11-14 イミュノジェン・インコーポレーテッド 細胞結合剤及び細胞毒性剤を含む複合体
EP2961434A2 (de) 2013-02-28 2016-01-06 ImmunoGen, Inc. Konjugate mit zellbindenden mitteln und zytostatika
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WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
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MA39776A (fr) 2014-03-24 2017-02-01 Hoffmann La Roche Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
WO2016036804A1 (en) 2014-09-03 2016-03-10 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
PT3189056T (pt) 2014-09-03 2020-09-04 Immunogen Inc Derivados citotóxicos de benzodiazepina
CN107454904A (zh) 2015-04-02 2017-12-08 分子组合公司 对血清白蛋白具有结合特异性的经设计的锚蛋白重复结构域
US10220180B2 (en) 2015-10-16 2019-03-05 Milestone Scientific, Inc. Method and apparatus for performing a peripheral nerve block
WO2018045184A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Engineered bacteria secreting therapeutic proteins and methods of use thereof
BR112019005587A2 (pt) 2016-09-22 2019-06-11 Molecular Partners Ag proteínas de ligação recombinantes e sua utilização
US10632255B2 (en) 2017-02-15 2020-04-28 Milestone Scientific, Inc. Drug infusion device
US10792372B2 (en) 2017-02-28 2020-10-06 Immunogen, Inc. Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
US20180346488A1 (en) 2017-04-20 2018-12-06 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
US11471595B2 (en) 2017-05-04 2022-10-18 Milestone Scientific, Inc. Method and apparatus for performing a peripheral nerve block
US11793885B2 (en) 2017-12-28 2023-10-24 Immunogen, Inc. Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders
AU2020240310A1 (en) 2019-03-21 2021-10-07 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
KR20220010481A (ko) 2019-03-29 2022-01-25 이뮤노젠 아이엔씨 비정상 세포 성장의 억제 또는 증식성 질환의 치료를 위한 세포독성 비스-벤조디아제핀 유도체 및 세포결합제와 이의 접합체
JP2022529854A (ja) 2019-04-26 2022-06-24 イミュノジェン・インコーポレーテッド カンプトテシン誘導体
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Also Published As

Publication number Publication date
AU2006268780A1 (en) 2007-01-18
ZA200710687B (en) 2008-11-26
WO2007006665A1 (en) 2007-01-18
CA2614512C (en) 2014-01-07
RU2008104174A (ru) 2009-08-20
US20150057186A1 (en) 2015-02-26
JP2009500027A (ja) 2009-01-08
BRPI0613593A2 (pt) 2011-01-18
RU2412249C2 (ru) 2011-02-20
EP1902131A1 (de) 2008-03-26
ATE448305T1 (de) 2009-11-15
DE602006010386D1 (en) 2009-12-24
IL188518A0 (en) 2008-04-13
NO20080665L (no) 2008-02-05
US9447142B2 (en) 2016-09-20
NZ564695A (en) 2009-02-28
KR101268939B1 (ko) 2013-05-30
CN101213299B (zh) 2013-03-27
CN101213299A (zh) 2008-07-02
EP1902131B1 (de) 2009-11-11
MX2008000345A (es) 2008-04-02
ES2335136T3 (es) 2010-03-22
IL188518A (en) 2011-04-28
US20110118146A1 (en) 2011-05-19
US8846577B2 (en) 2014-09-30
KR20080035603A (ko) 2008-04-23
CA2614512A1 (en) 2007-01-18
AU2006268780B2 (en) 2011-03-24
PL1902131T3 (pl) 2010-05-31
JP5042218B2 (ja) 2012-10-03
DK1902131T3 (da) 2010-03-01

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180630