HK1118823A1 - - Google Patents

Info

Publication number
HK1118823A1
HK1118823A1 HK08112617.0A HK08112617A HK1118823A1 HK 1118823 A1 HK1118823 A1 HK 1118823A1 HK 08112617 A HK08112617 A HK 08112617A HK 1118823 A1 HK1118823 A1 HK 1118823A1
Authority
HK
Hong Kong
Application number
HK08112617.0A
Inventor
Timothy D Machajewski
Cynthia M Shafer
Christopher Mcbride
William Antonios-Mccrea
Brandon M Doughan
Barry H Levine
Yi Xia
Maureen Mckenna
X Michael Wang
Kris Mendenhall
Yasheen Zhou
Baoqing Gong
Dan Gu
John Dolan
John Tulinsky
Kristin Brinner
Zhenhai Gao
Paul A Renhowe
Daniel Poon
Paul A Barsanti
Xiaodong Lin
Teresa Pick
Abran Costales
Nathan Brammeier
Alice Rico
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1118823A1 publication Critical patent/HK1118823A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
HK08112617.0A 2005-09-30 2008-11-19 HK1118823A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US83688606P 2006-08-09 2006-08-09
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (1)

Publication Number Publication Date
HK1118823A1 true HK1118823A1 (ja) 2009-02-20

Family

ID=37661234

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08112617.0A HK1118823A1 (ja) 2005-09-30 2008-11-19

Country Status (32)

Country Link
US (2) US7671059B2 (ja)
EP (1) EP1928875B1 (ja)
JP (2) JP5036002B2 (ja)
KR (1) KR101311757B1 (ja)
AR (1) AR058072A1 (ja)
AT (1) ATE514694T1 (ja)
AU (1) AU2006297124B2 (ja)
BR (1) BRPI0616701A2 (ja)
CA (1) CA2624253C (ja)
CR (1) CR9846A (ja)
CY (1) CY1112028T1 (ja)
DK (1) DK1928875T3 (ja)
EA (1) EA016152B1 (ja)
EC (1) ECSP088324A (ja)
GE (1) GEP20115231B (ja)
HK (1) HK1118823A1 (ja)
HR (1) HRP20110655T1 (ja)
IL (1) IL190446A0 (ja)
JO (1) JO2783B1 (ja)
MA (1) MA29885B1 (ja)
ME (1) ME01952B (ja)
MY (1) MY143604A (ja)
NO (1) NO342258B1 (ja)
NZ (1) NZ566914A (ja)
PE (1) PE20070621A1 (ja)
PL (1) PL1928875T3 (ja)
PT (1) PT1928875E (ja)
RS (1) RS51795B (ja)
SM (1) SMP200800029B (ja)
TN (1) TNSN08143A1 (ja)
TW (1) TWI373471B (ja)
WO (1) WO2007041362A1 (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
GEP20125718B (en) * 2008-02-01 2012-12-25 Takeda Pharmaceuticals Co Oxim derivatives as hsp90 inhibitors
US8759010B2 (en) 2008-09-26 2014-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Host cell kinases as targets for antiviral therapies against HCV infection
CA2742743C (en) * 2008-11-28 2017-05-23 Novartis Ag Pharmaceutical combinations comprising a pyrido [4,3-d] pyrimidine derived hsp90-inhibitor and a her2 inhibitor
JP2012510444A (ja) * 2008-11-28 2012-05-10 ノバルティス アーゲー 治療的処置のためのHsp90阻害剤
CA2744937C (en) * 2008-11-28 2017-02-28 Novartis Ag Pharmaceutical combination comprising a hsp 90 inhibitor and a mtor inhibitor
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
SG10201407012XA (en) * 2009-10-29 2014-11-27 Genosco Kinase inhibitors
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
RU2017119219A (ru) 2011-10-14 2018-11-02 Новартис Аг 2-карбоксамид циклоамино производные мочевины в комбинации с ингибиторами hsp90 для лечения пролиферативных заболеваний
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
IN2015DN04175A (ja) 2012-11-07 2015-10-16 Novartis Ag
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
EP3053578B1 (en) 2013-09-30 2020-12-23 Taiho Pharmaceutical Co., Ltd. Combination cancer therapy using azabicyclo compound
JP2017525734A (ja) * 2014-09-02 2017-09-07 ピエール、ファーブル、メディカマン 癌の治療において有用なイソキノリノン誘導体
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
CN115916752A (zh) * 2020-06-26 2023-04-04 日本农药株式会社 芳基四氢吡啶衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd 2−ピペラジノピリミジン誘導体
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
IL85347A0 (en) 1987-02-11 1988-07-31 May & Baker Ltd Cyclic diones
ATE305303T1 (de) * 2001-02-12 2005-10-15 Hoffmann La Roche 6-substituierte pyridopyrimidine
DE102004018198A1 (de) * 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
CA2584507C (en) 2004-10-20 2016-04-26 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US20100152206A1 (en) * 2005-01-07 2010-06-17 Ralph Mazitschek Bicyclic Dihydropyrimidines and Uses Thereof
AU2006236557A1 (en) * 2005-04-14 2006-10-26 Novartis Vaccines And Diagnostics Inc. 2-amino-quinazolin-5-ones as HSP90 inhibitors useful in treating proliferation diseases

Also Published As

Publication number Publication date
EA016152B1 (ru) 2012-02-28
IL190446A0 (en) 2008-11-03
KR20080057318A (ko) 2008-06-24
RS51795B (en) 2011-12-31
AU2006297124B2 (en) 2011-12-08
PE20070621A1 (es) 2007-09-06
AU2006297124A1 (en) 2007-04-12
ATE514694T1 (de) 2011-07-15
TWI373471B (en) 2012-10-01
EA200800992A1 (ru) 2008-10-30
NZ566914A (en) 2011-09-30
SMAP200800029A (it) 2008-05-07
SMP200800029B (it) 2008-05-07
JP2012158611A (ja) 2012-08-23
NO342258B1 (no) 2018-04-30
CA2624253A1 (en) 2007-04-12
EP1928875A1 (en) 2008-06-11
ME01952B (en) 2011-12-31
PT1928875E (pt) 2011-09-06
JP5036002B2 (ja) 2012-09-26
BRPI0616701A2 (pt) 2011-06-28
TW200728304A (en) 2007-08-01
NO20082069L (no) 2008-06-09
TNSN08143A1 (en) 2009-07-14
US20100004237A1 (en) 2010-01-07
US7671059B2 (en) 2010-03-02
JP2009510108A (ja) 2009-03-12
MA29885B1 (fr) 2008-10-03
EP1928875B1 (en) 2011-06-29
HRP20110655T1 (hr) 2011-10-31
ECSP088324A (es) 2008-04-28
KR101311757B1 (ko) 2013-09-26
PL1928875T3 (pl) 2011-11-30
AR058072A1 (es) 2008-01-23
WO2007041362A1 (en) 2007-04-12
DK1928875T3 (da) 2011-10-03
MY143604A (en) 2011-06-15
CA2624253C (en) 2015-06-16
JO2783B1 (en) 2014-03-15
CY1112028T1 (el) 2015-11-04
US20070123546A1 (en) 2007-05-31
CR9846A (es) 2008-08-01
GEP20115231B (en) 2011-06-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191001