HK1114173A1 - Methods and compositions for the detection of biological molecules using a two particle complex - Google Patents

Methods and compositions for the detection of biological molecules using a two particle complex

Info

Publication number
HK1114173A1
HK1114173A1 HK08103920.1A HK08103920A HK1114173A1 HK 1114173 A1 HK1114173 A1 HK 1114173A1 HK 08103920 A HK08103920 A HK 08103920A HK 1114173 A1 HK1114173 A1 HK 1114173A1
Authority
HK
Hong Kong
Prior art keywords
compositions
detection
methods
biological molecules
particle complex
Prior art date
Application number
HK08103920.1A
Other languages
English (en)
Chinese (zh)
Inventor
Allen Bard
Wujiam Miao
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1114173(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Texas filed Critical Univ Texas
Publication of HK1114173A1 publication Critical patent/HK1114173A1/xx

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
HK08103920.1A 2004-06-23 2008-04-08 Methods and compositions for the detection of biological molecules using a two particle complex HK1114173A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58171904P 2004-06-23 2004-06-23
PCT/US2005/022388 WO2006083305A2 (en) 2004-06-23 2005-06-23 Methods and compositions for the detection of biological molecules using a two particle complex

Publications (1)

Publication Number Publication Date
HK1114173A1 true HK1114173A1 (en) 2008-10-24

Family

ID=36777656

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08103920.1A HK1114173A1 (en) 2004-06-23 2008-04-08 Methods and compositions for the detection of biological molecules using a two particle complex

Country Status (9)

Country Link
US (3) US8188243B2 (ja)
EP (1) EP1787124A2 (ja)
JP (1) JP5118964B2 (ja)
KR (1) KR101076578B1 (ja)
CN (1) CN101057145B (ja)
AU (1) AU2005326758B2 (ja)
CA (1) CA2571283C (ja)
HK (1) HK1114173A1 (ja)
WO (1) WO2006083305A2 (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
JP5118964B2 (ja) 2004-06-23 2013-01-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物
SI2271938T1 (sl) * 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
WO2009137002A2 (en) 2008-05-08 2009-11-12 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
JP5455878B2 (ja) 2010-11-30 2014-03-26 シスメックス株式会社 被検物質の電気化学的検出方法
CN102183657B (zh) * 2011-02-24 2014-02-05 南京基蛋生物科技有限公司 一种依赖聚苯乙烯纳米粒大幅度增加化学发光磁酶免疫灵敏度的方法
US20150087526A1 (en) * 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
CN102854183A (zh) * 2012-09-04 2013-01-02 上海师范大学 一种固态电化学发光检测三聚氰胺的方法
GB201218555D0 (en) * 2012-10-16 2012-11-28 Mode Diagnostics Ltd Immunoassay using electrochemical detection
US20170059567A1 (en) * 2013-10-07 2017-03-02 The University Of Utah Research Foundation Methods and systems for electrochemically detecting or quantifying an analyte
CN106248659A (zh) * 2016-09-14 2016-12-21 燕山大学 一种晶相依赖有机半导体微纳电化学发光传感器及其应用
CN106596972B (zh) * 2016-12-16 2018-08-10 青岛科技大学 一种检测力竭运动小鼠心肌连接蛋白43含量的方法
CN108152275B (zh) * 2017-12-27 2019-07-19 福州大学 一种基于电化学发光体系的透明质酸酶检测方法
US11307206B2 (en) * 2018-04-27 2022-04-19 Deutsches Rheuma-Forschungszentrum Berlin Functionalized metal-labeled beads for mass cytometry
CN108827946B (zh) * 2018-04-30 2021-03-02 福建师范大学 一种共用共反应试剂类型的呕吐毒素比率型电致化学发光免疫传感器及其检测方法
CN109651621B (zh) * 2019-01-08 2021-05-14 安徽师范大学 一种锆基金属有机框架复合材料及其制备方法和应用
CN109946289B (zh) * 2019-04-16 2021-06-22 济南大学 一种基于自发光材料Ru@MOF-5检测雌二醇的无标型电致化学发光传感器的制备方法
CN110146692A (zh) * 2019-05-28 2019-08-20 迪瑞医疗科技股份有限公司 一种基于吖啶酯化学发光、链霉亲和素磁珠-生物素放大反应体系及检测试剂盒
US20220283094A1 (en) * 2019-07-31 2022-09-08 Hitachi High-Tech Corporation Biomolecular analysis method and biomolecular analyzer
CN112649605B (zh) * 2020-12-14 2022-11-01 哈尔滨理工大学 一种基于NaBiF4上转换纳米粒子的ECL生物传感器
CN113267629B (zh) * 2021-05-13 2022-06-24 广东优尼德生物科技有限公司 一种抗核抗体谱检测试剂盒及其制备方法
EP4430181A1 (en) * 2021-11-12 2024-09-18 Solventum Intellectual Properties Company Method of processing polynucleic acids
CN118234859A (zh) * 2021-11-12 2024-06-21 舒万诺知识产权公司 包含适用于多核酸加工的配体的固体载体、制品和方法
CN114113051B (zh) * 2021-12-16 2023-06-16 南京信息工程大学 一种psma电致化学发光传感器的制备方法及应用
CN114752374B (zh) * 2022-04-11 2023-02-03 北京艾维镝生物技术有限责任公司 一种均相化学发光免疫检测技术所用微球组合物的制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
CA1339465C (en) 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
US6271041B1 (en) 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US6881536B1 (en) 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
US5935779A (en) 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5182016A (en) 1990-03-22 1993-01-26 Regents Of The University Of Minnesota Polymer-coated carbon-clad inorganic oxide particles
IL100867A (en) * 1991-02-06 1995-12-08 Igen Inc Method and device for improved luminescence testing
ZA92803B (en) 1991-02-06 1992-11-25 Igen Inc Method and apparatus for magnetic microparticulate based luminescene asay including plurality of magnets
US5342774A (en) 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5336596A (en) 1991-12-23 1994-08-09 Tropix, Inc. Membrane for chemiluminescent blotting applications
US5369036A (en) * 1992-07-02 1994-11-29 Becton, Dickinson And Company Enhancement of signal in immunoassays using microparticles which contain different detectable substances
WO1994014459A1 (en) 1992-12-22 1994-07-07 Ludwig Institute For Cancer Research Methods for detection and treatment of individuals having abnormal cells expressing hla-a2/tyrosinase peptide antigens
US5620886A (en) 1993-03-18 1997-04-15 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
JPH06300763A (ja) * 1993-04-14 1994-10-28 Nippon Telegr & Teleph Corp <Ntt> 蛍光免疫測定用蛍光マイクロビーズ及びその製造方法
US5571711A (en) 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
US5610013A (en) 1993-07-22 1997-03-11 Ludwig Institute For Cancer Research Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors
US5935818A (en) 1995-02-24 1999-08-10 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
WO1995024483A1 (en) 1994-03-08 1995-09-14 Scotgen Biopharmaceuticals, Inc. Recombinant humanized anti-fb5 antibodies
US5589334A (en) 1994-06-03 1996-12-31 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor which is processed to an antigen presented by HLA-B44, and uses thereof
CA2130248A1 (en) 1994-08-16 1996-02-17 Harald D. H. Stover Method of forming polymer microspheres
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
CA2162210A1 (en) 1994-11-07 1996-05-08 Takumi Kunikiyo Process to form a coated film
AU4756296A (en) * 1995-01-06 1996-07-24 Igen, Inc. Electrogenerated chemiluminescence through enhanced particle luminescence
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US5939526A (en) 1995-03-21 1999-08-17 Ludwig Institute For Cancer Research Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5821122A (en) 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
EP0871887B1 (en) 1995-06-07 2007-03-28 BioVeris Corporation Electrochemiluminescent enzyme immunoassay
US5792621A (en) 1995-06-28 1998-08-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters
JP3545524B2 (ja) * 1995-12-28 2004-07-21 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生理活性物質を固定化した導電性磁気ビーズ
US6037124A (en) 1996-09-27 2000-03-14 Beckman Coulter, Inc. Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof
US6548246B1 (en) * 1997-05-16 2003-04-15 The Regents Of The University Of California Method and probes for the identification of microbial genes specifically induced during host infection
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312896B1 (en) 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
WO2000023785A2 (en) * 1998-10-20 2000-04-27 Ljl Biosystems, Inc. Improvements in luminescence assays
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6548264B1 (en) 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US6808939B2 (en) 2001-06-29 2004-10-26 Igen International, Inc. ECL labels having improved non-specific binding properties, methods of using and kits containing the same
US6919173B2 (en) 2001-09-10 2005-07-19 Meso Scale Technologies, Llc. Assay buffer, compositions containing the same, and methods of using the same
AU2003217552A1 (en) 2002-02-19 2003-09-09 Choicepoint Asset Company Selective extraction of dna from groups of cells
US7524630B2 (en) 2002-04-22 2009-04-28 University Of Florida Research Foundation, Inc. Functionalized nanoparticles and methods of use
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7741033B2 (en) 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
JP4087295B2 (ja) * 2003-06-06 2008-05-21 株式会社サタケ ダイオキシン類の測定方法及び装置
WO2005062982A2 (en) * 2003-12-23 2005-07-14 Xing-Xiang Li Signal amplification methods for analyte detection
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
JP5118964B2 (ja) * 2004-06-23 2013-01-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム ２粒子複合体を用いた生物学的分子の検出のための方法及び組成物

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US20150044669A1 (en) 2015-02-12
CA2571283A1 (en) 2006-08-10
KR20070049631A (ko) 2007-05-11
CA2571283C (en) 2013-10-22
CN101057145A (zh) 2007-10-17
US8188243B2 (en) 2012-05-29
JP2008504528A (ja) 2008-02-14
AU2005326758A1 (en) 2006-08-10
KR101076578B1 (ko) 2011-10-24
WO2006083305A2 (en) 2006-08-10
JP5118964B2 (ja) 2013-01-16
AU2005326758B2 (en) 2011-07-14
US9442117B2 (en) 2016-09-13
US20060078912A1 (en) 2006-04-13
WO2006083305A3 (en) 2007-04-05
US20120329173A1 (en) 2012-12-27
EP1787124A2 (en) 2007-05-23
WO2006083305A8 (en) 2010-04-22
BRPI0512611A (pt) 2008-03-25
CN101057145B (zh) 2014-10-22
US8871917B2 (en) 2014-10-28

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