HK1113393A1 - Secretion of antibodies without signal peptides from bacteria - Google Patents

Secretion of antibodies without signal peptides from bacteria

Info

Publication number
HK1113393A1
HK1113393A1 HK08108594.5A HK08108594A HK1113393A1 HK 1113393 A1 HK1113393 A1 HK 1113393A1 HK 08108594 A HK08108594 A HK 08108594A HK 1113393 A1 HK1113393 A1 HK 1113393A1
Authority
HK
Hong Kong
Prior art keywords
antibodies
secretion
bacteria
methods
signal peptides
Prior art date
Application number
HK08108594.5A
Other languages
English (en)
Inventor
Geoffrey Yarranton
Christopher R Bebbington
Original Assignee
Kalobios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalobios Pharmaceuticals Inc filed Critical Kalobios Pharmaceuticals Inc
Publication of HK1113393A1 publication Critical patent/HK1113393A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
HK08108594.5A 2005-07-22 2008-08-04 Secretion of antibodies without signal peptides from bacteria HK1113393A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70190205P 2005-07-22 2005-07-22
US11/273,906 US8211648B2 (en) 2005-07-22 2005-11-14 Secretion of antibodies without signal peptides from bacteria
PCT/US2006/026334 WO2007018853A2 (en) 2005-07-22 2006-07-07 Secretion of antibodies without signal peptides from bacteria

Publications (1)

Publication Number Publication Date
HK1113393A1 true HK1113393A1 (en) 2008-10-03

Family

ID=37679517

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08108594.5A HK1113393A1 (en) 2005-07-22 2008-08-04 Secretion of antibodies without signal peptides from bacteria

Country Status (12)

Country Link
US (2) US8211648B2 (zh)
EP (1) EP1907610B1 (zh)
JP (1) JP5087541B2 (zh)
KR (1) KR101014891B1 (zh)
CN (1) CN101568647B (zh)
AU (1) AU2006276823B2 (zh)
CA (1) CA2615776C (zh)
HK (1) HK1113393A1 (zh)
IL (1) IL188889A (zh)
NZ (1) NZ565126A (zh)
SG (1) SG177895A1 (zh)
WO (1) WO2007018853A2 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211648B2 (en) * 2005-07-22 2012-07-03 Kalobios Pharmaceuticals, Inc. Secretion of antibodies without signal peptides from bacteria
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
KR101852915B1 (ko) 2008-04-28 2018-04-27 휴머니건, 아이엔씨. 과립구-대식세포 콜로니 자극 인자에 대한 항체
CA2751433A1 (en) 2009-02-04 2010-08-12 Kalobios Pharmaceuticals, Inc. Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection
WO2010093814A1 (en) 2009-02-11 2010-08-19 Kalobios Pharmaceuticals, Inc. Methods of treating dementia using a gm-csf antagonist
ES2743558T3 (es) 2009-10-14 2020-02-19 Humanigen Inc Anticuerpos de-EphA3
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EA201391157A1 (ru) 2011-02-11 2014-02-28 АйАрЭм ЭлЭлСи Антагонисты pcsk9
JP5957443B2 (ja) * 2011-03-28 2016-07-27 長瀬産業株式会社 フェリチンの製造方法
WO2012168491A1 (en) 2011-06-10 2012-12-13 Novartis Ag Pharmaceutical formulations of pcsk9 antagonists
WO2012170607A2 (en) 2011-06-10 2012-12-13 Novartis Ag Use of pcsk9 antagonists
CN104144945A (zh) * 2012-03-02 2014-11-12 埃博灵克斯股份有限公司 结合铜绿假单胞菌pcrv的单可变结构域抗体
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
US10309969B2 (en) * 2013-01-24 2019-06-04 Abtlas Co., Ltd. Protein combination-based FV library, and preparation method therefor
AU2015273353B2 (en) * 2014-06-13 2020-09-10 Tenboron Oy Conjugates comprising an anti-EGFR1 antibody
RU2609627C2 (ru) * 2014-09-26 2017-02-02 Закрытое Акционерное Общество "Биокад" Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
KR20230006929A (ko) * 2016-01-13 2023-01-11 리제너론 파마슈티칼스 인코포레이티드 조작된 중쇄 다양성 영역을 갖는 설치류

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US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5576184A (en) 1988-09-06 1996-11-19 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
AU643189B2 (en) 1988-09-06 1993-11-11 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
AU627591B2 (en) 1989-06-19 1992-08-27 Xoma Corporation Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5563046A (en) 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US5914254A (en) 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
JPH07289267A (ja) * 1994-04-25 1995-11-07 Oriental Yeast Co Ltd 発現増強方法
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JPH09313191A (ja) 1996-03-28 1997-12-09 Mitsui Petrochem Ind Ltd 蛋白質の分泌生産法
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WO2005019819A1 (en) * 2003-08-20 2005-03-03 Biosite, Inc. Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
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JP4782700B2 (ja) 2004-01-20 2011-09-28 カロバイオス ファーマシューティカルズ インコーポレイティッド 最低限必須な結合決定基を用いた抗体特異性の移入
US8211648B2 (en) * 2005-07-22 2012-07-03 Kalobios Pharmaceuticals, Inc. Secretion of antibodies without signal peptides from bacteria

Also Published As

Publication number Publication date
KR20080031452A (ko) 2008-04-08
EP1907610B1 (en) 2013-09-11
EP1907610A2 (en) 2008-04-09
EP1907610A4 (en) 2009-12-23
CN101568647A (zh) 2009-10-28
CN101568647B (zh) 2012-10-03
CA2615776A1 (en) 2007-02-15
IL188889A (en) 2014-09-30
JP2009510998A (ja) 2009-03-19
WO2007018853A2 (en) 2007-02-15
US20120309055A1 (en) 2012-12-06
US8211648B2 (en) 2012-07-03
AU2006276823B2 (en) 2010-04-22
CA2615776C (en) 2014-05-13
SG177895A1 (en) 2012-02-28
NZ565126A (en) 2011-03-31
KR101014891B1 (ko) 2011-02-15
JP5087541B2 (ja) 2012-12-05
US9127046B2 (en) 2015-09-08
WO2007018853A3 (en) 2009-04-16
IL188889A0 (en) 2008-04-13
AU2006276823A1 (en) 2007-02-15
US20070020685A1 (en) 2007-01-25

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170707