EP1907610A4 - Secretion of antibodies without signal peptides from bacteria - Google Patents

Secretion of antibodies without signal peptides from bacteria

Info

Publication number
EP1907610A4
EP1907610A4 EP06786474A EP06786474A EP1907610A4 EP 1907610 A4 EP1907610 A4 EP 1907610A4 EP 06786474 A EP06786474 A EP 06786474A EP 06786474 A EP06786474 A EP 06786474A EP 1907610 A4 EP1907610 A4 EP 1907610A4
Authority
EP
European Patent Office
Prior art keywords
secretion
antibodies
bacteria
signal peptides
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06786474A
Other languages
German (de)
French (fr)
Other versions
EP1907610A2 (en
EP1907610B1 (en
Inventor
Geoffrey Yarranton
Christopher R Bebbington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Humanigen Inc
Original Assignee
Kalobios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalobios Pharmaceuticals Inc filed Critical Kalobios Pharmaceuticals Inc
Publication of EP1907610A2 publication Critical patent/EP1907610A2/en
Publication of EP1907610A4 publication Critical patent/EP1907610A4/en
Application granted granted Critical
Publication of EP1907610B1 publication Critical patent/EP1907610B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP06786474.4A 2005-07-22 2006-07-07 Secretion of antibodies without signal peptides from bacteria Not-in-force EP1907610B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70190205P 2005-07-22 2005-07-22
US11/273,906 US8211648B2 (en) 2005-07-22 2005-11-14 Secretion of antibodies without signal peptides from bacteria
PCT/US2006/026334 WO2007018853A2 (en) 2005-07-22 2006-07-07 Secretion of antibodies without signal peptides from bacteria

Publications (3)

Publication Number Publication Date
EP1907610A2 EP1907610A2 (en) 2008-04-09
EP1907610A4 true EP1907610A4 (en) 2009-12-23
EP1907610B1 EP1907610B1 (en) 2013-09-11

Family

ID=37679517

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06786474.4A Not-in-force EP1907610B1 (en) 2005-07-22 2006-07-07 Secretion of antibodies without signal peptides from bacteria

Country Status (12)

Country Link
US (2) US8211648B2 (en)
EP (1) EP1907610B1 (en)
JP (1) JP5087541B2 (en)
KR (1) KR101014891B1 (en)
CN (1) CN101568647B (en)
AU (1) AU2006276823B2 (en)
CA (1) CA2615776C (en)
HK (1) HK1113393A1 (en)
IL (1) IL188889A (en)
NZ (1) NZ565126A (en)
SG (1) SG177895A1 (en)
WO (1) WO2007018853A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211648B2 (en) * 2005-07-22 2012-07-03 Kalobios Pharmaceuticals, Inc. Secretion of antibodies without signal peptides from bacteria
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
KR101852915B1 (en) 2008-04-28 2018-04-27 휴머니건, 아이엔씨. Antibodies to granulocyte-macrophage colony-stimulating factor
WO2010091189A1 (en) 2009-02-04 2010-08-12 Kalobios Pharmaceuticals, Inc. Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection
WO2010093814A1 (en) 2009-02-11 2010-08-19 Kalobios Pharmaceuticals, Inc. Methods of treating dementia using a gm-csf antagonist
EP2488554B1 (en) 2009-10-14 2019-07-24 Humanigen, Inc. Antibodies to epha3
AR079336A1 (en) 2009-12-11 2012-01-18 Irm Llc ANTAGONISTS OF THE PRO-PROTEIN CONVERTASE-SUBTILISINE / TYPE 9 QUEXINE (PCSK9)
EP2673302A1 (en) 2011-02-11 2013-12-18 Irm Llc Pcsk9 antagonists
WO2012133119A1 (en) * 2011-03-28 2012-10-04 長瀬産業株式会社 Method for producing ferritin
WO2012168491A1 (en) 2011-06-10 2012-12-13 Novartis Ag Pharmaceutical formulations of pcsk9 antagonists
WO2012170607A2 (en) 2011-06-10 2012-12-13 Novartis Ag Use of pcsk9 antagonists
US10072098B2 (en) * 2012-03-02 2018-09-11 Ablynx N.V. Pseudomonas aeruginosa PCRV binding single variable domain antibodies
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
AU2014210475B2 (en) * 2013-01-24 2017-03-02 Abtlas Co., Ltd. Protein combination-based Fv library, and preparation method therefor
CA2952026A1 (en) * 2014-06-13 2015-12-17 Tenboron Oy Conjugates comprising an anti-egfr1 antibody
RU2609627C2 (en) * 2014-09-26 2017-02-02 Закрытое Акционерное Общество "Биокад" High affinity and aggregationally stable antibodies based on vl variable domains and vhh derivative
MA41044A (en) 2014-10-08 2017-08-15 Novartis Ag COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
RU2763320C2 (en) * 2016-01-13 2021-12-28 Регенерон Фармасьютикалз, Инк. Rodents having constructed section of heavy chain diversity

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0364096B1 (en) 1988-09-06 2000-03-08 Xoma Corporation Gene expression elements and the production of chimeric mouse-human antibodies
US5576184A (en) 1988-09-06 1996-11-19 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
AU627591B2 (en) 1989-06-19 1992-08-27 Xoma Corporation Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5563046A (en) 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US5914254A (en) 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
JPH07289267A (en) * 1994-04-25 1995-11-07 Oriental Yeast Co Ltd Method for enhancing expression
AU692728B2 (en) 1996-03-28 1998-06-11 Mitsui Chemicals, Inc. Method for secretory production of protein
JPH09313191A (en) 1996-03-28 1997-12-09 Mitsui Petrochem Ind Ltd Production of protein by secretion
AU770952B2 (en) * 1999-03-01 2004-03-11 Genentech Inc. Antibodies for cancer therapy and diagnosis
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
DE10325026B4 (en) 2003-06-02 2013-04-18 Genencor International,Inc. Bacteria with increased protein secretion, nucleotide sequences coding for a SecA protein with increased protein secretion and methods for the production of proteins
US20040266993A1 (en) 2003-06-30 2004-12-30 Evans Glen A. Non-immunoglobulin binding polypeptides
JP2007502991A (en) * 2003-08-20 2007-02-15 バイオサイト インコーポレイテッド Methods and compositions for measuring bioactive natriuretic peptides and for improving their therapeutic potential
EP1761561B1 (en) 2004-01-20 2015-08-26 KaloBios Pharmaceuticals, Inc. Antibody specificity transfer using minimal essential binding determinants
US8211648B2 (en) * 2005-07-22 2012-07-03 Kalobios Pharmaceuticals, Inc. Secretion of antibodies without signal peptides from bacteria

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOST S ET AL: "Prl mutations in the Escherichia coli secG gene", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 272, no. 7, 14 February 1997 (1997-02-14), pages 4087 - 4093, XP002498922, ISSN: 0021-9258 *
KHATIB KARIM ET AL: "A novel class of secA alleles that exert a signal-sequence-dependent effect on protein export in Escherichia coli.", GENETICS, vol. 162, no. 3, November 2002 (2002-11-01), pages 1031 - 1043, XP002551640, ISSN: 0016-6731 *
MALLIK IPSITA ET AL: "Recognition of secretory proteins in Escherichia coli requires signals in addition to the signal sequence and slow folding", BMC MICROBIOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 2, no. 1, 11 November 2002 (2002-11-11), pages 32, XP021014813, ISSN: 1471-2180 *
PRINZ WILLIAM A ET AL: "Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 15, no. 19, 1996, pages 5209 - 5217, XP002551638, ISSN: 0261-4189 *
See also references of WO2007018853A2 *
SMITH MARGARET A ET AL: "Modeling the effects of prl mutations on the Escherichia coli SecY complex", JOURNAL OF BACTERIOLOGY, vol. 187, no. 18, September 2005 (2005-09-01), pages 6454 - 6465, XP002551639, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
IL188889A (en) 2014-09-30
CN101568647B (en) 2012-10-03
KR101014891B1 (en) 2011-02-15
IL188889A0 (en) 2008-04-13
US9127046B2 (en) 2015-09-08
KR20080031452A (en) 2008-04-08
WO2007018853A3 (en) 2009-04-16
CN101568647A (en) 2009-10-28
HK1113393A1 (en) 2008-10-03
US20070020685A1 (en) 2007-01-25
US8211648B2 (en) 2012-07-03
US20120309055A1 (en) 2012-12-06
WO2007018853A2 (en) 2007-02-15
AU2006276823B2 (en) 2010-04-22
SG177895A1 (en) 2012-02-28
CA2615776C (en) 2014-05-13
CA2615776A1 (en) 2007-02-15
JP5087541B2 (en) 2012-12-05
EP1907610A2 (en) 2008-04-09
EP1907610B1 (en) 2013-09-11
JP2009510998A (en) 2009-03-19
NZ565126A (en) 2011-03-31
AU2006276823A1 (en) 2007-02-15

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