HK1112895A1 - 5-heteroaryl thiazoles and their use as pi3k inhibitors - Google Patents

5-heteroaryl thiazoles and their use as pi3k inhibitors

Info

Publication number
HK1112895A1
HK1112895A1 HK08101781.3A HK08101781A HK1112895A1 HK 1112895 A1 HK1112895 A1 HK 1112895A1 HK 08101781 A HK08101781 A HK 08101781A HK 1112895 A1 HK1112895 A1 HK 1112895A1
Authority
HK
Hong Kong
Prior art keywords
pi3k inhibitors
thiazoles
heteroaryl
heteroaryl thiazoles
pi3k
Prior art date
Application number
HK08101781.3A
Other languages
English (en)
Inventor
Malena Bengtsson
Joakim Larsson
Grigorios Nikitidis
Peter Storm
John Peter Bailey
Edward Jolyon Griffen
Jean-Claude Arnould
Thomas Geoffrey Colerick Bird
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1112895A1 publication Critical patent/HK1112895A1/xx

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
HK08101781.3A 2004-11-09 2008-02-19 5-heteroaryl thiazoles and their use as pi3k inhibitors HK1112895A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0402735A SE0402735D0 (sv) 2004-11-09 2004-11-09 Novel compounds
PCT/GB2005/004268 WO2006051270A1 (fr) 2004-11-09 2005-11-07 5-heteroarylthiazoles et leur utilisation en tant qu’inhibiteurs de la p13k

Publications (1)

Publication Number Publication Date
HK1112895A1 true HK1112895A1 (en) 2008-09-19

Family

ID=33488202

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08101781.3A HK1112895A1 (en) 2004-11-09 2008-02-19 5-heteroaryl thiazoles and their use as pi3k inhibitors

Country Status (21)

Country Link
US (1) US7868188B2 (fr)
EP (1) EP1841763B1 (fr)
JP (1) JP2008519021A (fr)
KR (1) KR20070085837A (fr)
CN (1) CN101098869A (fr)
AR (1) AR052232A1 (fr)
AT (1) ATE472546T1 (fr)
AU (1) AU2005303566A1 (fr)
BR (1) BRPI0517634A (fr)
CA (1) CA2585310A1 (fr)
DE (1) DE602005022116D1 (fr)
ES (1) ES2346333T3 (fr)
HK (1) HK1112895A1 (fr)
IL (1) IL182726A0 (fr)
MX (1) MX2007005546A (fr)
NO (1) NO20072259L (fr)
SE (1) SE0402735D0 (fr)
TW (1) TW200621762A (fr)
UY (1) UY29199A1 (fr)
WO (1) WO2006051270A1 (fr)
ZA (1) ZA200703714B (fr)

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TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
JP2008540539A (ja) 2005-05-10 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャンネルの調節因子としての二環系誘導体
EA017166B1 (ru) 2005-05-24 2012-10-30 Мерк Сероно С.А. Производные тиазола и их применение
EA200801716A1 (ru) 2006-01-18 2009-04-28 Амген Инк. Тиазольные соединения и их применение
CA2635830A1 (fr) * 2006-01-23 2007-07-26 Laboratoires Serono S.A. Derives de thiazole et leur utilisation
JP5430943B2 (ja) 2006-01-25 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連用途のための置換芳香族化合物
US8217037B2 (en) * 2006-04-07 2012-07-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
EP2016075A1 (fr) * 2006-05-03 2009-01-21 AstraZeneca AB Dérivés de thiazole et leur utilisation comme agents anti-tumoraux
DK1887359T3 (da) * 2006-08-03 2009-03-02 Cellzome Ag Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K
EP2061787A2 (fr) * 2006-09-01 2009-05-27 Vertex Pharmaceuticals Incorporated Dérivés du 5-(2-furyl)1,3-thiazole et leur utilisation comme inhibiteurs de la phosphatidinylinositol 3-kinase
GB0620059D0 (en) * 2006-10-10 2006-11-22 Ucb Sa Therapeutic agents
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US7868188B2 (en) 2011-01-11
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KR20070085837A (ko) 2007-08-27
US20080132502A1 (en) 2008-06-05
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ES2346333T3 (es) 2010-10-14
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