HK1112580A1 - Analogs of ghrelin (ghrelin) - Google Patents
Analogs of ghrelin (ghrelin)Info
- Publication number
- HK1112580A1 HK1112580A1 HK08107092.4A HK08107092A HK1112580A1 HK 1112580 A1 HK1112580 A1 HK 1112580A1 HK 08107092 A HK08107092 A HK 08107092A HK 1112580 A1 HK1112580 A1 HK 1112580A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ghrelin
- analogs
- Prior art date
Links
- 102000012004 Ghrelin Human genes 0.000 title 2
- 101800001586 Ghrelin Proteins 0.000 title 2
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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- G—PHYSICS
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
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- Diabetes (AREA)
- Molecular Biology (AREA)
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- Immunology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72155705P | 2005-09-28 | 2005-09-28 | |
US74890405P | 2005-12-09 | 2005-12-09 | |
US75077105P | 2005-12-15 | 2005-12-15 | |
PCT/US2006/037889 WO2007038678A2 (en) | 2005-09-28 | 2006-09-27 | Analogs of ghrelin |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1112580A1 true HK1112580A1 (en) | 2008-09-12 |
Family
ID=37900462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08107092.4A HK1112580A1 (en) | 2005-09-28 | 2008-06-26 | Analogs of ghrelin (ghrelin) |
Country Status (8)
Country | Link |
---|---|
US (1) | US8258094B2 (xx) |
EP (1) | EP1928489B1 (xx) |
JP (2) | JP4896140B2 (xx) |
CN (2) | CN101282738B (xx) |
CA (1) | CA2625920C (xx) |
ES (1) | ES2474643T3 (xx) |
HK (1) | HK1112580A1 (xx) |
WO (1) | WO2007038678A2 (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105381453B9 (zh) * | 2005-09-29 | 2019-01-11 | 益普生制药股份有限公司 | 用于刺激胃肠运动性的组合物和方法 |
US8299022B2 (en) | 2006-09-27 | 2012-10-30 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the N-terminal |
JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 安定化させたp53ペプチドおよびその使用法 |
KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
TW200916113A (en) * | 2007-08-08 | 2009-04-16 | Sod Conseils Rech Applic | Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue |
TWI461529B (zh) * | 2008-11-27 | 2014-11-21 | Intervet Int Bv | 產製RTX毒素ApxI之方法 |
CN102229652B (zh) * | 2009-10-23 | 2012-05-23 | 山东省医药生物技术研究中心 | 抗类风湿性关节炎的多肽及其在制药中的应用 |
CN108570097A (zh) | 2010-08-13 | 2018-09-25 | 爱勒让治疗公司 | 拟肽大环化合物 |
MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
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US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
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SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
EP2914256B1 (en) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
CN104345114B (zh) * | 2013-07-30 | 2016-01-13 | 希施生物科技(上海)有限公司 | 一种反相分离衍生化亮氨酸和异亮氨酸的方法 |
JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
WO2016138099A1 (en) | 2015-02-24 | 2016-09-01 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
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US20030211967A1 (en) | 2001-05-07 | 2003-11-13 | Bryant Henry Uhlman | Method for selectively inhibiting ghrelin action |
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WO2002008250A2 (en) | 2000-07-24 | 2002-01-31 | Ardana Bioscience Limited | Ghrelin antagonists |
AU2002254800B2 (en) | 2001-05-10 | 2006-09-28 | Queensland University Of Technology | Reproductive cancer diagnosis and therapy |
RU2373220C2 (ru) | 2002-07-23 | 2009-11-20 | Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) | Аналоги грелина |
US20050027648A1 (en) * | 2003-07-29 | 2005-02-03 | Knowles W. Jeffrey | System and method of account reconciliation for electronic transactions |
ES2300686T3 (es) * | 2003-10-16 | 2008-06-16 | F. Hoffmann-La Roche Ag | Peptidos sw grelina marcados fluorescentemente. |
US20060105393A1 (en) * | 2004-10-25 | 2006-05-18 | Christian Apfel | Ligand-receptor tracking assays |
CN105381453B9 (zh) * | 2005-09-29 | 2019-01-11 | 益普生制药股份有限公司 | 用于刺激胃肠运动性的组合物和方法 |
WO2007106385A2 (en) * | 2006-03-10 | 2007-09-20 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
US8299022B2 (en) * | 2006-09-27 | 2012-10-30 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the N-terminal |
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CN101282738B (zh) | 2015-09-16 |
CA2625920A1 (en) | 2007-04-05 |
WO2007038678A8 (en) | 2008-06-19 |
CN105111302A (zh) | 2015-12-02 |
JP2012072144A (ja) | 2012-04-12 |
EP1928489A4 (en) | 2009-11-11 |
WO2007038678A2 (en) | 2007-04-05 |
US20090156483A1 (en) | 2009-06-18 |
JP2009510088A (ja) | 2009-03-12 |
JP4896140B2 (ja) | 2012-03-14 |
CA2625920C (en) | 2014-12-23 |
EP1928489B1 (en) | 2014-03-26 |
CN101282738A (zh) | 2008-10-08 |
ES2474643T3 (es) | 2014-07-09 |
US8258094B2 (en) | 2012-09-04 |
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