HK1099688A1 - 1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity - Google Patents

1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity

Info

Publication number
HK1099688A1
HK1099688A1 HK07105654.9A HK07105654A HK1099688A1 HK 1099688 A1 HK1099688 A1 HK 1099688A1 HK 07105654 A HK07105654 A HK 07105654A HK 1099688 A1 HK1099688 A1 HK 1099688A1
Authority
HK
Hong Kong
Prior art keywords
pyrazole derivatives
trisubstituted
dihydro
antagonistic activity
compounds
Prior art date
Application number
HK07105654.9A
Other languages
English (en)
Inventor
Langeh Jm
Kruseg
Van Stuivenbergh
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of HK1099688A1 publication Critical patent/HK1099688A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
HK07105654.9A 2004-01-30 2007-05-29 1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity HK1099688A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53998304P 2004-01-30 2004-01-30
EP04100338 2004-01-30
PCT/EP2005/050339 WO2005074920A1 (fr) 2004-01-30 2005-01-27 Derives de 4,5-dihydro-1h-pyrazole 1,3,5-trisubstitues presentant une activite antagonistique a cb1

Publications (1)

Publication Number Publication Date
HK1099688A1 true HK1099688A1 (en) 2007-08-24

Family

ID=34839806

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07105654.9A HK1099688A1 (en) 2004-01-30 2007-05-29 1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity

Country Status (21)

Country Link
EP (1) EP1713475B1 (fr)
JP (1) JP4693787B2 (fr)
KR (1) KR20060131861A (fr)
CN (1) CN100563651C (fr)
AT (1) ATE402697T1 (fr)
AU (1) AU2005210163B2 (fr)
BR (1) BRPI0507005A (fr)
CA (1) CA2552940A1 (fr)
DE (1) DE602005008555D1 (fr)
DK (1) DK1713475T3 (fr)
ES (1) ES2311972T3 (fr)
HK (1) HK1099688A1 (fr)
HR (1) HRP20080549T3 (fr)
IL (1) IL176547A (fr)
MX (1) MXPA06008593A (fr)
NO (1) NO20063866L (fr)
PL (1) PL1713475T3 (fr)
PT (1) PT1713475E (fr)
RU (1) RU2360904C2 (fr)
SI (1) SI1713475T1 (fr)
WO (1) WO2005074920A1 (fr)

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EP1849776A1 (fr) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés de la pyrazoline azépane- ou azocane-substituées, leur préparation et utilisation comme médicaments
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WO2007009682A1 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Formulations pharmaceutiques orales comprenant des composes de pyrazoline substitues
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WO2007009720A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve S.A. Promedicaments de composes de pyrazoline, fabrication et utilisation comme medicaments
WO2007009690A1 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Composes de pyrazoline a substitution heterocyclyle, preparation et utilisation de ceux-ci comme medicaments
EP1749819A1 (fr) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Hydrates de (rac)-N-piperidinyl-5-(4-chlorphenyl)-1-(2,4-dichlorphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
EP1743888A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Composés de pyrazoline subsitués par un groupe carbonyle utiles comme modulateurs du recepteur CB1
EP1849784A1 (fr) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés de la pyrazoline Indoline-substituée, leur préparation and utilisation comme médicaments
ES2326952B1 (es) * 2005-07-15 2010-05-28 Laboratorios Del Dr. Esteve, S.A. Hidratos de (rac) -n-piperidinil-5-(4-clorofenil)-1-(2,4-diclorofenil)4,5-dihidro-1h-pirazol-3-carboxamida.
EP1757589A1 (fr) * 2005-07-29 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Une phase amorphe d`un pyrazoline substitué, sa préparation et son usage comme médicament
ES2326357B1 (es) * 2005-07-29 2010-04-21 Laboratorios Del Dr. Esteve, S.A. Fase amorfa de una pirazolina sustituida, su preparacion y su uso como medicamento.
WO2007017126A2 (fr) * 2005-07-29 2007-02-15 Laboratorios Del Dr. Esteve, S.A. Polymorphe d'une pyrazoline substituee, sa preparation et son utilisation comme medicaments
EP1911747A1 (fr) 2006-10-11 2008-04-16 Laboratorios del Dr. Esteve S.A. Dérivés de pyrazoline substitués par un groupe sulfonamide, leur préparation et leur utlisation comme des modulateurs de CB1
ES2330071B1 (es) * 2007-01-15 2010-07-05 Laboratorios Del Dr. Esteve, S.A. Combinacion de sustancias activas.
ES2328653B1 (es) * 2007-01-15 2010-05-28 Laboratorios Del Dr. Esteve S.A. Combinacion de sustancias activas para el tratamiento de la diabetes.
EP1944295A1 (fr) * 2007-01-15 2008-07-16 Laboratorios del Dr. Esteve S.A. Mélanges non racémiques de (R)-N-pipéridinyl-5-(4-chlorophényl)1-1(2,4-dichlorophényl)-4,5-dihydro-1H-pyrazole-3-carboxamide et (S)-N-pipéridinyl-5-(4-chlorophényl)-1-(2,4-dichlorophényl)-4,5-dihydro-1H-pyrazole-3-carboxamide
EP1946778A1 (fr) * 2007-01-16 2008-07-23 Laboratorios del Dr. Esteve S.A. Combinaison de substance active pour le traitement des diabètes
EP1946777A1 (fr) * 2007-01-16 2008-07-23 Laboratorios del Dr. Esteve S.A. Composés de pyrazoline substituée pour éviter la prise de poids
EP1946779A1 (fr) * 2007-01-16 2008-07-23 Laboratorios del Dr. Esteve S.A. Combination de pyrazoline substitués et de médicaments contre la dyslipidémie
EP1947089A1 (fr) * 2007-01-18 2008-07-23 Laboratorios del Dr. Esteve S.A. Polymorphe d'un pyrazoline substitué, sa préparation et utilisation dans le cadre de médicaments
EA201070019A1 (ru) * 2007-06-15 2010-06-30 Солвей Фармасьютикалс Б.В. 4,5-дигидро-(1н)-пиразольные производные как модуляторы каннабиноидных св-рецепторов
US8410135B2 (en) 2007-06-15 2013-04-02 Solvay Pharmaceuticals B.V. 4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
KR20100072037A (ko) 2007-09-20 2010-06-29 애보트 헬스케어 프로덕츠 비.브이. 칸나비노이드 ｃｂ₁수용체 효능제로서의 5-아릴-4,5-디하이드로-(1ｈ)-피라졸
EP2042175A1 (fr) * 2007-09-21 2009-04-01 Laboratorios del Dr. Esteve S.A. Ligands du récepteur CB1 au traitement de l'obésité
AR071487A1 (es) * 2008-04-23 2010-06-23 Solvay Pharm Bv Derivados de (5r)-1,5-diaril-4,5-dihidro-1h-pirazol-3-carboxamidina que tienen actividad antagonista cb1
JP6272626B2 (ja) 2012-11-13 2018-01-31 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ カンナビノイド受容体媒介性化合物
US11155521B2 (en) 2012-11-13 2021-10-26 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor mediating compounds
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WO2015172059A1 (fr) * 2014-05-09 2015-11-12 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Dérivés pyrazole et leur utilisation comme médiateurs des récepteurs aux cannabinoïdes

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PL1713475T3 (pl) 2009-03-31
AU2005210163B2 (en) 2010-05-13
IL176547A (en) 2010-06-30
IL176547A0 (en) 2006-10-31
NO20063866L (no) 2006-10-27
ATE402697T1 (de) 2008-08-15
SI1713475T1 (sl) 2008-12-31
RU2360904C2 (ru) 2009-07-10
JP4693787B2 (ja) 2011-06-01
CN100563651C (zh) 2009-12-02
EP1713475B1 (fr) 2008-07-30
WO2005074920A1 (fr) 2005-08-18
BRPI0507005A (pt) 2007-06-05
DK1713475T3 (da) 2008-12-01
KR20060131861A (ko) 2006-12-20
ES2311972T3 (es) 2009-02-16
MXPA06008593A (es) 2006-08-28
EP1713475A1 (fr) 2006-10-25
AU2005210163A1 (en) 2005-08-18
RU2006131132A (ru) 2008-03-10
JP2007519686A (ja) 2007-07-19
DE602005008555D1 (de) 2008-09-11
PT1713475E (pt) 2008-11-10
HRP20080549T3 (en) 2008-11-30
CN1913885A (zh) 2007-02-14
CA2552940A1 (fr) 2005-08-18

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