HK1098372A1 - Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein - Google Patents

Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein

Info

Publication number
HK1098372A1
HK1098372A1 HK07104918.4A HK07104918A HK1098372A1 HK 1098372 A1 HK1098372 A1 HK 1098372A1 HK 07104918 A HK07104918 A HK 07104918A HK 1098372 A1 HK1098372 A1 HK 1098372A1
Authority
HK
Hong Kong
Prior art keywords
inhibitor
pharmaceutical composition
fusion protein
benzodiazepine derivative
rsv fusion
Prior art date
Application number
HK07104918.4A
Other languages
English (en)
Inventor
Kenneth Powell
Richard Kelsey
Malcolm Carter
Dagmar Alber
Lara Wilson
Elisa Henderson
Phil Chambers
Debra Taylor
Stan Tyms
Verity Dowdell
Original Assignee
Arrow Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrow Therapeutics Ltd filed Critical Arrow Therapeutics Ltd
Publication of HK1098372A1 publication Critical patent/HK1098372A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK07104918.4A 2004-03-19 2007-05-08 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein HK1098372A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0406282.4A GB0406282D0 (en) 2004-03-19 2004-03-19 Therapeutic compounds
PCT/GB2005/001018 WO2005089769A1 (en) 2004-03-19 2005-03-18 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibit or of the rsv fusion protein

Publications (1)

Publication Number Publication Date
HK1098372A1 true HK1098372A1 (en) 2007-07-20

Family

ID=32118068

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07104918.4A HK1098372A1 (en) 2004-03-19 2007-05-08 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein

Country Status (19)

Country Link
US (1) US8853204B2 (zh)
EP (1) EP1727550B1 (zh)
JP (1) JP4940128B2 (zh)
KR (2) KR20130042593A (zh)
CN (1) CN1933842A (zh)
AT (1) ATE437643T1 (zh)
AU (2) AU2005224157B2 (zh)
BR (1) BRPI0507654A (zh)
CA (1) CA2558112C (zh)
CY (1) CY1109523T1 (zh)
DE (1) DE602005015686D1 (zh)
DK (1) DK1727550T3 (zh)
ES (1) ES2327757T3 (zh)
GB (1) GB0406282D0 (zh)
HK (1) HK1098372A1 (zh)
PL (1) PL1727550T3 (zh)
PT (1) PT1727550E (zh)
RU (1) RU2388476C2 (zh)
WO (1) WO2005089769A1 (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
ATE494896T1 (de) * 2006-11-21 2011-01-15 Novartis Ag Stabile parenterale formulierung mit einem rsv- hemmer einer benzodiazepin-struktur
GB201506448D0 (en) 2015-04-16 2015-06-03 Univ Durham An antimicrobial compound
LT3324977T (lt) 2015-07-22 2022-10-25 Enanta Pharmaceuticals, Inc. Benzodiazepino dariniai kaip rsv inhibitoriai
WO2017123884A1 (en) 2016-01-15 2017-07-20 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
GB201613942D0 (en) * 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound
WO2018129287A1 (en) 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
ES2923521T3 (es) 2017-02-16 2022-09-28 Enanta Pharm Inc Procesos para la preparación de derivados de benzodiazepina
US10752598B2 (en) 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
EP3687543B1 (en) * 2017-09-29 2024-03-20 Enanta Pharmaceuticals, Inc. Combinations of pharmaceutical agents as rsv inhibitors
EP3710009A4 (en) * 2017-11-13 2021-08-25 Enanta Pharmaceuticals, Inc. METHOD FOR THE RESOLUTION OF BENZODIAZEPIN-2-ONE AND BENZOAZEPIN-2-ONE DERIVATIVES
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
UY38614A (es) 2019-03-18 2020-10-30 Enanta Pharm Inc Derivados de benzodiazepinas como inhibidores del rsv
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds
MX2022003984A (es) 2019-10-04 2022-07-27 Enanta Pharm Inc Compuestos heterociclicos antivirales.
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
BR112023016970A2 (pt) 2021-02-26 2023-10-10 Enanta Pharm Inc Compostos heterocíclicos antivirais
US12080039B2 (en) 2021-06-08 2024-09-03 Kyndryl, Inc. Contextual policy-based computer vision control

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
EP0491218A1 (en) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones
HUP0001522A3 (en) * 1997-04-07 2001-08-28 Axys Pharmaceuticals Corp Sout Benzoimidazole derivatives, process for producing them and pharmaceutical compositions containing them
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) * 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
PL369432A1 (en) * 2001-12-10 2005-04-18 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
JP2004107494A (ja) * 2002-09-18 2004-04-08 National Institute For Materials Science 熱可塑性層状アルキルシロキサンとその製造方法
NZ538870A (en) * 2002-09-20 2007-04-27 Arrow Therapeutics Ltd Benzodiazepine derivatives and pharmaceutical compositions containing them
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds

Also Published As

Publication number Publication date
CA2558112A1 (en) 2005-09-29
JP2007529489A (ja) 2007-10-25
RU2006136880A (ru) 2008-04-27
CN1933842A (zh) 2007-03-21
WO2005089769A1 (en) 2005-09-29
CA2558112C (en) 2014-07-29
JP4940128B2 (ja) 2012-05-30
BRPI0507654A (pt) 2007-07-10
GB0406282D0 (en) 2004-04-21
ES2327757T3 (es) 2009-11-03
CY1109523T1 (el) 2014-08-13
KR101292431B1 (ko) 2013-07-31
RU2388476C2 (ru) 2010-05-10
KR20130042593A (ko) 2013-04-26
US8853204B2 (en) 2014-10-07
DE602005015686D1 (de) 2009-09-10
AU2005224157A1 (en) 2005-09-29
KR20070009629A (ko) 2007-01-18
US20070142403A1 (en) 2007-06-21
AU2005224157B2 (en) 2009-05-28
EP1727550B1 (en) 2009-07-29
EP1727550A1 (en) 2006-12-06
DK1727550T3 (da) 2009-10-19
PT1727550E (pt) 2009-08-28
ATE437643T1 (de) 2009-08-15
PL1727550T3 (pl) 2010-01-29
AU2009212826A1 (en) 2009-09-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150318