DK1727550T3 - Farmaceutisk sammensætning omfattende et benzodiazepin-derivat og en inhibitor for RVS-fusions-proteinet - Google Patents

Farmaceutisk sammensætning omfattende et benzodiazepin-derivat og en inhibitor for RVS-fusions-proteinet

Info

Publication number
DK1727550T3
DK1727550T3 DK05718061T DK05718061T DK1727550T3 DK 1727550 T3 DK1727550 T3 DK 1727550T3 DK 05718061 T DK05718061 T DK 05718061T DK 05718061 T DK05718061 T DK 05718061T DK 1727550 T3 DK1727550 T3 DK 1727550T3
Authority
DK
Denmark
Prior art keywords
inhibitor
pharmaceutical composition
fusion protein
rvs
benzodiazepine derivative
Prior art date
Application number
DK05718061T
Other languages
English (en)
Inventor
Kenneth Powell
Richard Kelsey
Malcolm Carter
Dagmar Alber
Lara Wilson
Elisa Henderson
Phil Chambers
Debra Taylor
Stan Tyms
Verity Dowdell
Original Assignee
Arrow Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrow Therapeutics Ltd filed Critical Arrow Therapeutics Ltd
Application granted granted Critical
Publication of DK1727550T3 publication Critical patent/DK1727550T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK05718061T 2004-03-19 2005-03-18 Farmaceutisk sammensætning omfattende et benzodiazepin-derivat og en inhibitor for RVS-fusions-proteinet DK1727550T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0406282.4A GB0406282D0 (en) 2004-03-19 2004-03-19 Therapeutic compounds
PCT/GB2005/001018 WO2005089769A1 (en) 2004-03-19 2005-03-18 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibit or of the rsv fusion protein

Publications (1)

Publication Number Publication Date
DK1727550T3 true DK1727550T3 (da) 2009-10-19

Family

ID=32118068

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05718061T DK1727550T3 (da) 2004-03-19 2005-03-18 Farmaceutisk sammensætning omfattende et benzodiazepin-derivat og en inhibitor for RVS-fusions-proteinet

Country Status (19)

Country Link
US (1) US8853204B2 (da)
EP (1) EP1727550B1 (da)
JP (1) JP4940128B2 (da)
KR (2) KR20130042593A (da)
CN (1) CN1933842A (da)
AT (1) ATE437643T1 (da)
AU (2) AU2005224157B2 (da)
BR (1) BRPI0507654A (da)
CA (1) CA2558112C (da)
CY (1) CY1109523T1 (da)
DE (1) DE602005015686D1 (da)
DK (1) DK1727550T3 (da)
ES (1) ES2327757T3 (da)
GB (1) GB0406282D0 (da)
HK (1) HK1098372A1 (da)
PL (1) PL1727550T3 (da)
PT (1) PT1727550E (da)
RU (1) RU2388476C2 (da)
WO (1) WO2005089769A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
US20100056500A1 (en) * 2006-11-21 2010-03-04 Thitiwan Buranachokaisan Stable Parenteral Formulation
GB201506448D0 (en) 2015-04-16 2015-06-03 Univ Durham An antimicrobial compound
AU2016297024B2 (en) 2015-07-22 2021-03-04 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
GB201613942D0 (en) 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound
WO2018129287A1 (en) 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
EP3582784B1 (en) 2017-02-16 2022-06-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
WO2018226801A1 (en) 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
MX2020004084A (es) * 2017-09-29 2020-07-29 Enanta Pharm Inc Agentes farmaceuticos como inhibidores del rsv para utilizar en combinacion.
CN111343990B (zh) 2017-11-13 2023-08-04 英安塔制药有限公司 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法
WO2019094920A1 (en) * 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2020190935A1 (en) 2019-03-18 2020-09-24 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CA3153297A1 (en) 2019-10-04 2021-04-08 Adam SZYMANIAK Antiviral heterocyclic compounds
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
BR112023016970A2 (pt) 2021-02-26 2023-10-10 Enanta Pharm Inc Compostos heterocíclicos antivirais

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
EP0491218A1 (en) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones
CN1251579A (zh) * 1997-04-07 2000-04-26 Axys药物公司 治疗与丝氨酸蛋白酶－特别是类胰蛋白酶－活性有关的疾病的化合物与组合物
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) * 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
EP1461036A4 (en) * 2001-12-10 2005-11-16 Bristol Myers Squibb Co BIS HYDROCHLORIDE SALT MONOHYDRATE OF A SYNCYTIAL RESPIRATORY VIRUS FUSION INHIBITOR (RSV)
JP2004107494A (ja) * 2002-09-18 2004-04-08 National Institute For Materials Science 熱可塑性層状アルキルシロキサンとその製造方法
BR0314595A (pt) * 2002-09-20 2005-08-09 Arrow Therapeutics Ltd Uso de um derivado de benzodiazepina ou um sal farmaceuticamente aceitável deste, inalador ou nebulisador, produto, usos de um produto e de um composto ou sal farmaceuticamente aceitável deste, derivado de benzodiazepina, composto, e, composição farmacêutica
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds

Also Published As

Publication number Publication date
US20070142403A1 (en) 2007-06-21
AU2009212826A1 (en) 2009-09-17
CA2558112A1 (en) 2005-09-29
RU2388476C2 (ru) 2010-05-10
EP1727550B1 (en) 2009-07-29
CN1933842A (zh) 2007-03-21
HK1098372A1 (en) 2007-07-20
PL1727550T3 (pl) 2010-01-29
ATE437643T1 (de) 2009-08-15
CY1109523T1 (el) 2014-08-13
GB0406282D0 (en) 2004-04-21
AU2005224157B2 (en) 2009-05-28
CA2558112C (en) 2014-07-29
WO2005089769A1 (en) 2005-09-29
PT1727550E (pt) 2009-08-28
RU2006136880A (ru) 2008-04-27
JP2007529489A (ja) 2007-10-25
JP4940128B2 (ja) 2012-05-30
AU2005224157A1 (en) 2005-09-29
KR20070009629A (ko) 2007-01-18
DE602005015686D1 (de) 2009-09-10
ES2327757T3 (es) 2009-11-03
EP1727550A1 (en) 2006-12-06
US8853204B2 (en) 2014-10-07
KR20130042593A (ko) 2013-04-26
BRPI0507654A (pt) 2007-07-10
KR101292431B1 (ko) 2013-07-31

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