HK1093988A1 - 用作靶向線粒體的抗氧化劑的線粒體醌衍生物 - Google Patents
用作靶向線粒體的抗氧化劑的線粒體醌衍生物Info
- Publication number
- HK1093988A1 HK1093988A1 HK06113105.9A HK06113105A HK1093988A1 HK 1093988 A1 HK1093988 A1 HK 1093988A1 HK 06113105 A HK06113105 A HK 06113105A HK 1093988 A1 HK1093988 A1 HK 1093988A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- derivatives used
- mitochondrially targeted
- targeted antioxidants
- mitoquinone
- mitoquinone derivatives
- Prior art date
Links
- OIIMUKXVVLRCAF-UHFFFAOYSA-N 10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium Chemical class O=C1C(OC)=C(OC)C(=O)C(CCCCCCCCCC[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1C OIIMUKXVVLRCAF-UHFFFAOYSA-N 0.000 title 1
- 239000003963 antioxidant agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ52780003 | 2003-08-22 | ||
| NZ52915303 | 2003-10-23 | ||
| NZ53355604 | 2004-06-14 | ||
| PCT/NZ2004/000196 WO2005019232A1 (en) | 2003-08-22 | 2004-08-23 | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1093988A1 true HK1093988A1 (zh) | 2007-03-16 |
Family
ID=37852364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK06113105.9A HK1093988A1 (zh) | 2003-08-22 | 2006-11-29 | 用作靶向線粒體的抗氧化劑的線粒體醌衍生物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7888335B2 (zh) |
| JP (1) | JP4648319B2 (zh) |
| KR (1) | KR101003960B1 (zh) |
| CN (1) | CN1839142B (zh) |
| AU (1) | AU2011201909A1 (zh) |
| ES (1) | ES2541769T3 (zh) |
| HK (1) | HK1093988A1 (zh) |
| IL (1) | IL173807A (zh) |
| NZ (1) | NZ546070A (zh) |
| SG (1) | SG145715A1 (zh) |
| ZA (1) | ZA200602304B (zh) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080275005A1 (en) * | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20070270381A1 (en) * | 2000-05-25 | 2007-11-22 | Antipodean Pharmaceuticals, Inc. | Mitochondrially targeted antioxidants |
| US20060229278A1 (en) * | 1998-11-25 | 2006-10-12 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US7888334B2 (en) * | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US9045505B2 (en) | 2006-09-28 | 2015-06-02 | University Of Otago | Nitric oxide donors |
| ES2391662T3 (es) * | 2006-09-28 | 2012-11-28 | Medical Research Council | Donadores de óxido nítrico de tionitrílo de trifenilfosfonio |
| EP2197890A1 (en) * | 2007-09-07 | 2010-06-23 | Gencia Corporation | Mitochondrial compositions and uses thereof |
| SG10201608068SA (en) | 2008-04-01 | 2016-11-29 | Antipodean Pharmaceuticals Inc | Compositions And Methods For Skin Care |
| US20100173024A1 (en) * | 2008-12-01 | 2010-07-08 | LifeSpan Extension, LLC | Methods and compositions for altering health, wellbeing, and lifespan |
| DE102008061340A1 (de) | 2008-12-11 | 2010-09-23 | Henkel Ag & Co. Kgaa | Antioxidative Zusammensetzungen |
| US8748369B2 (en) | 2009-06-05 | 2014-06-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Use of targeted nitroxide agents in bone healing |
| JP5659388B2 (ja) * | 2009-06-10 | 2015-01-28 | マイトテック ソシエテ アノニム | 医学及び獣医眼科の使用のための医薬組成物 |
| KR102111997B1 (ko) | 2011-04-26 | 2020-05-18 | 레트로토프 인코포레이티드 | Ｐｕｆａ와 관련된 신경퇴행성 질환 및 근육 질환 |
| WO2012148930A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Oxidative retinal diseases |
| US10154978B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Disorders implicating PUFA oxidation |
| KR102020579B1 (ko) | 2011-04-26 | 2019-09-10 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
| EP2758411A2 (en) * | 2011-09-19 | 2014-07-30 | Gencia Corporation | Modified creatine compounds |
| JP6356614B2 (ja) * | 2012-02-17 | 2018-07-11 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 薬剤のミトコンドリア輸送のためのナノ粒子 |
| AU2014256546B2 (en) * | 2013-04-24 | 2017-03-30 | Biotechnologicky Ustav Av Cr, V.V.I. | Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level |
| CA2941970A1 (en) | 2014-03-13 | 2015-09-17 | Retrotope, Inc. | Optic neuropathy treatment and reduction of steroid-induced oxidative stress with stabilized polyunsaturated substances |
| JP6158754B2 (ja) * | 2014-06-04 | 2017-07-05 | 信越化学工業株式会社 | レジスト下層膜形成用組成物、及びパターン形成方法 |
| CN105001261B (zh) * | 2015-07-16 | 2017-04-12 | 中国人民解放军第四军医大学 | 线粒体功能保护剂及其制备方法与应用 |
| US20190183927A1 (en) * | 2016-08-11 | 2019-06-20 | Sulfilatec, Inc. | Medical and nutritional compositions and methods of use |
| KR102580606B1 (ko) | 2016-11-17 | 2023-09-19 | 레트로토프 인코포레이티드 | 동위원소로 변형된 성분 및 이의 치료학적 용도 |
| US11497749B2 (en) | 2017-10-24 | 2022-11-15 | Lunella Biotech, Inc. | Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration |
| JP2022523053A (ja) * | 2019-01-25 | 2022-04-21 | ヴァンダービルト ユニバーシティー | ミトコンドリアを標的とするイソケタール／イソレブグランジンスカベンジャー |
| KR102630237B1 (ko) * | 2019-03-08 | 2024-01-29 | 울산과학기술원 | Tpp 유도체 화합물 및 이를 포함하는 노화 또는 노화 관련 질환의 치료 또는 예방을 위한 약학적 조성물 |
| KR20210076875A (ko) * | 2019-12-16 | 2021-06-24 | 주식회사 스마틴바이오 | 신생혈관형성인자의 억제를 위한 화합물 및 그 용도 |
| AU2021309106A1 (en) * | 2020-07-11 | 2023-03-09 | The Regents Of The University Of California | Compositions and methods for inhibiting and treating coronavirus infections |
| WO2022019362A1 (ko) * | 2020-07-24 | 2022-01-27 | 울산과학기술원 | Tpp 유도체 화합물 및 이를 포함하는 노화 또는 노화 관련 질환의 치료 또는 예방을 위한 약학적 조성물 |
| CA3191819A1 (en) | 2020-09-09 | 2022-03-17 | Hazel Szeto | Methods and compositions for delivery of biotin to mitochondria |
| CN114504583A (zh) * | 2020-11-17 | 2022-05-17 | 山东大学 | Mitoquinone在制备抗冠状病毒感染药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3532667A (en) | 1967-05-31 | 1970-10-06 | Du Pont | Polyamides stabilized with phosphonium halides |
| JPH0237338B2 (ja) | 1982-08-27 | 1990-08-23 | Takeda Chemical Industries Ltd | 99*3*44jimetokishii22hidorokishii66mechirubenzoiru*nonanoeetonoseizoho |
| ES2051841T3 (es) | 1987-04-27 | 1994-07-01 | Takeda Chemical Industries Ltd | Reduccion de esteres carboxilicos. |
| JP2764100B2 (ja) | 1989-08-11 | 1998-06-11 | 日本化学工業株式会社 | 有機ホスホニウム塩の製造方法 |
| US5296349A (en) | 1990-06-14 | 1994-03-22 | Emory University | Molecular genetic test for myoclonic epilepsy |
| NO172369C (no) | 1990-06-21 | 1993-07-07 | Neosign As | Klebbar, fluorescerende folie |
| EP0535283A1 (en) | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Cardioprotective tocopherol analogs |
| NO302519B1 (no) | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
| JPH07223991A (ja) | 1993-12-17 | 1995-08-22 | Takeda Chem Ind Ltd | アシル置換芳香族化合物の製造法 |
| CA2186636A1 (en) | 1994-03-30 | 1995-10-12 | Corinna Herrnstadt | Diagnosis, therapy and cellular and animal models for diseases associated with mitochondrial defects |
| JP2637705B2 (ja) | 1995-03-02 | 1997-08-06 | 株式会社ナード研究所 | ベンゾキノン系誘導体の製造法 |
| KR0157024B1 (ko) | 1996-04-17 | 1998-11-16 | 이능희 | 양이온성 비타민 e 유도체 및 그의 제조방법, 및 그를 이용하여 형성한 항산화 작용을 갖는 양친매성 고분자 베시클 |
| NZ505352A (en) | 1997-11-25 | 2002-12-20 | Univ Otago | Mitochondrially targeted antioxidants |
| US20030069208A1 (en) * | 1997-11-25 | 2003-04-10 | University Of Otago | Mitochondrially targeted antioxidants |
| US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
| US6133322A (en) | 1998-10-29 | 2000-10-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
| US20080275005A1 (en) | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20060229278A1 (en) | 1998-11-25 | 2006-10-12 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US20070270381A1 (en) | 2000-05-25 | 2007-11-22 | Antipodean Pharmaceuticals, Inc. | Mitochondrially targeted antioxidants |
| US6673908B1 (en) | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
| DE10003493A1 (de) | 2000-01-27 | 2001-08-09 | Wacker Chemie Gmbh | Verfahren zur Herstellung eines Koezym Q10-/y-Cyclodextrin Komplexes |
| DE10035513A1 (de) | 2000-07-21 | 2002-01-31 | Beiersdorf Ag | Wirkstoffkombinationen bzw. Addukte aus Cyclodextrinen und mindestens einem Chinon und/oder mindestens einem Hydrochinon und Verwendung solcher Wirkstoffkombinationen in kosmetischen Zubereitungen |
| US6300377B1 (en) * | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
| NZ513547A (en) * | 2001-08-13 | 2002-09-27 | Antipodean Biotechnology Ltd | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
| NZ534496A (en) | 2002-02-06 | 2006-08-31 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| CA2397684A1 (en) | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| AU2004266988B2 (en) | 2003-08-22 | 2011-05-26 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| SG10201608068SA (en) | 2008-04-01 | 2016-11-29 | Antipodean Pharmaceuticals Inc | Compositions And Methods For Skin Care |
-
2004
- 2004-08-23 SG SG200805813-3A patent/SG145715A1/en unknown
- 2004-08-23 ES ES04775122.7T patent/ES2541769T3/es active Active
- 2004-08-23 IL IL173807A patent/IL173807A/en active IP Right Grant
- 2004-08-23 JP JP2006523805A patent/JP4648319B2/ja active Active
- 2004-08-23 US US10/568,655 patent/US7888335B2/en active Active
- 2004-08-23 CN CN2004800241553A patent/CN1839142B/zh active Active
- 2004-08-23 KR KR1020097024866A patent/KR101003960B1/ko active IP Right Grant
- 2004-08-23 NZ NZ546070A patent/NZ546070A/en unknown
-
2006
- 2006-03-20 ZA ZA2006/02304A patent/ZA200602304B/en unknown
- 2006-11-29 HK HK06113105.9A patent/HK1093988A1/zh unknown
-
2011
- 2011-01-05 US US12/985,205 patent/US20110288055A1/en not_active Abandoned
- 2011-04-28 AU AU2011201909A patent/AU2011201909A1/en not_active Abandoned
-
2016
- 2016-10-14 US US15/294,519 patent/US20170246195A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR101003960B1 (ko) | 2010-12-30 |
| US7888335B2 (en) | 2011-02-15 |
| ES2541769T3 (es) | 2015-07-24 |
| IL173807A (en) | 2014-02-27 |
| ZA200602304B (en) | 2012-06-27 |
| CN1839142B (zh) | 2010-06-16 |
| IL173807A0 (en) | 2006-07-05 |
| US20170246195A1 (en) | 2017-08-31 |
| NZ546070A (en) | 2010-01-29 |
| AU2011201909A1 (en) | 2011-05-19 |
| US20110288055A1 (en) | 2011-11-24 |
| CN1839142A (zh) | 2006-09-27 |
| US20080161267A1 (en) | 2008-07-03 |
| SG145715A1 (en) | 2008-09-29 |
| KR20100003306A (ko) | 2010-01-07 |
| JP2007503387A (ja) | 2007-02-22 |
| JP4648319B2 (ja) | 2011-03-09 |
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