HK1092409A1 - Multiple laminar flow-based particle and cellular separation with laser steering - Google Patents

Multiple laminar flow-based particle and cellular separation with laser steering

Info

Publication number
HK1092409A1
HK1092409A1 HK06113128.2A HK06113128A HK1092409A1 HK 1092409 A1 HK1092409 A1 HK 1092409A1 HK 06113128 A HK06113128 A HK 06113128A HK 1092409 A1 HK1092409 A1 HK 1092409A1
Authority
HK
Hong Kong
Prior art keywords
laminar flow
based particle
laser steering
multiple laminar
cellular separation
Prior art date
Application number
HK06113128.2A
Other languages
English (en)
Chinese (zh)
Inventor
Neil Harris Rosenbaum
Amy Anderson
Lewis Gruber
Dan Mueth
Joseph Plewa
Jessica Shireman
Original Assignee
Premium Genetics Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/867,328 external-priority patent/US7150834B2/en
Application filed by Premium Genetics Uk Ltd filed Critical Premium Genetics Uk Ltd
Publication of HK1092409A1 publication Critical patent/HK1092409A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005Field flow fractionation
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/04Acceleration by electromagnetic wave pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/02Electro-statically separating liquids from liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04Processes or apparatus for producing holograms
    • G03H1/08Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/22Processes or apparatus for obtaining an optical image from holograms
    • G03H1/2294Addressing the hologram to an active spatial light modulator
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005Adaptation of holography to specific applications
    • G03H2001/0077Adaptation of holography to specific applications for optical manipulation, e.g. holographic optical tweezers [HOT]
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03HHOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04Processes or apparatus for producing holograms
    • G03H1/08Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • G03H1/0841Encoding method mapping the synthesized field into a restricted set of values representative of the modulator parameters, e.g. detour phase coding
    • G03H2001/085Kinoform, i.e. phase only encoding wherein the computed field is processed into a distribution of phase differences

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Electromagnetism (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK06113128.2A 2003-09-04 2006-11-30 Multiple laminar flow-based particle and cellular separation with laser steering HK1092409A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49995703P 2003-09-04 2003-09-04
US51145803P 2003-10-15 2003-10-15
US57114104P 2004-05-14 2004-05-14
US10/867,328 US7150834B2 (en) 2003-07-31 2004-06-13 Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
PCT/US2004/029053 WO2005023391A2 (fr) 2003-07-31 2004-09-03 Particule basee sur flux laminaire multiple et separation cellulaire a guidage laser

Publications (1)

Publication Number Publication Date
HK1092409A1 true HK1092409A1 (en) 2007-02-09

Family

ID=52347979

Family Applications (2)

Application Number Title Priority Date Filing Date
HK06113128.2A HK1092409A1 (en) 2003-09-04 2006-11-30 Multiple laminar flow-based particle and cellular separation with laser steering
HK07105556.8A HK1098980A1 (en) 2003-09-04 2007-05-28 Multiple laminar flow-based particle and cellular separation with laser steering

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK07105556.8A HK1098980A1 (en) 2003-09-04 2007-05-28 Multiple laminar flow-based particle and cellular separation with laser steering

Country Status (5)

Country Link
EP (1) EP1663460B1 (fr)
JP (6) JP5046645B2 (fr)
HK (2) HK1092409A1 (fr)
TW (1) TW200523534A (fr)
WO (1) WO2005023391A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
EP2188027A4 (fr) * 2007-09-11 2011-06-08 Arryx Inc Procédé de liaison et appareil pour trier des objets
EP2185261A4 (fr) * 2007-09-13 2013-08-28 Arryx Inc Procédés et appareils pour trier des objets dans une analyse médico-légale d'arn et dans des diagnostics médicaux
US9364831B2 (en) 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
EP2640844B1 (fr) * 2010-11-16 2021-03-24 1087 Systems, Inc. Système d'identification et de tri de cellules vivantes
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US20120225475A1 (en) 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
US8941062B2 (en) 2010-11-16 2015-01-27 1087 Systems, Inc. System for identifying and sorting living cells
US9176504B2 (en) 2011-02-11 2015-11-03 The Regents Of The University Of California High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation
US9259741B2 (en) * 2011-12-29 2016-02-16 Danmarks Tekniske Universitet System for sorting microscopic objects using electromagnetic radiation
WO2013128561A1 (fr) * 2012-02-28 2013-09-06 株式会社メニコン Instrument de manipulation de cellules
US9545472B2 (en) * 2012-03-02 2017-01-17 Medtronic, Inc. Extracorporeal blood circuit reservoir with angled venous inlet luer port
CA2909687A1 (fr) 2013-03-15 2014-09-25 The Regents Of The University Of California Production haute vitesse a la demande de gouttelettes microfluidiques et manipulation
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
KR20150014781A (ko) 2013-07-30 2015-02-09 삼성전자주식회사 유체를 여과하기 위한 장치 및 그를 이용한 입자를 분리하는 방법
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
LT3183568T (lt) * 2014-08-20 2023-01-25 Stem Sel S.R.L. Objektų frakcionavimo įrenginys ir frakcionavimo būdas
JP6832848B2 (ja) * 2014-10-20 2021-02-24 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション 組織試料処理システム及びそれに関連する方法
US20180163713A1 (en) * 2015-06-23 2018-06-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
JP6762695B2 (ja) * 2015-09-18 2020-09-30 浜松ホトニクス株式会社 流路装置
US20190366342A1 (en) * 2016-10-24 2019-12-05 Gpb Scientific, Llc Deterministic lateral displacement in the preparation of cells and compositions for therapeutic uses
WO2018235634A1 (fr) * 2017-06-21 2018-12-27 株式会社ニコン Dispositif pour fluides et son utilisation
EP3422364B1 (fr) * 2017-06-27 2019-12-11 Medizinische Universität Graz Procédé et dispositif d'analyse d'un échantillon fluidique comprenant des particules dispersées
EP3796998A1 (fr) 2018-05-23 2021-03-31 ABS Global, Inc. Systèmes et procédés de focalisation de particules dans des microcanaux
JP7162330B2 (ja) * 2018-07-11 2022-10-28 株式会社アタゴ 粘度計
JP2020082047A (ja) * 2018-11-30 2020-06-04 シスメックス株式会社 分離成否判定方法、粒子検出方法および粒子分離装置
WO2020175381A1 (fr) * 2019-02-27 2020-09-03 京セラ株式会社 Dispositif de mesure et de séparation de particules, et appareil de mesure et de séparation de particules
JP7212886B2 (ja) * 2019-03-22 2023-01-26 国立研究開発法人産業技術総合研究所 受精用精子液の製造方法及び凍結精子ストローの製造方法
EP3955735B1 (fr) 2019-04-18 2024-05-22 ABS Global, Inc. Système et procédé d'ajout en continu de cryoprotecteur
KR102266834B1 (ko) * 2019-08-13 2021-06-17 경희대학교 산학협력단 정자 처리를 위한 미세유체장치
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
JP2020157295A (ja) * 2020-06-10 2020-10-01 浜松ホトニクス株式会社 流路装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5890513A (ja) * 1981-11-26 1983-05-30 Asahi Chem Ind Co Ltd 血液成分の分取法および分取装置
JPS57131451A (en) * 1981-02-05 1982-08-14 Asahi Chemical Ind Method and apparatus for separating blood components
US4765899A (en) * 1983-10-11 1988-08-23 E. I. Du Pont De Nemours And Company Apparatus for continuous separation of leukocyte/platelet-enriched fraction from whole blood
JP2777385B2 (ja) * 1988-11-30 1998-07-16 株式会社日立製作所 生物細胞の培養方法,培養システム及び培養装置
GB9003253D0 (en) * 1990-02-13 1990-04-11 Amersham Int Plc Precipitating polymers
JPH0427866A (ja) * 1990-05-23 1992-01-30 Omron Corp 細胞選別装置
JPH0526799A (ja) * 1991-07-19 1993-02-02 Nippon Steel Corp 微粒子の分離方法
JPH0724309A (ja) * 1993-07-08 1995-01-27 Canon Inc 粒子の分離方法及び装置
US6797942B2 (en) * 2001-09-13 2004-09-28 University Of Chicago Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers
WO1997000442A1 (fr) * 1995-06-16 1997-01-03 The University Of Washington Procede et dispositif miniaturise d'extraction differentielle
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
AU3570797A (en) * 1996-06-14 1998-01-07 University Of Washington Absorption-enhanced differential extraction device
ATE211258T1 (de) * 1996-09-04 2002-01-15 Scandinavian Micro Biodevices Mikrofliesssystem für die teilchenanalyse und trennung
CA2277860C (fr) * 1997-01-08 2005-11-29 Bristol-Myers Squibb Company Centrifugeuse pour la separation du sang
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
DE19810195A1 (de) * 1998-03-10 1999-09-23 Reinhard Salinger Verfahren und Vorrichtung zur Sammlung und Weiterverarbeitung von spezifischen Blutkomponenten bei kontinuierlichen laminaren Strömungsverhältnissen
NZ551401A (en) * 2000-05-09 2009-12-24 Xy Inc A particle differentiation apparatus which differentiates between X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
JP2004534661A (ja) * 2001-05-14 2004-11-18 アリックス インコーポレイテッド 光勾配力を印加する改良された装置、システムおよび方法

Also Published As

Publication number Publication date
TW200523534A (en) 2005-07-16
JP2012020149A (ja) 2012-02-02
JP6154425B2 (ja) 2017-06-28
JP2012073268A (ja) 2012-04-12
JP2017026629A (ja) 2017-02-02
WO2005023391A2 (fr) 2005-03-17
JP6592414B2 (ja) 2019-10-16
JP2015164935A (ja) 2015-09-17
HK1098980A1 (en) 2007-08-03
JP5250674B2 (ja) 2013-07-31
JP5160622B2 (ja) 2013-03-13
JP5046645B2 (ja) 2012-10-10
EP1663460A4 (fr) 2008-01-09
EP1663460B1 (fr) 2015-07-08
WO2005023391A3 (fr) 2005-12-01
JP2007515936A (ja) 2007-06-21
JP2011079842A (ja) 2011-04-21
EP1663460A2 (fr) 2006-06-07
JP5789178B2 (ja) 2015-10-07

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190903