HK1089443A1 - Imidazol-4-yl-ethynyl-pyridine derivatives - Google Patents

Imidazol-4-yl-ethynyl-pyridine derivatives

Info

Publication number
HK1089443A1
HK1089443A1 HK06109889A HK06109889A HK1089443A1 HK 1089443 A1 HK1089443 A1 HK 1089443A1 HK 06109889 A HK06109889 A HK 06109889A HK 06109889 A HK06109889 A HK 06109889A HK 1089443 A1 HK1089443 A1 HK 1089443A1
Authority
HK
Hong Kong
Prior art keywords
imidazol
ethynyl
pyridine derivatives
pyridine
derivatives
Prior art date
Application number
HK06109889A
Other languages
English (en)
Inventor
Buettelmann Bernd
Ceccarelli Simona Maria
Jaeschke Georg
Kolczewski Sabine
Porter Richard Hugh Philip
Vieira Eric
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1089443A1 publication Critical patent/HK1089443A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06109889A 2003-03-10 2006-09-06 Imidazol-4-yl-ethynyl-pyridine derivatives HK1089443A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03004952 2003-03-10
PCT/EP2004/002276 WO2004080998A1 (en) 2003-03-10 2004-03-05 Imidazol-4-yl-ethynyl-pyridine derivatives

Publications (1)

Publication Number Publication Date
HK1089443A1 true HK1089443A1 (en) 2006-12-01

Family

ID=32981724

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109889A HK1089443A1 (en) 2003-03-10 2006-09-06 Imidazol-4-yl-ethynyl-pyridine derivatives

Country Status (31)

Country Link
US (1) US7153874B2 (de)
EP (1) EP1606277B8 (de)
JP (1) JP4404896B2 (de)
KR (1) KR100742019B1 (de)
CN (1) CN100358889C (de)
AR (1) AR043501A1 (de)
AT (1) ATE395345T1 (de)
AU (1) AU2004220382B2 (de)
BR (1) BRPI0408093A (de)
CA (1) CA2516682C (de)
CL (1) CL2004000449A1 (de)
CO (1) CO5601027A2 (de)
DE (1) DE602004013746D1 (de)
DK (1) DK1606277T3 (de)
ES (1) ES2305739T3 (de)
HK (1) HK1089443A1 (de)
HR (1) HRP20050774A2 (de)
IL (1) IL170129A (de)
MX (1) MXPA05009524A (de)
MY (1) MY135491A (de)
NO (1) NO20054136L (de)
NZ (1) NZ541643A (de)
PA (1) PA8597301A1 (de)
PE (1) PE20041061A1 (de)
PL (1) PL1606277T3 (de)
PT (1) PT1606277E (de)
RU (1) RU2342383C2 (de)
SI (1) SI1606277T1 (de)
TW (1) TWI292318B (de)
WO (1) WO2004080998A1 (de)
ZA (1) ZA200506834B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
EP1756086B1 (de) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
NZ551253A (en) * 2004-06-01 2010-07-30 Hoffmann La Roche Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
DE102006011574A1 (de) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2068872A1 (de) * 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
NZ577440A (en) 2006-12-21 2011-12-22 Hoffmann La Roche Polymorphs of a mglur5 receptor antagonist
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8586581B2 (en) 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
CA2829170C (en) 2011-04-26 2019-02-26 F. Hoffmann-La Roche Ag Ethynyl derivatives as positive allosteric modulators of the mglur5
UA116023C2 (uk) 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
EP3400220B1 (de) * 2016-01-05 2021-03-24 Hua Medicine (Shanghai) Ltd. Pyrazolderivate
TW201837026A (zh) 2017-01-10 2018-10-16 德商拜耳廠股份有限公司 作為除害劑之雜環衍生物（二）
KR102515694B1 (ko) 2017-01-10 2023-03-29 바이엘 악티엔게젤샤프트 해충 방제제로서의 헤테로사이클 유도체
CN114746408A (zh) * 2019-12-02 2022-07-12 豪夫迈·罗氏有限公司 炔基-(杂芳基)-甲酰胺hcn1抑制剂
CN111416154B (zh) * 2020-05-22 2021-08-06 松山湖材料实验室 高电压锂离子电池电解液硅基吡啶添加剂、电解液及其电池
US20240182420A1 (en) 2021-03-27 2024-06-06 Syngenta Crop Protection Ag Microbiocidal isonicotinic amide derivatives
WO2023089049A2 (en) 2021-11-19 2023-05-25 Syngenta Crop Protection Ag Microbiocidal isonicotinic amide derivatives
WO2024132901A1 (en) 2022-12-19 2024-06-27 Syngenta Crop Protection Ag Microbiocidal pyridazine dihydrooxadiazine derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303199A (en) * 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (de) 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en) 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
US4711962A (en) * 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
DE69025473T2 (de) 1989-06-30 1996-10-17 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
NZ502463A (en) 1997-08-14 2002-05-31 F 1-Phenyl vinyl substituted imidazole, triazole or tetrazole derivatives useful for controlling or preventing acute or chronic neurological disorders
JP4815083B2 (ja) 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法
WO2002046166A1 (en) 2000-12-04 2002-06-13 F. Hoffmann-La Roche Ag Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
JP2005516950A (ja) * 2001-12-19 2005-06-09 メルク　エンド　カムパニー　インコーポレーテッド 代謝型グルタミン酸受容体−５のヘテロアリール置換イミダゾールモジュレータ

Also Published As

Publication number Publication date
DE602004013746D1 (de) 2008-06-26
ES2305739T3 (es) 2008-11-01
SI1606277T1 (sl) 2008-08-31
PL1606277T3 (pl) 2008-10-31
KR20050109074A (ko) 2005-11-17
TWI292318B (en) 2008-01-11
PT1606277E (pt) 2008-07-08
TW200423935A (en) 2004-11-16
KR100742019B1 (ko) 2007-07-23
MXPA05009524A (es) 2005-10-18
HRP20050774A2 (en) 2006-09-30
MY135491A (en) 2008-04-30
CN1759111A (zh) 2006-04-12
ATE395345T1 (de) 2008-05-15
ZA200506834B (en) 2006-05-31
CO5601027A2 (es) 2006-01-31
CN100358889C (zh) 2008-01-02
EP1606277A1 (de) 2005-12-21
IL170129A (en) 2013-02-28
DK1606277T3 (da) 2008-08-18
CL2004000449A1 (es) 2005-01-07
US20040229917A1 (en) 2004-11-18
AU2004220382B2 (en) 2007-08-02
NO20054136D0 (no) 2005-09-06
RU2342383C2 (ru) 2008-12-27
EP1606277B1 (de) 2008-05-14
AR043501A1 (es) 2005-08-03
BRPI0408093A (pt) 2006-02-14
RU2005131165A (ru) 2007-04-20
PE20041061A1 (es) 2005-01-22
NZ541643A (en) 2008-03-28
CA2516682A1 (en) 2004-09-23
CA2516682C (en) 2010-02-02
WO2004080998A1 (en) 2004-09-23
JP2006519802A (ja) 2006-08-31
PA8597301A1 (es) 2004-09-16
AU2004220382A1 (en) 2004-09-23
NO20054136L (no) 2005-09-26
JP4404896B2 (ja) 2010-01-27
US7153874B2 (en) 2006-12-26
EP1606277B8 (de) 2008-10-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120305