HK1084657A1 - Interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators - Google Patents

Interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators

Info

Publication number
HK1084657A1
HK1084657A1 HK06104909.6A HK06104909A HK1084657A1 HK 1084657 A1 HK1084657 A1 HK 1084657A1 HK 06104909 A HK06104909 A HK 06104909A HK 1084657 A1 HK1084657 A1 HK 1084657A1
Authority
HK
Hong Kong
Prior art keywords
modulators
interleukin
necrosis factor
tumor necrosis
syntheses
Prior art date
Application number
HK06104909.6A
Other languages
English (en)
Inventor
Michael Palladino
Emmanuel Theodorakis
Original Assignee
Nereus Pharmaceuticals Inc
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc, The Regents Of The University Of California filed Critical Nereus Pharmaceuticals Inc
Publication of HK1084657A1 publication Critical patent/HK1084657A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
HK06104909.6A 1999-05-14 2006-04-25 Interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators HK1084657A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US18685300P 2000-03-03 2000-03-03

Publications (1)

Publication Number Publication Date
HK1084657A1 true HK1084657A1 (en) 2006-08-04

Family

ID=26832188

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06104909.6A HK1084657A1 (en) 1999-05-14 2006-04-25 Interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators

Country Status (18)

Country Link
US (3) US6365768B1 (pt)
EP (2) EP1178952B1 (pt)
JP (2) JP5059996B2 (pt)
KR (3) KR100840925B1 (pt)
CN (1) CN1361760A (pt)
AT (2) ATE370928T1 (pt)
AU (2) AU783372B2 (pt)
BR (1) BR0011522A (pt)
CA (1) CA2372962C (pt)
DE (2) DE60043400D1 (pt)
DK (1) DK1178952T5 (pt)
ES (2) ES2337264T3 (pt)
HK (1) HK1084657A1 (pt)
IL (3) IL146221A0 (pt)
MX (1) MXPA01011613A (pt)
NZ (3) NZ515675A (pt)
PT (2) PT1178952E (pt)
WO (1) WO2000073253A1 (pt)

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Also Published As

Publication number Publication date
IL146221A0 (en) 2002-07-25
BR0011522A (pt) 2002-06-04
DE60036101D1 (de) 2007-10-04
PT1591437E (pt) 2010-03-04
DE60036101T2 (de) 2008-05-15
CA2372962C (en) 2008-04-08
US6881857B2 (en) 2005-04-19
DE60043400D1 (de) 2010-01-07
ES2337264T3 (es) 2010-04-22
US6365768B1 (en) 2002-04-02
US20030040640A1 (en) 2003-02-27
JP2003500464A (ja) 2003-01-07
CN1361760A (zh) 2002-07-31
EP1591437B1 (en) 2009-11-25
EP1178952B1 (en) 2007-08-22
US7342125B2 (en) 2008-03-11
ES2295031T3 (es) 2008-04-16
DK1178952T3 (da) 2008-01-28
EP1591437A3 (en) 2006-03-08
JP2012211162A (ja) 2012-11-01
AU783372B2 (en) 2005-10-20
ATE370928T1 (de) 2007-09-15
KR100856353B1 (ko) 2008-09-04
MXPA01011613A (es) 2003-10-14
DK1178952T5 (da) 2008-03-17
EP1591437A2 (en) 2005-11-02
IL182272A0 (en) 2007-07-24
AU2006200240B2 (en) 2009-05-28
ATE449754T1 (de) 2009-12-15
JP5059996B2 (ja) 2012-10-31
PT1178952E (pt) 2007-12-04
US20050209325A1 (en) 2005-09-22
NZ529505A (en) 2005-09-30
KR20060110013A (ko) 2006-10-23
IL182272A (en) 2010-05-31
IL146221A (en) 2007-07-04
EP1178952A1 (en) 2002-02-13
KR100840925B1 (ko) 2008-06-24
AU2006200240A1 (en) 2006-02-16
NZ540001A (en) 2007-06-29
KR20060135080A (ko) 2006-12-28
WO2000073253A1 (en) 2000-12-07
NZ515675A (en) 2004-06-25
CA2372962A1 (en) 2000-12-07
AU5013300A (en) 2000-12-18
KR20020028878A (ko) 2002-04-17

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