DK1178952T5 - Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer - Google Patents

Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer

Info

Publication number
DK1178952T5
DK1178952T5 DK00932408T DK00932408T DK1178952T5 DK 1178952 T5 DK1178952 T5 DK 1178952T5 DK 00932408 T DK00932408 T DK 00932408T DK 00932408 T DK00932408 T DK 00932408T DK 1178952 T5 DK1178952 T5 DK 1178952T5
Authority
DK
Denmark
Prior art keywords
modulators
interleukin
necrosis factor
tumor necrosis
synthesis
Prior art date
Application number
DK00932408T
Other languages
Danish (da)
English (en)
Other versions
DK1178952T3 (da
Inventor
Michael Palladino
Emmanuel A Theodorakis
Original Assignee
Univ California
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Nereus Pharmaceuticals Inc filed Critical Univ California
Publication of DK1178952T3 publication Critical patent/DK1178952T3/da
Application granted granted Critical
Publication of DK1178952T5 publication Critical patent/DK1178952T5/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/32Unsaturated compounds containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/28Unsaturated compounds polycyclic
    • C07C61/29Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/35Unsaturated compounds having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
DK00932408T 1999-05-14 2000-05-12 Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer DK1178952T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US18685300P 2000-03-03 2000-03-03
PCT/US2000/013202 WO2000073253A1 (en) 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS

Publications (2)

Publication Number Publication Date
DK1178952T3 DK1178952T3 (da) 2008-01-28
DK1178952T5 true DK1178952T5 (da) 2008-03-17

Family

ID=26832188

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00932408T DK1178952T5 (da) 1999-05-14 2000-05-12 Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer

Country Status (18)

Country Link
US (3) US6365768B1 (pt)
EP (2) EP1178952B1 (pt)
JP (2) JP5059996B2 (pt)
KR (3) KR100840925B1 (pt)
CN (1) CN1361760A (pt)
AT (2) ATE370928T1 (pt)
AU (2) AU783372B2 (pt)
BR (1) BR0011522A (pt)
CA (1) CA2372962C (pt)
DE (2) DE60043400D1 (pt)
DK (1) DK1178952T5 (pt)
ES (2) ES2337264T3 (pt)
HK (1) HK1084657A1 (pt)
IL (3) IL146221A0 (pt)
MX (1) MXPA01011613A (pt)
NZ (3) NZ515675A (pt)
PT (2) PT1178952E (pt)
WO (1) WO2000073253A1 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211030T3 (es) * 1998-01-26 2004-07-01 Sae Han Pharm. Co., Ltd. Derivados diterpenos y agentes analgesicos anti-inflamatorios que comprenden a los mismos.
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7119223B2 (en) * 1999-05-14 2006-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
DK1178952T5 (da) * 1999-05-14 2008-03-17 Univ California Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2002255963A1 (en) * 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use
US20030087334A1 (en) * 2001-04-02 2003-05-08 Libraria, Inc. Method of flexibly generating diverse reaction chemistries
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
JP2005532992A (ja) * 2002-01-25 2005-11-04 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 肝炎治療剤及び予防剤または肝臓保護剤として有用なソムオガルピ(AcanthopanaxKoreanum)抽出物
US7517542B2 (en) * 2004-03-03 2009-04-14 Korea Research Institute Of Bioscience Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
ATE556046T1 (de) 2005-07-21 2012-05-15 Nereus Pharmaceuticals Inc Interleukin-1- und tumornekrosefaktor-a- modulatoren, synthese solcher modulatoren und verfahren unter anwendung solcher modulatoren
CA2670099A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP1925301A1 (en) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders
US7875853B2 (en) * 2007-07-23 2011-01-25 Honeywell International Inc. Low-cost PIR scanning mechanism
SI2252283T1 (sl) 2008-01-11 2019-02-28 Reata Pharmaceuticals, Inc. Sintetični triterpenoidi in postopki uporabe pri zdravljenju bolezni
ME02751B (me) 2008-04-18 2018-01-20 Reata Pharmaceuticals Inc Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline
EA020467B1 (ru) 2008-04-18 2014-11-28 Ритэ Фамэсутикл, Инк. Соединения, обладающие противовоспалительной активностью, и фармацевтическая композиция на их основе
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
MX2010011437A (es) 2008-04-18 2010-12-20 Reata Pharmaceuticals Inc Moduladores antioxidantes de inflamacion: derivados del acido oleanolico con saturacion en el anillo c.
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
US20110293653A1 (en) * 2010-03-11 2011-12-01 University Of Massachusetts Antagonists of mir-155 for the treatment of inflammatory liver disease
CA2795320C (en) 2010-04-12 2019-01-22 Reata Pharmaceuticals, Inc. Method of treating obesity using antioxidant inflammation modulators
EP2632892B1 (en) * 2010-10-27 2014-07-30 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Diterpenoid derivatives endowed of biological properties
NZ611427A (en) 2010-12-06 2015-08-28 Penn State Res Found Compositions and methods relating to proliferative diseases
US8513436B2 (en) 2010-12-17 2013-08-20 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
UY33946A (es) 2011-03-11 2012-08-31 Reata Pharmaceuticals Inc Derivados de c4-monometil triterpenoides y sus métodos de uso
RS56154B1 (sr) 2012-04-27 2017-11-30 Reata Pharmaceuticals Inc 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
ES2731758T3 (es) 2012-09-10 2019-11-18 Reata Pharmaceuticals Inc Derivados de alcanodiil y alquenodiil de c17 del ácido oleanólico y métodos de uso de los mismos
MX2018003569A (es) 2015-09-23 2018-11-29 Reata Pharmaceuticals Inc Derivados de acido oleanolico modificado en c4 para la inhibicion de il-17 y otros usos.
MX2019005401A (es) 2016-11-08 2019-08-05 Reata Pharmaceuticals Inc Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.
CN106928095A (zh) * 2017-03-14 2017-07-07 华东师范大学 氰基烯酮类三环二萜类似物及其制备方法和应用
US10463631B2 (en) * 2017-06-12 2019-11-05 University Of South Carolina Pimarane diterpenoids for use in wound healing and angiogenesis

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212708B2 (pt) 1974-05-14 1977-04-08
JPS522910B2 (pt) 1974-05-17 1977-01-25
GB1452053A (en) 1974-08-28 1976-10-06 Nippon Shinyaku Co Ltd Abietamide derivatives and a method for the preparation thereof
US4874891A (en) 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5192817A (en) 1990-03-06 1993-03-09 Otsuka Pharmaceutical Co., Ltd. Phenanthrene derivatives
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5653962A (en) 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
ES2119996T3 (es) 1992-11-27 1998-10-16 Napro Biotherapeutics Inc Composicion inyectable que comprende faclitaxel.
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
EP0721335B1 (en) 1993-10-01 2005-08-31 Roche Palo Alto LLC Mycophenolate mofetil high dose oral suspensions
KR0145941B1 (ko) * 1994-06-13 1998-08-17 김은영 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
ES2211030T3 (es) * 1998-01-26 2004-07-01 Sae Han Pharm. Co., Ltd. Derivados diterpenos y agentes analgesicos anti-inflamatorios que comprenden a los mismos.
US6051590A (en) 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
DK1178952T5 (da) * 1999-05-14 2008-03-17 Univ California Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer
AU2002255963A1 (en) 2001-03-28 2002-10-15 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use

Also Published As

Publication number Publication date
IL146221A0 (en) 2002-07-25
BR0011522A (pt) 2002-06-04
DE60036101D1 (de) 2007-10-04
PT1591437E (pt) 2010-03-04
DE60036101T2 (de) 2008-05-15
CA2372962C (en) 2008-04-08
US6881857B2 (en) 2005-04-19
DE60043400D1 (de) 2010-01-07
ES2337264T3 (es) 2010-04-22
US6365768B1 (en) 2002-04-02
US20030040640A1 (en) 2003-02-27
JP2003500464A (ja) 2003-01-07
CN1361760A (zh) 2002-07-31
HK1084657A1 (en) 2006-08-04
EP1591437B1 (en) 2009-11-25
EP1178952B1 (en) 2007-08-22
US7342125B2 (en) 2008-03-11
ES2295031T3 (es) 2008-04-16
DK1178952T3 (da) 2008-01-28
EP1591437A3 (en) 2006-03-08
JP2012211162A (ja) 2012-11-01
AU783372B2 (en) 2005-10-20
ATE370928T1 (de) 2007-09-15
KR100856353B1 (ko) 2008-09-04
MXPA01011613A (es) 2003-10-14
EP1591437A2 (en) 2005-11-02
IL182272A0 (en) 2007-07-24
AU2006200240B2 (en) 2009-05-28
ATE449754T1 (de) 2009-12-15
JP5059996B2 (ja) 2012-10-31
PT1178952E (pt) 2007-12-04
US20050209325A1 (en) 2005-09-22
NZ529505A (en) 2005-09-30
KR20060110013A (ko) 2006-10-23
IL182272A (en) 2010-05-31
IL146221A (en) 2007-07-04
EP1178952A1 (en) 2002-02-13
KR100840925B1 (ko) 2008-06-24
AU2006200240A1 (en) 2006-02-16
NZ540001A (en) 2007-06-29
KR20060135080A (ko) 2006-12-28
WO2000073253A1 (en) 2000-12-07
NZ515675A (en) 2004-06-25
CA2372962A1 (en) 2000-12-07
AU5013300A (en) 2000-12-18
KR20020028878A (ko) 2002-04-17

Similar Documents

Publication Publication Date Title
DK1178952T5 (da) Hidtil ukendte modulatorer af interleukin 1 og tumornekrosefaktor a, syntese af nævnte modulatorer og fremgangsmåder til anvendelse af nævnte modulatorer
WO2003006570A3 (en) Novel mesogens and methods for their synthesis and use
DE69325143T2 (de) Härtbare, polymere Zusammensetzung
CH0788360H1 (de) Boronsäure-und-esterverbindungen, deren synthese und verwendungen.
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
DK1183328T3 (da) Mikrocellulære polymerer som cellevækstmedier og nye polymerer
IS4967A (is) Bindill tengdur æxlisdrepthætti
NO993297D0 (no) Fast dyrkningsmedium for mikroorganismer, fremgangsmÕte for fremstilling herav og anvendelse herav
EP1445115A4 (en) IMIDENCES AND OPTICAL RECORDING MEDIA MANUFACTURED THEREOF
ITUD20000155A0 (it) Dispositivo per la produzione di pannelli di mosaico, relativo procedimento e pannelli di mosaico cosi' ottenuti
DE50204011D1 (de) Natursteinpaneel
NO20023412L (no) Fremgangsmåter, optiske registreringsanordninger som bruker slike fremgangsmåter og optiske registreringsmedium for bruk vedfremgangsmåtene og registreringsanordningene
TR199901386T2 (en) �midazopiridazinler.
EP1367048A4 (en) AMINO-PRODUCING COMPOUNDS USING LIGHT-EMITTING RADIATION, LIGHT-CURABLE COMPOSITIONS, AND LIGHT-EMITTING ADHESIVE COMPOSITIONS
ITUD960217A0 (it) Piastra a tenuta per terreno di coltura doppio
EP1048641A4 (en) APOPTOSIS-TIMER
DE59005057D1 (de) Mischgaspumpen-Antrieb.
IT1304846B1 (it) Composizione ecologica autoestinguente per la realizzazione di formeplastiche, stucchi, pannelli e simili.
WO1993021150A3 (en) Arthropodicidal aryl sulfonates
AU2003220415A8 (en) Polymer, producing method thereof, and photorefractive composition
ES2186164T3 (es) Kodaistatinas a, b, c y d, un procedimiento para su produccion y su uso.
AU2003241312A1 (en) Molecular interaction sites of vimentin rna and methods of modulating the same
ES1029667Y (es) Catamaran impulsado por el viento.
DE19780346D2 (de) Steinerne Heizplatte, vorzugsweise aus Naturstein
DE29809928U1 (de) Nährbodenträger