HK1084387A1 - Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicycloÄ3, 1, 0Ühexane-2-carboxamide, n-Ä3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropylÜ-3-Ä(2s)-2-ÄÄÄ1, 1-dimethylethylÜaminoÜcarbonyla minoÜ-3, 3-dimethyl-1-oxobutylÜ-6, 6-dimethyl - Google Patents

Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicycloÄ3, 1, 0Ühexane-2-carboxamide, n-Ä3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropylÜ-3-Ä(2s)-2-ÄÄÄ1, 1-dimethylethylÜaminoÜcarbonyla minoÜ-3, 3-dimethyl-1-oxobutylÜ-6, 6-dimethyl

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Publication number
HK1084387A1
HK1084387A1 HK06104536A HK06104536A HK1084387A1 HK 1084387 A1 HK1084387 A1 HK 1084387A1 HK 06104536 A HK06104536 A HK 06104536A HK 06104536 A HK06104536 A HK 06104536A HK 1084387 A1 HK1084387 A1 HK 1084387A1
Authority
HK
Hong Kong
Prior art keywords
dimethyl
äää1
oxobutylü
minoü
dioxopropylü
Prior art date
Application number
HK06104536A
Other languages
English (en)
Inventor
Park Jeonghan
Chen Minzhang
Nguyen Hoa
Zavialov Ilia
Sudhakar Anantha
Weber Juergen
Jeon Ingyu
Green Michael
Dahanukar Vilas
Orr Cecilia
Wong George
Iwama Tetsuo
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1084387A1 publication Critical patent/HK1084387A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06104536A 2003-06-17 2006-04-13 Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicycloÄ3, 1, 0Ühexane-2-carboxamide, n-Ä3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropylÜ-3-Ä(2s)-2-ÄÄÄ1, 1-dimethylethylÜaminoÜcarbonyla minoÜ-3, 3-dimethyl-1-oxobutylÜ-6, 6-dimethyl HK1084387A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951703P 2003-06-17 2003-06-17
PCT/US2004/018914 WO2004113294A1 (fr) 2003-06-17 2004-06-15 Procede et intermediaires pour preparer du (1r,2s,5s)-3-azabicyclo[3,1,0]hexane-2-carboxamide, n-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2s)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyle

Publications (1)

Publication Number Publication Date
HK1084387A1 true HK1084387A1 (en) 2006-07-28

Family

ID=33539185

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06104536A HK1084387A1 (en) 2003-06-17 2006-04-13 Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicycloÄ3, 1, 0Ühexane-2-carboxamide, n-Ä3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropylÜ-3-Ä(2s)-2-ÄÄÄ1, 1-dimethylethylÜaminoÜcarbonyla minoÜ-3, 3-dimethyl-1-oxobutylÜ-6, 6-dimethyl

Country Status (13)

Country Link
US (1) US7326795B2 (fr)
EP (1) EP1641754B1 (fr)
JP (1) JP5219368B2 (fr)
CN (2) CN1805932B (fr)
AR (1) AR044694A1 (fr)
AT (1) ATE390412T1 (fr)
CA (1) CA2526629C (fr)
DE (1) DE602004012746T2 (fr)
ES (1) ES2299850T3 (fr)
HK (1) HK1084387A1 (fr)
MX (1) MXPA05013753A (fr)
WO (1) WO2004113294A1 (fr)
ZA (1) ZA200509100B (fr)

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WO2005107745A1 (fr) * 2004-05-06 2005-11-17 Schering Corporation Inhibiteur de l'hepatite c
US20060276404A1 (en) * 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
PL1891089T3 (pl) 2005-06-02 2015-05-29 Merck Sharp & Dohme Inhibitory proteazy HCV w połączeniu z pokarmem
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
AU2006252553B2 (en) * 2005-06-02 2012-03-29 Merck Sharp & Dohme Corp. Combination of HCV protease inhibitors with a surfactant
NZ567262A (en) * 2005-09-30 2011-12-22 Scynexis Inc Cyclosporin derivatives and their use for the treatment and prevention of hepatitis C infection
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
CN101384551B (zh) * 2005-12-22 2012-08-29 先灵公司 制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物和其对映体盐的方法
JP5092289B2 (ja) * 2006-06-13 2012-12-05 三菱瓦斯化学株式会社 光学活性Ｎ−ｔｅｒｔ−ブチルカルバモイル−Ｌ−ｔｅｒｔ−ロイシンの製造方法
CN101610999A (zh) * 2006-12-15 2009-12-23 先灵公司 α-酮酰胺的亚硫酸氢盐纯化方法
EP2121568A2 (fr) 2006-12-19 2009-11-25 Schering Corporation Préparation du chlorhydrate de 3-amino-3-(cyclobutylmethyl)-2-(hydroxy)-propionamide
JP5431956B2 (ja) * 2006-12-20 2014-03-05 メルク・シャープ・アンド・ドーム・コーポレーション 重亜硫酸塩中間体を使用した６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサン化合物の調製方法
WO2008079216A1 (fr) * 2006-12-20 2008-07-03 Schering Corporation Procédé de préparation du (1r,2s,5s)-n-[(1s)-3-amino-1-(cyclobutylméthyl)-2,3-dioxopropryl]-3-[(2s)-2-[[[(1,1-diméthyléthyl)amino]-carbonyl]amino]-3,3-diméthyl-1-oxobutyl]-6,6-diméthyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
WO2009039361A2 (fr) * 2007-09-20 2009-03-26 Virobay, Inc. Procédé pour la préparation d'acide (s)-2-(3-tert-butyluréido)-3,3-diméthylbutanoïque
US8183408B2 (en) 2007-11-16 2012-05-22 Kaneka Corporation Process for production of N-carbamoyl-tert-leucine
US20090175824A1 (en) * 2007-11-20 2009-07-09 Craig Masse Peptides for the treatment of HCV infections
JP2011504929A (ja) * 2007-11-28 2011-02-17 シェーリング コーポレイション ６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサンを提供するのに有用な中間体調製のための脱塩化水素化プロセス
EP2238100B1 (fr) * 2007-12-21 2014-03-26 Merck Sharp & Dohme Corp. Procede de synthese du 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide ou de ses sels
CA2729823A1 (fr) * 2008-07-03 2010-01-07 Vertex Pharmaceuticals Incorporated Preparation d'esters et d'amides d'alpha-ceto-beta-amino proteges
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US20120244122A1 (en) 2009-05-28 2012-09-27 Masse Craig E Peptides for the Treatment of HCV Infections
MX2013012773A (es) * 2011-05-04 2013-11-21 Merck Sharp & Dohme Sustancias farmacologicas, composiciones farmaceuticas y metodos para la preparacion de las mismas.
WO2013189980A1 (fr) * 2012-06-20 2013-12-27 Sandoz Ag Synthèse de télaprévir et de bocéprévir, ou de sels ou de solvates pharmaceutiquement acceptables de ceux-ci et produits intermédiaires correspondants, notamment des acides ss-aminés, préparés par addition aldolique de mukaiyama
WO2014061034A1 (fr) * 2012-10-18 2014-04-24 Msn Laboratories Limited Procédé de préparation de boceprevir et de ses intermédiaires
US10238771B2 (en) * 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
CN103936627B (zh) * 2013-01-18 2016-08-31 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅶ及其制备方法和应用
WO2014164844A1 (fr) * 2013-03-11 2014-10-09 Virobay, Inc. Inhibiteurs de la cathepsine
WO2015004685A2 (fr) 2013-07-12 2015-01-15 Mylan Laboratories Ltd Procédé amélioré de purification du boceprevir
DK3054936T5 (da) 2013-10-10 2024-03-18 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzensulfonamid derivater som 12-lipoxygenase inhibitorer
CN104744291B (zh) * 2015-02-13 2017-01-11 宁波九胜创新医药科技有限公司 N-苄基-4-环丁基-2-羟基-3-硝基丁酰胺及其用途
US20220025424A1 (en) * 2016-08-16 2022-01-27 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100330553B1 (ko) * 1993-10-01 2002-11-27 노파르티스 아게 약물학적활성피리딘유도체및그의제조방법
PL206255B1 (pl) 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus

Also Published As

Publication number Publication date
CN102199111A (zh) 2011-09-28
EP1641754A1 (fr) 2006-04-05
EP1641754B1 (fr) 2008-03-26
CA2526629A1 (fr) 2004-12-29
ZA200509100B (en) 2011-06-29
ES2299850T3 (es) 2008-06-01
DE602004012746D1 (de) 2008-05-08
CA2526629C (fr) 2012-10-02
US7326795B2 (en) 2008-02-05
CN1805932A (zh) 2006-07-19
MXPA05013753A (es) 2006-03-08
WO2004113294A1 (fr) 2004-12-29
CN1805932B (zh) 2011-05-18
AR044694A1 (es) 2005-09-21
DE602004012746T2 (de) 2009-04-09
CN102199111B (zh) 2012-07-04
JP5219368B2 (ja) 2013-06-26
US20050059800A1 (en) 2005-03-17
ATE390412T1 (de) 2008-04-15
JP2006528133A (ja) 2006-12-14

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140615