HK1077825A1 - process for preparing 5-(4-fluorophenyl)-1-Ä2-(2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethylÜ-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide - Google Patents

process for preparing 5-(4-fluorophenyl)-1-Ä2-(2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethylÜ-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Info

Publication number
HK1077825A1
HK1077825A1 HK05109934A HK05109934A HK1077825A1 HK 1077825 A1 HK1077825 A1 HK 1077825A1 HK 05109934 A HK05109934 A HK 05109934A HK 05109934 A HK05109934 A HK 05109934A HK 1077825 A1 HK1077825 A1 HK 1077825A1
Authority
HK
Hong Kong
Prior art keywords
ethylü
pyran
fluorophenyl
pyrrole
tetrahydro
Prior art date
Application number
HK05109934A
Other languages
English (en)
Inventor
Jade Douglas Nelson
Pamment Michael Gerard
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HK1077825A1 publication Critical patent/HK1077825A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK05109934A 2002-08-06 2005-11-08 process for preparing 5-(4-fluorophenyl)-1-Ä2-(2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethylÜ-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide HK1077825A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40170702P 2002-08-06 2002-08-06
PCT/IB2003/003322 WO2004014896A1 (en) 2002-08-06 2003-07-25 Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Publications (1)

Publication Number Publication Date
HK1077825A1 true HK1077825A1 (en) 2006-02-24

Family

ID=31715723

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05109934A HK1077825A1 (en) 2002-08-06 2005-11-08 process for preparing 5-(4-fluorophenyl)-1-Ä2-(2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethylÜ-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Country Status (20)

Country Link
US (3) US6777560B2 (zh)
EP (1) EP1534704B1 (zh)
JP (1) JP2005539018A (zh)
CN (1) CN100357289C (zh)
AR (1) AR040777A1 (zh)
AT (1) ATE368661T1 (zh)
AU (1) AU2003247124A1 (zh)
BR (1) BR0313246A (zh)
CA (1) CA2494269A1 (zh)
DE (1) DE60315308T2 (zh)
ES (1) ES2287549T3 (zh)
HK (1) HK1077825A1 (zh)
IL (1) IL166119A0 (zh)
MX (1) MXPA05001427A (zh)
PL (1) PL375415A1 (zh)
RS (1) RS20050105A (zh)
RU (1) RU2279430C2 (zh)
TW (1) TW200413358A (zh)
WO (1) WO2004014896A1 (zh)
ZA (1) ZA200500049B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2494269A1 (en) * 2002-08-06 2004-02-19 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2004089894A1 (en) * 2003-04-14 2004-10-21 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
JP4901474B2 (ja) 2003-05-30 2012-03-21 ランバクシー ラボラトリーズ リミテッド 置換ピロール誘導体
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法
CN101205209B (zh) * 2007-12-25 2010-06-02 浙江新东港药业股份有限公司 一种阿伐他汀中间体的精制方法
WO2011028309A1 (en) 2009-09-04 2011-03-10 University Of Toledo PROCESSES FOR PRODUCING OPTICALLY PURE β-LACTONES FROM ALDEHYDES AND COMPOSITIONS PRODUCED THEREBY
CN106083656B (zh) * 2016-06-20 2018-11-13 连云港笃翔化工有限公司 一种地瑞那韦关键中间体的合成方法
CN116496496A (zh) * 2023-04-27 2023-07-28 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US509045A (en) * 1893-11-21 passburg
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5149837A (en) 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5248793A (en) 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
CZ294108B6 (cs) 1995-07-17 2004-10-13 Warner@Lambertácompany Krystalická forma I hydrátu atorvastatinuŹ tj@ semivápenaté soli kyseliny [R@}RgŹRgB]@}@fluorfenylB@betaŹdelta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové
HRP960313B1 (en) 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
US6087511A (en) 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
IL127058A (en) 1996-07-29 2001-07-24 Warner Lambert Co Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric
AU1058801A (en) * 1999-10-18 2001-04-30 Pohang University Of Science And Technology Preparing method of chiral ester
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US6562201B2 (en) * 2001-06-08 2003-05-13 Applied Semiconductor, Inc. Semiconductive polymeric system, devices incorporating the same, and its use in controlling corrosion
CA2494269A1 (en) * 2002-08-06 2004-02-19 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide

Also Published As

Publication number Publication date
WO2004014896A1 (en) 2004-02-19
DE60315308D1 (de) 2007-09-13
DE60315308T2 (de) 2007-12-20
EP1534704A1 (en) 2005-06-01
RU2005102839A (ru) 2005-07-10
JP2005539018A (ja) 2005-12-22
US6777560B2 (en) 2004-08-17
ATE368661T1 (de) 2007-08-15
RU2279430C2 (ru) 2006-07-10
MXPA05001427A (es) 2005-06-06
CN100357289C (zh) 2007-12-26
US20040068121A1 (en) 2004-04-08
RS20050105A (en) 2007-11-15
US7084282B2 (en) 2006-08-01
CA2494269A1 (en) 2004-02-19
AU2003247124A1 (en) 2004-02-25
IL166119A0 (en) 2006-01-15
ES2287549T3 (es) 2007-12-16
ZA200500049B (en) 2006-07-26
EP1534704B1 (en) 2007-08-01
BR0313246A (pt) 2005-06-14
TW200413358A (en) 2004-08-01
US20040220254A1 (en) 2004-11-04
US20060106228A1 (en) 2006-05-18
PL375415A1 (en) 2005-11-28
CN1675200A (zh) 2005-09-28
AR040777A1 (es) 2005-04-20

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110725