HK1077228A1 - Method of purifying polypeptides by simulated moving bed chromatography - Google Patents
Method of purifying polypeptides by simulated moving bed chromatographyInfo
- Publication number
- HK1077228A1 HK1077228A1 HK05111940.3A HK05111940A HK1077228A1 HK 1077228 A1 HK1077228 A1 HK 1077228A1 HK 05111940 A HK05111940 A HK 05111940A HK 1077228 A1 HK1077228 A1 HK 1077228A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- moving bed
- simulated moving
- bed chromatography
- purifying polypeptides
- polypeptides
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterized by the components to be separated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41050602P | 2002-09-13 | 2002-09-13 | |
PCT/US2003/028809 WO2004024284A2 (en) | 2002-09-13 | 2003-09-12 | Method of purifying polypeptides by simulated moving bed chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1077228A1 true HK1077228A1 (en) | 2006-02-10 |
Family
ID=31994146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05111940.3A HK1077228A1 (en) | 2002-09-13 | 2005-12-23 | Method of purifying polypeptides by simulated moving bed chromatography |
Country Status (11)
Country | Link |
---|---|
US (2) | US7220356B2 (xx) |
EP (1) | EP1545574B8 (xx) |
JP (1) | JP2006507249A (xx) |
CN (2) | CN1777435B (xx) |
AU (2) | AU2003272368C1 (xx) |
CA (1) | CA2498725C (xx) |
DK (1) | DK1545574T3 (xx) |
HK (1) | HK1077228A1 (xx) |
NZ (2) | NZ539297A (xx) |
SI (1) | SI1545574T1 (xx) |
WO (1) | WO2004024284A2 (xx) |
Families Citing this family (54)
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NZ539297A (en) | 2002-09-13 | 2008-04-30 | Biogen Idec Inc | Method of purifying polypeptides by simulated moving bed chromatography |
CN1771080B (zh) * | 2003-04-08 | 2010-12-15 | 诺沃挪第克公司 | 包括至少一个色谱处理步骤的生产治疗用多肽或其前体的方法 |
US7479222B2 (en) | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
EP1812131A1 (en) | 2004-10-01 | 2007-08-01 | 3M Innovative Properties Company | Method and apparatus for separating a target molecule from a liquid mixture |
EP1716900A1 (en) * | 2005-04-29 | 2006-11-02 | Eidgenössische Technische Hochschule Zürich | Method and device for chromatographic purification |
CN100434135C (zh) * | 2005-09-23 | 2008-11-19 | 中国科学院过程工程研究所 | 一种使用三相逆流色谱分离纯化天然产物的方法 |
US7544293B2 (en) | 2005-09-26 | 2009-06-09 | Semba Inc. | Valve and process for interrupted continuous flow chromatography |
US7413660B2 (en) | 2005-09-30 | 2008-08-19 | 3M Innovative Properties Company | Single pass method and apparatus for separating a target molecule from a liquid mixture |
WO2008048395A1 (en) * | 2006-08-30 | 2008-04-24 | Semba Biosciences, Inc. | Valve module and methods for simulated moving bed chromatography |
US8807164B2 (en) * | 2006-08-30 | 2014-08-19 | Semba Biosciences, Inc. | Valve module and methods for simulated moving bed chromatography |
US7790040B2 (en) | 2006-08-30 | 2010-09-07 | Semba Biosciences, Inc. | Continuous isocratic affinity chromatography |
AU2007351639B2 (en) * | 2007-04-17 | 2012-12-13 | Propharma Group Europe B.V. | Method and device for continuous membrane adsorption |
JP5571552B2 (ja) | 2007-06-15 | 2014-08-13 | ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー | クロマトグラフィー法 |
US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
JP5999899B2 (ja) | 2008-04-08 | 2016-09-28 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 抗体のクロマトグラフィー精製法 |
US8196603B2 (en) * | 2008-08-20 | 2012-06-12 | Semba Biosciences, Inc. | Valve block assembly |
EP2373391A1 (en) * | 2008-12-08 | 2011-10-12 | Novo Nordisk A/S | Counter current purification of polypeptides |
EP2445936A1 (en) | 2009-06-26 | 2012-05-02 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
KR20190018041A (ko) | 2009-08-06 | 2019-02-20 | 제넨테크, 인크. | 단백질 정제 시의 바이러스 제거의 개선방법 |
CN101781671A (zh) * | 2010-03-16 | 2010-07-21 | 黑龙江八一农垦大学 | 玉米抗氧化肽的分离纯化方法 |
CN101798587B (zh) * | 2010-03-22 | 2012-07-25 | 黑龙江八一农垦大学 | 玉米降血压肽的分离纯化方法 |
KR101152036B1 (ko) * | 2010-04-27 | 2012-06-08 | (주)셀트리온 | 컬럼 순환 및 시료 연속주입법을 이용한 단백질 a 크로마토그래피 정제 방법 |
US9428546B2 (en) | 2010-07-30 | 2016-08-30 | Pfizer Inc. | Tandem purification of proteins |
EP2618904A1 (en) * | 2010-09-20 | 2013-07-31 | AbbVie Inc. | Purification of antibodies using simulated moving bed chromatography |
BR112013013884A2 (pt) * | 2010-12-06 | 2016-09-13 | Pall Corp | métodos de processamento contínuo para produtos biológicos |
EP2578286A1 (en) | 2011-10-04 | 2013-04-10 | Merck Patent GmbH | Method and apparatus for chromatographic purification |
BR112015005389B1 (pt) | 2012-09-13 | 2022-10-18 | Indiana University Research And Technology Corporation | Molécula de ácido nucleico recombinante, proteína de substrato modificada de uma protease específica de patógeno de planta expressa através do patógeno de planta, vetor, e método para proteger uma planta da infecção por um patógeno de planta que secreta pelo menos uma protease específica |
RU2768003C2 (ru) | 2013-03-08 | 2022-03-22 | Джензим Корпорейшн | Интегрированное непрерывное производство терапевтических белковых лекарственных веществ |
TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
TWI671312B (zh) * | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
CN104263787B (zh) * | 2014-09-10 | 2015-05-20 | 中国海洋大学 | 一种脱除南极磷虾多肽中氟化物和灰分的方法 |
US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
GB201515339D0 (en) | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
US9821249B2 (en) | 2015-09-08 | 2017-11-21 | Orochem Technologies, Inc. | Continuous process for separation of proteins |
EP3368176A2 (en) | 2015-10-26 | 2018-09-05 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
CN109311948B (zh) | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 清洁和/或消毒分离基质的方法 |
US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
CA3031742A1 (en) | 2016-08-16 | 2018-02-22 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
DK3532838T3 (da) | 2016-10-25 | 2022-07-04 | Regeneron Pharma | Fremgangsmåder og systemer til kromatografidataanalyse |
GB201622343D0 (en) * | 2016-12-29 | 2017-02-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
GB201703116D0 (en) | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
GB201710130D0 (en) | 2017-06-26 | 2017-08-09 | Ge Healthcare Bioprocess R & D Ab | A Method of seperation |
CN109836479B (zh) * | 2017-11-27 | 2021-01-12 | 申联生物医药(上海)股份有限公司 | 应用模拟流动床分离纯化fmd灭活病毒抗原的方法 |
EP3769083A1 (en) | 2018-03-21 | 2021-01-27 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
US11642609B2 (en) * | 2018-04-20 | 2023-05-09 | Propharma Group Europe B.V. | Method for separation with simulated moving bed |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
US11369703B2 (en) | 2018-08-31 | 2022-06-28 | Genzyme Corporation | Sterile chromatography resin and use thereof in manufacturing processes |
EP3742160B1 (en) * | 2019-05-24 | 2023-08-09 | Sartorius Stedim Biotech GmbH | Chromatography method, method of determining the concentration of at least one compound in a chromatography method and method of obtaining at least one chromatography method parameter |
WO2023192810A2 (en) * | 2022-03-27 | 2023-10-05 | Purdue Research Foundation | Multi-dimension, multi-mode chromatography methods for producing high purity, high yield lithium, cobalt, nickel, and manganese salts from waste lithium-ion batteries and other feedstocks |
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US5770088A (en) * | 1992-06-30 | 1998-06-23 | Daicel Chemical Industries, Ltd. | Simulated moving bed chromatographic separation process |
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US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
CN1036050C (zh) * | 1994-12-07 | 1997-10-08 | 中国石化扬子石油化工公司 | 改进的模拟移动床的吸附分离方法 |
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US5645729A (en) * | 1995-02-13 | 1997-07-08 | Uop | Separations by simulated moving bed chromatography operating at low k' values using weakly interacting adsorbents as the stationary phase |
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DE19611094C2 (de) | 1996-03-21 | 1999-06-17 | Dresden Arzneimittel | Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens |
FR2750886B1 (fr) * | 1996-07-11 | 1998-09-25 | Inst Francais Du Petrole | Dispositif de rincage dans une unite d'adsorption en lit mobile simule et son utilisation |
US6641735B1 (en) * | 2000-03-23 | 2003-11-04 | Japan Chemical Innovation Institute | Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material |
DE19858892A1 (de) * | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße |
US6479300B1 (en) * | 1999-03-15 | 2002-11-12 | Millipore Corporation | Metal loaded ligand bound membranes for metal ion affinity chromatography |
US6280623B1 (en) * | 1999-03-23 | 2001-08-28 | Hsien-Chih Ma | Differential and continuous separation apparatus with controlled parameters for solids and liquids |
EP1231992A1 (de) | 1999-11-20 | 2002-08-21 | Scinu Tec GmbH | Verfahren zur separation von zellen und biomolekülen mittels gegenstromchromatographie |
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BR0210386A (pt) * | 2001-06-13 | 2004-09-14 | Taurus Hsa Llc | Purificação de albumina de soro humano |
CA2463198A1 (en) * | 2001-10-03 | 2003-04-17 | Ucb, S.A. | Pyrrolidinone derivatives |
NZ539297A (en) | 2002-09-13 | 2008-04-30 | Biogen Idec Inc | Method of purifying polypeptides by simulated moving bed chromatography |
US6805799B2 (en) * | 2002-12-21 | 2004-10-19 | Qi-Feng Ma | Simulated moving bed chromatographic focusing |
-
2003
- 2003-09-12 NZ NZ539297A patent/NZ539297A/en not_active IP Right Cessation
- 2003-09-12 CA CA2498725A patent/CA2498725C/en not_active Expired - Lifetime
- 2003-09-12 DK DK03754547.2T patent/DK1545574T3/da active
- 2003-09-12 CN CN03824460.8A patent/CN1777435B/zh not_active Expired - Fee Related
- 2003-09-12 US US10/661,086 patent/US7220356B2/en not_active Expired - Lifetime
- 2003-09-12 EP EP03754547.2A patent/EP1545574B8/en not_active Expired - Lifetime
- 2003-09-12 NZ NZ563078A patent/NZ563078A/en not_active IP Right Cessation
- 2003-09-12 WO PCT/US2003/028809 patent/WO2004024284A2/en active Application Filing
- 2003-09-12 CN CN201010541907.0A patent/CN102050865B/zh not_active Expired - Fee Related
- 2003-09-12 AU AU2003272368A patent/AU2003272368C1/en not_active Expired
- 2003-09-12 JP JP2004536270A patent/JP2006507249A/ja active Pending
- 2003-09-12 SI SI200332386T patent/SI1545574T1/sl unknown
-
2005
- 2005-12-23 HK HK05111940.3A patent/HK1077228A1/xx not_active IP Right Cessation
-
2007
- 2007-05-21 US US11/751,147 patent/US8608960B2/en active Active
-
2009
- 2009-03-04 AU AU2009200842A patent/AU2009200842B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP1545574A4 (en) | 2006-07-19 |
US20070215534A1 (en) | 2007-09-20 |
NZ539297A (en) | 2008-04-30 |
AU2009200842A1 (en) | 2009-03-26 |
AU2009200842B2 (en) | 2011-06-02 |
CN1777435B (zh) | 2011-01-12 |
SI1545574T1 (sl) | 2014-10-30 |
EP1545574B8 (en) | 2014-09-24 |
US20040241878A1 (en) | 2004-12-02 |
WO2004024284A2 (en) | 2004-03-25 |
EP1545574B1 (en) | 2014-08-20 |
AU2003272368B2 (en) | 2008-12-04 |
AU2003272368C1 (en) | 2009-07-23 |
CA2498725C (en) | 2014-07-08 |
NZ563078A (en) | 2009-07-31 |
US7220356B2 (en) | 2007-05-22 |
DK1545574T3 (da) | 2014-09-08 |
CA2498725A1 (en) | 2004-03-25 |
CN102050865A (zh) | 2011-05-11 |
EP1545574A2 (en) | 2005-06-29 |
AU2003272368A1 (en) | 2004-04-30 |
JP2006507249A (ja) | 2006-03-02 |
US8608960B2 (en) | 2013-12-17 |
CN1777435A (zh) | 2006-05-24 |
CN102050865B (zh) | 2014-03-12 |
WO2004024284A3 (en) | 2004-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20230907 |