HK1075654A1 - Hyperforin derivatives, the use thereof and formulations containing them - Google Patents

Hyperforin derivatives, the use thereof and formulations containing them

Info

Publication number
HK1075654A1
HK1075654A1 HK05107783A HK05107783A HK1075654A1 HK 1075654 A1 HK1075654 A1 HK 1075654A1 HK 05107783 A HK05107783 A HK 05107783A HK 05107783 A HK05107783 A HK 05107783A HK 1075654 A1 HK1075654 A1 HK 1075654A1
Authority
HK
Hong Kong
Prior art keywords
formulations containing
hyperforin
hyperforin derivatives
derivatives
adhyperforin
Prior art date
Application number
HK05107783A
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Antonella Riva
Nicola Fuzzati
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of HK1075654A1 publication Critical patent/HK1075654A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)
HK05107783A 2002-04-23 2005-09-05 Hyperforin derivatives, the use thereof and formulations containing them HK1075654A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000872A ITMI20020872A1 (it) 2002-04-23 2002-04-23 Derivati dell'iperforina loro uso e formulazioni che li contengono
PCT/EP2003/004100 WO2003091194A1 (en) 2002-04-23 2003-04-18 Hyperforin derivatives, the use thereof and formulations containing them

Publications (1)

Publication Number Publication Date
HK1075654A1 true HK1075654A1 (en) 2005-12-23

Family

ID=11449767

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107783A HK1075654A1 (en) 2002-04-23 2005-09-05 Hyperforin derivatives, the use thereof and formulations containing them

Country Status (19)

Country Link
US (2) USRE43280E1 (xx)
EP (1) EP1497250B1 (xx)
JP (1) JP4315818B2 (xx)
KR (1) KR100944052B1 (xx)
CN (1) CN1290816C (xx)
AT (1) ATE404519T1 (xx)
CA (1) CA2483205C (xx)
DE (1) DE60322871D1 (xx)
DK (1) DK1497250T3 (xx)
ES (1) ES2311697T3 (xx)
HK (1) HK1075654A1 (xx)
IL (1) IL164763A (xx)
IT (1) ITMI20020872A1 (xx)
NO (1) NO329176B1 (xx)
PL (1) PL205829B1 (xx)
PT (1) PT1497250E (xx)
RU (1) RU2320636C2 (xx)
SI (1) SI1497250T1 (xx)
WO (1) WO2003091194A1 (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
CN103732568A (zh) * 2011-06-03 2014-04-16 哈佛大学的校长及成员们 贯叶金丝桃素类似物、其合成方法及其用途
ITMI20131012A1 (it) * 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
US20180071269A1 (en) 2015-08-12 2018-03-15 Tianxin Wang Therapeutical methods, formulations and nutraceutical formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59907545D1 (de) 1998-02-13 2003-12-04 Schwabe Willmar Gmbh & Co Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
JP2002539070A (ja) 1998-02-13 2002-11-19 ドクトル．ヴイルマル シュヴアベ ゲーエムベーハーウント コンパニー 痴呆症の治療及び予防におけるハイパーフォリン及びハイパーフォリン含有抽出物の使用
IT1301679B1 (it) 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
EP1497250B1 (en) 2008-08-13
CN1290816C (zh) 2006-12-20
US7105705B2 (en) 2006-09-12
RU2320636C2 (ru) 2008-03-27
PL205829B1 (pl) 2010-05-31
USRE43280E1 (en) 2012-03-27
KR100944052B1 (ko) 2010-02-24
KR20040111519A (ko) 2004-12-31
PT1497250E (pt) 2008-11-12
DK1497250T3 (da) 2008-12-01
CN1646462A (zh) 2005-07-27
IL164763A (en) 2010-02-17
NO329176B1 (no) 2010-09-06
NO20044519L (no) 2004-11-02
EP1497250A1 (en) 2005-01-19
DE60322871D1 (de) 2008-09-25
ATE404519T1 (de) 2008-08-15
ES2311697T3 (es) 2009-02-16
JP2005523917A (ja) 2005-08-11
IL164763A0 (en) 2005-12-18
PL371347A1 (en) 2005-06-13
RU2004131210A (ru) 2005-04-10
WO2003091194A1 (en) 2003-11-06
SI1497250T1 (sl) 2008-12-31
ITMI20020872A0 (it) 2002-04-23
ITMI20020872A1 (it) 2003-10-23
CA2483205C (en) 2011-07-05
JP4315818B2 (ja) 2009-08-19
US20050165117A1 (en) 2005-07-28
AU2003222828A1 (en) 2003-11-10
CA2483205A1 (en) 2003-11-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170418