HK1071143A1 - Crystalline form of a ribofuranosyluronamide derivative; a human adenosine a2a receptor agonist - Google Patents

Crystalline form of a ribofuranosyluronamide derivative; a human adenosine a2a receptor agonist

Info

Publication number
HK1071143A1
HK1071143A1 HK05103825A HK05103825A HK1071143A1 HK 1071143 A1 HK1071143 A1 HK 1071143A1 HK 05103825 A HK05103825 A HK 05103825A HK 05103825 A HK05103825 A HK 05103825A HK 1071143 A1 HK1071143 A1 HK 1071143A1
Authority
HK
Hong Kong
Prior art keywords
ribofuranosyluronamide
derivative
crystalline form
receptor agonist
human adenosine
Prior art date
Application number
HK05103825A
Other languages
English (en)
Inventor
Silk Terence Vernon
Smith Julian Duncan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HK1071143A1 publication Critical patent/HK1071143A1/xx

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Nanotechnology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
HK05103825A 2001-12-06 2005-05-06 Crystalline form of a ribofuranosyluronamide derivative; a human adenosine a2a receptor agonist HK1071143A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0129273.9A GB0129273D0 (en) 2001-12-06 2001-12-06 Crystalline drug form
PCT/IB2002/004979 WO2003048180A1 (fr) 2001-12-06 2002-11-27 Forme cristalline d'un derive de la ribofuranosyluronamide, agoniste du recepteur humain a2a de l'adenosine

Publications (1)

Publication Number Publication Date
HK1071143A1 true HK1071143A1 (en) 2005-07-08

Family

ID=9927165

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05103825A HK1071143A1 (en) 2001-12-06 2005-05-06 Crystalline form of a ribofuranosyluronamide derivative; a human adenosine a2a receptor agonist

Country Status (41)

Country Link
US (3) US6852746B2 (fr)
EP (1) EP1456219B1 (fr)
JP (1) JP4184279B2 (fr)
KR (1) KR100554333B1 (fr)
CN (1) CN100381454C (fr)
AP (1) AP2004003056A0 (fr)
AR (2) AR038547A1 (fr)
AT (1) ATE364615T1 (fr)
AU (2) AU2002347509B2 (fr)
BR (1) BR0214747A (fr)
CA (1) CA2468847C (fr)
CY (1) CY1106822T1 (fr)
DE (1) DE60220713T2 (fr)
DK (1) DK1456219T3 (fr)
EA (1) EA006857B1 (fr)
EC (1) ECSP045141A (fr)
ES (1) ES2286303T3 (fr)
GB (1) GB0129273D0 (fr)
GT (2) GT200200256A (fr)
HK (1) HK1071143A1 (fr)
HN (1) HN2002000352A (fr)
HR (1) HRP20040516A2 (fr)
HU (1) HUP0700046A2 (fr)
IL (2) IL162101A0 (fr)
IS (1) IS7279A (fr)
MA (1) MA27151A1 (fr)
MX (1) MXPA04005505A (fr)
NO (1) NO20042837L (fr)
NZ (1) NZ533053A (fr)
OA (1) OA12737A (fr)
PA (2) PA8560501A1 (fr)
PE (2) PE20030822A1 (fr)
PL (1) PL370971A1 (fr)
PT (1) PT1456219E (fr)
RS (1) RS49504A (fr)
SV (1) SV2004001425A (fr)
TN (1) TNSN04103A1 (fr)
TW (2) TW200301130A (fr)
UY (1) UY27568A1 (fr)
WO (2) WO2003048180A1 (fr)
ZA (1) ZA200403967B (fr)

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US20030225089A1 (en) * 2002-04-10 2003-12-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
JPWO2021084791A1 (fr) * 2019-10-28 2021-05-06
CN115400140B (zh) * 2022-01-27 2024-02-20 宁波熙健医药科技有限公司 呋喃核糖基吡啶衍生物用于预防或治疗癫痫或惊厥的用途

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US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
GB9913932D0 (en) * 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
WO2001020089A1 (fr) 1999-09-10 2001-03-22 Maeda Corporation Structure de beton et procede de construction
GB0003960D0 (en) * 2000-02-18 2000-04-12 Pfizer Ltd Purine derivatives
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
TWI227240B (en) * 2000-06-06 2005-02-01 Pfizer 2-aminocarbonyl-9H-purine derivatives
EP1304005B1 (fr) 2000-07-26 2004-09-15 Swisscom Mobile AG Procede permettant d'etablir une station de base dans un reseau de telephonie mobile et de relier cette station de base au reseau de telephonie mobile
EP1395287A1 (fr) * 2001-05-25 2004-03-10 Pfizer Inc. Combinaison d'agoniste de recepteur d'adenosine a2a et d'agent anticholinergique permettant de traiter des maladies obstructives des voies aeriennes

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CA2468847A1 (fr) 2003-06-12
HUP0700046A2 (en) 2007-03-28
EP1456219B1 (fr) 2007-06-13
SV2004001425A (es) 2004-05-07
AU2002347509B2 (en) 2008-09-18
TNSN04103A1 (fr) 2006-06-01
AR037633A1 (es) 2004-11-17
AU2002351056A1 (en) 2003-06-17
US20050085437A1 (en) 2005-04-21
WO2003047597A1 (fr) 2003-06-12
US6852746B2 (en) 2005-02-08
PL370971A1 (en) 2005-06-13
EA006857B1 (ru) 2006-04-28
TW200301129A (en) 2003-07-01
US20030158145A1 (en) 2003-08-21
UY27568A1 (es) 2003-07-31
IS7279A (is) 2004-05-21
MA27151A1 (fr) 2005-01-03
BR0214747A (pt) 2004-09-14
EA200400638A1 (ru) 2004-10-28
PE20030822A1 (es) 2003-10-04
RS49504A (en) 2006-10-27
PT1456219E (pt) 2007-08-03
DE60220713D1 (de) 2007-07-26
DK1456219T3 (da) 2007-09-24
KR20050058272A (ko) 2005-06-16
JP2005513043A (ja) 2005-05-12
ES2286303T3 (es) 2007-12-01
DE60220713T2 (de) 2008-03-06
JP4184279B2 (ja) 2008-11-19
AU2002347509A1 (en) 2003-06-17
ZA200403967B (en) 2006-05-31
CY1106822T1 (el) 2012-05-23
ECSP045141A (es) 2004-07-23
IL162101A0 (en) 2005-11-20
AP2004003056A0 (en) 2004-06-30
PA8560501A1 (es) 2003-09-17
MXPA04005505A (es) 2005-06-03
IL162101A (en) 2010-04-29
US7022727B2 (en) 2006-04-04
CN1599745A (zh) 2005-03-23
CA2468847C (fr) 2008-10-21
AR038547A1 (es) 2005-01-19
WO2003048180A1 (fr) 2003-06-12
PA8560301A1 (es) 2003-11-12
TW200301130A (en) 2003-07-01
ATE364615T1 (de) 2007-07-15
KR100554333B1 (ko) 2006-02-22
HRP20040516A2 (en) 2004-10-31
NZ533053A (en) 2006-09-29
CN100381454C (zh) 2008-04-16
HN2002000352A (es) 2003-07-23
OA12737A (en) 2006-06-29
EP1456219A1 (fr) 2004-09-15
GT200200256A (es) 2003-07-03
NO20042837L (no) 2004-08-24
GT200200257A (es) 2003-07-11
GB0129273D0 (en) 2002-01-23
PE20030722A1 (es) 2003-08-29
US20030144243A1 (en) 2003-07-31

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