HK1068251A1 - Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents - Google Patents

Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents

Info

Publication number
HK1068251A1
HK1068251A1 HK05100340.2A HK05100340A HK1068251A1 HK 1068251 A1 HK1068251 A1 HK 1068251A1 HK 05100340 A HK05100340 A HK 05100340A HK 1068251 A1 HK1068251 A1 HK 1068251A1
Authority
HK
Hong Kong
Prior art keywords
conjugates
aminoderivatives
biotin
chelating agents
macrocyclic chelating
Prior art date
Application number
HK05100340.2A
Other languages
English (en)
Inventor
Giovanni Paganelli
Marco Chinol
Mauro Ginanneschi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of HK1068251A1 publication Critical patent/HK1068251A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
HK05100340.2A 2001-02-16 2005-01-13 Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents HK1068251A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000079A ITRM20010079A1 (it) 2001-02-16 2001-02-16 Amminoderivati della biotina e loro coniugati con chelanti macrociclici.
PCT/IT2002/000091 WO2002066075A2 (fr) 2001-02-16 2002-02-15 Aminoderives de biotine et leurs conjugues avec des agents de chelation macrocycliques

Publications (1)

Publication Number Publication Date
HK1068251A1 true HK1068251A1 (en) 2005-04-29

Family

ID=11455227

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05100340.2A HK1068251A1 (en) 2001-02-16 2005-01-13 Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents

Country Status (19)

Country Link
US (2) US7390828B2 (fr)
EP (1) EP1359943B1 (fr)
JP (1) JP4469133B2 (fr)
KR (1) KR100860062B1 (fr)
CN (1) CN100457192C (fr)
AT (1) ATE306283T1 (fr)
AU (1) AU2002237517B2 (fr)
BR (1) BR0207327A (fr)
CZ (1) CZ305442B6 (fr)
DE (1) DE60206599T2 (fr)
DK (1) DK1359943T3 (fr)
ES (1) ES2248522T3 (fr)
HK (1) HK1068251A1 (fr)
HU (1) HU229160B1 (fr)
IT (1) ITRM20010079A1 (fr)
MX (1) MXPA03007317A (fr)
PL (1) PL202898B1 (fr)
SK (1) SK286112B6 (fr)
WO (1) WO2002066075A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030196A1 (it) * 2003-04-24 2004-10-25 Sigma Tau Ind Farmaceuti Uso di reagenti per la preparazione di un medicamento
ITRM20040105A1 (it) * 2004-02-27 2004-05-27 Tecnogen Scpa Anticorpo monoclonale antitenascina umana.
ITRM20050345A1 (it) 2005-06-30 2007-01-01 Sigma Tau Ind Farmaceuti Sintesi di deossi-biotinil esametilen diammina-dota.
TWI381852B (zh) * 2005-09-27 2013-01-11 Sigma Tau Ind Farmaceuti 生物素二胺基衍生物類及其與大環螯合劑之共軛物
ATE512988T1 (de) 2007-04-04 2011-07-15 Sigma Tau Ind Farmaceuti Antikörper gegen epcam und anwendungen davon
GB0922369D0 (en) 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
BR112013009614A2 (pt) * 2010-10-22 2016-07-19 Centre Nat Rech Scient conjugados de pochoxime úteis para o tratamento de patologias relacionadas à hsp90
PL2739314T3 (pl) 2011-08-02 2019-09-30 Alfasigma S.P.A. Kompozycja farmaceutyczna utlenionej awidyny odpowiednia do inhalacji

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075010A (en) * 1992-06-09 2000-06-13 Neorx Corporation Small molecular weight ligand-hexose containing clearing agents
US5283342A (en) * 1992-06-09 1994-02-01 Neorx Corporation Biotinylated small molecules
US6416738B1 (en) * 1973-12-07 2002-07-09 Neorx Corporation Pretargeting methods and compounds
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
IT1245748B (it) 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
US5616690A (en) * 1992-06-09 1997-04-01 Neorx Corporation Hexose derivatized human serum albumin clearing agents
US5976535A (en) * 1992-06-09 1999-11-02 Neorx Corporation Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore
US6217869B1 (en) * 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
US5624896A (en) * 1992-06-09 1997-04-29 Neorx Corporation Clearing agents useful in pretargeting methods
US5578287A (en) * 1992-06-09 1996-11-26 Neorx Corporation Three-step pretargeting methods using improved biotin-active agent
ATE210464T1 (de) 1992-06-09 2001-12-15 Neorx Corp BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN
US5541287A (en) * 1992-06-09 1996-07-30 Neorx Corporation Pretargeting methods and compounds
US5911969A (en) * 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US5914312A (en) * 1992-06-09 1999-06-22 Neorx Corporation Pretargeting methods and compounds
US6358490B2 (en) * 1992-06-09 2002-03-19 Neorx Corporation Three-step pretargeting methods and compounds
US6120768A (en) * 1993-05-17 2000-09-19 Immunomedics, Inc. Dota-biotin derivatives
JPH0730748U (ja) * 1993-11-29 1995-06-13 花王株式会社 歯ブラシ
US5955605A (en) 1995-02-21 1999-09-21 Neorx Corporation Biotinidase resistant biotin-DOTA conjugates
CA2232411A1 (fr) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. Composes de biotine (radio) marques
JP3427871B2 (ja) 1996-06-24 2003-07-22 戸田工業株式会社 コバルト被着型針状磁性酸化鉄粒子粉末
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms

Also Published As

Publication number Publication date
ES2248522T3 (es) 2006-03-16
PL365279A1 (en) 2004-12-27
PL202898B1 (pl) 2009-08-31
CN100457192C (zh) 2009-02-04
ITRM20010079A0 (it) 2001-02-16
HUP0303151A3 (en) 2010-01-28
US8044081B2 (en) 2011-10-25
SK11152003A3 (sk) 2004-02-03
ATE306283T1 (de) 2005-10-15
EP1359943B1 (fr) 2005-10-12
JP2004524305A (ja) 2004-08-12
US20080085239A1 (en) 2008-04-10
WO2002066075A2 (fr) 2002-08-29
EP1359943A2 (fr) 2003-11-12
BR0207327A (pt) 2004-02-10
HU229160B1 (hu) 2013-09-30
DE60206599D1 (de) 2005-11-17
KR20030072627A (ko) 2003-09-15
KR100860062B1 (ko) 2008-09-24
CZ305442B6 (cs) 2015-09-23
SK286112B6 (sk) 2008-03-05
AU2002237517B2 (en) 2006-11-30
MXPA03007317A (es) 2004-06-30
ITRM20010079A1 (it) 2002-08-16
DE60206599T2 (de) 2006-06-22
HUP0303151A2 (hu) 2003-12-29
WO2002066075A3 (fr) 2003-01-30
DK1359943T3 (da) 2006-01-02
JP4469133B2 (ja) 2010-05-26
CN1531445A (zh) 2004-09-22
US20040067199A1 (en) 2004-04-08
CZ20031989A3 (cs) 2004-02-18
US7390828B2 (en) 2008-06-24

Similar Documents

Publication Publication Date Title
HK1068251A1 (en) Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents
IL176007A0 (en) Antibodies specific to c35 and pharmaceutical compositions containing the same
AU2003205077A1 (en) Imaging agents and methods of imaging naaladase of psma
MXPA02011656A (es) Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos.
YU50800A (sh) Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
PT1157041E (pt) Anticorpos para terapia e diagnostico de cancro
DE60112974D1 (en) Carbolinderivate
WO2002080754A3 (fr) Methodes d'utilisation d'une annexine permettant de visualiser la mort cellulaire in vivo et de traiter des etats pathologiques
MXPA03006093A (es) Derivados de n(fenilsulfonil)glicina y su uso terapeutico.
SG148031A1 (en) Use of cci-779 as an antineoplastic agent
HK1044723A1 (en) Mixing/charging port for medical treatment.
HUP0200763A2 (en) Compositions for the treatment and diagnosis of breast cancer and methods for their use
ZA200409492B (en) Compositions and methods for the diagnosis and treatment of tumor.
CY2538B1 (en) Tetrahydropyrido compounds
DE60216233D1 (en) Carbolinderivate
DE60033649D1 (de) Verbindungen und therapeutische methoden
IL146125A0 (en) Novel quinones as disease therapies
DE69938192D1 (en) Imidazonaphthyridine
HK1044725A1 (en) Mixing/charging port for medical treatment.
TW200744647A (en) Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents
WO2004047757A3 (fr) Diagnostic et traitement des cancers hematopoietiques
AU2002313726A1 (en) Compositions and methods for the therapy and diagnosis of breast cancer
PL366066A1 (en) Compositions and methods for the therapy and diagnosis of breast cancer
IL159479A (en) Glycopeptides, their preparation and use in the diagnosis or therapeutic treatment of multiple sclerosis
ZA200108256B (en) Compositions and methods for the treatment and diagnosis of breast cancer.

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210215