HK1063471A1 - Pyrrolidine derivatives as factor xa inhibitors. - Google Patents
Pyrrolidine derivatives as factor xa inhibitors.Info
- Publication number
- HK1063471A1 HK1063471A1 HK04106291A HK04106291A HK1063471A1 HK 1063471 A1 HK1063471 A1 HK 1063471A1 HK 04106291 A HK04106291 A HK 04106291A HK 04106291 A HK04106291 A HK 04106291A HK 1063471 A1 HK1063471 A1 HK 1063471A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- factor
- pyrrolidine derivatives
- pyrrolidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0114005.2A GB0114005D0 (en) | 2001-06-08 | 2001-06-08 | Chemical compounds |
| PCT/GB2002/002721 WO2002100830A1 (en) | 2001-06-08 | 2002-06-06 | Pyrrolidine derivatives as factor xa inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1063471A1 true HK1063471A1 (en) | 2004-12-31 |
Family
ID=9916209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK04106291A HK1063471A1 (en) | 2001-06-08 | 2004-08-23 | Pyrrolidine derivatives as factor xa inhibitors. |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US7186717B2 (hu) |
| EP (1) | EP1395553B1 (hu) |
| JP (1) | JP4242274B2 (hu) |
| KR (1) | KR100877245B1 (hu) |
| CN (1) | CN1256324C (hu) |
| AR (1) | AR036086A1 (hu) |
| AT (1) | ATE289294T1 (hu) |
| AU (1) | AU2002311451B2 (hu) |
| BR (1) | BR0210207A (hu) |
| CA (1) | CA2449629A1 (hu) |
| CO (1) | CO5540285A2 (hu) |
| CZ (1) | CZ20033325A3 (hu) |
| DE (1) | DE60203006T2 (hu) |
| DK (1) | DK1395553T3 (hu) |
| ES (1) | ES2235050T3 (hu) |
| GB (1) | GB0114005D0 (hu) |
| HK (1) | HK1063471A1 (hu) |
| HU (1) | HUP0400156A3 (hu) |
| IL (1) | IL159195A0 (hu) |
| MX (1) | MXPA03011384A (hu) |
| MY (1) | MY136859A (hu) |
| NO (1) | NO326689B1 (hu) |
| NZ (1) | NZ530004A (hu) |
| PL (1) | PL368082A1 (hu) |
| PT (1) | PT1395553E (hu) |
| SI (1) | SI1395553T1 (hu) |
| TW (1) | TWI298719B (hu) |
| WO (1) | WO2002100830A1 (hu) |
| ZA (1) | ZA200309367B (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0114005D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0130705D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Chemical compounds |
| GB0228533D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Crystalline form |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
| US20050119266A1 (en) * | 2003-10-01 | 2005-06-02 | Yan Shi | Pyrrolidine and piperidine derivatives as factor Xa inhibitors |
| EP1637141B1 (en) | 2004-09-21 | 2011-11-16 | Trobio AB | Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease |
| US7446210B2 (en) * | 2004-10-26 | 2008-11-04 | Janssen Pharmaceutica N.V. | Factor Xa compounds |
| WO2006110726A2 (en) * | 2005-04-11 | 2006-10-19 | Glaxo Group Limited | Dosage formulations and methods of treatment and prevention |
| CN102380100A (zh) * | 2005-09-22 | 2012-03-21 | 特罗比奥股份公司 | 稳定的蛋白酶组合物 |
| JP5080476B2 (ja) * | 2005-09-22 | 2012-11-21 | トルービオ・アーベー | 安定化プロテアーゼ組成物 |
| DE102007028319A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028407A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028406A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| PL2989095T3 (pl) * | 2013-04-26 | 2019-07-31 | Sanofi | Sól winianowa [(S)-2-[metylo-3-(2-oksopirolidyn-1-ylo)-benzenosulfonyloamino]-3-(4-metylopiperazyn-1-ylo)-3-oksopropylo]-amidu kwasu 5-chlorotiofeno-2-karboksylowego |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL92011A0 (en) | 1988-10-19 | 1990-07-12 | Abbott Lab | Heterocyclic peptide renin inhibitors |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4121947A1 (de) | 1991-07-03 | 1993-01-07 | Basf Ag | 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung |
| US5703208A (en) * | 1994-06-17 | 1997-12-30 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors |
| EP0937073A2 (en) | 1996-10-11 | 1999-08-25 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6281227B1 (en) | 1996-12-13 | 2001-08-28 | Aventis Pharma Deutschland Gmbh | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds |
| US6602864B1 (en) | 1996-12-13 | 2003-08-05 | Aventis Pharma Deutschland Gmbh | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds |
| HUP9904188A3 (en) | 1996-12-13 | 2003-02-28 | Aventis Pharmaceuticals Inc Co | Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds |
| US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| ES2255733T3 (es) * | 1997-09-30 | 2006-07-01 | Daiichi Pharmaceutical Co., Ltd. | Derivados sulfonilo. |
| KR20010034442A (ko) | 1998-01-27 | 2001-04-25 | 아벤티스 파마슈티칼즈 프로덕츠 인코포레이티드 | 치환된 옥소아자헤테로사이클릴 인자 Ｘａ 억제제 |
| US6281277B1 (en) | 1998-04-22 | 2001-08-28 | Showa Denko Kabushiki Kaisha | Homogeneously surface-fluorinated metal oxide particulates, process for manufacturing the same, and use of the same |
| PT1150976E (pt) | 1998-12-31 | 2003-07-31 | Aventis Pharma Inc | Lactamas 3-(tio amido substituidas) uteis como inibidores da metaloproteinase da matriz |
| AU756174B2 (en) | 1999-02-09 | 2003-01-09 | Bristol-Myers Squibb Company | Lactam inhibitors of FXa and method |
| AU3192500A (en) | 1999-03-16 | 2000-10-04 | C & C Research Laboratories | Substituted proline derivatives and medicinal compositions containing the same |
| WO2000069465A1 (fr) | 1999-05-12 | 2000-11-23 | Ono Pharmaceutical Co., Ltd. | Agents anticancereux contenant des antagonistes de ep1 en tant que principe actif |
| WO2001007436A2 (en) | 1999-07-28 | 2001-02-01 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
| JP2004518688A (ja) | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法 |
| GB0114004D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0114005D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0228533D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Crystalline form |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-06-08 GB GBGB0114005.2A patent/GB0114005D0/en not_active Ceased
-
2002
- 2002-06-06 AU AU2002311451A patent/AU2002311451B2/en not_active Ceased
- 2002-06-06 MX MXPA03011384A patent/MXPA03011384A/es active IP Right Grant
- 2002-06-06 NZ NZ530004A patent/NZ530004A/en unknown
- 2002-06-06 SI SI200230101T patent/SI1395553T1/xx unknown
- 2002-06-06 DK DK02738368T patent/DK1395553T3/da active
- 2002-06-06 AR ARP020102128A patent/AR036086A1/es unknown
- 2002-06-06 AT AT02738368T patent/ATE289294T1/de not_active IP Right Cessation
- 2002-06-06 PL PL02368082A patent/PL368082A1/xx unknown
- 2002-06-06 WO PCT/GB2002/002721 patent/WO2002100830A1/en active IP Right Grant
- 2002-06-06 BR BR0210207-2A patent/BR0210207A/pt not_active Application Discontinuation
- 2002-06-06 IL IL15919502A patent/IL159195A0/xx unknown
- 2002-06-06 KR KR1020037016070A patent/KR100877245B1/ko not_active IP Right Cessation
- 2002-06-06 US US10/479,545 patent/US7186717B2/en not_active Expired - Fee Related
- 2002-06-06 TW TW091112153A patent/TWI298719B/zh active
- 2002-06-06 CZ CZ20033325A patent/CZ20033325A3/cs unknown
- 2002-06-06 CA CA002449629A patent/CA2449629A1/en not_active Abandoned
- 2002-06-06 ES ES02738368T patent/ES2235050T3/es not_active Expired - Lifetime
- 2002-06-06 JP JP2003503599A patent/JP4242274B2/ja not_active Expired - Fee Related
- 2002-06-06 HU HU0400156A patent/HUP0400156A3/hu unknown
- 2002-06-06 CN CNB028154002A patent/CN1256324C/zh not_active Expired - Fee Related
- 2002-06-06 PT PT02738368T patent/PT1395553E/pt unknown
- 2002-06-06 EP EP02738368A patent/EP1395553B1/en not_active Expired - Lifetime
- 2002-06-06 MY MYPI20022097A patent/MY136859A/en unknown
- 2002-06-06 DE DE60203006T patent/DE60203006T2/de not_active Expired - Lifetime
-
2003
- 2003-12-02 ZA ZA200309367A patent/ZA200309367B/en unknown
- 2003-12-05 CO CO03107408A patent/CO5540285A2/es not_active Application Discontinuation
- 2003-12-05 NO NO20035440A patent/NO326689B1/no not_active IP Right Cessation
-
2004
- 2004-08-23 HK HK04106291A patent/HK1063471A1/xx not_active IP Right Cessation
-
2006
- 2006-10-11 US US11/548,404 patent/US7326785B2/en not_active Expired - Fee Related
- 2006-10-11 US US11/548,402 patent/US7517879B2/en not_active Expired - Fee Related
- 2006-10-11 US US11/548,395 patent/US7429587B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110606 |