HK1061566A1 - Proteins producing an altered immunogenic response and methods of making and using the same - Google Patents

Proteins producing an altered immunogenic response and methods of making and using the same

Info

Publication number
HK1061566A1
HK1061566A1 HK04104503.8A HK04104503A HK1061566A1 HK 1061566 A1 HK1061566 A1 HK 1061566A1 HK 04104503 A HK04104503 A HK 04104503A HK 1061566 A1 HK1061566 A1 HK 1061566A1
Authority
HK
Hong Kong
Prior art keywords
methods
making
same
immunogenic response
altered immunogenic
Prior art date
Application number
HK04104503.8A
Other languages
English (en)
Inventor
David A Estell
Grant C Ganshaw
Fiona A Harding
Edmund A Larenas
Ayrookaran J Poulose
Elizabeth Ellen Sikorski
Russell Philip Elliott
Original Assignee
Danisco Us Inc
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Procter & Gamble filed Critical Danisco Us Inc
Publication of HK1061566A1 publication Critical patent/HK1061566A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
HK04104503.8A 2001-03-23 2004-06-23 Proteins producing an altered immunogenic response and methods of making and using the same HK1061566A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27845901P 2001-03-23 2001-03-23
PCT/US2002/009205 WO2002077187A2 (fr) 2001-03-23 2002-03-22 Proteines provoquant une reaction immunogene modifiee, et methodes de production et d'utilisation desdites proteines

Publications (1)

Publication Number Publication Date
HK1061566A1 true HK1061566A1 (en) 2004-09-24

Family

ID=23065053

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04104503.8A HK1061566A1 (en) 2001-03-23 2004-06-23 Proteins producing an altered immunogenic response and methods of making and using the same

Country Status (11)

Country Link
US (3) US6929939B2 (fr)
EP (1) EP1373296B1 (fr)
CN (1) CN100489094C (fr)
AT (1) ATE527276T1 (fr)
AU (1) AU2002254374A1 (fr)
CA (1) CA2441595C (fr)
DK (1) DK1373296T3 (fr)
HK (1) HK1061566A1 (fr)
PL (1) PL210859B1 (fr)
RU (1) RU2311458C2 (fr)
WO (1) WO2002077187A2 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
ES2367505T3 (es) * 1997-10-23 2011-11-04 Danisco Us Inc. Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes.
AU2002254374A1 (en) * 2001-03-23 2002-10-08 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US20030157645A1 (en) * 2001-12-21 2003-08-21 Direvo Bio Tech Ag. Subtilisin variants with improved characteristics
BR0215415A (pt) * 2001-12-31 2005-04-05 Genencor Int Proteases produzindo uma resposta imunológica alterada e métodos de preparar e usar as mesmas
US20050170488A1 (en) * 2002-01-16 2005-08-04 Poulose Ayrookaran J. Multiply-substituted protease variants
AU2003210552A1 (en) * 2002-01-16 2003-09-02 Genencor International, Inc. Multiply-substituted protease variants
AU2003272517A1 (en) * 2002-09-13 2004-04-30 Zicam, Llc. Compositions to reduce congestion and methods for application thereof to the nasal membrane
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US7202202B2 (en) * 2003-06-27 2007-04-10 The Procter & Gamble Company Consumable detergent composition for use in a lipophilic fluid
EP1651751B1 (fr) * 2003-08-06 2015-11-18 University Of Maryland Biotechnology Institute Proteases du genie genetique pour purification par affinite et traitement des proteines de fusion
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
EP1692505B1 (fr) * 2003-11-03 2012-09-05 Danisco US Inc. Epitopes cd4+ de proteines morphogenetiques osseuses
AU2004297616B2 (en) 2003-12-04 2008-12-18 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
DK1700119T3 (da) * 2003-12-18 2010-06-07 Genencor Int Beta-lactamase-CD4+-T-celleepitoper
WO2005092925A2 (fr) 2004-03-24 2005-10-06 Xencor, Inc. Variantes d'immunoglobuline a l'exterieur de la region fc
ATE491025T1 (de) * 2004-04-02 2010-12-15 Novozymes As Subtilasevarianten mit veränderter immunogenität
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
WO2006019447A1 (fr) 2004-07-15 2006-02-23 Xencor, Inc. Variantes genetiques de fc optimisees
KR101019525B1 (ko) 2004-11-12 2011-03-07 젠코어 인코포레이티드 ＦcRn에 대한 변경된 결합성을 갖는 Ｆc 변이체
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
DK1874812T3 (da) * 2005-04-27 2013-12-09 Danisco Us Inc Fremgangsmåder til bestemmelse af proteasers allergenicitet
KR20080017039A (ko) * 2005-06-24 2008-02-25 노보자임스 에이/에스 약학적 용도의 프로테아제
DK1931709T3 (en) 2005-10-03 2017-03-13 Xencor Inc FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
US20080287320A1 (en) * 2006-10-04 2008-11-20 Codon Devices Libraries and their design and assembly
WO2009086320A1 (fr) 2007-12-26 2009-07-09 Xencor, Inc Variants de fc avec une liaison altérée à fcrn
US20110160071A1 (en) * 2008-06-03 2011-06-30 Baynes Brian M Novel Proteins and Methods for Designing the Same
JP5647976B2 (ja) 2008-06-06 2015-01-07 ダニスコ・ユーエス・インク 変異体微生物プロテアーゼを含む組成物及び方法
EP2216391A1 (fr) * 2009-02-02 2010-08-11 The Procter & Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP2216392B1 (fr) * 2009-02-02 2013-11-13 The Procter and Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP2213713B1 (fr) * 2009-02-02 2014-03-12 The Procter and Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP3023483A1 (fr) * 2009-02-02 2016-05-25 The Procter and Gamble Company Composition de détergent liquide pour lavage de la vaisselle à la main
EP2216390B1 (fr) * 2009-02-02 2013-11-27 The Procter and Gamble Company Méthode pour lavage de la vaisselle à la main
ES2484002T3 (es) * 2009-02-02 2014-08-08 The Procter & Gamble Company Composición detergente líquida para lavado de vajillas a mano
CN103923895A (zh) * 2009-04-01 2014-07-16 丹尼斯科美国公司 包含具有改变的性质的α-淀粉酶变体的组合物和方法
WO2011028952A1 (fr) 2009-09-02 2011-03-10 Xencor, Inc. Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes
WO2011072099A2 (fr) * 2009-12-09 2011-06-16 Danisco Us Inc. Compositions et procédés comprenant des variants de protéase
CN102858970B (zh) * 2010-04-15 2017-07-21 丹尼斯科美国公司 包含变体蛋白酶的组合物和方法
CA2798451C (fr) * 2010-05-06 2020-10-06 Danisco Us Inc. Compositions et methodes comprenant des variants de subtilisine avec des substitutions t022a-e271f
DE102010063458A1 (de) * 2010-12-17 2012-06-21 Henkel Ag & Co. Kgaa Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Amylase
US9039689B2 (en) 2011-05-11 2015-05-26 Icecure Medical Ltd. Phase separation of cryogen in cryosurgical instrument
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
EP2793944A4 (fr) 2011-12-23 2015-09-02 Nicholas B Lydon Immunoglobulines et variants dirigés contre des microbes pathogènes
GB201212934D0 (en) * 2012-07-20 2012-09-05 Dupont Nutrition Biosci Aps Method

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34606A (en) * 1862-03-04 Improvement in machines for combing cotton
US3755560A (en) 1971-06-30 1973-08-28 Dow Chemical Co Nongreasy cosmetic lotions
US3929678A (en) 1974-08-01 1975-12-30 Procter & Gamble Detergent composition having enhanced particulate soil removal performance
JPS5333919A (en) * 1976-09-10 1978-03-30 Nippon Steel Corp Production of cold rolled aluminum killed steel sheet with excellent deep drawability
JPS51125468A (en) 1975-03-27 1976-11-01 Sanyo Chem Ind Ltd Method of preparing resins of high water absorbency
US4152416A (en) 1976-09-17 1979-05-01 Marra Dorothea C Aerosol antiperspirant compositions delivering astringent salt with low mistiness and dustiness
NL190101C (nl) 1978-11-13 1993-11-01 Givaudan & Cie Sa Dibenzoylmethaanverbinding en tegen licht beschermend preparaat.
US4261868A (en) 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
US4421769A (en) 1981-09-29 1983-12-20 The Procter & Gamble Company Skin conditioning composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
IE81141B1 (en) 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
US5204015A (en) * 1984-05-29 1993-04-20 Genencor International, Inc. Subtilisin mutants
US5185258A (en) 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US4663157A (en) 1985-02-28 1987-05-05 The Proctor & Gamble Company Sunscreen compositions
EP0209071B2 (fr) * 1985-07-10 1998-07-15 Novartis AG Kit pour l'entretien des lentilles de contact
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
IE65767B1 (en) 1986-04-30 1995-11-15 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
US4999186A (en) 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
US4937370A (en) 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DE3856315T2 (de) 1987-10-22 1999-10-14 Procter & Gamble Chelatbildner enthaltende Lichtschutzmittel
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
US5116741A (en) * 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
US5087372A (en) 1989-03-24 1992-02-11 Asahi Kasei Kogyo Kabushiki Kaisha Method for removing heavy metal ions from contaminated water and a porous membrane usable therefor
AU618675B2 (en) * 1989-05-17 1992-01-02 Amgen, Inc. Multiply mutated subtilisins
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
US5011681A (en) 1989-10-11 1991-04-30 Richardson-Vicks, Inc. Facial cleansing compositions
US5264365A (en) * 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US5073371A (en) 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
US5073372A (en) 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
EP0561907B1 (fr) * 1990-12-05 1998-09-02 Novo Nordisk A/S Proteines presentant des epitopes modifies et procedes de preparation de ces proteines
DK132892D0 (da) 1992-10-30 1992-10-30 Novo Nordisk As Proteiner
ES2199978T3 (es) * 1993-10-14 2004-03-01 THE PROCTER & GAMBLE COMPANY Composiciones de blanqueo que comprenden enzimas proteasa.
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
JP2888985B2 (ja) * 1993-10-14 1999-05-10 ザ、プロクター、エンド、ギャンブル、カンパニー プロテアーゼ含有クリーニング組成物
FR2712286B1 (fr) * 1993-11-12 1995-12-22 Oreal Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
US6068834A (en) 1994-03-04 2000-05-30 The Procter & Gamble Company Skin lightening compositions
FR2719481B1 (fr) 1994-05-05 1996-05-31 Oreal Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
KR970703749A (ko) 1994-06-15 1997-08-09 레이서 제이코버스 코넬리스 포유동물의 피부에서 과잉색소침착된 부위를 미백시키기 위한 조성물
GB9415421D0 (en) 1994-07-30 1994-09-21 Procter & Gamble Cosmetic compositions and processes for manufacture thereof
ES2132752T3 (es) 1994-11-28 1999-08-16 Procter & Gamble Composiciones topicas para el cuidado de la piel que contienen esteres de acido carboxilico y poliol espesados como agentes acondicionadores de la piel.
CA2206852A1 (fr) 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide a allergenicite reduite
WO1996040791A1 (fr) 1995-06-07 1996-12-19 Novo Nordisk A/S Modification de polypeptides
WO1997030148A1 (fr) 1996-02-15 1997-08-21 Novo Nordisk A/S Conjugaison de polypeptides
US5627508A (en) * 1996-05-10 1997-05-06 The United States Of America As Represented By The Secretary Of The Navy Pilot vehicle which is useful for monitoring hazardous conditions on railroad tracks
US5827508A (en) 1996-09-27 1998-10-27 The Procter & Gamble Company Stable photoprotective compositions
WO1998022085A1 (fr) 1996-11-22 1998-05-28 The Procter & Gamble Company Compositions cosmetiques
US5966485A (en) * 1996-11-22 1999-10-12 Siecor Corporation Method of producing core protrusion relative to cladding in an optical fiber of a fiber optic connector
MA25044A1 (fr) * 1997-10-23 2000-10-01 Procter & Gamble Compositions de lavage contenant des variants de proteases multisubstituees.
KR20010034697A (ko) 1998-03-26 2001-04-25 데이비드 엠 모이어 아미노산 치환을 갖는 세린 프로테아제 변이체
US6642011B2 (en) 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US5935556A (en) 1998-07-30 1999-08-10 The Procter & Gamble Company Sunscreen compositions
US5989528A (en) 1998-07-30 1999-11-23 The Procter & Gamble Company Sunscreen compositions
US5972316A (en) 1998-10-16 1999-10-26 The Procter & Gamble Company UV protection compositions
US5968485A (en) 1998-10-16 1999-10-19 The Procter & Gamble Company UV protection compositions
AU1275599A (en) 1998-10-23 2000-05-15 Procter & Gamble Company, The Skin care compositions
MXPA02000840A (es) * 1999-07-22 2002-07-30 Procter & Gamble Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
US6428799B1 (en) * 1999-08-02 2002-08-06 The Procter & Gamble Company Personal care articles
WO2001057578A1 (fr) 2000-01-31 2001-08-09 Sercalo Microtechnology Ltd. Circuit pour guide de rayonnement
US20030170846A1 (en) * 2000-04-24 2003-09-11 Weisgerber David John Enzyme variants having one or more D-amino acid substitutions
WO2002040997A2 (fr) 2000-10-02 2002-05-23 Genencor International, Inc. Proteines produisant une reponse immunogene modifiee et procedes de fabrication et d'utilisation de ces proteines
AU2002254374A1 (en) * 2001-03-23 2002-10-08 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same

Also Published As

Publication number Publication date
WO2002077187A2 (fr) 2002-10-03
RU2311458C2 (ru) 2007-11-27
PL210859B1 (pl) 2012-03-30
DK1373296T3 (da) 2012-01-09
WO2002077187A3 (fr) 2003-04-24
EP1373296A2 (fr) 2004-01-02
CN100489094C (zh) 2009-05-20
US6929939B2 (en) 2005-08-16
US20030118605A1 (en) 2003-06-26
EP1373296B1 (fr) 2011-10-05
AU2002254374A1 (en) 2002-10-08
PL364138A1 (en) 2004-12-13
CA2441595C (fr) 2012-07-03
CA2441595A1 (fr) 2002-10-03
US20050202552A1 (en) 2005-09-15
CN1512998A (zh) 2004-07-14
US20050202551A1 (en) 2005-09-15
ATE527276T1 (de) 2011-10-15
EP1373296A4 (fr) 2007-03-28
RU2003131177A (ru) 2005-01-20
US7476528B2 (en) 2009-01-13

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