WO1997030148A1 - Conjugaison de polypeptides - Google Patents

Conjugaison de polypeptides Download PDF

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Publication number
WO1997030148A1
WO1997030148A1 PCT/DK1997/000051 DK9700051W WO9730148A1 WO 1997030148 A1 WO1997030148 A1 WO 1997030148A1 DK 9700051 W DK9700051 W DK 9700051W WO 9730148 A1 WO9730148 A1 WO 9730148A1
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
polypeptide
kda
polymeric carrier
carrier molecule
Prior art date
Application number
PCT/DK1997/000051
Other languages
English (en)
Inventor
Henrik Bisgård-Frantzen
Arne Agerlin Olsen
Annette PRENTØ
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to EP97901524A priority Critical patent/EP0894128A1/fr
Priority to AU15406/97A priority patent/AU725287B2/en
Priority to JP9528900A priority patent/JP2000506119A/ja
Publication of WO1997030148A1 publication Critical patent/WO1997030148A1/fr
Priority to US09/123,787 priority patent/US6106828A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/02—Shaving preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/384—Animal products
    • C11D3/3845—Antibodies
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention porte sur des conjugués de polypeptides à allergénicité réduite comportant une molécule support polymérique à laquelle son fixées deux ou plus de deux molécules de polypeptides. L'invention porte également sur un procédé de production desdits conjugués, sur des compositions les contenant, et sur leur utilisation dans un grand nombre d'applications industrielles telles que des produits pour soins personnel et des détergents.
PCT/DK1997/000051 1996-02-15 1997-02-07 Conjugaison de polypeptides WO1997030148A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97901524A EP0894128A1 (fr) 1996-02-15 1997-02-07 Conjugaison de polypeptides
AU15406/97A AU725287B2 (en) 1996-02-15 1997-02-07 Conjugation of polypeptides
JP9528900A JP2000506119A (ja) 1996-02-15 1997-02-07 ポリペプチドのコンジュゲーション
US09/123,787 US6106828A (en) 1996-02-15 1998-07-28 Conjugation of polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK15496 1996-02-15
DK0154/96 1996-02-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/123,787 Continuation US6106828A (en) 1996-02-15 1998-07-28 Conjugation of polypeptides

Publications (1)

Publication Number Publication Date
WO1997030148A1 true WO1997030148A1 (fr) 1997-08-21

Family

ID=8090373

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1997/000051 WO1997030148A1 (fr) 1996-02-15 1997-02-07 Conjugaison de polypeptides

Country Status (6)

Country Link
EP (1) EP0894128A1 (fr)
JP (1) JP2000506119A (fr)
CN (1) CN1273589C (fr)
AU (1) AU725287B2 (fr)
CA (1) CA2242488A1 (fr)
WO (1) WO1997030148A1 (fr)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030682A1 (fr) * 1997-01-10 1998-07-16 Novo Nordisk A/S Enzyme couplee a des molecules polymeres pour les soins de la peau
WO1999053038A2 (fr) * 1998-04-15 1999-10-21 Genencor International, Inc. Proteines mutantes avec une reponse allergene plus faible chez l'homme et methodes pour construire, identifier, et produire ces proteines
WO1999057252A1 (fr) * 1998-05-01 1999-11-11 The Procter & Gamble Company Compositions de detergent a lessive et/ou d'entretien de tissus contenant une enzyme modifiee
WO1999067370A1 (fr) * 1998-06-23 1999-12-29 Novozymes A/S Conjugue polypeptide-polymere
WO2000004138A1 (fr) * 1998-07-17 2000-01-27 Novozymes A/S Conjugue polypeptide-polymeres a efficacite de lavage amelioree
WO2000022103A1 (fr) * 1998-10-13 2000-04-20 Novozymes A/S Polypeptide modifie a reponse immunitaire reduite
WO2001064176A1 (fr) * 2000-03-01 2001-09-07 Henkel Kommanditgesellschaft Auf Aktien Gel nettoyant pour la peau a effet chauffant
DE10047481A1 (de) * 2000-09-26 2002-04-25 Henkel Kgaa Wasch- und Reinigungsmittel
US6416756B1 (en) 1997-01-10 2002-07-09 Novozymes A/S Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
EP1234584A1 (fr) * 2001-02-21 2002-08-28 Grisotech S.A. Complexes d'immunoglobulines et polysaccharides absorption orale ou transmucosale
WO2002077187A2 (fr) 2001-03-23 2002-10-03 Genencor International, Inc. Proteines provoquant une reaction immunogene modifiee, et methodes de production et d'utilisation desdites proteines
US6461849B1 (en) 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
US6468955B1 (en) 1998-05-01 2002-10-22 The Proctor & Gamble Company Laundry detergent and/or fabric care compositions comprising a modified enzyme
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6566115B1 (en) 1999-07-22 2003-05-20 The Procter & Gamble Company Protease conjugates having sterically protected clip sites
US6569663B1 (en) 1998-03-26 2003-05-27 The Procter & Gamble Company Serine protease variants having amino acid substitutions
US6586223B1 (en) 1999-07-22 2003-07-01 The Procter & Gamble Company Subtilisin protease variants having amino acid substitutions in defined epitope regions
US6586224B1 (en) 1999-07-22 2003-07-01 The Procter & Gamble Company Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
US6638526B1 (en) 1998-06-23 2003-10-28 Novozymes A/S Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
US6642011B2 (en) 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
WO2003099242A1 (fr) * 2002-05-29 2003-12-04 Henkel Kommanditgesellschaft Auf Aktien Agents cosmetiques comprenant une disulfidisomerase proteinique
DE10227238A1 (de) * 2002-06-19 2004-01-15 Wella Ag Hochaffine kosmetische Mittel
WO2004030701A1 (fr) * 2002-09-11 2004-04-15 Fresenius Kabi Deutschland Gmbh Conjugue amidon hydroxyalkyle-allergene
US6838269B1 (en) 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6897049B1 (en) 1998-04-15 2005-05-24 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
WO2005077319A2 (fr) * 2004-02-12 2005-08-25 Unilever Plc Compositions de traitement capillaire
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
JP2005535652A (ja) * 2002-07-09 2005-11-24 サンド・アクチエンゲゼルシヤフト １，２−プロピレングリコールを含有するヒト成長ホルモン（ｈＧＨ）の高濃度液体製剤
WO2006050691A2 (fr) * 2004-11-02 2006-05-18 Imasys Ag Dispositif de pose, dispositif d'etablissement de contact, systeme d'avance, unite de pose et d'etablissement de contact, installation de production, procede de production et ensemble transpondeur
WO2007123271A2 (fr) * 2006-04-21 2007-11-01 Kao Corporation Composition d'agent de lutte contre un biofilm
US7332320B2 (en) 2001-12-31 2008-02-19 Genencor International, Inc. Protease producing an altered immunogenic response and methods of making and using the same
DE202008017456U1 (de) 2007-08-27 2009-08-27 Biogenerix Ag Flüssig-Formulierung von G-CSF-Konjugaten
US7632669B2 (en) 1998-11-27 2009-12-15 Novozymes A/S Lipolytic enzyme variants
EP2113563A3 (fr) * 1998-11-27 2010-01-13 Novozymes A/S Variants d'enzyme lipolytique
EP2270036A2 (fr) 2004-03-11 2011-01-05 Fresenius Kabi Deutschland GmbH Polypeptides hasylés
WO2014067933A1 (fr) * 2012-10-31 2014-05-08 C-Lecta Gmbh Préparation de support bioactif pour une sécurité améliorée dans les produits de soin et les aliments
CN104125838A (zh) * 2011-12-20 2014-10-29 辉瑞公司 制备肽缀合物和连接基的改进方法
US8916518B2 (en) 2002-03-06 2014-12-23 Fresenius Kabi Deutschland Gmbh Coupling proteins to a modified polysaccharide

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021436B2 (en) * 2007-09-27 2011-09-20 The Procter & Gamble Company Cleaning and/or treatment compositions comprising a xyloglucan conjugate
EP2070950A1 (fr) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Dérivés hydroxyalkylés de l'amidon et leur procédé de préparation

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
EP0183503A2 (fr) * 1984-11-30 1986-06-04 Beecham Group Plc Conjugués de protéines d'utilité pharmaceutique
EP0223221A2 (fr) * 1985-11-21 1987-05-27 Roche Diagnostics GmbH Dérivé stabilisé et soluble dans l'eau de la peroxydase, son procédé de préparation et utilisation pour la détermination du peroxyde d'hydrogène
US5006333A (en) * 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5133968A (en) * 1990-08-20 1992-07-28 Kanebo, Ltd. Modified protease, method of producing the same and cosmetic products containing the modified protease
US5230891A (en) * 1990-08-20 1993-07-27 Kanebo Limited Modified protease, method of producing the same and cosmetic products containing the modified protease
WO1996017929A1 (fr) * 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide a allergenicite reduite
WO1996040791A1 (fr) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification de polypeptides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
EP0183503A2 (fr) * 1984-11-30 1986-06-04 Beecham Group Plc Conjugués de protéines d'utilité pharmaceutique
EP0223221A2 (fr) * 1985-11-21 1987-05-27 Roche Diagnostics GmbH Dérivé stabilisé et soluble dans l'eau de la peroxydase, son procédé de préparation et utilisation pour la détermination du peroxyde d'hydrogène
US5006333A (en) * 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5133968A (en) * 1990-08-20 1992-07-28 Kanebo, Ltd. Modified protease, method of producing the same and cosmetic products containing the modified protease
US5230891A (en) * 1990-08-20 1993-07-27 Kanebo Limited Modified protease, method of producing the same and cosmetic products containing the modified protease
WO1996017929A1 (fr) * 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide a allergenicite reduite
WO1996040791A1 (fr) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification de polypeptides

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030682A1 (fr) * 1997-01-10 1998-07-16 Novo Nordisk A/S Enzyme couplee a des molecules polymeres pour les soins de la peau
US6416756B1 (en) 1997-01-10 2002-07-09 Novozymes A/S Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6569663B1 (en) 1998-03-26 2003-05-27 The Procter & Gamble Company Serine protease variants having amino acid substitutions
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
WO1999053038A3 (fr) * 1998-04-15 2000-02-10 Genencor Int Proteines mutantes avec une reponse allergene plus faible chez l'homme et methodes pour construire, identifier, et produire ces proteines
US6897049B1 (en) 1998-04-15 2005-05-24 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6838269B1 (en) 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6936249B1 (en) 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6596525B1 (en) 1998-04-15 2003-07-22 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
EP1997897A1 (fr) 1998-04-15 2008-12-03 Genencor International, Inc. Protéines mutantes disposant d'une réponse allergénique inférieure chez les humains et procédés de construction, d'identification et de production de telles protéines
WO1999053038A2 (fr) * 1998-04-15 1999-10-21 Genencor International, Inc. Proteines mutantes avec une reponse allergene plus faible chez l'homme et methodes pour construire, identifier, et produire ces proteines
US6468955B1 (en) 1998-05-01 2002-10-22 The Proctor & Gamble Company Laundry detergent and/or fabric care compositions comprising a modified enzyme
WO1999057250A1 (fr) * 1998-05-01 1999-11-11 The Procter & Gamble Company Detergent de lavage et/ou compositions respectant les tissus comprenant une enzyme modifiee
WO1999057252A1 (fr) * 1998-05-01 1999-11-11 The Procter & Gamble Company Compositions de detergent a lessive et/ou d'entretien de tissus contenant une enzyme modifiee
WO1999067370A1 (fr) * 1998-06-23 1999-12-29 Novozymes A/S Conjugue polypeptide-polymere
US6638526B1 (en) 1998-06-23 2003-10-28 Novozymes A/S Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
WO2000004138A1 (fr) * 1998-07-17 2000-01-27 Novozymes A/S Conjugue polypeptide-polymeres a efficacite de lavage amelioree
WO2000022103A1 (fr) * 1998-10-13 2000-04-20 Novozymes A/S Polypeptide modifie a reponse immunitaire reduite
US6461849B1 (en) 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
EP2113563A3 (fr) * 1998-11-27 2010-01-13 Novozymes A/S Variants d'enzyme lipolytique
US7851176B2 (en) 1998-11-27 2010-12-14 Novozymes A/S Lipolytic enzyme variants
US7632669B2 (en) 1998-11-27 2009-12-15 Novozymes A/S Lipolytic enzyme variants
US8679774B2 (en) 1998-11-27 2014-03-25 Novozymes A/S Lipolytic enzyme variants
US6586224B1 (en) 1999-07-22 2003-07-01 The Procter & Gamble Company Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
US6586223B1 (en) 1999-07-22 2003-07-01 The Procter & Gamble Company Subtilisin protease variants having amino acid substitutions in defined epitope regions
US6566115B1 (en) 1999-07-22 2003-05-20 The Procter & Gamble Company Protease conjugates having sterically protected clip sites
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
US6641825B2 (en) 2000-03-01 2003-11-04 Henkel Kommanditgesellschaft Auf Aktien Skin cleansing gel having a heating effect
WO2001064176A1 (fr) * 2000-03-01 2001-09-07 Henkel Kommanditgesellschaft Auf Aktien Gel nettoyant pour la peau a effet chauffant
DE10047481A1 (de) * 2000-09-26 2002-04-25 Henkel Kgaa Wasch- und Reinigungsmittel
EP1234584A1 (fr) * 2001-02-21 2002-08-28 Grisotech S.A. Complexes d'immunoglobulines et polysaccharides absorption orale ou transmucosale
US6913746B2 (en) 2001-02-21 2005-07-05 Grisotech S.A. Complexes of immunoglobulins polysaccharides for oral and transmucosal absorption
US7476528B2 (en) 2001-03-23 2009-01-13 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
WO2002077187A2 (fr) 2001-03-23 2002-10-03 Genencor International, Inc. Proteines provoquant une reaction immunogene modifiee, et methodes de production et d'utilisation desdites proteines
US6929939B2 (en) 2001-03-23 2005-08-16 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US7332320B2 (en) 2001-12-31 2008-02-19 Genencor International, Inc. Protease producing an altered immunogenic response and methods of making and using the same
US8916518B2 (en) 2002-03-06 2014-12-23 Fresenius Kabi Deutschland Gmbh Coupling proteins to a modified polysaccharide
WO2003099243A1 (fr) * 2002-05-29 2003-12-04 Henkel Kommanditgesellschaft Auf Aktien Agents cosmetiques comprenant une disulfidisomerase proteinique
WO2003099242A1 (fr) * 2002-05-29 2003-12-04 Henkel Kommanditgesellschaft Auf Aktien Agents cosmetiques comprenant une disulfidisomerase proteinique
DE10227238A1 (de) * 2002-06-19 2004-01-15 Wella Ag Hochaffine kosmetische Mittel
JP2005535652A (ja) * 2002-07-09 2005-11-24 サンド・アクチエンゲゼルシヤフト １，２−プロピレングリコールを含有するヒト成長ホルモン（ｈＧＨ）の高濃度液体製剤
WO2004030701A1 (fr) * 2002-09-11 2004-04-15 Fresenius Kabi Deutschland Gmbh Conjugue amidon hydroxyalkyle-allergene
WO2005077319A2 (fr) * 2004-02-12 2005-08-25 Unilever Plc Compositions de traitement capillaire
WO2005077319A3 (fr) * 2004-02-12 2006-08-24 Unilever Plc Compositions de traitement capillaire
US8840879B2 (en) 2004-03-11 2014-09-23 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
EP2270036A2 (fr) 2004-03-11 2011-01-05 Fresenius Kabi Deutschland GmbH Polypeptides hasylés
EP2270037A2 (fr) 2004-03-11 2011-01-05 Fresenius Kabi Deutschland GmbH Facteur IX hasylés
WO2006050691A3 (fr) * 2004-11-02 2006-09-21 Imasys Ag Dispositif de pose, dispositif d'etablissement de contact, systeme d'avance, unite de pose et d'etablissement de contact, installation de production, procede de production et ensemble transpondeur
WO2006050691A2 (fr) * 2004-11-02 2006-05-18 Imasys Ag Dispositif de pose, dispositif d'etablissement de contact, systeme d'avance, unite de pose et d'etablissement de contact, installation de production, procede de production et ensemble transpondeur
WO2007123271A2 (fr) * 2006-04-21 2007-11-01 Kao Corporation Composition d'agent de lutte contre un biofilm
WO2007123271A3 (fr) * 2006-04-21 2008-02-21 Kao Corp Composition d'agent de lutte contre un biofilm
EP2578235A2 (fr) 2007-08-27 2013-04-10 BioGeneriX AG Formulation liquide de conjugué de G-CSF
DE202008017456U1 (de) 2007-08-27 2009-08-27 Biogenerix Ag Flüssig-Formulierung von G-CSF-Konjugaten
CN104125838A (zh) * 2011-12-20 2014-10-29 辉瑞公司 制备肽缀合物和连接基的改进方法
WO2014067933A1 (fr) * 2012-10-31 2014-05-08 C-Lecta Gmbh Préparation de support bioactif pour une sécurité améliorée dans les produits de soin et les aliments

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AU725287B2 (en) 2000-10-12
EP0894128A1 (fr) 1999-02-03
CA2242488A1 (fr) 1997-08-21
CN1211278A (zh) 1999-03-17
CN1273589C (zh) 2006-09-06
JP2000506119A (ja) 2000-05-23
AU1540697A (en) 1997-09-02

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