HK1060882A1 - Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues - Google Patents
Process for preparing intermediates for the manufacture of discodermolide and discodermolide analoguesInfo
- Publication number
- HK1060882A1 HK1060882A1 HK04103857A HK04103857A HK1060882A1 HK 1060882 A1 HK1060882 A1 HK 1060882A1 HK 04103857 A HK04103857 A HK 04103857A HK 04103857 A HK04103857 A HK 04103857A HK 1060882 A1 HK1060882 A1 HK 1060882A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- discodermolide
- sub
- analogues
- manufacture
- preparing intermediates
- Prior art date
Links
- AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical compound C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title abstract 4
- AADVCYNFEREWOS-UHFFFAOYSA-N (+)-DDM Natural products C=CC=CC(C)C(OC(N)=O)C(C)C(O)C(C)CC(C)=CC(C)C(O)C(C)C=CC(O)CC1OC(=O)C(C)C(O)C1C AADVCYNFEREWOS-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000001336 alkenes Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0101599.9A GB0101599D0 (en) | 2001-01-22 | 2001-01-22 | Organic compounds |
| PCT/EP2002/000570 WO2002057251A2 (en) | 2001-01-22 | 2002-01-21 | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1060882A1 true HK1060882A1 (en) | 2004-08-27 |
Family
ID=9907244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK04103857A HK1060882A1 (en) | 2001-01-22 | 2004-05-28 | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6974875B2 (xx) |
| EP (1) | EP1368334B1 (xx) |
| JP (1) | JP4301810B2 (xx) |
| CN (2) | CN1775774A (xx) |
| AT (1) | ATE372332T1 (xx) |
| AU (1) | AU2002228057A1 (xx) |
| BR (1) | BR0206585A (xx) |
| CA (1) | CA2435371A1 (xx) |
| DE (1) | DE60222244T2 (xx) |
| ES (1) | ES2292726T3 (xx) |
| GB (1) | GB0101599D0 (xx) |
| HK (1) | HK1060882A1 (xx) |
| WO (1) | WO2002057251A2 (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY127609A (en) * | 2000-08-07 | 2006-12-29 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
| WO2004009574A1 (en) * | 2002-07-22 | 2004-01-29 | Novartis Ag | Synthesis of discodermolide |
| US7321046B2 (en) | 2002-09-06 | 2008-01-22 | University Of Pittsburgh | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof |
| AU2003263090A1 (en) | 2002-09-06 | 2004-03-29 | University Of Pittsburgh | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof |
| WO2005084349A2 (en) * | 2004-03-02 | 2005-09-15 | Kosan Biosciences, Inc. | Compounds useful for the synthesis of (+)-discodermolide and methods therefor |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| US20090069591A1 (en) * | 2005-04-19 | 2009-03-12 | Eisai R & D Management Co., Ltd. | Calcium Bis [ (2S) -3- [3-[ (2S) -3- (4-Chloro-2-Cyanophenoxy) -2- Fluoropropoxy]Phenyl] -2- Isopropoxypropionate] and Intermediate Thereof |
| US7816405B2 (en) | 2005-04-19 | 2010-10-19 | Eisai R&D Management Co., Ltd. | Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof |
| US7297807B1 (en) | 2006-05-31 | 2007-11-20 | The Research Foundation Of State University Of New York | Intermediates for the synthesis of polypropionate antibiotics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US6096904A (en) * | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US5789605A (en) * | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| AU7267298A (en) * | 1997-04-30 | 1998-11-24 | Regents Of The University Of California, The | Synthesis of discodermolide and analogs |
-
2001
- 2001-01-22 GB GBGB0101599.9A patent/GB0101599D0/en not_active Ceased
-
2002
- 2002-01-21 CA CA002435371A patent/CA2435371A1/en not_active Abandoned
- 2002-01-21 AU AU2002228057A patent/AU2002228057A1/en not_active Abandoned
- 2002-01-21 DE DE60222244T patent/DE60222244T2/de not_active Expired - Fee Related
- 2002-01-21 JP JP2002557932A patent/JP4301810B2/ja not_active Expired - Fee Related
- 2002-01-21 AT AT02710021T patent/ATE372332T1/de not_active IP Right Cessation
- 2002-01-21 US US10/466,728 patent/US6974875B2/en not_active Expired - Fee Related
- 2002-01-21 CN CNA2005101126328A patent/CN1775774A/zh active Pending
- 2002-01-21 CN CNB028039920A patent/CN1261428C/zh not_active Expired - Fee Related
- 2002-01-21 ES ES02710021T patent/ES2292726T3/es not_active Expired - Lifetime
- 2002-01-21 EP EP02710021A patent/EP1368334B1/en not_active Expired - Lifetime
- 2002-01-21 WO PCT/EP2002/000570 patent/WO2002057251A2/en active IP Right Grant
- 2002-01-21 BR BR0206585-1A patent/BR0206585A/pt not_active IP Right Cessation
-
2004
- 2004-05-28 HK HK04103857A patent/HK1060882A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002057251A3 (en) | 2002-10-10 |
| JP4301810B2 (ja) | 2009-07-22 |
| ES2292726T3 (es) | 2008-03-16 |
| JP2004517891A (ja) | 2004-06-17 |
| AU2002228057A1 (en) | 2002-07-30 |
| BR0206585A (pt) | 2003-12-16 |
| WO2002057251A2 (en) | 2002-07-25 |
| US20040073049A1 (en) | 2004-04-15 |
| CN1775774A (zh) | 2006-05-24 |
| US6974875B2 (en) | 2005-12-13 |
| DE60222244T2 (de) | 2008-05-29 |
| CA2435371A1 (en) | 2002-07-25 |
| CN1261428C (zh) | 2006-06-28 |
| DE60222244D1 (de) | 2007-10-18 |
| EP1368334B1 (en) | 2007-09-05 |
| GB0101599D0 (en) | 2001-03-07 |
| ATE372332T1 (de) | 2007-09-15 |
| EP1368334A2 (en) | 2003-12-10 |
| CN1487929A (zh) | 2004-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE2018C008I2 (xx) | ||
| PL369740A1 (en) | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments | |
| ES2169709A1 (es) | Metodo para la preparacion de citalopram | |
| WO2004103977A3 (en) | Process for the preparation of pyrimidine derivatives | |
| AU5932300A (en) | Synthesis of zsm-5 and zsm-11 | |
| HK1060882A1 (en) | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues | |
| MY145079A (en) | 1-substituted-4-nitroimidazole compound and method for preparing the same | |
| NO20040388L (no) | Fremgangsmåte for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmåten | |
| GB0317920D0 (en) | Solid-phase synthesis | |
| GR1003795B (el) | Μεθοδος παρασκευης της σιταλοπραμης. | |
| PL367774A1 (en) | Synthesis and intermediates | |
| WO2003024958A3 (en) | Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles | |
| MXPA03002493A (es) | Proceso eficiente para preparacion de un inhibidor del factor xa. | |
| IL141394A0 (en) | Process for the preparation of imidazodiazepine intermediates | |
| MXPA03006057A (es) | Proceso para preparar (+) trans-4-p-fluorofenil -3 hidroximetil. | |
| IL154466A0 (en) | Process for preparing a substituted imidazopyridine compound | |
| MX2009013336A (es) | Sintesis de 3-aminopirazoles sustituidos. | |
| MXPA04003086A (es) | Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos. | |
| GR3036403T3 (en) | Process for the preparation of sulfonylurea derivatives and intermediates for this process | |
| WO2005054175A3 (en) | New process for the preparation of nitrooxyderivatives of paracetamol | |
| GB0320738D0 (en) | Novel process | |
| IL144526A0 (en) | Process for producing hmg-coa reductase inhibitor | |
| CZ20012070A3 (cs) | Způsob přípravy kyseliny 1-(aminomethyl)cyklohexyloctové | |
| BG109794A (en) | METHOD FOR OBTAINING A CITAL TRAIN | |
| WO2005051904A3 (en) | Novel processes for the synthesis of cyclopropyl compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20120121 |