HK1052168A1 - N-deacetylthiocolchincine derivatives and pharmaceutical compositions containing them. - Google Patents

N-deacetylthiocolchincine derivatives and pharmaceutical compositions containing them.

Info

Publication number
HK1052168A1
HK1052168A1 HK03104265A HK03104265A HK1052168A1 HK 1052168 A1 HK1052168 A1 HK 1052168A1 HK 03104265 A HK03104265 A HK 03104265A HK 03104265 A HK03104265 A HK 03104265A HK 1052168 A1 HK1052168 A1 HK 1052168A1
Authority
HK
Hong Kong
Prior art keywords
deacetylthiocolchincine
derivatives
pharmaceutical compositions
compositions containing
pharmaceutical
Prior art date
Application number
HK03104265A
Other languages
English (en)
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of HK1052168A1 publication Critical patent/HK1052168A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK03104265A 2000-03-17 2003-06-16 N-deacetylthiocolchincine derivatives and pharmaceutical compositions containing them. HK1052168A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000554A IT1318401B1 (it) 2000-03-17 2000-03-17 Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
PCT/EP2001/002739 WO2001068597A1 (en) 2000-03-17 2001-03-12 N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
HK1052168A1 true HK1052168A1 (en) 2003-09-05

Family

ID=11444502

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03104265A HK1052168A1 (en) 2000-03-17 2003-06-16 N-deacetylthiocolchincine derivatives and pharmaceutical compositions containing them.

Country Status (22)

Country Link
US (1) US6627774B2 (de)
EP (1) EP1263719B1 (de)
JP (1) JP4614608B2 (de)
KR (1) KR100761577B1 (de)
CN (1) CN1169788C (de)
AU (2) AU4834101A (de)
CA (1) CA2403110C (de)
CZ (1) CZ303386B6 (de)
DE (1) DE60139306D1 (de)
DK (1) DK1263719T3 (de)
ES (1) ES2327386T3 (de)
HK (1) HK1052168A1 (de)
HU (1) HU228790B1 (de)
IL (2) IL151715A0 (de)
IT (1) IT1318401B1 (de)
NO (1) NO329428B1 (de)
PL (1) PL201575B1 (de)
PT (1) PT1263719E (de)
RU (1) RU2257379C2 (de)
SI (1) SI1263719T1 (de)
SK (1) SK287108B6 (de)
WO (1) WO2001068597A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20040164A1 (it) 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
LT3248600T (lt) * 2005-02-18 2020-07-27 Abraxis Bioscience, Llc Terapinių agentų deriniai bei įvedimo būdai ir kombinuotas gydymas
EP3345632A1 (de) * 2005-02-18 2018-07-11 Abraxis BioScience, LLC Arzneimittel mit verbesserter hydrophobie zur einarbeitung in medizinische vorrichtungen
CN101568332A (zh) * 2006-08-31 2009-10-28 阿布拉科斯生物科学公司 抑制血管生成及治疗血管生成相关疾病的方法
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
US20120189701A1 (en) * 2009-03-13 2012-07-26 Desai Neil P Combination therapy with thiocolchicine derivatives
EP2924022A1 (de) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphe Form eines Thiocolchicin-Derivats

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1359637A (fr) * 1962-10-29 1964-04-30 Roussel Uclaf Dérivés de la cochicine et de la thiocolchicine et procédé de préparation
US4533675A (en) 1984-04-17 1985-08-06 The United States Of America As Represented By The Department Of Health And Human Services Carbamates of colchicine for treatment of gout
WO1989010758A1 (en) * 1988-05-02 1989-11-16 Zynaxis Technologies, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
US5433675A (en) * 1993-11-29 1995-07-18 Excelermatic Inc. Traction roller transmission
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono
IT1283110B1 (it) * 1996-06-07 1998-04-07 Indena Spa Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Also Published As

Publication number Publication date
CZ303386B6 (cs) 2012-08-29
SK287108B6 (sk) 2009-12-07
SI1263719T1 (sl) 2009-10-31
KR20020091123A (ko) 2002-12-05
JP4614608B2 (ja) 2011-01-19
AU4834101A (en) 2001-09-24
SK13102002A3 (sk) 2002-12-03
US20030055111A1 (en) 2003-03-20
JP2003527371A (ja) 2003-09-16
RU2002124524A (ru) 2004-03-20
DE60139306D1 (de) 2009-09-03
PL201575B1 (pl) 2009-04-30
DK1263719T3 (da) 2009-11-16
ES2327386T3 (es) 2009-10-29
HUP0300557A2 (hu) 2003-07-28
IT1318401B1 (it) 2003-08-25
CN1418190A (zh) 2003-05-14
AU2001248341B2 (en) 2005-01-27
HU228790B1 (en) 2013-05-28
NO20024354L (no) 2002-09-12
NO329428B1 (no) 2010-10-18
US6627774B2 (en) 2003-09-30
WO2001068597A1 (en) 2001-09-20
CA2403110A1 (en) 2001-09-20
EP1263719B1 (de) 2009-07-22
HUP0300557A3 (en) 2004-08-30
PT1263719E (pt) 2009-08-20
IL151715A (en) 2007-12-03
EP1263719A1 (de) 2002-12-11
ITMI20000554A1 (it) 2001-09-17
CA2403110C (en) 2009-12-15
NO20024354D0 (no) 2002-09-12
RU2257379C2 (ru) 2005-07-27
CN1169788C (zh) 2004-10-06
KR100761577B1 (ko) 2007-10-04
IL151715A0 (en) 2003-04-10
PL357375A1 (en) 2004-07-26
ITMI20000554A0 (it) 2000-03-17

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20210311