HK1046412B - 乙磺酰基哌啶衍生物 - Google Patents

乙磺酰基哌啶衍生物

Info

Publication number
HK1046412B
HK1046412B HK02108022.3A HK02108022A HK1046412B HK 1046412 B HK1046412 B HK 1046412B HK 02108022 A HK02108022 A HK 02108022A HK 1046412 B HK1046412 B HK 1046412B
Authority
HK
Hong Kong
Prior art keywords
ethanesulfonyl
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
HK02108022.3A
Other languages
English (en)
Other versions
HK1046412A1 (en
Inventor
Alanine Alexander
Burner Serge
Buettelmann Bernd
Heitz Neidhart Marie-Paule
Jaeschke Georg
Pinard Emmanuel
Wyler Rene
Original Assignee
Evotec Int Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Int Gmbh filed Critical Evotec Int Gmbh
Publication of HK1046412A1 publication Critical patent/HK1046412A1/xx
Publication of HK1046412B publication Critical patent/HK1046412B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK02108022.3A 1999-06-08 2002-11-05 乙磺酰基哌啶衍生物 HK1046412B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99111126 1999-06-08
PCT/EP2000/004953 WO2000075109A1 (en) 1999-06-08 2000-05-31 Ethanesulfonyl-piperidine derivatives

Publications (2)

Publication Number Publication Date
HK1046412A1 HK1046412A1 (en) 2003-01-10
HK1046412B true HK1046412B (zh) 2004-07-09

Family

ID=8238316

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108022.3A HK1046412B (zh) 1999-06-08 2002-11-05 乙磺酰基哌啶衍生物

Country Status (38)

Country Link
US (1) US6310213B1 (zh)
EP (1) EP1189886B1 (zh)
JP (1) JP3645856B2 (zh)
KR (1) KR100571162B1 (zh)
CN (1) CN1142141C (zh)
AR (1) AR024282A1 (zh)
AT (1) ATE315025T1 (zh)
AU (1) AU770787B2 (zh)
BR (1) BR0011419A (zh)
CA (1) CA2376091C (zh)
CO (1) CO5160328A1 (zh)
CZ (1) CZ299483B6 (zh)
DE (1) DE60025348T2 (zh)
DK (1) DK1189886T3 (zh)
EG (1) EG26101A (zh)
ES (1) ES2254183T3 (zh)
GC (1) GC0000256A (zh)
GT (1) GT200000089A (zh)
HK (1) HK1046412B (zh)
HR (1) HRP20010885B1 (zh)
HU (1) HU228591B1 (zh)
IL (2) IL146750A0 (zh)
JO (1) JO2260B1 (zh)
MA (1) MA26797A1 (zh)
MX (1) MXPA01012585A (zh)
MY (1) MY128818A (zh)
NO (1) NO320613B1 (zh)
PA (1) PA8496601A1 (zh)
PE (1) PE20010218A1 (zh)
PL (1) PL196053B1 (zh)
RS (1) RS50033B (zh)
RU (1) RU2242464C2 (zh)
SI (1) SI1189886T1 (zh)
TN (1) TNSN00125A1 (zh)
TR (1) TR200103532T2 (zh)
TW (1) TWI254043B (zh)
WO (1) WO2000075109A1 (zh)
ZA (1) ZA200109706B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE273953T1 (de) * 2000-03-22 2004-09-15 Hoffmann La Roche Piperidin- und pirazinverbindungen zur verwendung in der behandlung von alzheimer
PT1278728E (pt) * 2000-04-20 2004-10-29 Hoffmann La Roche Derivados de pirrolidina e de piperidina e sua utilizacao no tratamento de disturbios neurodegenerativos
PA8525601A1 (es) * 2000-08-21 2002-04-25 Hoffmann La Roche Profarmacos de (3s,4s)-4-bencil-1-[2-(4-hidroxi-bencenosulfonil)-etil]-piperidin-3-ol
CA2425187A1 (en) * 2000-10-09 2002-04-18 Kay Double Detection of neurodegenerative disorders
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
CA2719749A1 (en) * 2008-03-27 2009-10-01 Evotec Neurosciences Gmbh Methods for treating disorders using nmda nr2b-subtype selective antagonist
WO2013012871A1 (en) * 2011-07-18 2013-01-24 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives

Also Published As

Publication number Publication date
AU770787B2 (en) 2004-03-04
NO20015920D0 (no) 2001-12-04
PL352723A1 (en) 2003-09-08
EG26101A (en) 2013-02-17
PE20010218A1 (es) 2001-02-28
EP1189886B1 (en) 2006-01-04
HUP0201916A2 (en) 2002-10-28
ES2254183T3 (es) 2006-06-16
WO2000075109A1 (en) 2000-12-14
HRP20010885B1 (en) 2010-07-31
HK1046412A1 (en) 2003-01-10
HU228591B1 (hu) 2013-04-29
HRP20010885A2 (en) 2004-02-29
JO2260B1 (en) 2004-10-07
CN1354745A (zh) 2002-06-19
SI1189886T1 (sl) 2006-04-30
BR0011419A (pt) 2002-02-26
GC0000256A (en) 2006-11-01
KR20020008850A (ko) 2002-01-31
IL146750A0 (en) 2002-07-25
DK1189886T3 (da) 2006-05-15
CZ20014349A3 (cs) 2002-05-15
JP2003501415A (ja) 2003-01-14
AR024282A1 (es) 2002-09-25
TR200103532T2 (tr) 2002-05-21
CA2376091A1 (en) 2000-12-14
JP3645856B2 (ja) 2005-05-11
TWI254043B (en) 2006-05-01
MA26797A1 (fr) 2004-12-20
IL146750A (en) 2006-12-10
DE60025348T2 (de) 2006-08-24
AU5218100A (en) 2000-12-28
HUP0201916A3 (en) 2003-05-28
YU86501A (sh) 2004-09-03
KR100571162B1 (ko) 2006-04-17
CZ299483B6 (cs) 2008-08-13
GT200000089A (es) 2001-11-29
CA2376091C (en) 2006-03-14
EP1189886A1 (en) 2002-03-27
CN1142141C (zh) 2004-03-17
DE60025348D1 (de) 2006-03-30
RS50033B (sr) 2008-11-28
TNSN00125A1 (fr) 2005-11-10
US6310213B1 (en) 2001-10-30
PA8496601A1 (es) 2001-12-14
ZA200109706B (en) 2003-02-26
PL196053B1 (pl) 2007-11-30
NO320613B1 (no) 2005-12-27
CO5160328A1 (es) 2002-05-30
MY128818A (en) 2007-02-28
NO20015920L (no) 2001-12-04
RU2242464C2 (ru) 2004-12-20
ATE315025T1 (de) 2006-02-15
MXPA01012585A (es) 2002-04-10

Similar Documents

Publication Publication Date Title
EG23817A (en) 4-Phenyl-pyridine derivatives
HUP0201535A2 (en) 5-cyano-2-aminopyrimidine derivatives
IL148167A0 (en) Amino-triazolopyridine derivatives
GC0000183A (en) 3-Phenyl-pyridine derivatives
IL145739A0 (en) 13-methyl-erythromycin derivatives
GC0000338A (en) 5-Phenyl-pyrimidine derivatives
IL148837A0 (en) Isoxazolecarboxamide derivatives
GC0000191A (en) 4-Phenyl-pyrimidine derivatives
GB9925880D0 (en) B-Carboline derivatives
IL150132A0 (en) Cyclopenteneone derivatives
IL147636A0 (en) 3-amino-2-benzyl-1-phenyl-propane derivatives
GC0000256A (en) Ethanesulfonyl-piperidine derivatives
IL145949A0 (en) 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
PL351407A1 (en) Thio-oxindole derivatives
GB9907134D0 (en) Antimor napthylcombretastatin derivatives
IL146282A0 (en) Thio-oxindole derivatives
HK1043987A1 (zh) 硫-羥吲衍生物
SI1178984T1 (en) 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
SI1200445T1 (en) Thienopyranecarboxamide derivatives
SI1226131T1 (en) Isoxazolecarboxamide derivatives

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150531