HK1042495B - 噻吩並嘧啶化合物及其生產和用途 - Google Patents

噻吩並嘧啶化合物及其生產和用途

Info

Publication number
HK1042495B
HK1042495B HK02104325.6A HK02104325A HK1042495B HK 1042495 B HK1042495 B HK 1042495B HK 02104325 A HK02104325 A HK 02104325A HK 1042495 B HK1042495 B HK 1042495B
Authority
HK
Hong Kong
Prior art keywords
production
thienopyrimidine compounds
thienopyrimidine
compounds
Prior art date
Application number
HK02104325.6A
Other languages
English (en)
Other versions
HK1042495A1 (en
Inventor
Furuya Shuichi
Suzuki Nobuhiro
Choh Nobuo
Nara Yoshi
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of HK1042495A1 publication Critical patent/HK1042495A1/xx
Publication of HK1042495B publication Critical patent/HK1042495B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK02104325.6A 1999-03-24 2002-06-07 噻吩並嘧啶化合物及其生產和用途 HK1042495B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7937199 1999-03-24
JP2000018019 2000-01-25
PCT/JP2000/001777 WO2000056739A1 (en) 1999-03-24 2000-03-23 Thienopyrimidine compounds, their production and use

Publications (2)

Publication Number Publication Date
HK1042495A1 HK1042495A1 (en) 2002-08-16
HK1042495B true HK1042495B (zh) 2004-10-08

Family

ID=26420391

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104325.6A HK1042495B (zh) 1999-03-24 2002-06-07 噻吩並嘧啶化合物及其生產和用途

Country Status (28)

Country Link
US (1) US6340686B1 (zh)
EP (1) EP1163244B1 (zh)
JP (1) JP3240293B2 (zh)
KR (2) KR100533483B1 (zh)
CN (1) CN1349536A (zh)
AR (1) AR023152A1 (zh)
AT (1) ATE261449T1 (zh)
AU (1) AU764019B2 (zh)
BR (1) BR0009297A (zh)
CA (1) CA2368108C (zh)
CZ (1) CZ294747B6 (zh)
DE (1) DE60008862T2 (zh)
DK (1) DK1163244T3 (zh)
ES (1) ES2212992T3 (zh)
HK (1) HK1042495B (zh)
HU (1) HUP0200550A3 (zh)
ID (1) ID30393A (zh)
IL (1) IL145549A (zh)
MX (1) MXPA01009566A (zh)
MY (1) MY124726A (zh)
NO (1) NO20014603L (zh)
NZ (1) NZ514737A (zh)
OA (1) OA11920A (zh)
PL (1) PL351202A1 (zh)
PT (1) PT1163244E (zh)
SK (1) SK13552001A3 (zh)
TW (1) TWI225863B (zh)
WO (1) WO2000056739A1 (zh)

Families Citing this family (36)

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US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
WO2001064683A1 (fr) * 2000-02-29 2001-09-07 Takeda Chemical Industries, Ltd. Procedes de production de derives de thienopyramidine
US20030134863A1 (en) * 2000-04-13 2003-07-17 Shuichi Furuya Preventives/remedies for alzheimer's disease
CA2407472A1 (en) * 2000-06-14 2002-10-23 Takeda Chemical Industries, Ltd. Sustained release compositions
CA2423329A1 (en) * 2000-09-22 2003-03-20 Takeda Chemical Industries, Ltd. Solid preparations
AU2002218494A1 (en) * 2000-11-29 2002-06-11 Takeda Chemical Industries Ltd. Medicinal compositions and process for producing the same
AU2002221139A1 (en) * 2000-12-15 2002-06-24 Takeda Chemical Industries Ltd. Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
EP1374855A1 (en) * 2001-03-30 2004-01-02 Takeda Chemical Industries, Ltd. Medicinal solutions
AU2002321878A1 (en) 2001-08-02 2003-02-17 Neurocrine Biosciences, Inc. Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists
CA2455235A1 (en) 2001-08-02 2003-02-13 Joseph Pontillo 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists
JP2005505525A (ja) 2001-08-02 2005-02-24 ニューロクライン バイオサイエンシーズ， インコーポレイテッド 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
EP1412363A1 (en) 2001-08-02 2004-04-28 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
EP1479684A4 (en) 2002-01-30 2006-01-04 Takeda Pharmaceutical THIENOPYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE
AU2003236039A1 (en) * 2002-04-12 2003-10-27 Takeda Pharmaceutical Company Limited Preventives/remedies for hotflash
WO2004018479A1 (en) * 2002-08-21 2004-03-04 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
AU2004207706B2 (en) 2003-01-29 2010-03-04 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
US20060083017A1 (en) * 2004-10-18 2006-04-20 Bwt Propety, Inc. Solid-state lighting apparatus for navigational aids
CA2615795C (en) 2005-07-22 2013-05-28 Takeda Pharmaceutical Company Limited Premature ovulation preventive agent
EP2329823A4 (en) 2008-09-03 2013-04-03 Takeda Pharmaceutical METHOD FOR IMPROVING CAPACITY OF PREPARATION TO BE ABSORBED AND PREPARATION WHICH CAPACITY TO BE ABSORBED IS IMPROVED
CN105732649B (zh) * 2012-02-28 2019-02-05 株式会社蒂奥姆生物 促性腺激素释放激素受体拮抗剂、其制备方法和包含该拮抗剂的药物组合物
SI2900675T1 (sl) * 2012-09-28 2019-06-28 Takeda Pharmaceutical Company Limited Postopek za pridobivanje tienopirimidin derivata
PT3263110T (pt) * 2015-02-26 2023-08-01 Takeda Pharmaceuticals Co Comprimido compreendendo um derivado de metoxiureia e partículas de manitol
ES2912929T3 (es) 2016-09-30 2022-05-30 Myovant Sciences Gmbh Métodos de tratamiento de fibromas uterinos y endometriosis
IL300071A (en) 2016-09-30 2023-03-01 Takeda Pharmaceuticals Co Prostate cancer treatment
KR101973074B1 (ko) * 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
US20220267347A1 (en) * 2019-07-29 2022-08-25 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidinedione compounds and uses thereof
CN111574534B (zh) * 2020-05-25 2021-06-04 东莞市东阳光新药研发有限公司 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途
CN111909168B (zh) * 2020-07-31 2022-02-01 广东东阳光药业有限公司 含氮杂环基取代的嘧啶二酮类化合物及其用途
CN111925379B (zh) * 2020-07-31 2022-02-15 广东东阳光药业有限公司 含氮杂芳基取代的嘧啶二酮类化合物及其用途
CN112047957B (zh) * 2020-09-09 2022-02-01 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN113754679B (zh) * 2020-09-09 2023-04-07 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN113429423B (zh) * 2020-12-30 2022-05-17 上海博志研新药物技术有限公司 瑞卢戈利中间体及其制备方法
CN115260211B (zh) * 2021-04-29 2024-02-06 长春金赛药业有限责任公司 含噻吩稠环类衍生物、药物组合物及其制备方法和应用
CN113717149A (zh) * 2021-09-29 2021-11-30 成都伊诺达博医药科技有限公司 一种瑞卢戈利关键中间体及其制备方法

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TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
UY23948A1 (es) * 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
US5627786A (en) * 1995-02-10 1997-05-06 Micron Quantum Devices, Inc. Parallel processing redundancy scheme for faster access times and lower die area
EP0816316A4 (en) * 1995-03-10 1999-06-02 Nitto Chemical Industry Co Ltd PROCESS FOR PRODUCING 1,2-ETHANEDIOL DERIVATIVES

Also Published As

Publication number Publication date
SK13552001A3 (sk) 2002-03-05
NZ514737A (en) 2003-10-31
HUP0200550A2 (en) 2002-06-29
US6340686B1 (en) 2002-01-22
AU3326200A (en) 2000-10-09
JP3240293B2 (ja) 2001-12-17
EP1163244B1 (en) 2004-03-10
NO20014603D0 (no) 2001-09-21
WO2000056739A1 (en) 2000-09-28
DE60008862T2 (de) 2005-01-27
KR20010090430A (ko) 2001-10-18
DE60008862D1 (de) 2004-04-15
CZ20013419A3 (cs) 2002-02-13
HK1042495A1 (en) 2002-08-16
PT1163244E (pt) 2004-07-30
IL145549A0 (en) 2002-06-30
JP2001278884A (ja) 2001-10-10
AR023152A1 (es) 2002-09-04
DK1163244T3 (da) 2004-07-12
KR100533483B1 (ko) 2005-12-05
PL351202A1 (en) 2003-03-24
MY124726A (en) 2006-06-30
EP1163244A1 (en) 2001-12-19
OA11920A (en) 2006-04-12
CA2368108C (en) 2009-12-22
ES2212992T3 (es) 2004-08-16
AU764019B2 (en) 2003-08-07
ID30393A (id) 2001-11-29
CZ294747B6 (cs) 2005-03-16
MXPA01009566A (es) 2002-05-14
IL145549A (en) 2005-11-20
KR20010015920A (ko) 2001-02-26
CA2368108A1 (en) 2000-09-28
ATE261449T1 (de) 2004-03-15
TWI225863B (en) 2005-01-01
BR0009297A (pt) 2001-12-18
HUP0200550A3 (en) 2004-07-28
CN1349536A (zh) 2002-05-15
KR100370981B1 (ko) 2003-02-06
NO20014603L (no) 2001-11-26

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Legal Events

Date Code Title Description
PF Patent in force
CHRG Changes in the register
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100323