IL148419A0 - Benzodiazepine derivatives, the production and use thereof - Google Patents
Benzodiazepine derivatives, the production and use thereofInfo
- Publication number
- IL148419A0 IL148419A0 IL14841900A IL14841900A IL148419A0 IL 148419 A0 IL148419 A0 IL 148419A0 IL 14841900 A IL14841900 A IL 14841900A IL 14841900 A IL14841900 A IL 14841900A IL 148419 A0 IL148419 A0 IL 148419A0
- Authority
- IL
- Israel
- Prior art keywords
- production
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19946289A DE19946289A1 (en) | 1999-09-28 | 1999-09-28 | Benzodiazepine derivatives, their production and use |
PCT/EP2000/009023 WO2001023386A2 (en) | 1999-09-28 | 2000-09-15 | Benzodiazepin derivatives, the production and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL148419A0 true IL148419A0 (en) | 2002-09-12 |
Family
ID=7923476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14841900A IL148419A0 (en) | 1999-09-28 | 2000-09-15 | Benzodiazepine derivatives, the production and use thereof |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1222191B1 (en) |
JP (1) | JP2003510324A (en) |
KR (1) | KR20020031602A (en) |
CN (1) | CN1376156A (en) |
AR (1) | AR025721A1 (en) |
AT (1) | ATE310003T1 (en) |
AU (1) | AU7656700A (en) |
BG (1) | BG106444A (en) |
BR (1) | BR0014326A (en) |
CA (1) | CA2384265A1 (en) |
DE (2) | DE19946289A1 (en) |
ES (1) | ES2251405T3 (en) |
HK (1) | HK1048994A1 (en) |
HU (1) | HUP0203225A3 (en) |
IL (1) | IL148419A0 (en) |
NO (1) | NO20021379D0 (en) |
PL (1) | PL354118A1 (en) |
SK (1) | SK3802002A3 (en) |
TR (1) | TR200200820T2 (en) |
WO (1) | WO2001023386A2 (en) |
ZA (2) | ZA200104196B (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2218110T3 (en) | 1999-01-11 | 2004-11-16 | Agouron Pharmaceuticals, Inc. | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES. |
AU2003236686A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors |
US7786344B2 (en) | 2002-07-26 | 2010-08-31 | Basf Plant Science Gmbh | Selection method |
US7223759B2 (en) | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2006019832A1 (en) | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
BRPI0609283A2 (en) | 2005-03-08 | 2010-11-23 | Basf Plant Science Gmbh | methods for identifying an intron with plant expression enhancing properties, to enrich the number of introns with plant expression enhancing properties, to isolate, supply or produce an intron with plant expression enhancing properties, to provide an expression cassette and to enhance expression of a nucleic acid sequence in a plant or a plant cell, computer algorithm, computer device or data storage device, recombinant DNA expression construct, expression vector, transgenic cell, or nonhuman organism transgenic material, cell culture, propagating parts or material, and, use of a transgenic organism or cell cultures, transgenic propagating material parts derived from these |
WO2006101937A1 (en) | 2005-03-18 | 2006-09-28 | Janssen Pharmaceutica N.V. | Acylhydrazones as kinase modulators |
BR112012012444A2 (en) | 2009-11-27 | 2015-09-22 | Basf Plant Science Co Gmbh | "chimeric endonuclease, isolated polynucleotide, expression cassette, vector, non-human organism, method for providing a chimeric endonuclease, method for homologous polynucleotide recombination, method for targeted polynucleotide mutation, and method for homologous recombination or targeted mutation" |
EP2504439B1 (en) | 2009-11-27 | 2016-03-02 | BASF Plant Science Company GmbH | Optimized endonucleases and uses thereof |
DE112010004583T5 (en) | 2009-11-27 | 2012-10-18 | Basf Plant Science Company Gmbh | Chimeric endonucleases and applications thereof |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
IL289834B1 (en) | 2012-06-13 | 2024-03-01 | Incyte Holdings Corp | Substituted tricyclic compounds as fgfr inhibitors |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
JP2015533783A (en) * | 2012-09-05 | 2015-11-26 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | Use of benzodiazepinones and benzoazepinones or their salts as active substances against abiotic plant stress |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
SI2986610T1 (en) | 2013-04-19 | 2018-04-30 | Incyte Holdings Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2015174511A1 (en) | 2014-05-16 | 2015-11-19 | 塩野義製薬株式会社 | Tricyclic heterocyclic derivative having hiv replication-inhibiting effect |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
ES2751669T3 (en) | 2015-02-20 | 2020-04-01 | Incyte Corp | Bicyclic heterocycles as FGFR inhibitors |
CN111138458A (en) * | 2015-05-29 | 2020-05-12 | 盐野义制药株式会社 | Nitrogen-containing tricyclic derivatives having HIV replication inhibiting effect |
CN105153195B (en) * | 2015-09-01 | 2017-09-26 | 汤文建 | A kind of tricyclic pyrazole [1,5 d] [1,4] benzo oxygen azatropylidene ketone derivatives and preparation method thereof and purposes |
AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
MX2020011639A (en) | 2018-05-04 | 2021-02-15 | Incyte Corp | Salts of an fgfr inhibitor. |
EP3788047A2 (en) | 2018-05-04 | 2021-03-10 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
BR112022007163A2 (en) | 2019-10-14 | 2022-08-23 | Incyte Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
KR20220131900A (en) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Derivatives of FGFR inhibitors |
US11897891B2 (en) | 2019-12-04 | 2024-02-13 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them |
CZ30398A3 (en) * | 1995-08-02 | 1998-06-17 | Newcastle University Ventures Limited | Benzimidazole compounds, pharmaceutical preparation in which the compounds are comprised and use of the compounds as chemotherapeutic agents |
ECSP003637A (en) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES |
-
1999
- 1999-09-28 DE DE19946289A patent/DE19946289A1/en not_active Withdrawn
-
2000
- 2000-09-15 HU HU0203225A patent/HUP0203225A3/en unknown
- 2000-09-15 IL IL14841900A patent/IL148419A0/en unknown
- 2000-09-15 KR KR1020027003975A patent/KR20020031602A/en not_active Application Discontinuation
- 2000-09-15 ES ES00966022T patent/ES2251405T3/en not_active Expired - Lifetime
- 2000-09-15 JP JP2001526538A patent/JP2003510324A/en not_active Ceased
- 2000-09-15 AU AU76567/00A patent/AU7656700A/en not_active Abandoned
- 2000-09-15 PL PL00354118A patent/PL354118A1/en not_active Application Discontinuation
- 2000-09-15 WO PCT/EP2000/009023 patent/WO2001023386A2/en active IP Right Grant
- 2000-09-15 CN CN00813443A patent/CN1376156A/en active Pending
- 2000-09-15 EP EP00966022A patent/EP1222191B1/en not_active Expired - Lifetime
- 2000-09-15 AT AT00966022T patent/ATE310003T1/en not_active IP Right Cessation
- 2000-09-15 BR BR0014326-0A patent/BR0014326A/en not_active IP Right Cessation
- 2000-09-15 DE DE50011656T patent/DE50011656D1/en not_active Expired - Lifetime
- 2000-09-15 SK SK380-2002A patent/SK3802002A3/en unknown
- 2000-09-15 CA CA002384265A patent/CA2384265A1/en not_active Abandoned
- 2000-09-15 TR TR2002/00820T patent/TR200200820T2/en unknown
- 2000-09-20 AR ARP000104924A patent/AR025721A1/en unknown
-
2001
- 2001-05-23 ZA ZA200104196A patent/ZA200104196B/en unknown
-
2002
- 2002-02-22 ZA ZA200201494A patent/ZA200201494B/en unknown
- 2002-02-26 BG BG06444A patent/BG106444A/en unknown
- 2002-03-20 NO NO20021379A patent/NO20021379D0/en not_active Application Discontinuation
-
2003
- 2003-02-18 HK HK03101161.8A patent/HK1048994A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2003510324A (en) | 2003-03-18 |
BG106444A (en) | 2002-09-30 |
NO20021379L (en) | 2002-03-20 |
AU7656700A (en) | 2001-04-30 |
CN1376156A (en) | 2002-10-23 |
WO2001023386A2 (en) | 2001-04-05 |
EP1222191A2 (en) | 2002-07-17 |
ATE310003T1 (en) | 2005-12-15 |
AR025721A1 (en) | 2002-12-11 |
CA2384265A1 (en) | 2001-04-05 |
DE50011656D1 (en) | 2005-12-22 |
TR200200820T2 (en) | 2002-09-23 |
KR20020031602A (en) | 2002-05-02 |
BR0014326A (en) | 2002-05-28 |
HUP0203225A3 (en) | 2003-05-28 |
SK3802002A3 (en) | 2003-03-04 |
HK1048994A1 (en) | 2003-04-25 |
NO20021379D0 (en) | 2002-03-20 |
ZA200201494B (en) | 2003-12-31 |
HUP0203225A2 (en) | 2003-01-28 |
EP1222191B1 (en) | 2005-11-16 |
ZA200104196B (en) | 2002-07-25 |
ES2251405T3 (en) | 2006-05-01 |
WO2001023386A3 (en) | 2002-05-10 |
PL354118A1 (en) | 2003-12-29 |
DE19946289A1 (en) | 2001-03-29 |
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