HK1041272B - 通過肽配基連接的多免疫原成分的hbv核心抗原微粒 - Google Patents

通過肽配基連接的多免疫原成分的hbv核心抗原微粒

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Publication number
HK1041272B
HK1041272B HK02101300.1A HK02101300A HK1041272B HK 1041272 B HK1041272 B HK 1041272B HK 02101300 A HK02101300 A HK 02101300A HK 1041272 B HK1041272 B HK 1041272B
Authority
HK
Hong Kong
Prior art keywords
hbv
hbv core
particles
core antigen
capsid
Prior art date
Application number
HK02101300.1A
Other languages
English (en)
Other versions
HK1041272A1 (en
Inventor
Kenneth Murray
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of HK1041272A1 publication Critical patent/HK1041272A1/xx
Publication of HK1041272B publication Critical patent/HK1041272B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/08—Antiallergic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • G01N2333/01—DNA viruses
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier

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  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
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HK02101300.1A 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的hbv核心抗原微粒 HK1041272B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11091198P 1998-12-04 1998-12-04
PCT/US1999/028755 WO2000032625A1 (en) 1998-12-04 1999-12-03 Hbv core antigen particles with multiple immunogenic components attached via peptide ligands

Publications (2)

Publication Number Publication Date
HK1041272A1 HK1041272A1 (en) 2002-07-05
HK1041272B true HK1041272B (zh) 2012-08-03

Family

ID=22335607

Family Applications (3)

Application Number Title Priority Date Filing Date
HK02101300.1A HK1041272B (zh) 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的hbv核心抗原微粒
HK12100867.6A HK1160652A1 (zh) 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的 核心抗原微粒
HK12101763.9A HK1161606A1 (zh) 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的 核心抗原微粒

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK12100867.6A HK1160652A1 (zh) 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的 核心抗原微粒
HK12101763.9A HK1161606A1 (zh) 1998-12-04 2002-02-21 通過肽配基連接的多免疫原成分的 核心抗原微粒

Country Status (23)

Country Link
US (5) US6627202B2 (zh)
EP (3) EP1135408B1 (zh)
JP (2) JP2002532387A (zh)
KR (1) KR100715954B1 (zh)
CN (1) CN1179973C (zh)
AT (1) ATE525388T1 (zh)
AU (1) AU770225B2 (zh)
BR (1) BR9915942A (zh)
CA (1) CA2352738A1 (zh)
CZ (1) CZ20011907A3 (zh)
DK (1) DK1135408T3 (zh)
EA (1) EA004497B1 (zh)
EE (1) EE200100292A (zh)
HK (3) HK1041272B (zh)
HU (1) HU229222B1 (zh)
IL (1) IL143475A0 (zh)
IS (1) IS5957A (zh)
NO (1) NO20012760L (zh)
NZ (1) NZ512056A (zh)
PL (1) PL348766A1 (zh)
SK (1) SK7602001A3 (zh)
TR (1) TR200102423T2 (zh)
WO (1) WO2000032625A1 (zh)

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