HK1041271A1 - 膽汁酸取代的苯基鏈烯酰基胍、其製備方法、其作為藥物或診斷劑的應用以及含有它們的藥物 - Google Patents

膽汁酸取代的苯基鏈烯酰基胍、其製備方法、其作為藥物或診斷劑的應用以及含有它們的藥物 Download PDF

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Publication number
HK1041271A1
HK1041271A1 HK02102812.0A HK02102812A HK1041271A1 HK 1041271 A1 HK1041271 A1 HK 1041271A1 HK 02102812 A HK02102812 A HK 02102812A HK 1041271 A1 HK1041271 A1 HK 1041271A1
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HK
Hong Kong
Prior art keywords
alkyl
hydrogen
phenyl
independently
benzyl
Prior art date
Application number
HK02102812.0A
Other languages
English (en)
Chinese (zh)
Inventor
A‧维切特
A‧維切特
A‧恩森
E‧法尔克
H-W‧简森
W‧克拉莫
E‧法爾克
J-R‧施瓦克
H‧J‧朗
H-W‧簡森
Original Assignee
萨诺费－阿文蒂斯德国有限公司
薩諾費-阿文蒂斯德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 萨诺费－阿文蒂斯德国有限公司, 薩諾費-阿文蒂斯德國有限公司 filed Critical 萨诺费－阿文蒂斯德国有限公司
Publication of HK1041271A1 publication Critical patent/HK1041271A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK02102812.0A 1998-10-28 1999-10-15 膽汁酸取代的苯基鏈烯酰基胍、其製備方法、其作為藥物或診斷劑的應用以及含有它們的藥物 HK1041271A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19849722.9 1998-10-28
DE19849722A DE19849722A1 (de) 1998-10-28 1998-10-28 Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PCT/EP1999/007828 WO2000024761A1 (de) 1998-10-28 1999-10-15 Gallensauer substituierte phenyl-alkenoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikamente oder diagnostika sowie sie enthaltendes medikament

Publications (1)

Publication Number Publication Date
HK1041271A1 true HK1041271A1 (zh) 2002-07-05

Family

ID=7885948

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102812.0A HK1041271A1 (zh) 1998-10-28 1999-10-15 膽汁酸取代的苯基鏈烯酰基胍、其製備方法、其作為藥物或診斷劑的應用以及含有它們的藥物

Country Status (22)

Country Link
US (1) US6166002A (enExample)
EP (1) EP1124841B1 (enExample)
JP (1) JP4616479B2 (enExample)
KR (1) KR20010085973A (enExample)
CN (1) CN1325403A (enExample)
AT (1) ATE236191T1 (enExample)
AU (1) AU757365B2 (enExample)
BR (1) BR9914929A (enExample)
CA (1) CA2349523A1 (enExample)
CZ (1) CZ20011429A3 (enExample)
DE (2) DE19849722A1 (enExample)
DK (1) DK1124841T3 (enExample)
ES (1) ES2191466T3 (enExample)
HK (1) HK1041271A1 (enExample)
HU (1) HUP0103751A3 (enExample)
ID (1) ID29025A (enExample)
PL (1) PL348108A1 (enExample)
PT (1) PT1124841E (enExample)
RU (1) RU2232769C2 (enExample)
TR (1) TR200101163T2 (enExample)
WO (1) WO2000024761A1 (enExample)
ZA (1) ZA200103106B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19941764A1 (de) 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
EP1646371A4 (en) 2003-06-26 2010-09-22 Biotron Ltd ANTIVIRAL COMPOSITIONS AND METHODS
DE10338554A1 (de) * 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7390837B2 (en) 2004-01-30 2008-06-24 Ethicon, Inc. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US6891069B1 (en) 2004-01-30 2005-05-10 Ethicon, Inc. Synthesis of 4-substituted phthalaldehyde
US20050171215A1 (en) * 2004-01-30 2005-08-04 Ethicon, Inc. Germicidal compositions containing halogenated phthalaldehyes, and methods of using such compositions for disinfection or sterilization
US7476767B2 (en) 2004-01-30 2009-01-13 Ethicon, Inc. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US7291649B2 (en) 2005-06-29 2007-11-06 Ethicon, Inc. Forming germicidal aromatic dialdehydes with acetals
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
EP3351248B1 (en) 2008-12-31 2021-06-09 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR102287207B1 (ko) 2013-04-12 2021-08-09 알데릭스, 인코포레이티드 Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス， インコーポレイテッド Ｎｈｅ媒介性アンチポートの阻害薬
CN110267944B (zh) 2017-01-09 2024-03-08 阿德利克斯股份有限公司 可用于治疗胃肠道病症的化合物
WO2020041673A1 (en) 2018-08-23 2020-02-27 President And Fellows Of Harvard College Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes
US12419897B2 (en) 2018-12-04 2025-09-23 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW289021B (enExample) * 1993-05-08 1996-10-21 Hoechst Ag
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
JPH0959162A (ja) * 1995-08-28 1997-03-04 Makoto Takahashi 胆石溶解剤
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
DE59904875D1 (de) 2003-05-08
ATE236191T1 (de) 2003-04-15
WO2000024761A1 (de) 2000-05-04
CN1325403A (zh) 2001-12-05
AU6203299A (en) 2000-05-15
US6166002A (en) 2000-12-26
ZA200103106B (en) 2002-08-28
HUP0103751A3 (en) 2002-12-28
DK1124841T3 (da) 2003-07-28
EP1124841B1 (de) 2003-04-02
RU2232769C2 (ru) 2004-07-20
BR9914929A (pt) 2001-07-10
JP2002528460A (ja) 2002-09-03
AU757365B2 (en) 2003-02-20
HUP0103751A2 (hu) 2002-04-29
TR200101163T2 (tr) 2001-08-21
ES2191466T3 (es) 2003-09-01
KR20010085973A (ko) 2001-09-07
PL348108A1 (en) 2002-05-06
CZ20011429A3 (cs) 2001-08-15
JP4616479B2 (ja) 2011-01-19
DE19849722A1 (de) 2000-05-04
CA2349523A1 (en) 2000-05-04
EP1124841A1 (de) 2001-08-22
PT1124841E (pt) 2003-08-29
ID29025A (id) 2001-07-26

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