HK1038010A1 - Tricyclic delta3-piperidines as alpha2-antagonists - Google Patents

Tricyclic delta3-piperidines as alpha2-antagonists

Info

Publication number
HK1038010A1
HK1038010A1 HK01108631A HK01108631A HK1038010A1 HK 1038010 A1 HK1038010 A1 HK 1038010A1 HK 01108631 A HK01108631 A HK 01108631A HK 01108631 A HK01108631 A HK 01108631A HK 1038010 A1 HK1038010 A1 HK 1038010A1
Authority
HK
Hong Kong
Prior art keywords
alpha2
piperidines
antagonists
delta3
tricyclic
Prior art date
Application number
HK01108631A
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Leybus Frans Maria Alfons Den
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1038010A1 publication Critical patent/HK1038010A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
HK01108631A 1998-10-06 2001-12-10 Tricyclic delta3-piperidines as alpha2-antagonists HK1038010A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98203370 1998-10-06
PCT/EP1999/007419 WO2000020421A2 (en) 1998-10-06 1999-10-01 TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS

Publications (1)

Publication Number Publication Date
HK1038010A1 true HK1038010A1 (en) 2002-03-01

Family

ID=8234191

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01108631A HK1038010A1 (en) 1998-10-06 2001-12-10 Tricyclic delta3-piperidines as alpha2-antagonists

Country Status (31)

Country Link
US (1) US6495555B1 (ja)
EP (1) EP1119571B1 (ja)
JP (1) JP4590101B2 (ja)
KR (1) KR20010071843A (ja)
CN (1) CN1131230C (ja)
AR (1) AR024216A1 (ja)
AT (1) ATE232869T1 (ja)
AU (1) AU760502B2 (ja)
BG (1) BG64872B1 (ja)
BR (1) BR9913507A (ja)
CA (1) CA2345622C (ja)
CZ (1) CZ20011104A3 (ja)
DE (1) DE69905478T2 (ja)
DK (1) DK1119571T3 (ja)
EE (1) EE04770B1 (ja)
ES (1) ES2193751T3 (ja)
HK (1) HK1038010A1 (ja)
HU (1) HUP0104002A3 (ja)
ID (1) ID28032A (ja)
IL (1) IL142443A0 (ja)
NO (1) NO20011270L (ja)
NZ (1) NZ510115A (ja)
PL (1) PL347894A1 (ja)
PT (1) PT1119571E (ja)
RU (1) RU2230744C2 (ja)
SI (1) SI1119571T1 (ja)
SK (1) SK285585B6 (ja)
TR (1) TR200100952T2 (ja)
TW (1) TWI248441B (ja)
UA (1) UA69420C2 (ja)
WO (1) WO2000020421A2 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142444A0 (en) * 1998-10-06 2002-03-10 Janssen Pharmaceutica Nv TRICYCLIC δ3-PIPERIDINES AS PHARMACEUTICALS
EP1490338B1 (en) * 2002-04-03 2011-08-24 Orion Corporation Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
BRPI0509893A (pt) 2004-04-12 2007-10-30 Taisho Pharmaceutical Co Ltd composto de amina cìclica
WO2006006740A1 (ja) * 2004-07-14 2006-01-19 Japan Tobacco Inc. ３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤
KR101042490B1 (ko) * 2004-07-15 2011-06-16 니뽄 다바코 산교 가부시키가이샤 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제
US7906508B2 (en) * 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
KR101727650B1 (ko) 2009-05-14 2017-04-17 얀센 파마슈티카 엔.브이. 류코트리엔 ａ4 하이드롤라아제의 조절제로서의 2개의 융합된 바이사이클릭 헤테로아릴 부분을 갖는 화합물
AP2016009303A0 (en) * 2013-12-19 2016-06-30 Bayer Pharma AG Substituted piperidinyl-tetrahydroquinolines
JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
JP2017503778A (ja) 2013-12-19 2017-02-02 バイエル ファーマ アクチエンゲゼルシャフト アドレナリン受容体α２Ｃ拮抗薬としての置換されたビピペリジニル誘導体
CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522959A1 (de) * 1985-06-27 1987-01-08 Merck Patent Gmbh Indolderivate
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
US4971974A (en) 1988-06-16 1990-11-20 Neurex Corporation Benzothiophenes as appetite suppressants
US5100891A (en) * 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
PT942911E (pt) * 1996-12-06 2002-04-29 Abbott Lab Compostos alfa 1 adrenergicos de benzopiranopirrolo e benzopiranopiridina
KR100588249B1 (ko) 1997-12-25 2006-06-13 메이지 세이카 가부시키가이샤 테트라하이드로벤즈인돌 유도체
IL142444A0 (en) * 1998-10-06 2002-03-10 Janssen Pharmaceutica Nv TRICYCLIC δ3-PIPERIDINES AS PHARMACEUTICALS

Also Published As

Publication number Publication date
CN1131230C (zh) 2003-12-17
BG64872B1 (bg) 2006-07-31
AR024216A1 (es) 2002-09-25
JP2002526545A (ja) 2002-08-20
TR200100952T2 (tr) 2001-10-22
ES2193751T3 (es) 2003-11-01
ATE232869T1 (de) 2003-03-15
EE04770B1 (et) 2007-02-15
TWI248441B (en) 2006-02-01
SI1119571T1 (en) 2003-08-31
SK285585B6 (sk) 2007-04-05
HUP0104002A2 (hu) 2002-03-28
IL142443A0 (en) 2002-03-10
KR20010071843A (ko) 2001-07-31
EE200100209A (et) 2002-06-17
DK1119571T3 (da) 2003-05-26
CN1332744A (zh) 2002-01-23
WO2000020421A3 (en) 2000-08-03
WO2000020421A2 (en) 2000-04-13
HUP0104002A3 (en) 2003-12-29
AU760502B2 (en) 2003-05-15
BR9913507A (pt) 2001-06-05
JP4590101B2 (ja) 2010-12-01
EP1119571B1 (en) 2003-02-19
UA69420C2 (uk) 2004-09-15
CZ20011104A3 (cs) 2001-12-12
AU6334199A (en) 2000-04-26
NO20011270D0 (no) 2001-03-13
CA2345622A1 (en) 2000-04-13
DE69905478T2 (de) 2004-03-18
PT1119571E (pt) 2003-06-30
NZ510115A (en) 2002-11-26
EP1119571A2 (en) 2001-08-01
RU2230744C2 (ru) 2004-06-20
CA2345622C (en) 2007-12-04
PL347894A1 (en) 2002-04-22
NO20011270L (no) 2001-03-13
ID28032A (id) 2001-05-03
BG105332A (en) 2001-11-30
US6495555B1 (en) 2002-12-17
DE69905478D1 (de) 2003-03-27
SK4322001A3 (en) 2002-01-07

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20071001