HK1032916A1 - N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents - Google Patents
N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agentsInfo
- Publication number
- HK1032916A1 HK1032916A1 HK01103633A HK01103633A HK1032916A1 HK 1032916 A1 HK1032916 A1 HK 1032916A1 HK 01103633 A HK01103633 A HK 01103633A HK 01103633 A HK01103633 A HK 01103633A HK 1032916 A1 HK1032916 A1 HK 1032916A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- substituted
- carbon atoms
- sulfonyl
- bis
- alkyl groups
- Prior art date
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000002429 hydrazines Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004417 unsaturated alkyl group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/61—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/963,182 US6040338A (en) | 1997-11-03 | 1997-11-03 | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents |
| PCT/US1998/022266 WO1999022726A1 (en) | 1997-11-03 | 1998-10-21 | N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1032916A1 true HK1032916A1 (en) | 2001-08-10 |
Family
ID=25506863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK01103633A HK1032916A1 (en) | 1997-11-03 | 2001-05-25 | N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6040338A (xx) |
| EP (1) | EP1028721B1 (xx) |
| JP (1) | JP4331889B2 (xx) |
| KR (1) | KR100566688B1 (xx) |
| CN (1) | CN1124846C (xx) |
| AT (1) | ATE241976T1 (xx) |
| AU (1) | AU735349B2 (xx) |
| BR (1) | BR9813923A (xx) |
| CA (1) | CA2308315C (xx) |
| DE (1) | DE69815380T2 (xx) |
| ES (1) | ES2200383T3 (xx) |
| HK (1) | HK1032916A1 (xx) |
| WO (1) | WO1999022726A1 (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6715188B1 (en) * | 2002-09-24 | 2004-04-06 | 3M Innovative Properties Company | Hinged tab for slot and tab closure systems |
| WO2004098504A2 (en) * | 2003-04-30 | 2004-11-18 | Yale University | Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and methods of treating tumors |
| US6855695B2 (en) * | 2003-06-13 | 2005-02-15 | Vion Pharmaceuticals, Inc. | Water-soluble SHPs as novel alkylating agents |
| CN101014353A (zh) * | 2004-03-26 | 2007-08-08 | 维奥恩药品公司 | 包含CloretazineTM的治疗组合物 |
| US7405317B2 (en) * | 2004-09-21 | 2008-07-29 | Vion Pharmaceuticals Inc. | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents |
| AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684747A (en) * | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
| US4892887A (en) * | 1984-12-20 | 1990-01-09 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
| US4962114A (en) * | 1986-01-21 | 1990-10-09 | Yale University | 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
| US4806531A (en) * | 1986-02-20 | 1989-02-21 | Yale University | 2,3-bis(aziridinyl)-1,4-naphthoquinone sulfonate derivatives having antineoplastic activity |
| JP2563176B2 (ja) * | 1986-08-05 | 1996-12-11 | 富士写真フイルム株式会社 | ハロゲン化銀カラ−写真感光材料 |
| US5214068A (en) * | 1989-09-06 | 1993-05-25 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
| US5101072A (en) * | 1989-09-06 | 1992-03-31 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
| US5256820A (en) * | 1991-11-08 | 1993-10-26 | Yale University | 1-alkyl-2-acyl-1,2-disulfonylhydrazines |
| US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
| US5637619A (en) * | 1995-07-05 | 1997-06-10 | Yale University | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines |
-
1997
- 1997-11-03 US US08/963,182 patent/US6040338A/en not_active Expired - Fee Related
-
1998
- 1998-10-21 DE DE69815380T patent/DE69815380T2/de not_active Expired - Lifetime
- 1998-10-21 AT AT98953830T patent/ATE241976T1/de not_active IP Right Cessation
- 1998-10-21 WO PCT/US1998/022266 patent/WO1999022726A1/en active IP Right Grant
- 1998-10-21 KR KR1020007004771A patent/KR100566688B1/ko not_active IP Right Cessation
- 1998-10-21 EP EP98953830A patent/EP1028721B1/en not_active Expired - Lifetime
- 1998-10-21 CN CN98810755A patent/CN1124846C/zh not_active Expired - Fee Related
- 1998-10-21 CA CA002308315A patent/CA2308315C/en not_active Expired - Fee Related
- 1998-10-21 AU AU11103/99A patent/AU735349B2/en not_active Ceased
- 1998-10-21 BR BR9813923-1A patent/BR9813923A/pt not_active Application Discontinuation
- 1998-10-21 JP JP2000518660A patent/JP4331889B2/ja not_active Expired - Fee Related
- 1998-10-21 ES ES98953830T patent/ES2200383T3/es not_active Expired - Lifetime
-
2001
- 2001-05-25 HK HK01103633A patent/HK1032916A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU735349B2 (en) | 2001-07-05 |
| CN1124846C (zh) | 2003-10-22 |
| AU1110399A (en) | 1999-05-24 |
| EP1028721B1 (en) | 2003-06-04 |
| BR9813923A (pt) | 2000-09-26 |
| CA2308315A1 (en) | 1999-05-14 |
| ATE241976T1 (de) | 2003-06-15 |
| CA2308315C (en) | 2009-01-06 |
| ES2200383T3 (es) | 2004-03-01 |
| DE69815380T2 (de) | 2004-05-13 |
| JP2001521893A (ja) | 2001-11-13 |
| KR20010031708A (ko) | 2001-04-16 |
| CN1278169A (zh) | 2000-12-27 |
| EP1028721A4 (en) | 2001-01-31 |
| WO1999022726A1 (en) | 1999-05-14 |
| JP4331889B2 (ja) | 2009-09-16 |
| KR100566688B1 (ko) | 2006-04-03 |
| DE69815380D1 (de) | 2003-07-10 |
| EP1028721A1 (en) | 2000-08-23 |
| US6040338A (en) | 2000-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20101021 |