HK1027562A1 - Cyanoguanidines as cell proliferation inhibitors - Google Patents
Cyanoguanidines as cell proliferation inhibitorsInfo
- Publication number
- HK1027562A1 HK1027562A1 HK00106580A HK00106580A HK1027562A1 HK 1027562 A1 HK1027562 A1 HK 1027562A1 HK 00106580 A HK00106580 A HK 00106580A HK 00106580 A HK00106580 A HK 00106580A HK 1027562 A1 HK1027562 A1 HK 1027562A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stands
- alkoxycarbonyl
- trifluoromethyl
- carboxy
- cyano
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical class NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 nitro, amino Chemical group 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711125.6A GB9711125D0 (en) | 1997-05-29 | 1997-05-29 | Novel cyanoguanidines |
| PCT/DK1998/000196 WO1998054144A1 (fr) | 1997-05-29 | 1998-05-15 | Cyanoguanidines utiles comme inhibiteurs de la proliferation cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1027562A1 true HK1027562A1 (en) | 2001-01-19 |
Family
ID=10813255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK00106580A HK1027562A1 (en) | 1997-05-29 | 2000-10-18 | Cyanoguanidines as cell proliferation inhibitors |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6346541B1 (fr) |
| EP (1) | EP0984938B1 (fr) |
| JP (1) | JP4408455B2 (fr) |
| KR (1) | KR100496220B1 (fr) |
| CN (1) | CN1116283C (fr) |
| AT (1) | ATE249438T1 (fr) |
| AU (1) | AU733142B2 (fr) |
| CA (1) | CA2292895C (fr) |
| CZ (1) | CZ294842B6 (fr) |
| DE (1) | DE69818041T2 (fr) |
| DK (1) | DK0984938T3 (fr) |
| ES (1) | ES2206932T3 (fr) |
| GB (1) | GB9711125D0 (fr) |
| HK (1) | HK1027562A1 (fr) |
| HU (1) | HUP0002921A3 (fr) |
| NZ (1) | NZ501071A (fr) |
| PL (1) | PL190314B1 (fr) |
| PT (1) | PT984938E (fr) |
| RO (1) | RO120541B1 (fr) |
| RU (1) | RU2195453C2 (fr) |
| WO (1) | WO1998054144A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| US6255323B1 (en) | 1999-04-09 | 2001-07-03 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| CA2447021C (fr) * | 2001-05-24 | 2010-08-10 | Leo Pharma A/S | Composants de cyanoguanidine |
| ES2290454T3 (es) * | 2002-05-17 | 2008-02-16 | Leo Pharma A/S | Profarmacos de cianoguanidina. |
| CN1662502A (zh) * | 2002-05-17 | 2005-08-31 | 利奥制药有限公司 | 氰基胍前药 |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| WO2006037468A1 (fr) * | 2004-09-30 | 2006-04-13 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Inhibiteurs de la transcriptase inverse du vih |
| WO2006066584A1 (fr) | 2004-12-22 | 2006-06-29 | Leo Pharma A/S | Composes de cyanoguanidine |
| WO2006110298A2 (fr) * | 2005-03-25 | 2006-10-19 | Glaxo Group Limited | Nouveaux composes |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| US8211912B2 (en) | 2007-09-26 | 2012-07-03 | Gemin X Pharmaceuticals Canada | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl tranferase inhibitor |
| WO2009086835A1 (fr) * | 2008-01-11 | 2009-07-16 | Topotarget A/S | Nouvelles cyanoguanidines |
| JP5688367B2 (ja) | 2008-08-29 | 2015-03-25 | トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ | 新規なウレアおよびチオウレア誘導体 |
| WO2010088842A1 (fr) * | 2009-02-06 | 2010-08-12 | 天津和美生物技术有限公司 | Compositions pharmaceutiques contenant des pyridyl-cyanoguanidines, leurs méthodes de préparation et utilisations |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| KR20140020823A (ko) | 2010-09-03 | 2014-02-19 | 포르마 티엠, 엘엘씨. | Ｎａｍｐｔ의 억제를 위한 구아니딘 화합물 및 조성물 |
| EP2634173A4 (fr) | 2010-10-26 | 2014-04-02 | Tianjin Hemay Bio Tech Co Ltd | Composé polymorphe de n-(6-(4-chlorophénoxy)hexyl)-n'-cyano-n''-(4-pyridyl)guanidine, et préparation de celui-ci et utilisation de celui-ci |
| CA3039589A1 (fr) | 2016-10-18 | 2018-04-26 | Seattle Genetics, Inc. | Administration ciblee d'inhibiteurs de la voie de recuperation de nicotinamide adenine dinucleotide |
| WO2018201087A1 (fr) | 2017-04-27 | 2018-11-01 | Seattle Genetics, Inc. | Conjugués d'inhibiteur de la voie de récupération du nicotinamide adénine dinucléotide quaternarisé |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
-
1997
- 1997-05-29 GB GBGB9711125.6A patent/GB9711125D0/en active Pending
-
1998
- 1998-05-15 CZ CZ19994234A patent/CZ294842B6/cs not_active IP Right Cessation
- 1998-05-15 AU AU76386/98A patent/AU733142B2/en not_active Expired
- 1998-05-15 RU RU99128082/04A patent/RU2195453C2/ru active
- 1998-05-15 ES ES98924055T patent/ES2206932T3/es not_active Expired - Lifetime
- 1998-05-15 EP EP98924055A patent/EP0984938B1/fr not_active Expired - Lifetime
- 1998-05-15 KR KR10-1999-7011131A patent/KR100496220B1/ko not_active IP Right Cessation
- 1998-05-15 AT AT98924055T patent/ATE249438T1/de not_active IP Right Cessation
- 1998-05-15 RO RO99-01251A patent/RO120541B1/ro unknown
- 1998-05-15 NZ NZ501071A patent/NZ501071A/en not_active IP Right Cessation
- 1998-05-15 JP JP50011499A patent/JP4408455B2/ja not_active Expired - Lifetime
- 1998-05-15 PT PT98924055T patent/PT984938E/pt unknown
- 1998-05-15 DE DE69818041T patent/DE69818041T2/de not_active Expired - Lifetime
- 1998-05-15 DK DK98924055T patent/DK0984938T3/da active
- 1998-05-15 CA CA002292895A patent/CA2292895C/fr not_active Expired - Lifetime
- 1998-05-15 WO PCT/DK1998/000196 patent/WO1998054144A1/fr active IP Right Grant
- 1998-05-15 PL PL98337030A patent/PL190314B1/pl not_active IP Right Cessation
- 1998-05-15 CN CN98805595A patent/CN1116283C/zh not_active Expired - Lifetime
- 1998-05-15 HU HU0002921A patent/HUP0002921A3/hu unknown
- 1998-05-15 US US09/424,632 patent/US6346541B1/en not_active Expired - Lifetime
-
2000
- 2000-10-18 HK HK00106580A patent/HK1027562A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9711125D0 (en) | 1997-07-23 |
| DK0984938T3 (da) | 2004-01-12 |
| DE69818041D1 (de) | 2003-10-16 |
| RU2195453C2 (ru) | 2002-12-27 |
| KR20010013148A (ko) | 2001-02-26 |
| NZ501071A (en) | 2001-08-31 |
| CZ9904234A3 (cs) | 2001-02-14 |
| KR100496220B1 (ko) | 2005-06-21 |
| JP4408455B2 (ja) | 2010-02-03 |
| CZ294842B6 (cs) | 2005-03-16 |
| CA2292895C (fr) | 2007-03-06 |
| EP0984938B1 (fr) | 2003-09-10 |
| CA2292895A1 (fr) | 1998-12-03 |
| ES2206932T3 (es) | 2004-05-16 |
| CN1258279A (zh) | 2000-06-28 |
| EP0984938A1 (fr) | 2000-03-15 |
| AU7638698A (en) | 1998-12-30 |
| ATE249438T1 (de) | 2003-09-15 |
| WO1998054144A1 (fr) | 1998-12-03 |
| CN1116283C (zh) | 2003-07-30 |
| US6346541B1 (en) | 2002-02-12 |
| HUP0002921A3 (en) | 2002-10-28 |
| HUP0002921A2 (hu) | 2001-01-29 |
| PT984938E (pt) | 2004-02-27 |
| JP2001526694A (ja) | 2001-12-18 |
| DE69818041T2 (de) | 2004-07-08 |
| PL337030A1 (en) | 2000-07-31 |
| AU733142B2 (en) | 2001-05-10 |
| PL190314B1 (pl) | 2005-11-30 |
| RO120541B1 (ro) | 2006-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL337030A1 (en) | Cyanoguanidines as inhibitors of cell proliferation | |
| RS20050915A (sr) | Supstituisani derivati indazolil (indolil)maleimida kao inhibitori kinaze | |
| HK1053463A1 (en) | Aminobenzophenones as inhibitors of il-1B and TNF-a. | |
| EP1496892A4 (fr) | Derives de 1h-benzo(f)indazol-5-yl utilises en tant que modulateurs selectifs du recepteur glucocorticoide | |
| DE69928697D1 (de) | Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren | |
| MXPA05006740A (es) | Imidazoquinolinas arilo-sustituidas. | |
| NZ508990A (en) | Pyrazoline derivatives, their preparation and application as medicaments | |
| WO2006109075A3 (fr) | Composes pharmaceutiques | |
| NO955211D0 (no) | Fluoralkoksysubstituerte benzamider og deres anvendelse som hemmere av cyklisk nukleotid fosfodiesterase | |
| NO20005448L (no) | Indolderivater og deres anvendelse for behandling av maligne og andre sykdommer som er basert på patologisk celleproliferering | |
| BG104248A (en) | Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides | |
| NO20065948L (no) | Quinazolin-4-yl-piperidin- and cinnolin-4-yl-piperidin-derivatives som PDE10-inhibitorer for behandling av CNS forstyrrelser | |
| PL338452A1 (en) | Novel substituted 6-phenylphenatridines | |
| ATE495162T1 (de) | Azabicyclo-octan und nonan derivate mit ddp-iv hemmender wirkung | |
| BG103867A (en) | Cyanoguanidines as cell proliferation inhibitors | |
| DK0966424T3 (da) | Aminobenzophenoner som inhibitorer for interleukin og TNF | |
| WO2004022528A3 (fr) | Derives d'arylglycine et leur utilisation comme inhibiteurs du transport de la glycine | |
| CA2214759A1 (fr) | Inhibiteurs d'epaississement de l'intima | |
| BR0212925A (pt) | Derivados de idol como inibidores de cox ii | |
| HK1027568A1 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| WO2002014281A8 (fr) | Inhibiteurs de p38 | |
| BR9710230A (pt) | Derivados de indol para o tratamento de osteoporose | |
| HK1048303A1 (en) | Aminobenzophenoses as inhibitors of il-1b and tnf -a. | |
| HK1048464B (zh) | 作為IL-1β和TNF-α的抑制劑的氨基二苯酮 | |
| YU73200A (sh) | 2-aminopiridini koji sadrže spojene ciklične supstituente kao inhibitori nitro oksid sintaze |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PE | Patent expired |
Effective date: 20180514 |