HK1024462A1 - Aminoindan derivatives. - Google Patents

Aminoindan derivatives.

Info

Publication number
HK1024462A1
HK1024462A1 HK00103684A HK00103684A HK1024462A1 HK 1024462 A1 HK1024462 A1 HK 1024462A1 HK 00103684 A HK00103684 A HK 00103684A HK 00103684 A HK00103684 A HK 00103684A HK 1024462 A1 HK1024462 A1 HK 1024462A1
Authority
HK
Hong Kong
Prior art keywords
dementia
alkyl
compounds
directed
hydrogen
Prior art date
Application number
HK00103684A
Other languages
English (en)
Inventor
Michael Chorev
Tamar Goren
Yacov Herzig
Jeffrey Sterling
Marta Weinstock-Rosin
Moussa B H Youdim
Original Assignee
Teva Pharma
Yissum Res Dev Co
Technion Res & Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11985396A external-priority patent/IL119853A0/xx
Priority claimed from IL12051097A external-priority patent/IL120510A0/xx
Application filed by Teva Pharma, Yissum Res Dev Co, Technion Res & Dev Foundation filed Critical Teva Pharma
Publication of HK1024462A1 publication Critical patent/HK1024462A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Centrifugal Separators (AREA)
HK00103684A 1996-12-18 2000-06-19 Aminoindan derivatives. HK1024462A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11985396A IL119853A0 (en) 1996-12-18 1996-12-18 Aminoindan derivatives
IL12051097A IL120510A0 (en) 1997-03-24 1997-03-24 Phenylethylamine derivatives
PCT/US1997/024155 WO1998027055A1 (en) 1996-12-18 1997-12-18 Aminoindan derivatives

Publications (1)

Publication Number Publication Date
HK1024462A1 true HK1024462A1 (en) 2000-10-13

Family

ID=26323338

Family Applications (2)

Application Number Title Priority Date Filing Date
HK00103684A HK1024462A1 (en) 1996-12-18 2000-06-19 Aminoindan derivatives.
HK05110547A HK1076098A1 (en) 1996-12-18 2005-11-22 Aminoindan derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK05110547A HK1076098A1 (en) 1996-12-18 2005-11-22 Aminoindan derivatives

Country Status (14)

Country Link
US (4) US6303650B1 (da)
EP (2) EP0966435B1 (da)
JP (1) JP4222632B2 (da)
AT (2) ATE292619T1 (da)
AU (1) AU5726898A (da)
CA (1) CA2275425C (da)
DE (2) DE69738275T2 (da)
DK (1) DK0966435T3 (da)
ES (1) ES2241064T3 (da)
HK (2) HK1024462A1 (da)
HU (1) HU229507B1 (da)
IL (1) IL130528A (da)
PT (1) PT966435E (da)
WO (1) WO1998027055A1 (da)

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EP1565185A4 (en) * 2002-11-07 2011-01-05 Technion Res & Dev Foundation NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
EP1686973A4 (en) * 2003-11-25 2009-03-25 Technion Res & Dev Foundation COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISEASES
US8097608B2 (en) 2003-11-25 2012-01-17 Technion Research And Development Foundation Ltd. Methods for treatment of cardiovascular disorders and diseases
JP2005232148A (ja) * 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd 神経保護剤としてプロパルギルアミンの使用
EP1574498A1 (en) * 2004-02-19 2005-09-14 PPG-Sipsy Process for the synthesis of substituted alpha-aminoindan derivatives
JP2008507586A (ja) * 2004-07-26 2008-03-13 テバ ファーマシューティカル インダストリーズ リミティド ラサグリンを含む、医薬投与剤
WO2006014968A2 (en) * 2004-07-27 2006-02-09 Teva Pharmaceutical Industries, Ltd. Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
EP1797030A1 (en) 2004-09-08 2007-06-20 Teva Pharmaceuticals USA, Inc. Improved process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
PL1848415T3 (pl) * 2005-02-17 2013-10-31 Teva Pharma Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego
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DE69732984D1 (de) 2005-05-12
DE69732984T2 (de) 2006-02-16
ATE377585T1 (de) 2007-11-15
CA2275425A1 (en) 1998-06-25
US6538025B2 (en) 2003-03-25
DK0966435T3 (da) 2005-08-15
ATE292619T1 (de) 2005-04-15
EP1535902B1 (en) 2007-11-07
AU5726898A (en) 1998-07-15
HK1076098A1 (en) 2006-01-06
ES2241064T3 (es) 2005-10-16
JP4222632B2 (ja) 2009-02-12
IL130528A (en) 2004-12-15
HUP0101130A3 (en) 2003-02-28
USRE39616E1 (en) 2007-05-08
HU229507B1 (en) 2014-01-28
PT966435E (pt) 2005-06-30
US6462222B1 (en) 2002-10-08
EP0966435A1 (en) 1999-12-29
EP0966435A4 (en) 2003-04-16
HUP0101130A2 (hu) 2001-08-28
US20020188020A1 (en) 2002-12-12
EP1535902A1 (en) 2005-06-01
WO1998027055A1 (en) 1998-06-25
CA2275425C (en) 2009-08-04
US6303650B1 (en) 2001-10-16
JP2001506269A (ja) 2001-05-15
EP0966435B1 (en) 2005-04-06
DE69738275D1 (de) 2007-12-20
DE69738275T2 (de) 2008-08-28

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