CA2477218A1

CA2477218A1 - Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors

Info

Publication number: CA2477218A1
Application number: CA002477218A
Authority: CA
Inventors: Eran Blaugrund; Yaacov Herzig; Jeffrey Sterling
Original assignee: Individual
Current assignee: Teva Pharmaceutical Industries Ltd
Priority date: 2002-02-27
Filing date: 2003-02-27
Publication date: 2003-09-04
Also published as: JP2005523289A; EP1490324A2; WO2003072055A2; AU2003219913A8; AU2003219913A1; WO2003072055A3; EP1490324A4

Abstract

The subject invention provides derivatives of propargylamino indan (PAI) and propargylamino tetralin that selectively inhibit monoamine oxidase (MAO) in the brain, having the structure:, wherein R1 is OC (O) R9 and R2 is H, wherein R9 i s branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 is OC
(O) R4 and R2 is OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted; wherein R3 is H or C1 to C6 alkyl; wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.
Additionally, the subject invention provides methods of treating neurological disorders using these compounds, uses of these compounds for the manufacture of medicaments for treating neurological disorders and processes for synthesis of these compounds.

Description

FROPARGYLAMINO INDAN DERIVATIVES AND PROPARGYLAMINO
TETRALIN DERIVATIVES AS BRAIN-SELECTIVE MAO INHIBITORS
This .application claims the benefit of U.S, Serial No.
10/085,674, filed February 27, 2002, the contents of which are hereby incorporated by reference.
Throughout this application, various references are referenced by short citations within parenthesis. Full citations for these references may be found at the end of the specification, immediately preceding the claims. These references, in their entireties, are hereby incorporated by reference to more fully describe the state of the art to which this invention pertains.
Field of the Invention The subject of this invention provides for derivatives of propargylaminoindans and propargylaminotetralins that are irreversible inhibitors of the enzyme monoamine oxidase A and/or B and also for prodrugs far the administration of these compounds. Such compounds may be useful in the treatment of Parkinson's disease, Alzheimer's disease, depression and other neurological disorders.
Background of the Invention The enzyme monoamine oxidase (MAO) plays an essential role in the metabolic degradation of important amine neurotransmitters including dopamine, serotonin and noradrenaline. Thus, agents that inhibit MAO are of potential therapeutic benefit for a variety of neurological disease indications, including Parkinson's disease, Alzheimer's~disease, depression, epilepsy, narcolepsy, amyotrophic lateral sclerosis (ALS), etc. (Szelnyi, I.; Bentue-Ferrer et al.; .Loscher et al.; White et al.; U.S.
Patent No. 5,744,500). Other diseases and conditions which have _7_ been associated with toxic levels of monoamine oxidase-B are memory disorders (The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats), panic, post-traumatic stress disorder (PTSD), sexual dysfunction, attention deficit and hyperactivity syndrome (ADHD)(Potential applications for monoamine oxidase B inhibitors), attention deficit disorder (ICleywegt), and Tourette's syndrome (Treatment of Tourette's:
Overview).
Many inhibitors of MAO are chiral molecules (U~.S. Patent No.
5,744,500). Although one enantiomer often shows some stereoselectivity in relative potency towards MAO-A and -B, a given enantiomeric configuration is not always more selective than its isomer in discriminating between MAO-A and -B
(Hazelhoff et al., Naunyn-Schmeideberg's Arch. Pharmacol.).
MAO inhibitors can also be classified as reversible inhibitors which inhibit the enzyme by a competitive mechanism or as irreversible inhibitors which are generally mechanism based (suicide inhibitors) (Dostert). For example, moclobemide is a reversible MAO-A-specific inhibitor (Fitton et al.) developed as an anti-depressant. Likewise, rasagiline (U.S. Patent No.
5,744,500) and selegiline,(Chrisp et al.) are MAO-B-selective irreversible inhibitors.

Irreversible ,inhibitors have the advantage of lower, less frequent dosing since their MAO inhibition is not based directly on the drugs' pharmacokinetic behavior, but rather on the de novo regeneration of the MAO enzyme.
MAO also plays an essential role in the oxidative deamination of biogenic and food-derived amines, both in the central nervous system and in peripheral tissues.. MAO is found in two functional isoenzyme forms, MAO-A and MAO-B, each of which shows preferential affinity for substrates and specificity toward inhibitors. Thus, MAO-A preferentially oxidizes serotonin, noradrenaline and adrenaline, whereas MAO-B preferentially metabolizes phenylethylamine. Dopamine is a substrate fpr both forms of the enzyme(Szelenyi, I.).
N-Propargyl-(1R)-aminoindan is known to be a potent B-selective inhibitor of MAO (U. S. Patent No. 5,457,133). Various derivatives of this compound have been prepared and shown to have varying degrees of potency and selectivity for the inhibition of MAO-A andlor -B. There is no currently accepted theory explaining the effect of structure on the activity (SAR) of the various substituted propargylaminoindans.
The dopamine agonistic activity and MAO inhibitory properties of 7-(methyl-prop-2-ynylamino)-tetralin-2-of and 7-(methyl-prop-2-ynylamino)-tetralin-2,3-diol have been reported (Hazelhoff et al., Eur. J. Pharmacol.). The details of the synthesis of these compounds have not been published, however.
?0 6,7-di-0-benzoyl-2-aminotetralin has been reported as a prodrug of the dopaminergic agonist 6,7-di-hydroxy-2-aminotetralin (Horn et al.). However, no N-propargyl derivatives were reported and the compounds were not shown to have MAO inhibitory or neuroprotective activities.
7-(propyl-prop-2-ynylamino)-tetralin-2-of has been reported as an intermediate in the preparation .of 7-[(3-iodoallyl)-propylamino]-tetralin-2-ol. Only the latter has been pharmacologically characterized as D3-dopamine receptor ligand (Churnpradit et al.). No other N-alkyl substituents were described.
Florvall et al. report the preparation of amino acid-based prodrugs of amiflamine analogues. Amiflamine is a reversible MAO-A inhibitor. , PCT International Application No. PCT/US97/24155 concerns carbamate aminoindan derivatives, including propargylamines, as inhibitors of MAO-A and M.AO-B for the treatment of Alzheimer's disease and other neurological conditions. However, the compounds of PCT/US97/24155 are not selective for MAO over acetylcholinesterase ("AChE"). Thus, the compounds generally inhibit acetylcholinesterase along with MAO.
Acetylcholinesterase inhibition is a route implicated in certain neurological disorders, but is a different route from the route of MAO inhibition.
U.S. Patent No. 6,303,650 discloses derivatives of 1-aminoindan as selective MAO B inhibitors that additionally inhibit acetylcholinesterase. The reference teaches that its compounds can be used to treat depression, Attention Deficit Disorder (ADC), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementias such as senile dementia, dementia of the Parkinson's type., vascular~dementia and Lewy body dementia.
Many irreversible MAO inhibitors contain the propargyl amine functionality. This pharmacophore is responsible for the MAO
inhibitory activity of such compounds. Some propargylamines have been shown to have neuroprotective/neurorescue properties independent of their MAO inhibition activity (U.S. Patent No.
4,844,033; Krageten et al.).
PCT International Application No. PCTlIL96/00115 relates to pharmaceutical compositions comprising racemic, (S), and (R)-N-propargyl-1-aminoindan. (R)-N-propargyl-1-aminoindan selectively inhibits MAO-B in the treatment of Parkinson's disease and other neurological disorders(PCT/IL96/00115).
Derivatives of 1-aminoindan, including propargyl aminoindan, and their salts are described in many U. S . patents (U. S . . Patents No.

5,639,913, 5,877,221, 5,880,159, 5,877,218, 5,914,349, 5,994,408) and a PCT International Application (PCT/US95100245).
These references disclose racemic, R and S enantiomer~ of 1-aminoindan derivatives for the treatment of Parkinson's disease S and other neurological conditions (U. S. Patents No. 5,639,913, 5,87.7,221, 5,880,159, 5,877,218, 5,914,349, 5,994,408, PCT/US95/00245).
pCT International Application No. PCT/US97/24155 concerns 10. aminoindan derivatives, including propargyl aminoindan, as inhibitors of MAO-A and MAO-B for the treatment of Parkinson's disease and other neurological conditions. The publication reveals that the disclosed compounds exhibit a greater selectivity for MAO-A and MAO-B in the brain than in the liver 15 or intestine.
U.S. Patent No. 6,316,504 discloses that the R(+) enantiomer of N-propargyl-1-aminoindan is a selective irreversible inhibitor of MAQ-B. The patent indicates that (R)-20 N-propargyl-1-aminoindan is useful for the treatment of Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an affective illness, a neurodegenerative disease, a neurotoxic injury, stroke, again ischemia, a head trauma injury, a spinal traumG injury, neurotrauma, 25 schizophrenia, an attention deficit disorder, , multiple sclerosis, and withdrawal symptoms.
European Patent No. 436492 discloses the R enantiomer of N-propargyl-1-aminoindan as a selective irreversible inhibitor of 30 MAO-B in the treatment of Parkinson's disease and other neurological conditions. Numerous U.S. patents also relate to the MAO B inhibition of (R) -N-propargyl-1-aminoindan and its use for treating patients suffering from Parkinson's Disease and other neurological disorders (U. S. Patents No. 5,387,612, 35 5,453,446, 5,457,13.3, 5,519,061, 5,532,415, 5,576,353, 5,668,181, 5,744,500, 5,786,390 and 5,891,923).
PCT International Application No. PCT/IL97/00205 disclpses 5-(-)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for the treatment of a neurological disorder of neurotrauma or for improving memory. The compounds were found to be neuroprotective, but not inhibitory of MAO-A or MAO-B
(PCT/IL97/00205).
U.S. Patent No. 5,486,541 provides N-propargyl-1-amonoindan monofluorinated in the phenyl ring as selective inhibitors. of MAO-B. These compounds are presented as useful in the.treatment of Parkinson's disease, memory disorders, dementia of the Alzheimer's type, depression and the hyperactive .syndrome in children.
Among.the many derivatives of propargylaminoindan mentioned in the prior art are hydroxy-propargylaminoindans. U.S. Patent No.
3,513,244 lists some racemic N-propargylamino indanols and tetralinols for use as antihypertensives. These compounds are not exemplified chemically and are not pharmacologically, characterized (U.S.'Patent No. 3,513,244).
N-propargylamino indanol also appears in E.P. 267024 as a hydrofluorene derivative, i.e., 3-amino-4-indanol (7-OH
fluorene). The hydrofluorene derivatives and salts in E.P.
267024 are employed as cerebral activators in.the treatment of anoxemia and hypoxemia. In addition, such derivatives help prevent arrhythmia and heart failure caused by lack of oxygen (E.P. 267024). The derivatives also act as antioxidants and cholinergic nerve system activating agents (E. P. 267024).

_'7_ Summary of the Invention The subject invention provides a compound having the structure:

~~ ) m Wd.
( n R;
wherein R1 is OC(0)R4 and Rz is H, wherein R9 is branched or unbranched C, to C6 alkyl, aryl, or aralkyl, or R1 i s OC ( 0 ) R4 and RZ i s OC ( O ) RQ , wherein R9 is branched or unbranched C1 to, Cs alkyl, aryl, aralkyl or NRSR6, wherein RS and RE are each independently H, C1 to CB alkyl, CE to C1z aryl, C6 to C,z aralkyl or C6 to Cia cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.

_g_ The subject invention also provides a compound having the structure:

~m \~' ( n N

wherein Rl is OH;
wherein R2 is H or OC(0)R9 when R1 is attached to the "a"
carbon or the "d" carbon, or R~ is OC (0) Rq when R1 is attached to the "b" carbon or the "c" carbon;
wherein R9 is C1 to C6 branched or unbranched alkyl' aryl , aralkyl or NRSR6, wherein RS and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C1z cycloalkyl, each optionally substituted;
wherein n is 0 or 1, and m is 1 or 2; and wherein R3 is H or Me when n is 1 and m is 1, or R3 is H or C1 to C6 alkyl when n is 0 or m is 2 ' or a pharmaceutically acceptable salt thereof.

In addition, the subject invention provides a compound having the structure:

s. ~ia ) m ~~d ( n N

R., . wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein R2 is H;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.
The subject invention further provides a compound having the structure:
R7 ~

wherein R, is H, Cl to C6 alkyl, aryl, aralkyl or C(O)R9, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein RS and R6are each independently H, C1 to C8 alkyl, C6 to Clz aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein R8 is H or t-butoxycarbonyl (Boc).

The subject invention also provides a method of treating a~
subject afflicted with a neurological disease comprising administering to the subject a compound having the structure:
m ~d R ( n N

2 wherein R1 is~ OH or OC (O) R9, and wherein Ro is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
RZ is H or OC (O) R4, or both R1 and R~ are OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR;R6, wherein RS and R6 are each independently H, Cl to Ce alkyl, C6 to Clz aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or l; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, or a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in the subject.

Furthermore, the subject invention provides a method of treating a subject afflicted with a neurological disease comprising administering to the subject a compound having the structure:
y ~/a ~ ~ .
~a ( n N

wherein R1 is OH or OC(0)R9;
wherein Ra is H or OC (O) R9, wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein RS and R6 are each independently H, C1 to' Ca alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof , or a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in the subject.

The subject invention additionally provides a process for preparing a compound having the structure:
)m ( n N

wherein n is 0 or 1, and m is 1 or 2;
wherein R~ is H or C1 to C6 alkyl; and wherein R~ is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
comprising the step of reacting ~ )m HO' ~ ( n boc or )m Ho/

with R9 \Cl in the presence of.an acid or 4-dimethylaminopyridine (DMAP) to form the compound.

The subject invention also provides a process for preparing a compound having the structure:

O

HN
0 R"
wherein R~ is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR~R6, wherein R~ and R6 are each independently H, Cl to Ce alkyl, C6 to C1z aryl, C6 to C12 aralkyl or C6 to Cla cycloalkyl, each optionally substituted;
which process comprises:

(a) reacting a compound having the structure:
M e~
Me O
l0 with A1C1, or BBr3 in the presence of toluene to produce a compound having the structure:
HO
HO
O

(b) reacting the product formed in step (a) with benzyl chloride and KZC03 in the presence of dimethyl formamide (DMF) to produce a compound having the structure: , Phy Phi to O
(c) reacting the product formed in step (b) with MeNH2~HCl, NaCNBH3 in tetrahydrofuran (THF) /MeOH to produce a compound having the structure:
Phi O
Phi 0 HN
(d) reacting the product formed in step (c) with.H2, Pd/C and MeOH to produce a compound having the structure:
HN' (e) reacting the product formed in step (d) with BoczO, dioxane/Hz0 and NaHC03 to produce a compound having the structure:
HO
HO
boc (f) reacting the product formed in step (e) with R4COC1, Et3N
in CH2Clz in the presence of Q-dimethylaminopyridine (DMAP) to produce a compound having the structure:

O

boc (g) reacting the product formed in step (f) with HC1/dioxane to produce a compound having the structure:

O
io o R4 (h) reacting the product formed in step (g) with propargyl bromide, K~CO, in CH3CN and then with HC1/ether and MeOH
to produce a compound having the structure:

O
O
HN
0 Re The subject invention also provides the use of a compound or a prodrug of a compound which becomes the compound ,having the structure:
R
wherein Rl is OH or OC (O) R4;
'wherein R2 is H, OH or OC (O) R9, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl. or NRSR6, wherein RS and R6 are each independently H, C1 to CB alkyl , C~ to C1~ aryl , C6 to C12 aralkyl or C6 to ClZ cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1. or 2, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating a subject afflicted with a neurological disease, wherein the compound is to be periodically administered to the subject in a therapeutically effective dose.

Additionally, the subject invention provides the use of a compound or a prodrug of a compound which becomes the compound having the structure:
~~~d N

wherein R1 is OH or OC (O) R9, and wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
R2 is H or OC(0)Rg, or both R1 and R2 are OC(O)R4, wherein RQ is C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein RS and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to ClZ aralkyl or C6 to . C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating neurological disease in a subject, wherein the compound is to be periodically administered to the ,subject in a therapeutically effective dose.

Descrit~tion of the Drawings .
Figure 1 presents routes for the manufacture of compounds with the following structures:
5. ~ ~ )m HO ~ n N
R-. and ~4 ~ ~ ( n N
° I

Figure 2 displays~routes for the manufacture of a compound with the following structure:

O
O
N

In Figure 2, the letters a) - i) are used to designat a the following: a) A1C13, toluene; b) BnCl, KzC03, DMF; c) R3-NHz, HC1, NaCNBH3, THF/MeOH; d) H2, Pd/C, MeOH; e) Boc20, dioxane/H20, NaHC03; f) RS-COCl, Et3N, DMAP, CH2C12; g) HC1/dioxane; h) propargyl bromide, KaC03, CH3CN; and i) HC1/ether, MeOH.

Figure 3 depicts routes for the manufacture of compounds with the structures:
O Rq O
O ~ N
O Rq and In Figure 3, the letters g) - 1) are used to designate the following: g.) NaCNBHj, NH90Ac; h) propargyl bromide, ACN, KzC03;
i ) NaCNBH3 , paraf ormaldehyde ; j ) N-methylpropargylamine, NaCNBH3 ;
k ) BBr3 ; and 1 ) RqCOCl , TFA or DMAP .

Detailed Description of the Invention The subject invention provides a compound having the structure:
) m ~d C n N

R~
wherein R1 is OC (0) Ro and Ra is H, wherein Rq is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 i s OC ( 0 ) R4 and Rz i s OC ( O ) R4 , wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein R~ and R6 are each independently H, C1 to ' Ce alkyl , CE to C12 aryl , CE to C12 aralkyl or C6 to Cl~ cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.
In one embodiment, the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or fumarate salt.

In another embodiment, the compound has the structure:
m In a further embodiment, the compound has the structure:

R-, In yet another embodiment, the compound has the structure:
Rg In one embodiment, n is 1.

In a further embodiment, the compound has the structure:
O
Ph \0 In an added embodiment, n is U.
In yet another embodiment, the compound has the structure:

R o 0 .~i/N
~3 In still another embodiment, the compound has the structure:

_5 Rg O ~ N

In one embodiment, R9 is Me and R3 is H.
In another embodiment, R9 is tBu and R3 is H. , In a further embodiment, R9 is nBu and R3 is H.
In yet another embodiment, R~ is CHaPh and R, is H.
In an additional embodiment, R9 is Ph and R3 is H.
In still another embodiment, wherein R9 is Me and R3 is Me..
In a further embodiment, R9 is nBu and R3 is Me In one embodiment, R9 is Ph and R3 is Me.
In an added embodiment, R9 is tBu and R3 is Me.
In another embodiment, R9 is Ph(Me) and R3 is Me.
In still another embodiment, R9 is Ph(OMe)2 and R3 is Me.
In a further embodiment , R4 i s Ph ( OMe ) Z and R3 i s H .

_'7~_ In one embodiment, the compound has the structure:
0 R;

R~
In.an additional embodiment, R3 is Me and R9 is Me.
In a further embodiment, R3 is Me and R9 is Ph.
In another embodiment , R3 i s Me and R9 i s Ph ( OMe ) z .
In yet another embodiment, the compound has the structure:
Ro In an added embodiment, R; is Me and R9 is Me.
In still another embodiment, R3 is H and R9 is Ph.
In one embodiment,. R3 is H and R9 is Ph (OMe) 2 .

O Ph In mother embodiment, the compound has the structure:
O R4 , O
O ~ C n \N
O~ \R R

In a further embodiment, n is 0.
In yet another embodiment, R4 is Ph and R3 is Me.
In one embodiment, n is 1.

In still another embodiment, R3 is Me.
In an added embodiment, the compound has the structure:
O
O
0 Ph The subject invention also provides a compound having the structure:

wherein Rl is OH;
wherein R~ is H or OC (O) R~ when ' Rl is attached to the "a"
carbon or the "d" carbon, or RZ is OC (0) R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl, aralkyl or NRSR6, wherein RS and RE, are each independently H, C1 to C~ alkyl , C6 to Clz aryl , C6 to C12 aralkyl or C6 to C1~ cycloalkyl, each optionally substituted;
wherein.n is 0 or 1, and m is 1 or 2; and wherein R; is H or Me when n is 1 and m is 1, or R3 is H or C1 to C6 alkyl when n is 0 or m is 2, or a pharmaceutically acceptable salt thereof.
In one embodiment, the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or' fumarate salt.

In another embodiment, the compound has the structure:
N
.

In an additional embodiment, R,.is H.
In a'further embodiment, R3 is Me.
In yet another embodiment, the compound has the structure:

In still another embodiment, R3 is H.
In one embodiment, R3 is Me.
In a further embodiment, n is 0.

Additionally, the subject invention provides a compound having the structure:

~~a m ~d R/
R, wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein Rz is H;
wherein R3 is H or Cs to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.
In one embodiment, the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or fumarate salt.
In a further embodiment, the compound has the structure:
HO

3 In another embodiment, the compound has the structure:
HO
R, In an added embodiment, R3 is H.
In yet another embodiment, R3 is Me.
In a further embodiment, the compound has the structure:
HO ~ .~~''i~~, .
In one embodiment, R3 is H.
In another embodiment, R3 is Me.

The subject invention further provides a compound raving the structure:

NR3Rs wherein R~ is H, C1 to C6 alkyl, aryl, aralkyl or C (O) R4, wherein R~ is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR~R6, wherein RS and RE are each independently H, C1 to Ce alkyl , C6 to C12 aryl , C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R~ is H or C1 to C6 alkyl;' wherein Re is H or t-butoxycarbonyl (Boc).
In one errJ~odiment, the compound has the structure:
HO
HO
/ N \
Boc In another embodiment, the compound has the structure:
_/
HN

In still another 'embodiment, the compound has the structure:
Phi O
Phi 0 In an added embodiment,, the compound has the structure:
l0 ~ R4 0',~ R

4 BOC
In yet another embodiment, Ft9 is Ph.
In one embodiment, the compound has the structure:

30 i d ~4

5 PCT/US03/05871 In a further embodiment, R4 is Ph.
The subject invention additionally provides a pharmaceutical composition comprising a compound having the structure:

) \G
R~ ( wherein R1 is OC (O) Ro and R2 is H, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or Rl i s OC ( O ) R4 and Rz i s OC ( 0 ) R4 , wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein RS and R6 are each independently H, C1 to C8 alkyl , C6 to C12 aryl , C6 to C1z aralkyl or C6 to Cla cycloalkyl, each optionally substituted;
wherein R3 is H or C1 ~to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.

The subject invention further provides a pharmaceutical composition comprising a compound having the structure:

)_ m ~d R ~~ ( n N

wherein R1 is OH; .
wherein R2 is H or OC(O)R4 when Rl is attached to the "a"
carbon or the "d" carbon, or RZ is OC (0) R9 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl, aralkyl or NRSR6, wherein R5 and R6 are each independently H, Cl to Ce alkyl, CE to C1z aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein n is 0 or 1, and m is 1 or 2; and wherein R3 is H or Me when n is 1 and m is 1, or R3 is H or C1 to C6 alkyl when n is 0 or m is 2, or a pharmaceutically.acceptable salt thereof.

The subject invention also provides a pharmaceutical composition comprising a compound having the structure:

m ~d N

wherein the compound is an optically pure enantiomer;
wherein R1 i s OH;
wherein Rz is H;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.
The subject invention also provides a method of treating a subject afflicted with a neurological disease comprising administering to the subject a compound having the structure:
R, 2$
N .

wherein Rl is OH or OC (0) R4;
wherein R~ is H, OH o~r OC(0)R4, wherein R4 is branched or unbranched C1 to C6 , alkyl , aryl, aralkyl or NRSRE, wherein RS and R6 are each independently H, C1 to Ce alkyl, C6 to Cla aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to CE alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof , or a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in the subject.
Additionally, the subject invention' provides a method of treating a subject afflicted with a neurological disease, . comprising administering to the subject a compound having the structure:

~ia m N
R , ( n when ein R1 is OH or OC (0) R9, and Rz is H or OC (0) R9, or both Rl and R2 are OC ( 0 ) R9 , .
wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl; .
wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein R~ and Rbare each independently H, C1 to Ce alkyl, C6 to C~2 aryl, C6 to Cla aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, or. a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in. the subject.
In one embodiment of the method, the compound has the structure:
Rl~/a ) m N
R., J
wherein Rl is OC (0) Ra and RZ is H, wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 i s OC ( 0 ) R9 and R2 i s OC ( O ) R4 , wherein R~ is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, .
wherein RS and R6 are each independently H, C1 to Ca alkyl, C6 to Clz aryl, C6 to Cla aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 i s H or C1 to C6 alkyl ;
wherein n is 0 or 1; and wherein m is 1 or 2.
In another embodiment of the method, the compound has the structure:
~~i a ) ~d N

wherein Rl is OH;
wherein R2 is H or OC(0)RQ when Rl is, attached to the "a"
carbon or the "d" carbon, or .
RZ is OC (0) R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl , aralkyl or NRSR6, wherein RS and Rsare each independently H, C1 to Ce alkyl, C6 to C12 aryl, CE to C12 aralkyl or C6 to Clz cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and "wherein m is 1 or 2.
In a further embodiment of the method, the compound has the structure:

. ~ia ) m RG ( n N

wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein R2 is H; .
wherein R; is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.

In one embodiment, the subject is human.
In a further embodiment, the aaministration comprises oral, parenteral, intravenous, transdermal, or rectal administration.
In one embodiment, the effective amount is from about 0.01 mg per day to about 100.0 mg per day.
In yet another embodiment, the effective amount is from about 0.01 mg per day to about 50.0 mg per day.
In still another embodiment, the effective amount is from about 0.1 mg per day to about 100.0 mg per day.
In an added embodiment, the effective amount is from about 0.1 mg per day to about 10.0 mg per day.
In yet another embodiment, the effective amount is from about 0.01 mg to about 100.0 mg.
In one embodiment, the effective amount is from about 0.01 mg to about 50.0 mg.
In a further embodiment, the effective amount is from about 0.1 mg to about 100.0 mg.
In another embodiment, the ef f active amount i s, from about 0 .1 mg to about 10.0 mg.
In an additional embodiment, the neurological disease is Parkinson's disease, Alzheimer's disease, depression,. epilepsy, narcolepsy, amyotrophic lateral sclerosis (ALS), memory disorders, panic, post-traumatic stress disorder (PTSD), sexual dysfunction, attention deficit and hyperactivity syndrome (ADHD), attention deficit disorder, or Tourette's syndrome. The disease may also be neuropathy, hyperactive syndrome, neurotrauma, stroke, Parkinson's disease, Huntington's disease, and other dementia such as senile dementia, dementia ,of the vascular dementia or Lewy body dementia.
In still another embodiment, the ,neurological disease is depression.
In still another embodiment, the compound has the structure:
HO
HO ~ or H/
H

The subject invention further provides a process for p.r,eparing a compound having the structure:
) , ( n N
Rs Rz wherein n is 0 or 1, and m is 1 or 2;
wherein R3 i s H or C1 to CE alkyl ; and wherein RG is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
comprising the step of reacting )m HO' ~ ~ n _ H
boc or ?5 . H

with R9 \C 1 in the presence of an acid or 4-dimethylaminopyridine (DMAP) to form the compound.

The subject invention also provides a process for preparing a compound having the structure:
~m 0 ~ n Ro wherein R5 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
~ ) n' H0~ n NH 2 with a compound having the structure:
X
5~ wherein X is a leaving group, to produce a compound having the structure:
)m H
( n (b) reacting the compound formed in step (a) with a compound having the structure:
O
R9 \C 1 in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to produce a compound having the structure:
)m O
( . n NH
R9 .
In one embodiment, the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (b) is CHC13.

The subject invention further provides a process for preparing a compound having the structure:
S
r /
Ph O ( n which comprises:
(a) reacting a compound having the structure:
t )m IS H0~ n NH 2 with a compound having the structure:
z~ x wherein X is a leaving group, to produce a compound. having the structure:
25 / ) m HO~ ( n 30 (b) N-protecting the compound formed in step (a) with tert-butoxycarbonyl _(Boc) to produce a compound having the structure:

~m //
HO t n boc (c) reac ing the compound formed in step (b) with a compound having the structure:
O
Ph C1 in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
. o Ph O
boc (d) deprotecting the compound formed in step (c) with HC1 to produce a compound having the structure:
\ ) O ~ ~ ( n NH
Ph In one embodiment, the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (b) is CHC13.

The subject invention additionally provides a process for preparing a compound having the structure:

( n IM
Rs I
wherein Ra is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
( ) w H0~ n NH a ?0 with a compound having the structure:
x ?5 wherein X is a leaving group, to produce a compound having the structure:

)m HO ~ ( n NH
(b) reacting the compound formed in step (a) with NaCNBH3 and paraformaldehyde to produce a compound having the structure:
l0 \ )m ~/ N
Ho (c) reacting the compound formed in step (b) with a compound having the structure:

R9 \C1 in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:
O ~ ) m .-R OA ~ ( n N

In one embodiment, the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (c) is CHC13.

The subject invention provides another process for preparing a compound having the structure: .
R
.9 wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl; .
which process comprises:
(a) reacting a compound having the structure:
w HO~ n NH

with ethyl formate to produce a compound having the structure:
~m s H ~\ ( NH H
n (b) reacting the compound formed in step (a) with lithium aluminum hydride to produce a compound having the structure:
. ~m ( n NH

(c) reacting the compound formed in step (b) with a compound having the structure:
wherein X is a leaving group, to form a compound having the structure:
H( (d) reacting the compound formed in step (c) with a compound having the structure:
O
0 R~ ~C1 in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:
O
Rg C
In one embodiment, the aprotic solvent in step (c) is CHC13.

The subject invention provides yet another process for preparing a compound having the structure:

wherein R9 is branched or unbranched C; to Cs alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
is / c ) m H 0~ j, NH 2 with NaCNBH3/paraformaldehyde to produce a compound having the structure:
)m H0~ ~ ( n NH
(b) reacting the compound formed in step (a) with a compound having the structure:
x~~
wherein X is a leaving group, IS to form a compound having the structure:

)m I
(c) reacting the compound formed in step (b) with a compound having the structure:

Rg -C 1 in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:
o ~ ) m.
Ra ~ ~ ( n N
-In one embodiment, the aprotic solvent in step (d) is CHC13.

Additionally, the subject invention provides a process for preparing a compound having the structure:
o ~ )m Ph D~ ~ ( n which comprises:
(a) reacting a compound having the structure:
c )m ' HO~ n NI-:2 with a compound having the structure:
X
wherein X is a leaving group, to produce a compound having the structure:

)m .
H ~ ( n NH
(b) reacting the compound formed in step (a) with NaCNBH3 and paraformaldehyde to produce G compound having the structure:
)m H ~ ~ , ( n N
(c) reacting the compound formed in step (b) with a compound having the structure:

Ph \C1 in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:
)m ( n N
Ph 0 In one embodiment, the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (c) is CHC13.

The subject .invention provides another process for preparing a compound having the structure:
)m O
( n . N
Ph which comprises:
(a) reacting a compound having the structure:
( ) NH ~
H O
with ethyl formate to produce a compound having the structure:
. ~ )m H ~\ ( NH~CHO
n (b) reacting the compound formed in step (a) with lithium aluminum hydride to produce a compound having the structure:
)m NH
H ~ .( n.
.

(c) reacting the compound formed in step (b) with a compound having the structure:
x~
wherein X is a leaving group, to form a compound having the structure:
)m HO~ ~ ( (d) reacting the compound formed in step (c) with a compound having the structure:

?0 ph C1 in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:
2s ~ ) m o n N
Ph ~ I
In one embodiment, the aprotic solvent in step (c) is CHC13.

The subject invention provides yet another process for preparing a compound having the structure:
o ~ )m Ph ( n which comprises:
(a) reacting a compound having the structure:
() H 0~ " NH
1$
with NaCNBH3/paraformaldehyde to produce a compound having the structure:
) n, NH
HO/ ( n 2$ (b) reacting the compound formed in step (a) with a compound having the structure:
X
wherein X is a leaving group, to form a compound having the structure:

)m HO/ ~ ( n N
(c) reacting the compound formed in step (b)~with a compound having the structure:
O
Ph C 1 in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:
?0 )m O
Ph ~ ~ ( In one embodiment, the aprotic solvent in step (d) is CHC13.

The subject invention further provides a process for preparing a compound having the structure:
~ ~4 O~~R4 ~HN
which comprises:
(a) reacting a compound having the structure:
M~
M

with A1C13 or BBr3 in the presence of toluene to produce a compound having the structure: .
HO
HO
O

(b) reacting the product formed in step (a) with benzyl chloride and KzC03 in the presence of dimethyl formamide (DMF) to produce a compound having the structure: , Phi 0 Ph~O
O
(c) reacting the product formed in step (b) with MeNH2~HC1, NaCNBH; in tetrahydrofuran (THF)/MeOH to produce a compound having the structure:
Phi 0 Ph~O
HN' (d) reacting the product formed in step (c) with Ha, Pd/C and MeOH to produce a compound having the structure:
HO
HO
HN' .

(e) reacting the product formed in step (d) with Boc20, dioxane/H~0 and NaHCO; to produce a compound having the structure:
HO
HO
~N~
bo \c (f) reacting the product formed in step (e) with RQCOCl, Et3N
in CH2Clz in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
n n 0'~R4 ~N~
bo \c (g) reacting the product formed in step (f) with HClldioxane to produce a compound having the structure:

NH
O ~R4 (h) reacting the product formed in step (g) with propargyl bromide, K~C03 in CH3CN and then with HCllether and MeOH
to produce a compound having the structure:
, / HN
0 Rd Also, the subject invention provides a process for preparing a compound having the structure:
0 Ph O

O Ph which comprises:
(a) reacting a compound having the structure:
M
M
O
with A1C13 or BBr3 in the presence of toluene to produce a compound having the structure:

(b) reacting the product formed in step (a) with benzyl chloride and K~C03 in the presence of dimethyl formamide (DMF) to produce a compound having the structure: , Ph~O
Ph~O
O
(c) reacting the product formed in step (b) with MeNH2~HC1, NaCNBH3 in tetrahydrofuran (THF)/MeOH to produce a compound having the structure:
Ph~O
Phi 0 HN

(d) reacting the product formed in step (c) with Hz, Pd/C and MeOH to produce a compound having the structure:
HO
HO

(e) reacting the product formed in step (d) with Boc20, dioxane/Hz0 and NaHC03 to produce a compound having the structure: .
HO
HO
~N~
bo \c (f) reacting the product formed in step (e) with PhCOCl, Et3N
in CH~Clz in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
, O Ph boc (g) reacting the product formed in step (f) with HClldioxane to produce a compound having the structure:
O Ph O
O
O Ph (h) 'reacting the product formed in step (g) with propargyl bromide, KzC03 in CH3CN and then with HC1/ether and,lMeOH
to produce a compound having the structure:
O Ph / HN
0 Ph ' The subject invention further provides the use of a compound or a prodrug of a compound which becomes the compound having the structure: , ~~a ~
m __ ~d ( n N
R~
wherein R1 is OH or OC (O) Rs;
wherein R2 is H, OH or OC (O) R9, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NRSR6, wherein RS and R6 are each independently H, C1 to Ce alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C1~ cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and whexein m is 1 or 2, , or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating a subject afflicted with a neurological disease, wherein the compound is to be periodically aaministered to the subject in a therapeutically effective dose.
The subject invention also provides the use of a compound or a prodrug of a compound which becomes the compound having the structure:
~~ia m ~,d R2 ( n N

wherein Rl is OH or OC (O) R9, and wherein Ro is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
R2 is H or OC (O) RQ, or both R1 and RZ are OC (0) R9, wherein Rg is branched or unbranched Cl to CE alkyl, aryl, aralkyl or NR~R6, wherein RS and R6are each independently H, C1 to Ce alkyl, C6 to Cla aryl, CE to C1~ aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 ~ s H or C1 to C6 alkyl ;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating neurological disease in a Subject, wherein the compound is to be periodically aaministered to the subject in a therapeutically effective dose.
In one embodiment of the use, the compound has the structure:
R
~N
n ?5 . Rs wherein Rl is OC (0) R9 and RZ is H, wherein R9 is branched or unbranched C1 to. CE alkyl, aryl, or aralkyl, or R1 is OC (0) RQ and Ra ~is OC (O) R9, wherein R9 is branched or unbranched Cl to C6 alkyl, $ aryl , arahkyl or NR5R6, wherein RS and RE are each independently H, Cl to CE alkyl, C6 to C1z aryl, C6 to C12 aralkyl or C6 to Clz cycloalkyl, each optionally substituted;
wherein. R, is H or C1 .to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.
In another embodiment of the use, the compound has the structure:
1$

~~a ) m R~~d ' ( wherein R1 is OH; .
wherein Rz is H or OC(0)R9 when R~ is attached to the "a"
carbon or the "d" carbon, or RZ is OC (O) R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein RQ is C1 to C6 branched or unbrariched alkyl, aryl, aralkyl or NRSRs.
wherein RS and R6 are each independently H, C1 to CE alkyl, C6 to C1~ aryl, C6 to Cla aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.
In an additional embodiment of the use, the compound,has the structure:

\~a ) m ~d R~ ~ n N

'wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein Rz is H;
wherein R, is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.
In a further embodiment of the use; the subject is human.
In yet another embodiment of the use, the medicament is formulated for oral, parenteral, intravenous, transdermal, or rectal administration.
25~ In an embodiment of the use, the therapeutically effective amount is from about 0.01 mg per day to about 50.0 mg per day.
In an added embodiment of the use, the therapeutically effective amount is from about O.l mg per day to about 100.0 mg per day.
Iw still another embodiment of the use, the therapeutically effective amount is from about 0.1 mg per day to about 10.0 mg per day.

In an embodiment of the use, the neurological disease is Parkinson's disease, Alzheimer's disease, depression, epilepsy, narcolepsy, amyotrophic lateral sclerosis (ALS), , memory disorders, panic, post-traurr~atic stress disorder (PTSD), sexual dysfunction, attention deficit and hyperactivity syndrome (P.DHD), attention deficit disorder, or Tourette's syndrome.
In a further embodiment of the use, the neurological disease is depression. In one embodiment, the compound has the structure:
\ \
HO ~ ~ HO
o r ~N
The subject invention thus discloses various derivatives and isomers of hydroxylated propargylamino indan and tetralin which have surprisingly varied potency and selectivity for MAO
inhibition. The subject invention also provides modifications of the hydroxy compounds which have surprisingly varied MAO
inhibitory properties depending upon the substitution pattern, however, the hydroxy compound is always a m~re potent inhibitor than the modified version. Thus, the modified version may be considered a prodrug of the more active hydroxy compound into which it will be metabolized in vivo.
In one embodiment of the invention, the prodrug compound is a carboxylic acid ester of the hydroxy compound. In another embodiment, the parent is a carbamate derivative of the hydroxy compound.
As discussed above, carbamate propargylamino indans and tetralins have been reported in PCT International Application No. PCT/US97/24155 as both MAO inhibitors and AchE inhibitors.
However, it is a further embodiment of this invention that such a prodrug compound will not be a potent inhibitor of AchE (ICS, >500 micromolar), and the ICSO for MAO-A inhibition of the corresponding hydroxy metabolite be at least 100 times more potent than the prodrug.
In one embodiment, the compounds are dihydroxy derivatives of propargylamino indan .or tetralin. These derivatives are expected to be antioxidants, as well as MAO inhibitors. In another embodiment, the subject invention provides ester prodrugs.
Thus, the subject invention provides esters or carbamat~es of propargylamino indanols, propargylamino indandiols, propargylamino tetralinols or propargylamino tetralindiols, and may be prepared by methods of esterification or carbamoylation of hydr~oxy compounds. Ester derivatives (Figur.e 1) when Ra equals hydrogen were prepared by reacting the propargylamino indanols with acyl chlorides in the presence of a strong organic acid such as trifluoroacetic acid or an acylation catalyst such as 4-dimethylaminopyridine (DMAP), with or without an inert orcranic solvent such as chloroform. Compounds when R3 equals hydrogen were prepared either by direct acylation as described above, or by first N-protecting the amine moiety, e.g. , by a tert-butoxycarbonyl (Boc) group, followed by acylation as above, and finally removing the protecting group. The preparation of compounds of the subject invention which are carbamates is described in PCT/US97/24155.
Propargylamino indanols may :be prepared by reacting amino indanols with propargyl bromide in a polar organic solvent such as N,N-dimethylacetamide or acetonitrile in the presence of a.
base such as potassium carbonate. N-Methyl, N-pr.oparaylamino indanols may be prepared by reductive alkylation of propargylamino indanols by methods known to those skilled in the art, e.g., with NaCNBH, and paraformaldehyde. Alternatively, N-methyl,N-propargylamino indanols were prepared by first methylating amino indanols either by NaCNBH3/paraformaldehyde or by ethyl formate followed by LiAlH~ reduction, and then reacting the N-methylamino indanols thus obtained with propargyl bromide as described above.
The N-propargyl derivatives of, inter alia, 3-amino-indan-4-ol, 1-amino-indan-4-ol, 3-amino-indan-5-of and 7-amino-5,6,7,8-tetrahydro-naphthalen-2-of were prepared.
Compounds of the subject invention with both R1 and Rz equal to OCOR4 (see Figure 2, compound numbered 9) were prepared by propargylation of 5,6-di-0-benzoyl-1-methylamino-1-indan (Figure 2, compound numbered 8), as described above. 5,6-Di-O-benzoyl-1-methylamino-1-indan (Figure 2, compound numbered 8) was prepared from 5;6-bis-benzyloxy-1-indanone 3 as follows:
1) reductive amination of the compound numbered 3 in Figure 2 as described above gave 5,6-bis-benzyloxy-1 indanyl)methylamine (Figure 2, compound numbered 4);
2) the compound numbered 4 in Figure 2 was debenzylated by catalytic hydrogenation and protected by the Boc group to give N-Boc-1-methylamino-indan-5,6-diol (Figure 2, compound numbered 6); and 3) Compound 6 in Figure 2 was esterified as described above and the protecting group removed as previously described to give 5,6-di-0-benzoyl-1-methylamino-1-indan (Figure 2, compound numbered 8).
The diester tetralin derivative numbered 12 (Figure 3) was prepared by esterification of the dihydr.oxy tetralin numbered 11 (Figure 3).

_77_ Table 1. Chemical Data cmpd ster Rz R, R, R3 n m mp . formula yield #i pos 100* S H OH 6 H 0 1 175-7 C,3H"NO,S45 , 101 R H OH I 6 H 0 1 173-5 C,3H"N04S42 *

102 S H OCOMe 6 H 0 1 13S-40 C,aH,6C1N0z46 103 R H OCOMe 6 H 0 1 156-8 C,4H,6C1N0277 104 S H OCOtBu 6 H 0 1 126-8 C,~H::CINOZ67 I ~

105 R H OCOtBu 6 H 0 1 128-30 C,~H_,C1N0246 106 S H OCOnBu 6 H 0 1 149-50 C,~HZ:CINOZ37 107 R H OCOnBu 6 H 0 1 155-7 C,~H2,CINOi85 . I

108 S H OCOCH:Ph 6 H 0 1 144-5 C~oHzoClNOz22 I

109 R H OCOCH:Ph 6 H 0 1 145-7 C~oH~oCINO252 110 S H . OCOPh 6 H 0 1 202-4 C,9H,eC1N0z~ 18 111 R H OCOPh 6 H 0 1 210-I1 C,9H,HClN0261 I

112 rac H OH 6 Me 0 1 210-11 C,;H,~CINO70 I

113 S H OH 6 Me 0 1 82-4 C,3H,6C1N072 114 R H OH 6 Me 0 1 71-2 C,3H,6C1N078 115 S H OCOMe 6 Me 0 1 168-70 C,sH,gCINOz95 116 R H OCOMe 6 Me 0 1 168-70 C,SH,eCIN0293 117 rac H OH 4 Me 0 1 160-62 C,3H,6NC1089 118 rac H OH 7 Me 0 1 83-5 C,3H,6NCI053 119 rac H OCOA9e 4 Me 0 1 148-50 C,SH,pC1N02.72 120 rac H OCOPh 4 Me 0 1 176-8 C,a1-l2oCIN0259 _ 121 rac H OCOPh(OMe)24 Me 0 1 183-5 Cz,HZ,C1N0439 _ 122 rac H OCOPh 7 Me 0 1.185-7 C:oH2oC1N0245 123 rac H OH 7 Me 1 1 220-1 C,4H,8NC1066 124 rac H OCOPh 7 Me 1 1 104-6 CZ,HZ:C1N0271 125 S H OCOnBu 6 Me 0 1 78-80 C,$H2,C1N0273 126 R H OCOnBu 6 Me 0 1 96-8 C,aHZ4CIN0272 ~

127 S H OCOPh 6 Me 0 I 73-5 CZOHzoC1N0252 128 R H OCOPh 6 Me 0 1 82-4 C_oHzoC1N0256 _78_ Table 1. Chemical Data cont.
129 S H . OCOtBu 6 Me 0 1 153-5 C,BHZ,ClN0273 130 R H OCOtBu 6 Me 0 I 155-7 C,eH2aCIN0=78 ..
131 S H OCOPh(Me 6 Me 0 1 Cz,Hz:CINO,51 ) 132 R H OCOPh(Me) 6 Me 0 1 82-4 C2,H22C1NOz46 133 S H OCOPh(OMe)6 Me .01 118-20C~:H"CINO=58 134 R H OCOPh(OMe)6 Me 0 1 73-5 ~C2:H2,C1N0,68 Z

135 rac H OH 7 H 0 1 166-8 C,.H,QC1N035 136 ra H OH 4 H I 1 196-8 ~ C,,H"C1N066 c 0 137 rac OCOPh OCOPh ~ Me 0 1 114-5 C:~HZ,C1N0459 (5-pos) 6 138 rac OCOPh OCOPh 7 Me 1 1 180-2 CZaH=6C1N0458 ( 6-pos) stet = stereochemistry pos = position mesylate salts ,»
wide range, hygroscopic Table 2. 1H-iv~lR Data (Rl = R3 = H) (300 142-iz, dimethyl sulfoxide ,,".~rc~W _.a ~
~ ._ L. , ~.
, Cmpd Ph indan Pg R4 ~:

7.52(d) $ 102 7.35(d)4.79(m)2.43(m)2.83(m)3.88(m)3.71 2.27 10.2 (m) (Me,s) (br s) 103 7.10(dd) 2.28(m)3.12(m) 7.48(a) 104 7.36(d)4.79(m)2.45(m)2.85(m)3.90(m)3.72(m)1.30 10.15 (tBu,s) 105 7.07(dd) 2.27(m)3.12(m) (br s) l~ 7.48(d) 108 7.36(d)4.80(m)2.45(m)2.85(m)3.91(m)3.72(m)7.38(m,IN)10.2 109 ~7.07(dd) 2.28(m)3.13(m) 7.33(m,4H)(br s) 3.99(CH2,s) 7.48(d) 2.57(t,2H) 106 7.35(d)4.79(m)2.45(m)2.85(m)3.90(m)3.71(m)1.61(m,2H)10.1 15 107 7.08(dd) 2.26(m)3.11(m) 1.38(m,2H)(br s) 0.91 (t,3H) , 7.67(d) 110 7.42(d)4.83(m)2.46(m)2.86(m)3.93(m)3.72(m)8.13(d,2H)10.15 11I 7.28(dd) 2.30(m)3.16(m) 7.76(t,lH)(d) 7.61(t,2H) Table 3. 1H-NMR Data (R1 = H, R3 = Me) (300 Mhiz,DzO) Cmpd Ph Indan Propargyl Ra N-Me C3-H C2-H C1-H CH, CH

7.50(d) 116 7.35(d) 5.22(m)2.46(m)3.07(m)4.05 3.15(m)2.37(Me,s)2.83(s) (m) 115 7:25(dd) 2.60(m)3.17(m) 7.50(d) 2.69(t,2H) 126 7.33(d) 5.23(m)2.49(m)3.07(m)4.05(m)3.17(m)1.73(m 2.82(s) ~ ~H) 125 7.22(dd) 2.62(m)3.17(m) 1.44(m,2H) 0.97(t,3H) 7.50(d) 8.11 (dd,2H) 128 7.40(d) 5.17(m)2.57(m)3.06(m)4.00(m)3.15(m)7.74(dt,lH)2.81(s) 127 7.29(dd) 2.47(m)3.17(m) 7.57(t,2H) 7.49(d) .

129 7.28(d) 5.20(m)2.60(m)3.05(m)4.03(m)3.17(m)1.37(s,9H)2.81(s) 130 7.21(dd) 2.45(m)3.16(m) 7.90(d,lH) For Ar H's, 131 7.44(t.lH)5.02 2.50(m)3.08(m)3.93(m)3.14(m)see 2.72(s) (m) 132 7.36(m.2H) 2.40(m)2.95(m) under.Ph.

7.21(m.2H) 2.43(s.Me) , 7.OS

(dd.l ' H) For Ar H's, 133 7.5-7.1 5.05 2.50(m)3.08(m)3.92(m)3.16(m)see 2.73(s) 134 (m,4H) (br 2.41(m)2.95(m) under d) Ph.

6.74(dd,2H) 3.84 (s,6H, OMe) Table 3. 'H-NMR Data (R1 = H, R3 = Me) (300 I~3z,Dz0) cont.

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120 7.44(t,lH) 2.80(m) 7.77(t,2H) *

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~'xperimental Details EXAMPLE 1: GENERAL PROCEDURE FOR PROPYN-2-YLAMINO
(PROPARGYLP.MINO) INDANOLS (R3-H)H) A mixture of amino indanol ( 3 5 mmol ) , propargyl bromide ( 3 5 mmol ) and potassium carbonate (35 mmol) in DMA (100 ml) was stirred at room temperature (RT) for 24 hours. The reaction mixture was filtered, diluted with water (200 ml) and extracted with toluene (4 x 100 ml). The organic extracts were combined, dried and evaporated to dryness under reduced pressure. The residue was then subjected to flash column chromatography (hexane . EtOAc, 1:1).~ The free base was optionally converted to an acid addition salt.
Alternatively, the' propargylation reaction was run in acetonitrile at elevated temperature, e.g., 60°C ~or 4 hours.
The reaction mixture was then filtered, and the cake washed with acetonitrile. The combined layers were evaporated. to dryness, and the residue (brown oil) subjected to flash column chromatography (hexane : EtOAc, 2:1). The product (white solid) was thus obtained in 40 - 55 ~ yield.
Thus were prepared: (R)-3-prop-2-ynylamino-5-indanol mesylate, (S)-3-prop-2-ynylamino-5-indanol mesylate, 1-prop-2-ynylamino-4-indanol HC1, and 3-prop-2-ynylamino-4-indanol HC1.

EXAMPLE 2: GENERAL PROCEDURES FOR N-METHYL-PROP-2-YNYLAMINO
INDPNOLS (R;=Me) EXEMPLIFIED BY f-(METHYL-PROP-2-YNYL AMINO)-5-INDANOL
Experiment 2A
A mixture of (S)-3-prop-2-ynylamino-5-indanol (5.0 g, 26.7 mmol) , paraformaldehyde (3 .6 g, 30 mmol) and NaCNBH3 (1.96 g, 31.2 mmol) in abs MeOH (90 ml) was refluxed under argon for 4 hours. The crude product obtained after evaporation .of the solvent was purified by flash chromatography (hexane: EtOAc, 70:30) and was converted to its HC1 salt (etheral HC1: 4.2g(17.6 mmol, 66~)). 1H NMR (DMSO-d6):11.7(br d,NH), 9.62(br s, OH), 6.8-7.3(3H), 4.98(m,lH), 3.98(ABq,2H), 3.0(m;lH), 2.90(m,lH), 2.77(s,Me), 2.48(m1H), 2.40(m,lH)ppm.
1H NMR(D20):7.29(d,lH),6,.95-7.02(2H),5.09(m,lH),4.0(AB q, 2H), 3.0(m,lH),2.90(m,lH),2.77(s,Me),2.48(m,lH),2.40(m,lH)ppm.
Thus were prepared (R)3-(methyl-prop-2-ynylamino)-5-indanol and 1-(methyl-prop-2-ynylamino)-4-indanol.
Example 2B: 3-(methyl-prop-2-ynylamino)-4-indanol Experiment 2B1 3-amino-4-indanol (3.70 g, 24.8 mmol) in ethylformate (200 ml) was refluxed for 18 hr. The solvent was then removed under reduced pressure, and the residue was purifed by flash chromatography to give 4 .10 g ( 93 0 ) of N- ( 7-hydroxy-indan-1-yl ) formamide as a yellow solid.
Experiment 2B2 Lithium aluminium hydride (4.-5 g) was added portionwise to stirred and cooled dry T.HF (100 ml) at 0°C. A solution of N-(7-hydroxy-indan-1-yl)-f.ormamide (4.1 g) in dry THF (70 ml) was added while maintaining the temperature at 5-'! 0°C. The reaction mixture was stirred at ambient temperature for 9 hr, cooled and treated with water (100 ml). The pH was adjusted to,8-9, water (200 ml) was added, and the mixture was extracted with ether (6 X 300 ml). The etheral extract was evaporated to dryness to give 3.2 g (94~).
Experiment 2B3 3-Methylamino-4-indanol was reacted with propargyl bromide in acetonitrile as described in Example 1.
Example 2C
7-lmethyl-prop-2-ynylamino)-2-tetralinol and 6-(methyl-prop-2-ynylamino)-2,3-tetralindiol were prepared according to Chumpradit et al. and Horn et al.

EXAMPLE 3: GENERAL PROCEDURE FOR ESTERIFICATION OF PROP-2-YNYL
AMINO II~1DANOLS P.ND TERALINOLS EXEMPLIFIED BY PENTANOIC ACID
(R)-3-PROP-2-1'NYLP.MINO-INDAN-5-YL ESTER HCL (Cmnd # 107) To a solution of (R)3-prop-2-ynylamino-5-indanol (2.5 g, 13.4 mmol) in CHC13(30m1) and TFA (5 ml), was added valeryl chloride (2.03 g, 2.0 ml, 16.7 mmo1) . The solution was heated at 60° for

8 hours and cooled to RT. Water (250 ml) was added, and the pH
adjusted to 7 by means of concentrated aqueous ammonia.
Extracted with methylene chloride (4x100 ml), dried and evaporated to dryness under reduced pressure. The residue (brown oil, 3.65 g) was purified by flash chromatography (Si02, CHZCIz:MeOH 99:1) . The free base thus obtained (3.25 g) was dissolved in dry ether (80 ml), and 20~ etheral HC1 was added.
The resulting suspension was stirred for 2 hours at RT, the solid product was collected by filtration and washed with ether (20 ml) and dried at 60° to give 3.45 g (11.2 mmol, 85~) of the ester HC1.

Ex.Pr?PLE 4: ALTERNATIVE PROCEDURE EXEMPLIFIED BY BENZOIC ACID
(R)-3-PROP-2-YNYLAMINO-INDAN-5-YL ESTER (Cm~d # 111) (R) 3-prop-2-ynylamino-5-indanol (3.0 g, 16 mmol) was dissolved in dry THF (75 ml), and triethylamine~ (3.15 ml, 22.6 mmol) followed by BoczO(4.5 g, 20.6 mmol) was added. The solution was stirred at RT for 24 hours and evaporated to dryness. The residue was taken up in water (200 ml) and extracted with CHzCl2(4x100 ml). The organic layers were combined, dried and evaporated to dryness. The crude product was purified by flash column chromatography (hexane: EtOAc 3:1) to give 3.75 g (81.50 of a white solid.
1H h'I~lR ( DMSO-d6 ) ( a 1 : 1 mixture of 2 rotamers ) : 9 . 17 ( s , OH) , 7 . 0 (d,lH), 6.62 (dd, 1H), 6.5(br s, 1H), 5.51 & 5.22 (brs, 1H), 4.05, 3.72, 3.60, 3.38(m,2H), 3.06(br s, 1H), 2.83 (m,lH), 2. 64 (m, 1H) , 2.30 (br s, 1H, 2 .10 (br s, 1H) , 1 .4 & 1.27 (2s, 9H)ppm.
(R) N-Boc 3-prop-2-ynylamino-5-indanol(2.65 g, 9.23 mmol) was dissolved in dry methylene chloride (20 ml), and triethylamine (2.65 ml, 18.5, mmol), DMAP (0.11 g, 0.9 mmol) and benzoyl chloride (1.7 ml, 18.5 mmol) was added. The solution was stirred at RT for 3 hours, water (100 ml) was added and acidified to pH 4 (aq HC1). The organic layer was separated and washed with 10~ HC1. The aqueous layer was washed with methylene chloride (100 ml), and the combined organic phases were dried and evaporated to dryness in vacuo. The crude product ~(5.2 g brown oil) was purified ,by flash column chromatography (hexane: EtOAc 3:1) to give 4.1 g (90~) of a white solid.
(R) N-Boc-3-prop-2-ynylamino-5-benzoyloxy indan (2.55 g, 6.5 mmol) was dissolved in dioxan~~(25 ml), and HC1/dioxan (25 ml) was added. The mixture was stirred at RT for 4 hours and the solvent was evaporated to dryness in vacuo. Ether (50 ml) was added, the suspension was then stirred at RT for 2 hours. The solid was~collected by filtration, washed with ether and dried (1.5 g). The crude product was crystallized from iPrOH (90 ml) to give 1.3 g (3.96 mmol, 61~), mp 210-2°C. .

EXAMPLE 5- PREPARATION OF BENZOIC ACID iS)-3-(METHYL-PROP-2-YNYL-AMINO)-INDAN-5-YL ESTER HCL Cmpd # 127 (S)3-(methyl-prop-2-ynylamino)-5-indanol (1.5 g, 7.46 mmol) was dissolved in dry methylene chloride (15 ml), and triethylamine 5~ (2.15 ml, 15.5 mmol), DMAP (0.08 g, 0.66 mmol) and benzoyl chloride .(2.1 ml, 18.1 mmol) was added. The solution was stirred at RT for 2 hours, water (100 ml) was added and acidified to pH 4 (aq HC1). The organic layer was separated, washed with 10~ HC1. The ac_ueous layer was washed with methylene chloride (4x100 ml), and the combined organic phases were dried evaporated to dryness in vacuo. The crude product (3.78 g brown oil) was purified by flash column chromatography (hexane: EtOAc 4:1) to give 1.6 g (5.3 mmol, 71~) of a yellow oil. The free base was converted to the HC1 salt (etheral HCl, IS 2 hours, RT), 1.39g (4.07 mmol, 77~, 55~ from the hydroxy compound).
By the same procedure was prepared 7-O-benzoyl-2-(methyl-prop-2-ynylamino)-tetralin Hcl, 1HNMR (D~0): 7.20, 6.98, 6.95 (3H, ArOCO); 8.05, 7.71, 7.53 (5H, PhC00), 4.15 (m, 2H, CH2CCH), 3.80 (m, 1H, C~-H) , 3 .15 (t, 1H, CHaCCH) , 3 .14, 3 .01 (m, 2H, C8-H) , 2.8-3.0 (m, 2H, C5-H), 2.31, 1.87 (m, 2H, C6-H), 3.0 (S, 3H, Me) ppm.
The same procedure was also used to prepare 6,7-di-O-benzoyl-2-(methyl-prop-2-ynylamino)-tetralin HC1, 1HNMR (DM80-d6): 7.91 (dd, 4H) , 7 .65 (t,2H) , 7.46 (t, 4H) , 7.28 (s, 2H) , 4.24 (br s, 2H), 3.87 (br s, 1H), 3.74 (m, 1H), 3.35-2.90 (m, 4H), 2.87 (s, 3H), 2.39 (m, 1H), 1.90 (m, 1H) ppm.

EXAMPLE 6' PREPARATION OF 5 6-DI-O-3ENZOYL-1-(METHYL-PROP-2-YNYL-P.MINO)-INDAN HCL Cmpd ~ 137):
Experiment 6A: (5,6-Bis-benzylcxy-1-indan-1-yl)-methylamiae HCl (Figure 2, Compound 4) 5.
A mixture of 5,6-dibenzyloxy-1-indanone (10.0 g, 29 mmol), 8M
ethanolic methylamine (~30 ml, 240 mmol), methylamine HC1 (7.15 g, 106 mmol), and NaCNBH3 (2.95 g, 47 mmol) in dry THF (750 ml) and methanol (250 ml) was refluxed under nitrogen for 4 hours.
The reaction mixture was cooled to 5°C, acidified with concentrated HC1 to pH 1.5, and evaporated to dryness. The solid residue was treated with a mixture of methylene chloride (600 ml) and water (400 ml). The aqueous layer was separated, extracted with rnethylene chloride (4x100 ml), and the combined organic layers were evaporated to dryness. The crude product thus obtained was slurried in EtOAc (80 ml) for 30 min at RT, filtered and purified by flash column chromatography (CHZC12 .
MeOH, 80:20), to give 6.3 g (54.8 ~), mp: 180-182°C.
Experiment 6B: 1- Methylamino -1-indan- 5,6-diol HC1 (Figure 2,.
Compound 5) A solution of (5,6-bis-ben~zyloxy-1-indan-1-yl)-methylamiize HC1 (3.15 g, 7.96 mmol) in MeOH (250 ml) was hydrogenated (44 psi) over 10~ Pd/C (1.05 g) at RT for 3 hours. The mixture was filtered (Filteraid), and the filtrate evaporated to dryness.
The residue was treated with charcoal in boiling MeOH, filtered and evaporated to dryness, to give 1.6 g of a light grey solid, mp.. 153-5°C.
1H NMR (DM80-d6): 9.3-8.8 (3H, br m, OH, NH2), 7.02 (s, 1H, Ar), ~6 . 08 (s, 1H, Ar) , 4 .7 (dd, 1H, C3-H) , 2 . 92 (m, 1H, C1-H) . 2. 66 (m, 1H, Cl-H), 2.44 (s, 3H, Me), 2.33 (m, 1H, CZ-H), 2.11 (m, 1H, C2-H' ) PPm.

Experiment 6C: N-Boc-1- methylamino -1-indan- 5,6-diol (Figure 2, Compound 6) To a solution of 1-methylamino-1-indan-5,6-diol HC1 (0.5 g, 2.32 mmol) in water (30 ml) was added dioxane (30 ml), NaHC03 (0.6 g) and BocaO (0.6 g). The reaction mixture was stirred at RT for 4 hours under nitrogen, evaporated to dryness, and the solid residue taken up in a mixture of water (100 ml)~and methylene chloride (100 ml). The aqueous layer was separated and extracted with methylene chloride (5x50 ml). The latter was filtered, washed with water, dried and evaporated to dryness to give a viscous oil which was purified by flash column chromatography (CHZC12 . MeOH, 95:5) to give 0.35 g (54 ~) of a viscous oil which soon solidified.
Experiment 6D: N-Boc=(5,6-di-O-benzoyl-1-indan-1-yl)-methylamine (Figure 2, Compound 7) To a solution of N-Boc-1-methylamino-1-indan-5,6-diol (0.34 g, 1.22 mmol) in methylene chloride (15 ml) was added triethylamine (0.49 g, 4.88 mmol), DMAP (0.03 g, 0.244 mmol) and benzoyl chloride (0.69 g, 4.88 mmol), and the solution was stirred at RT
for 4.5 hours. V~later (100 ml) was added, acidified to pH 4 with dilute HC1. The organic layer was separated and washed with 10$
HC1. The aqueous layer was extracted with methylene chloride (2x75 ml.) , and the latter was washed with 10~ HC1. , The combined organic layers were dried, evaporated to dryness, and the residue purified by flash column chromatography (hexane : EtOAc, 50:50) to give 0.50 g (40~) of a yellow oil.

Experiment 6E: (5,6-di-O-Benzoyl-1-indan-1-yl)-methylamine HC1 (Figure 2, Compound 8) To a solution of N-Boc-(5,6-di-0-benzoyl-1-indan-1-yl)-methylamine (0.29 g, 0.59 mmol) in dioxane (5 ml) was added 20~
HCl,in dioxane (5 ml), and the mixture stirred at RT for 4 hours under nitrogen. The solvent was removed and ether (40 ml) was added to the residue, and the suspension stirred at RT for 1 hour. The solvent was removed'to give 0.11 g (89 ~) of a white solid, mp . 192-3°C.
1H NMR (CDC13) : 8.1-7.2 (12H, Ar) , 4.79 (br s, 1H, C3-H) , 3.40 (m, 1H, C1-H), 3.01 (m,lH,C1-H), 2.60 (s, 3H, Me), 2.50 (m, 1H, C2-H) , 1 . 83 (m, 1H, C2-H' ) ppm.
Experiment 6F: 5,6-di-O-Benzoyl-1-(methyl-prop-2-ynyl-amino)-indan HC1 (Figure 2, Compound 9 (Cmpd # 137)) To a solution of (5,6-di-O-benzoyl-1-indan-1-yl)-methylamine HC1 (~0.2 g, 0.48 mmol) in acetonitrile (100 ml) was added KzC03 (130 mg, 0.96 mmol), followed after 15 min by a solution of propargyh bromide (56 mg, 0.48 mmol) in acetonitrile (10 ml).
The reaction mixture was stirred under nitrogen at RT for 20 hours, filtered and evaporated to dryness. The crude product was purified by flash column chromatography (hexane . EtOAc, 50:50I) to give 0.15 g (0.35 mmol, 75 0) of a viscous light tan oil.
The free base. was dissolved in MeOH (30 ml), and saturated etheral HC1 (4 ml) was added. The solution was stirred at RT
for 30 min and evaporated to dryness. The oily residue was triturated three times in ether, to give 120 mg (0.26 mmol, 74~) .of a light tan solid.
NMR (CDC13): 8.1 - 7.2 (m, 12H, Ar), 5.1 (br d, 1H, C1-H), 3.91 (br s, 2H, CHZCCH) , 3 .6 - 2.5 (m, 8H, indan CHZ's, Me, CHZCCH) .

EXAMPLE 7: INHIBITION OF MAO ACTIVITY IN VITRO
EXPERIMENTAL PROTOCOL
The MAO enzyme source was a homogenate of rat brain in 0.3 M
sucrose 1:20 w/v. The homogenate was pre-incubated with serial dilutions of the test compounds (Table 5) for 60 minutes at 37°C. 19C-labeled substrates (2-phenylethylamine, hereinafter PEA; 5-hydroxytryptamine, hereinafter 5-HT) were then added, and the incubation continued for a further 20 minutes (PEA?, or 30-45 minutes (5-HT) . In the case of PEA, the enzyme concentration was chosen so that not more than 10~ of the substrate was metabolized during the course of the reaction. The reaction was then stopped by addition of citric acid. Radioactivity indicates the production of 5-HT and~PER metabolites formed as a result of MAO activity. Activity of MAO in the sample was expressed as a percentage of control activity in the absence of test compounds after subtraction of appropriate blank values.
The activity determined using PEA as substrate is referred to as MAO-B, and that determined using 5-HT as MAO-A.

EX.AS'lPLE 8: INHIBITION OF MAO ACTIVITY IN VIVO: CHRONIC TREATMENT
EXPERIMENTAL PROTOCOL
Rats were treated with the test compounds (Table 5) at several dose levels by oral administration, one dose daily for 7-21 5' days, and decapitated 2 hours after the last dose. The activities of MAO-A and MAO-B were determined in the brain, liver and intestine as described in the previous example.
Inhibition'I of MAO activity was calculated by dividing MAO
activity in the treated rats by MAO activity in. the control rats (saline treated, MAO activity in these rats was taken as 1000 .
A mixture of toluene: ethyl acetate (1:1) was added to the reaction and mixed for 10 minutes, followed by 5 minutes of centrifugation at 1760 g. The upper phase was taken for radioactive determination by liquid scintillation spectrometry.

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Claims

1. A compound having the structure:
wherein Rl is OC (O) R9 and R2 i s H , wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 is OC (O) R4 and R2 is OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, Cl to C8 alkyl , C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1, wherein the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or fumarate salt.

3. The compound of claim 1 having the structure:

4. The compound of claim 1 having the structure:

5. The compound of claim 1 having the structure:

6. The compound of claim 5, wherein n is 1.

7. The compound of claim 6 having the structure:

8. The compound of claim 5, wherein n is 0.

9. The compound of claim 8 having the structure:

10. The compound of claim 8 having the structure:

11. The compound of claim 8, wherein R9 is Me and R3 is H.

12. The compound of claim 8, wherein R9 is tBu and R3 is H.

13. The compound of claim 8, wherein R9 is nBu and R3 is H.

14. The compound of claim 8, wherein R9 is CH2Ph and R3 is H.

15. The compound of claim 8, wherein R9 is Ph and R3 is H.

16. The compound of claim 8, wherein R9 is Me and R3 is Me.

17. The compound of claim 8, wherein R9 is nBu and R3 is Me.

18. The compound of claim 8, wherein R9 is Ph and R3 is Me.

19. The compound of claim 8, wherein R9 is tBu and R3 is Me.

20. The compound of claim 8, wherein R9 is Ph(Me) and R3 is Me.

21. The compound of claim 8, wherein R9 is Ph(OMe)2 and R3 is Me.

22. The compound of claim 8, wherein R9 is Ph(OMe)2 and R3 is H.

23. The compound of claim 1 having the structure:

24. The compound of claim 23, wherein R3 is Me and R9 is Me.

25. The compound of claim 23, wherein R3 is Me and R9 is Ph.

26. The compound of claim 23, wherein R3 is Me and R9 is Ph(OMe)2.

27. The compound of claim 1 having the structure:

28. The compound of claim 27, wherein R3 is Me and R9 is Me.

29. The compound of claim 27, wherein R3 is H and R9 is Ph.

30. The compound of claim 27, wherein R3 is H and R9 is Ph(OMe)2.

31. The compound of claim 1 having the structure:

32. The compound of claim 31, wherein n is 0.

33. The compound of claim 32, wherein R4 is Ph and R3 is Me.

34. The compound of claim 31, wherein n is 1.

35. The compound of claim 34, wherein R3 is Me.

36. The compound of claim 31 having the structure:

37. A compound having the structure:

wherein R1 is OH;
wherein R2 is H or OC(O)R4 when R1 is attached to the "a"
carbon or the "d" carbon, or R2 is OC(O)R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein n is 0 or 1, and m is 1 or 2; and wherein R3 is H or Me when n is 1 and m is 1, or R3 is H or C1 to C6 alkyl when n is 0 or m is 2, or a pharmaceutically acceptable salt thereof.

38. The compound of claim 37, wherein the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or fumarate salt.

39. The compound of claim 37 having the structure:

40. The compound of claim 39, wherein R3 is H.

41. The compound of claim 39, wherein R3 is Me.

42. The compound of claim 37 having the structure:

43. The compound of claim 42, wherein R3 is H.

44. The compound of claim 42, wherein R3 is Me.

45. A compound having the structure:

wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein R2 is H;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof.

46. The compound of claim 45, wherein the pharmaceutically acceptable salt is the acetate salt, mesylate salt, esylate, tartarate salt, hydrogen tartarate salt, benzoate salt, phenylbutyrate salt, phosphate salt, citrate salt, ascorbate salt, mandelate salt, adipate salt, octanoate salt, the myristate salt, the succinate salt, or fumarate salt.

47. The compound of claim 45 having the structure:

48. The compound of claim 47 having the structure:

49. The compound of claim 48, wherein R3 is H.

50. The compound of claim 48, wherein R3 is Me.

51. The compound of claim 47 having the structure:

52. The compound of claim 51, wherein R3 is H.

53. The compound of claim 51, wherein R3 is Me.

54. A compound having the structure:

wherein R7 is H, C1 to C6 alkyl, aryl, aralkyl or C(O)R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein R8 is H or t-butoxycarbonyl (Boc).

55. The compound of claim 54 having the structure:

56. The compound of claim 54 having the structure:

57. The compound of claim 54 having the structure:

58. The compound of claim 54 having the structure:

59. The compound of claim 58, wherein R4 is Ph.

60. The compound of claim 54 having the structure:

61. The compound of claim 60, wherein R4 is Ph.

62. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

63. A pharmaceutical composition comprising the compound of claim 37 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

64. A pharmaceutical composition comprising the compound of claim 45 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

65. A method of treating a subject afflicted with a neurological disease comprising administering to the subject a compound having the structure:
wherein R1 is OH or OC (O) R4;
wherein R2 is H, OH or OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 i s H or C1 to C6 alkyl ;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, or a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in the subject, wherein the neurological disease is epilepsy, narcolepsy, panic, post-traumatic stress disorder (PTSD) or sexual dysfunction.

66. A method of treating a subject afflicted with a neurological disease comprising administering to the subject a compound having the structure:
wherein R1 is OH or OC(O)R9, and wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
R2 is H or OC (O) R4, or both R1 and R2 are OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, or a prodrug which becomes the compound in the subject, so as to thereby treat the neurological disease in the subject.

67. The method of claim 66, wherein the compound has the structure:
wherein R1 is OC (O) R9 and R2 is H, wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 is OC (O) R4 and R2 is OC (O) R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl , C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.

58. The method of claim 66, wherein the compound has the structure:
wherein R1 is OH;
wherein R2 is H or OC (O) R4 when R1 is attached to the "a"
carbon or the "d" carbon, or R2 is OC (O) R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl , C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;

wherein n is 0 or 1; and wherein m is 1 or 2.

69. The method of claim 66, wherein the compound has the structure:
wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein R2 is H;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.

70. The method of claim 66, wherein the subject is human.

71. The method of claim 66, wherein the administration comprises oral, parenteral, intravenous, transdermal, or rectal administration.

72. The method of claim 66, wherein the effective amount is from about 0.01 mg per day to about 50.0 mg per day.

73. The method of claim 66, wherein the effective amount is from about 0.1 mg per day to about 100.0 mg per day.

74. The method of claim 73, wherein the effective amount is from about 0.1 mg per day to about 10.0 mg per day.

75. The method of claim 66, wherein the neurological disease is Parkinson's disease, Alzheimer's disease, depression, epilepsy, narcolepsy, amyotrophic lateral sclerosis (ALS), memory disorders, panic, post-traumatic stress disorder (PTSD), sexual dysfunction, attention deficit and hyperactivity syndrome (ADHD), attention deficit disorder, or Tourette's syndrome.

76. The method of claim 75, wherein the neurological disease is depression.

77. The method of claim 75, wherein the compound has the structure:

78. A process for preparing a compound having the structure:
wherein n is 0 or 1, and m is 1 or 2;
wherein R3 is H or C1 to C6 alkyl; and wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
comprising the step of reacting in the presence of an acid or 4-dimethylaminopyridine (DMAP) to form the compound.

79. The process of claim 78 for preparing a compound having the structure:
wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
with a compound having the structure:
wherein X is a leaving group, to produce a compound having the structure:

(b) reacting the compound formed in step (a) with a compound having the structure:
in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to produce a compound having the structure:

80. The process of claim 79, wherein the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (b) is CHCl3.

81. The process of claim 78 for preparing a compound having the structure:
which comprises:
(a) reacting a compound having the structure:
with a compound having the structure:
wherein X is a leaving group, to produce a compound having the structure:
(b) N-protecting the compound formed in step (a) with tert-butoxycarbonyl (Boc) to produce a compound having the structure:

(c) reacting the compound formed in step (b) with a compound having the structure:
in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
(d) deprotecting the compound formed in step (c) with HCl to produce a compound having the structure:

82. The process of claim 81, wherein the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (b) is CHCl3.

83. The process of claim 78 for preparing a compound having the structure:
wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
with a compound having the structure:
wherein X is a leaving group, to produce a compound having the structure:
(b) reacting the compound formed in step (a) with NaCNBH3 and paraformaldehyde to produce a compound having the structure:
(c) reacting the compound formed in step (b) with a compound having the structure:
in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:

84. The process of claim 83, wherein the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (c) is CHCl3.

85. The process of claim 78 for preparing a compound having the structure:
wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6;
which process comprises:
(a) reacting a compound having the structure:
with ethyl formate to produce a compound having the structure:
b) reacting the compound formed in step (a) with lithium aluminum hydride to produce a compound having the structure:
(c) reacting the compound formed in step (~) with a compound having the structure:
wherein X is a leaving group, to form a compound having the structure:
(d) reacting the compound formed in step (c) with a compound having the structure:
in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:

86. The process of claim 85, wherein the aprotic solvent in step (c) is CHCl3.

87. The process of claim 78 for preparing a compound having the structure:
wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
which process comprises:
(a) reacting a compound having the structure:
with NaCNBH3/paraformaldehyde to produce a compound having the structure:
(b) reacting the compound formed in step (a) with a compound having the structure:
wherein X is a leaving group, to form a compound having the structure:

(c) reacting the compound formed in step (b) with a compound having the structure:
in the presence of trifluoroacetic acid (TFA) and an aprotic solvent to form a compound having the structure:

88. The process of claim 87, wherein the aprotic solvent in step (d) is CHCl3.

89. The process of claim 78 for preparing a compound having the structure:
which comprises:
(a) reacting a compound having the structure:
with a compound having the structure:
wherein X is a leaving group, to produce a compound having the structure:

(b) reacting the compound formed in step (a) with NaCNBH3 and paraformaldehyde to produce a compound having the structure:
(c) reacting the compound formed in step (b) with a compound having the structure:
in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:

90. The method of claim 89, wherein the leaving group in step (a) is selected from the group consisting of a halogen and benzene sulfonate and the aprotic solvent in step (c) is CHCl3.

91. The process of claim 78 for preparing a compound having the structure:
which comprises:
(a) reacting a compound having the structure:
with ethyl formate to produce a compound having the structure:
(b) reacting the compound formed in step (a) with lithium aluminum hydride to produce a compound having the structure:
(c) reacting the compound formed in step (b) with a compound having the structure:
wherein X is a leaving group, to form a compound having the structure:
(d) reacting the compound formed in step (c) with a compound having the structure:
in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:

92. The process of claim 91, wherein the aprotic solvent in step (c) is CHCl3.

93. The process of claim 78 for preparing a compound having the structure:
which comprises:
(a) reacting a compound having the structure:
with NaCNBH3/paraformaldehyde to produce a compound having the structure:
(b) reacting the compound formed in step (a) with a compound having the structure:
wherein X is a leaving group, to form a compound having the structure:

(c) reacting the compound formed in step (b) with a compound having the structure:
in the presence of 4-dimethylaminopyridine (DMAP) and an aprotic solvent to form a compound having the structure:

94. The process of claim 93, wherein the aprotic solvent in step (d) is CHCl3.

95. A process for preparing a compound having the structure:
wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
which process comprises:
(a) reacting a compound having the structure:
with AlCl3 or BBr3 in the presence of toluene to produce a compound having the structure:
(b) reacting the product formed in step (a) with benzyl chloride and K2CO3 in the presence of dimethyl formamide (DMF) to produce a compound having the structure:
(c) reacting the product formed in step (b), with MeNH2HCl, NaCNBH3 in tetrahydrofuran (THF)/MeOH to produce a compound having the structure:
(d) reacting the product formed in step (c) with H2, Pd/C and MeOH to produce a compound having the structure:
(e) reacting the product formed in step (d) with Boc2O, dioxane/H2O and NaHCO3 to produce a compound having the structure:
(f) reacting the product formed in step (e) with R4COCl, Et3N
in CH2Cl2 in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
(g) reacting the product formed in step (f) with HCl/dioxane to produce a compound having the structure:
(h) reacting the product formed in step (g) with propargyl bromide, K2CO3 in CH3CN and then with HCl/ether and MeOH
to produce a compound having the structure:

96. The process of claim 95 for preparing a compound having the structure:
which comprises:
(a) reacting a compound having the structure:
with AlCl3 or BBr3 in the presence of toluene to produce a compound having the structure:
(b) reacting the product formed in step (a) with benzyl chloride and K2CO3 in the presence of dimethyl formamide (DMF) to produce a compound having the structure:
(c) reacting the product formed in step (b) with MeNH2 HCl, NaCNBH3 in tetrahydrofuran (THF)/MeOH to produce a compound having the structure:
(d) reacting the product formed in step (c) with H2, Pd/C and MeOH to produce a compound having the structure:
(e) reacting the product formed in step (d) with Boc2O, dioxane/H20 and NaHCO3 to produce a compound having the structure:
(f) reacting the product formed in step (e) with PhCOCl, Et3N
in CH2Cl2 in the presence of 4-dimethylaminopyridine (DMAP) to produce a compound having the structure:
(g) reacting the product formed in step (f) with HCl/dioxane to produce a compound having the structure:
(h) reacting the product formed in step (g) with propargyl bromide, K2CO3 in CH3CN and then with HCl/ether and MeOH
to produce a compound having the structure:

97. Use of a compound or a prodrug of a compound which becomes the compound having the structure:
wherein R1 is OH or OC(O)R4;
wherein R2 is H, OH or OC (O)R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl , C6 to C12 aryl , C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating a subject afflicted with a neurological disease, wherein the compound is to be periodically administered to the subject in a therapeutically effective dose, wherein the neurological disease is epilepsy, narcolepsy, panic, post-traumatic stress disorder (PTSD) or sexual dysfunction.

90. Use of a compound or a prodrug of a compound which becomes the compound having the structure:
wherein R1 i s OH or OC(O)R9, and wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl;
R2 is H or OC(O)R4, or both R1 and R2 are OC(O)R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating neurological disease in a subject, wherein the compound is to be periodically administered to the subject in a therapeutically effective dose.

99. The use of claim 98, wherein the compound has the structure:
wherein R1 is OC(O)R9 and R2 is H , wherein R9 is branched or unbranched C1 to C6 alkyl, aryl, or aralkyl, or R1 is OC(O)R4 and R2 is OC(O)R4, wherein R4 is branched or unbranched C1 to C6 alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.

100. The use of claim 98, wherein the compound has the structure:
wherein R1 is OH;
wherein R2 is H or OC(O)R4 when R1 is attached to the "a"

carbon or the "d" carbon, or R2 is OC(O)R4 when R1 is attached to the "b" carbon or the "c" carbon;
wherein R4 is C1 to C6 branched or unbranched alkyl, aryl, aralkyl or NR5R6, wherein R5 and R6 are each independently H, C1 to C8 alkyl, C6 to C12 aryl, C6 to C12 aralkyl or C6 to C12 cycloalkyl, each optionally substituted;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or 2.

101. The use of claim 98, wherein the compound has the structure:
wherein the compound is an optically pure enantiomer;
wherein R1 is OH;
wherein R2 is H;
wherein R3 is H or C1 to C6 alkyl;
wherein n is 0 or 1; and wherein m is 1 or,2.

102. The use of claim 98, wherein the subject is human.

103. The use of claim 98, wherein the medicament is formulated for oral, parenteral, intravenous, transdermal, or rectal administration.

104. The use of claim 98, wherein the therapeutically effective amount is from about 0.01 mg per day to about 50.0 mg per day.

105. The use of claim 98, wherein the therapeutically effective amount is from about 0.1 mg per day to about 100.0 mg per day.

106. The use of claim 105, wherein the therapeutically effective amount is from about 0.1 mg per day to about 10.0 mg per day.

107. The use of claim 98, wherein the neurological disease is Parkinson's disease, Alzheimer's disease, depression, epilepsy, narcolepsy, amyotrophic lateral sclerosis (ALS), memory disorders, panic, post-traumatic stress disorder (PTSD), sexual dysfunction, attention deficit and hyperactivity syndrome (ADHD), attention deficit disorder, or Tourette's syndrome.

108. The use of claim 107, vuherein the neurological disease is depression.

109. The use of claim 108, wherein the compound has the structure: