HK1023995A1 - Synthesis of acridine derivative multidrug-resistant inhibitors - Google Patents

Synthesis of acridine derivative multidrug-resistant inhibitors

Info

Publication number
HK1023995A1
HK1023995A1 HK00103130A HK00103130A HK1023995A1 HK 1023995 A1 HK1023995 A1 HK 1023995A1 HK 00103130 A HK00103130 A HK 00103130A HK 00103130 A HK00103130 A HK 00103130A HK 1023995 A1 HK1023995 A1 HK 1023995A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
multidrug
acridine derivative
formula
resistant inhibitors
Prior art date
Application number
HK00103130A
Other languages
English (en)
Inventor
Matthew Jude Sharp
Catherine J Mader
Calum Strachan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of HK1023995A1 publication Critical patent/HK1023995A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
HK00103130A 1997-05-23 2000-05-25 Synthesis of acridine derivative multidrug-resistant inhibitors HK1023995A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710612.4A GB9710612D0 (en) 1997-05-23 1997-05-23 Synthesis of acridine derivatives
PCT/EP1998/002991 WO1998052923A1 (en) 1997-05-23 1998-05-22 Synthesis of acridine derivative multidrug-resistant inhibitors

Publications (1)

Publication Number Publication Date
HK1023995A1 true HK1023995A1 (en) 2000-09-29

Family

ID=10812906

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00103130A HK1023995A1 (en) 1997-05-23 2000-05-25 Synthesis of acridine derivative multidrug-resistant inhibitors

Country Status (19)

Country Link
US (1) US6248891B1 (ja)
EP (1) EP0983246B1 (ja)
JP (1) JP4390861B2 (ja)
KR (1) KR100536155B1 (ja)
CN (1) CN1178918C (ja)
AT (1) ATE228506T1 (ja)
AU (1) AU744402B2 (ja)
BR (1) BR9809143A (ja)
CA (1) CA2289492C (ja)
DE (1) DE69809733T2 (ja)
DK (1) DK0983246T3 (ja)
ES (1) ES2187984T3 (ja)
GB (1) GB9710612D0 (ja)
HK (1) HK1023995A1 (ja)
HU (1) HUP0002083A3 (ja)
IL (1) IL132593A (ja)
PL (1) PL190109B1 (ja)
PT (1) PT983246E (ja)
WO (1) WO1998052923A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
ATE316969T1 (de) 1998-10-08 2006-02-15 Smithkline Beecham Plc Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
DE60030283T2 (de) * 1999-05-17 2007-09-20 Cancer Research Ventures Ltd. Zusammensetzungen zur erhöhung der bioverfügbarkeit von oral verabreichten pharmazeutischen verbindungen
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
US7829578B1 (en) 2005-12-12 2010-11-09 Oregon Health & Science University Aromatic ketones and uses thereof
WO2008064011A1 (en) 2006-11-13 2008-05-29 The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs Acridone compounds
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity
BR112020018669A2 (pt) * 2018-03-21 2020-12-29 Izumi Technology, Llc Análogos deuterados de elacridar

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2783680B2 (ja) * 1991-01-11 1998-08-06 ラボラトワール、グラクソ、ソシエテ、アノニム アクリジン誘導体
KR970705997A (ko) * 1994-10-05 1997-11-03 그래함 브레레톤 N-{4-[2-(1, 2, 3, 4-테트라히드로-6, 7-디메톡시-2-이소퀴놀리닐)-에틸]-페닐}-9, 10-디히드로-5-메톡시-9-옥소-4-아크리딘 카르복사미드 화합물(gf120918a)을 포함하는 비경구 제약 조성물(parenteral pharmaceutical compositions containing gf120918a)

Also Published As

Publication number Publication date
CN1178918C (zh) 2004-12-08
IL132593A (en) 2004-07-25
EP0983246B1 (en) 2002-11-27
HUP0002083A2 (hu) 2001-04-28
AU8434498A (en) 1998-12-11
GB9710612D0 (en) 1997-07-16
CA2289492C (en) 2009-03-24
EP0983246A1 (en) 2000-03-08
CA2289492A1 (en) 1998-11-26
US6248891B1 (en) 2001-06-19
HUP0002083A3 (en) 2002-03-28
PT983246E (pt) 2003-04-30
CN1255918A (zh) 2000-06-07
ATE228506T1 (de) 2002-12-15
PL336937A1 (en) 2000-07-17
KR100536155B1 (ko) 2005-12-14
ES2187984T3 (es) 2003-06-16
JP2002502371A (ja) 2002-01-22
DE69809733D1 (de) 2003-01-09
DK0983246T3 (da) 2003-03-24
PL190109B1 (pl) 2005-10-31
IL132593A0 (en) 2001-03-19
KR20010012817A (ko) 2001-02-26
BR9809143A (pt) 2000-08-01
WO1998052923A1 (en) 1998-11-26
DE69809733T2 (de) 2003-09-18
AU744402B2 (en) 2002-02-21
JP4390861B2 (ja) 2009-12-24

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110522