PT983246E - Sintese de inibidores resistentes a farmacos multiplos derivados de acridina - Google Patents

Sintese de inibidores resistentes a farmacos multiplos derivados de acridina

Info

Publication number
PT983246E
PT983246E PT98934892T PT98934892T PT983246E PT 983246 E PT983246 E PT 983246E PT 98934892 T PT98934892 T PT 98934892T PT 98934892 T PT98934892 T PT 98934892T PT 983246 E PT983246 E PT 983246E
Authority
PT
Portugal
Prior art keywords
synthesis
acridine
resisting
inhibitors
multiple drugs
Prior art date
Application number
PT98934892T
Other languages
English (en)
Inventor
Matthew Jude Sharp
Catherine J Mader
Calum Strachan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PT983246E publication Critical patent/PT983246E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT98934892T 1997-05-23 1998-05-22 Sintese de inibidores resistentes a farmacos multiplos derivados de acridina PT983246E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9710612.4A GB9710612D0 (en) 1997-05-23 1997-05-23 Synthesis of acridine derivatives

Publications (1)

Publication Number Publication Date
PT983246E true PT983246E (pt) 2003-04-30

Family

ID=10812906

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98934892T PT983246E (pt) 1997-05-23 1998-05-22 Sintese de inibidores resistentes a farmacos multiplos derivados de acridina

Country Status (19)

Country Link
US (1) US6248891B1 (pt)
EP (1) EP0983246B1 (pt)
JP (1) JP4390861B2 (pt)
KR (1) KR100536155B1 (pt)
CN (1) CN1178918C (pt)
AT (1) ATE228506T1 (pt)
AU (1) AU744402B2 (pt)
BR (1) BR9809143A (pt)
CA (1) CA2289492C (pt)
DE (1) DE69809733T2 (pt)
DK (1) DK0983246T3 (pt)
ES (1) ES2187984T3 (pt)
GB (1) GB9710612D0 (pt)
HK (1) HK1023995A1 (pt)
HU (1) HUP0002083A3 (pt)
IL (1) IL132593A (pt)
PL (1) PL190109B1 (pt)
PT (1) PT983246E (pt)
WO (1) WO1998052923A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
DE69929704T2 (de) 1998-10-08 2006-07-20 Smithkline Beecham Plc, Brentford Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
EP1749540B1 (en) * 1999-05-17 2010-10-13 Cancer Research Ventures Limited Compositions for improving bioavailability of orally administered drugs
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
US7829578B1 (en) 2005-12-12 2010-11-09 Oregon Health & Science University Aromatic ketones and uses thereof
WO2008064011A1 (en) 2006-11-13 2008-05-29 The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs Acridone compounds
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity
BR112020018669A2 (pt) * 2018-03-21 2020-12-29 Izumi Technology, Llc Análogos deuterados de elacridar

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012132A1 (en) * 1991-01-11 1992-07-23 Laboratoires Glaxo S.A. Acridine derivatives
WO1996011007A1 (en) * 1994-10-05 1996-04-18 Glaxo Wellcome Inc. Parenteral pharmaceutical compositions containing gf120918a

Also Published As

Publication number Publication date
AU744402B2 (en) 2002-02-21
CN1255918A (zh) 2000-06-07
HUP0002083A3 (en) 2002-03-28
KR20010012817A (ko) 2001-02-26
ATE228506T1 (de) 2002-12-15
CA2289492A1 (en) 1998-11-26
PL336937A1 (en) 2000-07-17
GB9710612D0 (en) 1997-07-16
CA2289492C (en) 2009-03-24
DK0983246T3 (da) 2003-03-24
PL190109B1 (pl) 2005-10-31
EP0983246A1 (en) 2000-03-08
AU8434498A (en) 1998-12-11
HUP0002083A2 (hu) 2001-04-28
US6248891B1 (en) 2001-06-19
DE69809733T2 (de) 2003-09-18
JP2002502371A (ja) 2002-01-22
WO1998052923A1 (en) 1998-11-26
ES2187984T3 (es) 2003-06-16
IL132593A (en) 2004-07-25
IL132593A0 (en) 2001-03-19
EP0983246B1 (en) 2002-11-27
JP4390861B2 (ja) 2009-12-24
CN1178918C (zh) 2004-12-08
HK1023995A1 (en) 2000-09-29
BR9809143A (pt) 2000-08-01
DE69809733D1 (de) 2003-01-09
KR100536155B1 (ko) 2005-12-14

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