HK1021976A1 - Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging - Google Patents

Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging

Info

Publication number
HK1021976A1
HK1021976A1 HK00100860A HK00100860A HK1021976A1 HK 1021976 A1 HK1021976 A1 HK 1021976A1 HK 00100860 A HK00100860 A HK 00100860A HK 00100860 A HK00100860 A HK 00100860A HK 1021976 A1 HK1021976 A1 HK 1021976A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
substituted
metal chelates
diagnostic imaging
optionally hydroxylated
Prior art date
Application number
HK00100860A
Other languages
English (en)
Inventor
Dominique Meyer
Marc Port
Olivier Rousseaux
Christian Simonot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of HK1021976A1 publication Critical patent/HK1021976A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
HK00100860A 1997-12-10 2000-02-12 Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging HK1021976A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9715642A FR2772025B1 (fr) 1997-12-10 1997-12-10 Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique

Publications (1)

Publication Number Publication Date
HK1021976A1 true HK1021976A1 (en) 2000-07-21

Family

ID=9514428

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00100860A HK1021976A1 (en) 1997-12-10 2000-02-12 Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging

Country Status (23)

Country Link
US (1) US6187285B1 (xx)
EP (1) EP0922700B1 (xx)
JP (1) JP3020938B2 (xx)
KR (1) KR100473240B1 (xx)
CN (1) CN1132822C (xx)
AT (1) ATE223906T1 (xx)
AU (1) AU743361B2 (xx)
BR (1) BR9805801A (xx)
CA (1) CA2254261A1 (xx)
CZ (1) CZ293218B6 (xx)
DE (1) DE69807830T2 (xx)
DK (1) DK0922700T3 (xx)
EA (1) EA001387B1 (xx)
ES (1) ES2183303T3 (xx)
FR (1) FR2772025B1 (xx)
HK (1) HK1021976A1 (xx)
HU (1) HU221604B (xx)
IL (1) IL127467A (xx)
NO (1) NO318037B1 (xx)
NZ (1) NZ333264A (xx)
PL (1) PL330214A1 (xx)
PT (1) PT922700E (xx)
TR (1) TR199802559A3 (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2829492B1 (fr) * 2001-09-11 2005-01-28 Guerbet Sa Procede de preparation de la disorbitylamine
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
UA81634C2 (ru) 2002-07-18 2008-01-25 Хеликс Биофарма Корп. Фармацевтическая композиция уреазы для ингибирования роста раковых клеток и ее применение
US20050026844A1 (en) * 2003-04-03 2005-02-03 Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) * 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
NZ551335A (en) 2004-06-18 2010-03-26 Ambrx Inc Antibodies and fragments thereof comprising an non naturally encoded amino acid coupled to a linker
FR2886294B1 (fr) 2005-05-26 2007-07-20 Rhodia Chimie Sa Procede de preparation de composes organosiliciques
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
EP2192922A4 (en) 2007-09-17 2010-09-29 Univ California INTERNALIZING HUMAN MONOCLONAL ANTIBODIES TARGING PROSTATE <I> IN SITU CANCER CELLS </ I>
EP2491007B1 (en) * 2009-10-23 2013-09-25 Boehringer Ingelheim International GmbH Inhibitors of the microsomal prostaglandin E2 synthase-1
US20140170068A1 (en) 2011-03-11 2014-06-19 Board Of Regents Of The University Of Nebraska Biomarker for coronary artery disease
US20160145304A1 (en) 2013-07-12 2016-05-26 Helmholtz-Zentrum für Infektionsforschung GmbH Cystobactamides
CA2968270C (en) 2014-11-26 2022-11-01 Helmholtz-Zentrum Fur Infektionsforschung Gmbh Further natural cystobactamides, synthetic derivatives thereof, and use thereof in treating bacterial infections
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
PT3383920T (pt) 2015-11-30 2024-04-15 Univ California Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais
EP3538551A4 (en) 2016-11-10 2020-11-11 Fortis Therapeutics, Inc. CD46 SPECIFIC EFFECTOR CELLS AND USES THEREOF
FR3069245B1 (fr) * 2017-07-21 2019-07-26 Guerbet Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales
CN108610274B (zh) * 2018-02-12 2021-09-28 中国人民解放军第二军医大学 一组环γ-聚谷氨酸系列分子及其制备方法和应用
WO2020191329A1 (en) * 2019-03-21 2020-09-24 Massachusetts Institute Of Technology Aramid amphiphile self-assembled nanostructures
EP4192511A1 (en) 2020-08-07 2023-06-14 Fortis Therapeutics, Inc. Immunoconjugates targeting cd46 and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648063A (en) * 1981-07-24 1997-07-15 Schering Aktiengesellschaft Sterile composition comprising a chelate complex for magnetic resonance imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1993000165A1 (en) * 1991-06-21 1993-01-07 Mobil Oil Corporation Olefin oligomerization process
ES2156143T3 (es) * 1993-12-30 2001-06-16 Guerbet Sa Ligandos poliaminados, complejos metalicos, procedimiento de preparacion, aplicaciones diagnosticas y terapeuticas.
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
IT1272870B (it) * 1995-01-10 1997-07-01 Ing Ruggeri Guido Dr Apparecchiatura per il prelievo multiplo di campioni liquidi e procedimento per il suo impiego
JPH11508766A (ja) * 1995-06-20 1999-08-03 ザ・ジェネラル・ホスピタル・コーポレイション Ｂ型肝炎複製の抑制
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye

Also Published As

Publication number Publication date
BR9805801A (pt) 2001-03-20
DK0922700T3 (da) 2003-01-20
HU221604B (hu) 2002-11-28
NO985762D0 (no) 1998-12-09
TR199802559A2 (xx) 1999-06-21
FR2772025A1 (fr) 1999-06-11
IL127467A (en) 2001-04-30
AU743361B2 (en) 2002-01-24
KR19990063025A (ko) 1999-07-26
CN1132822C (zh) 2003-12-31
HU9802849D0 (en) 1999-02-01
CZ405498A3 (cs) 1999-06-16
ATE223906T1 (de) 2002-09-15
PL330214A1 (en) 1999-06-21
CA2254261A1 (fr) 1999-06-10
EP0922700A1 (fr) 1999-06-16
US6187285B1 (en) 2001-02-13
NZ333264A (en) 2000-05-26
PT922700E (pt) 2002-12-31
EA199800998A3 (ru) 1999-12-29
HUP9802849A3 (en) 2001-09-28
NO985762L (no) 1999-06-11
JPH11279163A (ja) 1999-10-12
DE69807830D1 (de) 2002-10-17
ES2183303T3 (es) 2003-03-16
KR100473240B1 (ko) 2005-05-16
DE69807830T2 (de) 2003-08-07
JP3020938B2 (ja) 2000-03-15
TR199802559A3 (tr) 1999-06-21
HUP9802849A2 (hu) 1999-10-28
CN1225922A (zh) 1999-08-18
EA199800998A2 (ru) 1999-08-26
EP0922700B1 (fr) 2002-09-11
EA001387B1 (ru) 2001-02-26
CZ293218B6 (cs) 2004-03-17
NO318037B1 (no) 2005-01-24
IL127467A0 (en) 1999-10-28
AU9613398A (en) 1999-07-01
FR2772025B1 (fr) 2000-03-03

Similar Documents

Publication Publication Date Title
HK1021976A1 (en) Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging
GR3031271T3 (en) Adhesion-receptor antagonists.
IL88762A0 (en) Macrocyclic chelating agents and chelates thereof
GB8900376D0 (en) Iodinated esters
MX9800867A (es) Halogenobencimidazoles y su empleo como microbicidas.
SG43963A1 (en) Molecular sieve-enclosed paramagnetic ion of texas system
IL111083A0 (en) Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same
GR3026249T3 (en) Macrocyclic polymer-complexing, their complexes, method for their production and pharmaceutical agents containing them
EP0417870A3 (en) Chelates for complexation of radioactive isotopes, their metal complexes and their use in diagnosis and therapy
IL106164A0 (en) Polyazamacrocyclic compounds and their complexes with metal ions
HK1011971A1 (en) Quinoxalines, process for their preparation and their use
EP0783035A3 (de) Bleichmittelsysteme enthaltend Bis- und Tris-(mu-oxo)-di-Mangan-Komplexsalze
YU2502A (sh) Jedinjenja titana, njihovo pripremanje i primena
WO1997010852A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope
TW254945B (xx)
IL110254A0 (en) Phenalkylamines and their use
TR199701716T1 (xx) Poliaminoasitlerin metal kompleksleri.
IL98534A0 (en) The use of macrocyclic aminophosphonic acid complexes as imaging agents
WO1997012636A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope
DE69701301D1 (de) Substituierte Benzylderivate von Polyalkylenpolyaminen und ihre Verwendung in kosmetischen und pharmazeutischen Zusammensetzungen
IL96324A0 (en) 5-amino-2,4,6-triiodo-1,3-benzenecarboxylic acid derivatives and methods utilizing the same as contrast agents
HUP0303151A2 (hu) Biotin aminoszármazékai és ezek makrociklusos kelátképző szerekkel képzett konjugátumai
WO1997012850A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsny für radioaktive isotope
ES2021944A6 (es) Procedimiento para preparar nuevos derivados de 1,3,5,-triamino-2,4,6-triyodobenceno.
IT1242026B (it) Composizione farmaceutica contenente un complesso ferro-schizokinene per il trattamento dell&#39;anemia ferropenica.

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20071210