BR9805801A - Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico - Google Patents
Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnósticoInfo
- Publication number
- BR9805801A BR9805801A BR9805801-0A BR9805801A BR9805801A BR 9805801 A BR9805801 A BR 9805801A BR 9805801 A BR9805801 A BR 9805801A BR 9805801 A BR9805801 A BR 9805801A
- Authority
- BR
- Brazil
- Prior art keywords
- application
- diagnostic imaging
- chelates
- carboxylic derivatives
- polyamino carboxylic
- Prior art date
Links
- 238000002059 diagnostic imaging Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polyamides (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Polyesters Or Polycarbonates (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: <B>"QUELATOS METáLICOS DE DERIVADOS MACROCìCLICOS POLIAMINOCARBOXìLICOS E SUA APLICAçãO EM FORMAçãO DE IMAGEM PARA DIAGNóSTICO"<B>. Quelatos dos compostos de fórmula na qual R é um grupo hidrófilo que envolve 3 ou 4 núcleos fenilas sucessivos e m é 1 ou 2, com íons metálicos, para uma utilização em forma de imagem para diagnóstico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9715642A FR2772025B1 (fr) | 1997-12-10 | 1997-12-10 | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9805801A true BR9805801A (pt) | 2001-03-20 |
Family
ID=9514428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9805801-0A BR9805801A (pt) | 1997-12-10 | 1998-12-10 | Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico |
Country Status (23)
Country | Link |
---|---|
US (1) | US6187285B1 (pt) |
EP (1) | EP0922700B1 (pt) |
JP (1) | JP3020938B2 (pt) |
KR (1) | KR100473240B1 (pt) |
CN (1) | CN1132822C (pt) |
AT (1) | ATE223906T1 (pt) |
AU (1) | AU743361B2 (pt) |
BR (1) | BR9805801A (pt) |
CA (1) | CA2254261A1 (pt) |
CZ (1) | CZ293218B6 (pt) |
DE (1) | DE69807830T2 (pt) |
DK (1) | DK0922700T3 (pt) |
EA (1) | EA001387B1 (pt) |
ES (1) | ES2183303T3 (pt) |
FR (1) | FR2772025B1 (pt) |
HK (1) | HK1021976A1 (pt) |
HU (1) | HU221604B (pt) |
IL (1) | IL127467A (pt) |
NO (1) | NO318037B1 (pt) |
NZ (1) | NZ333264A (pt) |
PL (1) | PL330214A1 (pt) |
PT (1) | PT922700E (pt) |
TR (1) | TR199802559A2 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
FR2829492B1 (fr) * | 2001-09-11 | 2005-01-28 | Guerbet Sa | Procede de preparation de la disorbitylamine |
FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
PT1530482E (pt) | 2002-07-18 | 2014-01-15 | Helix Biopharma Corp | Utilização de urease para inibição de crescimento de células cancerigenas |
AU2004228028B2 (en) * | 2003-04-03 | 2009-12-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
FR2867473B1 (fr) * | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
KR20070034512A (ko) | 2004-06-18 | 2007-03-28 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
FR2886294B1 (fr) | 2005-05-26 | 2007-07-20 | Rhodia Chimie Sa | Procede de preparation de composes organosiliciques |
FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
CA2699394C (en) | 2007-09-17 | 2020-03-24 | The Regents Of The University Of California | Internalizing human monoclonal antibodies targeting prostate cancer cells in situ |
EP2491007B1 (en) * | 2009-10-23 | 2013-09-25 | Boehringer Ingelheim International GmbH | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
CN105388287A (zh) | 2011-03-11 | 2016-03-09 | 内布拉斯加大学董事委员会 | 冠状动脉疾病的生物标志物 |
EP3019615B1 (en) | 2013-07-12 | 2021-04-07 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamides |
AU2015353077B2 (en) * | 2014-11-26 | 2020-03-05 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Novel cystobactamides |
GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
PT3383920T (pt) | 2015-11-30 | 2024-04-15 | Univ California | Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais |
FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
CN108610274B (zh) * | 2018-02-12 | 2021-09-28 | 中国人民解放军第二军医大学 | 一组环γ-聚谷氨酸系列分子及其制备方法和应用 |
WO2020191329A1 (en) * | 2019-03-21 | 2020-09-24 | Massachusetts Institute Of Technology | Aramid amphiphile self-assembled nanostructures |
CN116419747A (zh) | 2020-08-07 | 2023-07-11 | 福蒂斯治疗公司 | 靶向cd46的免疫偶联物及其使用方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648063A (en) * | 1981-07-24 | 1997-07-15 | Schering Aktiengesellschaft | Sterile composition comprising a chelate complex for magnetic resonance imaging |
US5422096A (en) * | 1985-05-08 | 1995-06-06 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
MX174467B (es) * | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
US5679810A (en) * | 1990-01-19 | 1997-10-21 | Salutar, Inc. | Linear oligomeric polychelant compounds |
DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
WO1993000165A1 (en) * | 1991-06-21 | 1993-01-07 | Mobil Oil Corporation | Olefin oligomerization process |
EP0661279B1 (fr) * | 1993-12-30 | 2001-03-07 | Guerbet | Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques |
GB9407435D0 (en) * | 1994-04-14 | 1994-06-08 | Nycomed Salutar Inc | Compounds |
IT1274038B (it) * | 1994-07-29 | 1997-07-14 | Bracco Spa | Chelanti macrociclici loro chelati e relativi usi in campo diagnostico |
IT1272870B (it) * | 1995-01-10 | 1997-07-01 | Ing Ruggeri Guido Dr | Apparecchiatura per il prelievo multiplo di campioni liquidi e procedimento per il suo impiego |
AU699398B2 (en) * | 1995-06-20 | 1998-12-03 | General Hospital Corporation, The | Inhibition of hepatitis B replication |
FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
US5900228A (en) * | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
-
1997
- 1997-12-10 FR FR9715642A patent/FR2772025B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-09 TR TR1998/02559A patent/TR199802559A2/xx unknown
- 1998-12-09 AU AU96133/98A patent/AU743361B2/en not_active Ceased
- 1998-12-09 CA CA002254261A patent/CA2254261A1/fr not_active Abandoned
- 1998-12-09 DE DE69807830T patent/DE69807830T2/de not_active Expired - Fee Related
- 1998-12-09 DK DK98403108T patent/DK0922700T3/da active
- 1998-12-09 CZ CZ19984054A patent/CZ293218B6/cs not_active IP Right Cessation
- 1998-12-09 PT PT98403108T patent/PT922700E/pt unknown
- 1998-12-09 ES ES98403108T patent/ES2183303T3/es not_active Expired - Lifetime
- 1998-12-09 EP EP98403108A patent/EP0922700B1/fr not_active Expired - Lifetime
- 1998-12-09 AT AT98403108T patent/ATE223906T1/de not_active IP Right Cessation
- 1998-12-09 US US09/207,513 patent/US6187285B1/en not_active Expired - Fee Related
- 1998-12-09 NZ NZ333264A patent/NZ333264A/xx unknown
- 1998-12-09 IL IL12746798A patent/IL127467A/en not_active IP Right Cessation
- 1998-12-09 HU HU9802849A patent/HU221604B/hu not_active IP Right Cessation
- 1998-12-09 EA EA199800998A patent/EA001387B1/ru not_active IP Right Cessation
- 1998-12-09 NO NO19985762A patent/NO318037B1/no unknown
- 1998-12-10 PL PL98330214A patent/PL330214A1/xx not_active Application Discontinuation
- 1998-12-10 JP JP10377822A patent/JP3020938B2/ja not_active Expired - Fee Related
- 1998-12-10 CN CN98126925A patent/CN1132822C/zh not_active Expired - Fee Related
- 1998-12-10 BR BR9805801-0A patent/BR9805801A/pt not_active Application Discontinuation
- 1998-12-10 KR KR10-1998-0054764A patent/KR100473240B1/ko not_active IP Right Cessation
-
2000
- 2000-02-12 HK HK00100860A patent/HK1021976A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 257/02, A61K 49/06, A61K 51/00 Ipc: C07D 257/02 (2007.01), A61K 49/06 (2007.01), A61K |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO PELO PRESENTE PEDIDO DE PATENTE DE ACORDO COM ARTIGO 8O DA LPI. |