BR9805801A - Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico - Google Patents

Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico

Info

Publication number
BR9805801A
BR9805801A BR9805801-0A BR9805801A BR9805801A BR 9805801 A BR9805801 A BR 9805801A BR 9805801 A BR9805801 A BR 9805801A BR 9805801 A BR9805801 A BR 9805801A
Authority
BR
Brazil
Prior art keywords
application
diagnostic imaging
chelates
carboxylic derivatives
polyamino carboxylic
Prior art date
Application number
BR9805801-0A
Other languages
English (en)
Inventor
Dominique Meyer
Marc Port
Olivier Rousseaux
Christian Simonot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of BR9805801A publication Critical patent/BR9805801A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"QUELATOS METáLICOS DE DERIVADOS MACROCìCLICOS POLIAMINOCARBOXìLICOS E SUA APLICAçãO EM FORMAçãO DE IMAGEM PARA DIAGNóSTICO"<B>. Quelatos dos compostos de fórmula na qual R é um grupo hidrófilo que envolve 3 ou 4 núcleos fenilas sucessivos e m é 1 ou 2, com íons metálicos, para uma utilização em forma de imagem para diagnóstico.
BR9805801-0A 1997-12-10 1998-12-10 Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico BR9805801A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9715642A FR2772025B1 (fr) 1997-12-10 1997-12-10 Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique

Publications (1)

Publication Number Publication Date
BR9805801A true BR9805801A (pt) 2001-03-20

Family

ID=9514428

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9805801-0A BR9805801A (pt) 1997-12-10 1998-12-10 Quelatos metálicos de derivados macrocìclicos poliaminocarboxìlicos e sua aplicação em formação de imagem para diagnóstico

Country Status (23)

Country Link
US (1) US6187285B1 (pt)
EP (1) EP0922700B1 (pt)
JP (1) JP3020938B2 (pt)
KR (1) KR100473240B1 (pt)
CN (1) CN1132822C (pt)
AT (1) ATE223906T1 (pt)
AU (1) AU743361B2 (pt)
BR (1) BR9805801A (pt)
CA (1) CA2254261A1 (pt)
CZ (1) CZ293218B6 (pt)
DE (1) DE69807830T2 (pt)
DK (1) DK0922700T3 (pt)
EA (1) EA001387B1 (pt)
ES (1) ES2183303T3 (pt)
FR (1) FR2772025B1 (pt)
HK (1) HK1021976A1 (pt)
HU (1) HU221604B (pt)
IL (1) IL127467A (pt)
NO (1) NO318037B1 (pt)
NZ (1) NZ333264A (pt)
PL (1) PL330214A1 (pt)
PT (1) PT922700E (pt)
TR (1) TR199802559A2 (pt)

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FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2829492B1 (fr) * 2001-09-11 2005-01-28 Guerbet Sa Procede de preparation de la disorbitylamine
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
PT1530482E (pt) 2002-07-18 2014-01-15 Helix Biopharma Corp Utilização de urease para inibição de crescimento de células cancerigenas
AU2004228028B2 (en) * 2003-04-03 2009-12-10 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) * 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
KR20070034512A (ko) 2004-06-18 2007-03-28 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
FR2886294B1 (fr) 2005-05-26 2007-07-20 Rhodia Chimie Sa Procede de preparation de composes organosiliciques
FR2914303A1 (fr) * 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
CA2699394C (en) 2007-09-17 2020-03-24 The Regents Of The University Of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
EP2491007B1 (en) * 2009-10-23 2013-09-25 Boehringer Ingelheim International GmbH Inhibitors of the microsomal prostaglandin E2 synthase-1
CN105388287A (zh) 2011-03-11 2016-03-09 内布拉斯加大学董事委员会 冠状动脉疾病的生物标志物
EP3019615B1 (en) 2013-07-12 2021-04-07 Helmholtz-Zentrum für Infektionsforschung GmbH Cystobactamides
AU2015353077B2 (en) * 2014-11-26 2020-03-05 Helmholtz-Zentrum Fur Infektionsforschung Gmbh Novel cystobactamides
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
PT3383920T (pt) 2015-11-30 2024-04-15 Univ California Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais
FR3069245B1 (fr) * 2017-07-21 2019-07-26 Guerbet Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales
CN108610274B (zh) * 2018-02-12 2021-09-28 中国人民解放军第二军医大学 一组环γ-聚谷氨酸系列分子及其制备方法和应用
WO2020191329A1 (en) * 2019-03-21 2020-09-24 Massachusetts Institute Of Technology Aramid amphiphile self-assembled nanostructures
CN116419747A (zh) 2020-08-07 2023-07-11 福蒂斯治疗公司 靶向cd46的免疫偶联物及其使用方法

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Publication number Priority date Publication date Assignee Title
US5648063A (en) * 1981-07-24 1997-07-15 Schering Aktiengesellschaft Sterile composition comprising a chelate complex for magnetic resonance imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1993000165A1 (en) * 1991-06-21 1993-01-07 Mobil Oil Corporation Olefin oligomerization process
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
IT1272870B (it) * 1995-01-10 1997-07-01 Ing Ruggeri Guido Dr Apparecchiatura per il prelievo multiplo di campioni liquidi e procedimento per il suo impiego
AU699398B2 (en) * 1995-06-20 1998-12-03 General Hospital Corporation, The Inhibition of hepatitis B replication
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye

Also Published As

Publication number Publication date
DE69807830T2 (de) 2003-08-07
CN1132822C (zh) 2003-12-31
JP3020938B2 (ja) 2000-03-15
AU743361B2 (en) 2002-01-24
EA199800998A3 (ru) 1999-12-29
NO985762D0 (no) 1998-12-09
NZ333264A (en) 2000-05-26
ES2183303T3 (es) 2003-03-16
PL330214A1 (en) 1999-06-21
HK1021976A1 (en) 2000-07-21
FR2772025B1 (fr) 2000-03-03
NO985762L (no) 1999-06-11
US6187285B1 (en) 2001-02-13
IL127467A (en) 2001-04-30
HUP9802849A3 (en) 2001-09-28
KR19990063025A (ko) 1999-07-26
CZ405498A3 (cs) 1999-06-16
EP0922700B1 (fr) 2002-09-11
DE69807830D1 (de) 2002-10-17
JPH11279163A (ja) 1999-10-12
FR2772025A1 (fr) 1999-06-11
TR199802559A3 (tr) 1999-06-21
HU9802849D0 (en) 1999-02-01
EA199800998A2 (ru) 1999-08-26
CN1225922A (zh) 1999-08-18
EP0922700A1 (fr) 1999-06-16
CA2254261A1 (fr) 1999-06-10
IL127467A0 (en) 1999-10-28
CZ293218B6 (cs) 2004-03-17
NO318037B1 (no) 2005-01-24
AU9613398A (en) 1999-07-01
DK0922700T3 (da) 2003-01-20
EA001387B1 (ru) 2001-02-26
HU221604B (hu) 2002-11-28
ATE223906T1 (de) 2002-09-15
HUP9802849A2 (hu) 1999-10-28
KR100473240B1 (ko) 2005-05-16
TR199802559A2 (xx) 1999-06-21
PT922700E (pt) 2002-12-31

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: C07D 257/02, A61K 49/06, A61K 51/00

Ipc: C07D 257/02 (2007.01), A61K 49/06 (2007.01), A61K

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO PELO PRESENTE PEDIDO DE PATENTE DE ACORDO COM ARTIGO 8O DA LPI.