HK1014881A1 - Epidural administration of therapeutic compounds with sustained rate of release - Google Patents

Epidural administration of therapeutic compounds with sustained rate of release

Info

Publication number
HK1014881A1
HK1014881A1 HK99100207A HK99100207A HK1014881A1 HK 1014881 A1 HK1014881 A1 HK 1014881A1 HK 99100207 A HK99100207 A HK 99100207A HK 99100207 A HK99100207 A HK 99100207A HK 1014881 A1 HK1014881 A1 HK 1014881A1
Authority
HK
Hong Kong
Prior art keywords
release
therapeutic compounds
sustained rate
epidural administration
epidural
Prior art date
Application number
HK99100207A
Other languages
English (en)
Inventor
Sinil Kim
Andras Gruber
Sharad B Murdande
Taehee Kim
Original Assignee
Skyepharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyepharma Inc filed Critical Skyepharma Inc
Publication of HK1014881A1 publication Critical patent/HK1014881A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • Y10S977/907Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK99100207A 1995-07-14 1999-01-15 Epidural administration of therapeutic compounds with sustained rate of release HK1014881A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/502,569 US5931809A (en) 1995-07-14 1995-07-14 Epidural administration of therapeutic compounds with sustained rate of release
PCT/US1996/011642 WO1997003652A1 (en) 1995-07-14 1996-07-12 Epidural administration of therapeutic compounds with sustained rate of release

Publications (1)

Publication Number Publication Date
HK1014881A1 true HK1014881A1 (en) 1999-10-08

Family

ID=23998405

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99100207A HK1014881A1 (en) 1995-07-14 1999-01-15 Epidural administration of therapeutic compounds with sustained rate of release

Country Status (13)

Country Link
US (2) US5931809A (de)
EP (2) EP0839027A4 (de)
JP (4) JP4592119B2 (de)
KR (2) KR20060012027A (de)
CN (1) CN1085944C (de)
AU (1) AU699177B2 (de)
BR (1) BR9609717A (de)
CA (1) CA2226870C (de)
HK (1) HK1014881A1 (de)
NO (1) NO326261B1 (de)
NZ (1) NZ312963A (de)
RU (1) RU2215522C2 (de)
WO (1) WO1997003652A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002139A1 (en) * 1997-07-10 1999-01-21 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6440455B1 (en) 1997-09-02 2002-08-27 Children's Medical Center Corporation Methods for modulating the axonal outgrowth of central nervous system neurons
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
CA2304096C (en) 1997-09-18 2003-09-09 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
NZ504188A (en) 1997-11-14 2001-10-26 Skyepharma Inc Emulsification process for preparing multivesicular liposomes
PT1685839E (pt) 1997-12-22 2013-07-08 Euro Celtique Sa Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
DE69935435T2 (de) * 1998-08-12 2007-12-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Mittels Ammoniumsulfatgradient hergestellte liposomale analgetische Zusammensetzungen
EP1190705A4 (de) * 1999-06-24 2009-03-18 Kyowa Hakko Kogyo Kk Verfahren zur regulation des herausdiffundierens von in liposomen verkapseltem arzneistoff
KR20130010512A (ko) * 1999-10-29 2013-01-28 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
KR20090016517A (ko) 1999-12-23 2009-02-13 벨루스 헬스 (인터내셔널) 리미티드 대뇌 아밀로이드 혈관병증을 조절하는 화합물 및 방법
US7172871B1 (en) 2000-09-07 2007-02-06 Children's Medical Center Corporation Methods and compositions for modulating axonal outgrowth of central nervous system neurons
ATE517607T1 (de) 2000-11-30 2011-08-15 Vectura Ltd Verfahren zur herstellung von partikeln zur verwendung in einer pharmazeutischen zusammensetzung
ES2689704T3 (es) * 2000-11-30 2018-11-15 Vectura Limited Partículas para usar en una composición farmacéutica
DE60238756D1 (de) 2001-05-11 2011-02-10 Endo Pharmaceuticals Inc Opioid enthaltende arzneiform gegen missbrauch
DE20308437U1 (de) 2002-04-05 2003-11-13 Euroceltique S.A., Luxemburg/Luxembourg Matrix zur verzögerten, gleichbleibenden und unabhängigen Freisetzung von Wirkstoffen
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US8708993B1 (en) * 2003-10-15 2014-04-29 Physician Technologies, Inc. Infusion catheter procedure and system
US8912144B2 (en) 2003-12-16 2014-12-16 Children's Medical Center Corporation Method for treating stroke via administration of NEP1-40 and inosine
NZ551990A (en) * 2004-06-04 2011-01-28 Camurus Ab Liquid depot formulations
EP1604666A1 (de) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
EP1702558A1 (de) 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
US20070110674A1 (en) * 2005-07-29 2007-05-17 Yuhong Xu Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems
US20070253994A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain
CA2661302A1 (en) * 2006-08-16 2008-02-21 Auspex Pharmaceuticals, Inc. Preparation and utility of opioid analgesics
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
PT2405915T (pt) 2009-03-10 2019-01-29 Euro Celtique Sa Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona
JP5911435B2 (ja) * 2010-02-22 2016-04-27 エッジ セラピューティクス インコーポレイテッド 脳の出血状態を治療するための方法及び組成物
CN102462662A (zh) * 2010-08-16 2012-05-23 重庆富进生物医药有限公司 脂质体包裹重组人睫状神经营养因子
EP2630953B1 (de) * 2010-12-27 2017-08-09 Terumo Kabushiki Kaisha Liposomzusammensetzung und herstellungsverfahren dafür
US10842849B2 (en) 2011-02-28 2020-11-24 The Schepens Eye Research Institute, Inc. Methods for promoting neuronal outgrowth by insulin-like growth factor binding protein-like 1 (IGFBPL-1) in glaucoma or leber's optic neuropathy
RU2678433C2 (ru) 2012-05-10 2019-01-29 Пейнреформ Лтд. Депо-составы гидрофобного активного ингредиента и способы их получения
JP5918909B2 (ja) 2012-06-25 2016-05-18 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 標的化治療薬
AU2013294915C1 (en) 2012-07-26 2019-11-21 Camurus Ab Opioid formulations
KR20160029731A (ko) 2013-03-12 2016-03-15 더 제너럴 하스피탈 코포레이션 변형된 뮐러관 억제 물질(mis) 단백질 및 질환 치료를 위한 그 용도
CA2902343C (en) 2013-03-14 2022-08-02 Becton Dickinson France S.A.S. Injectable morphine formulations
EP2968729B1 (de) 2013-03-14 2018-08-15 Fresenius Kabi Deutschland GmbH Verpackungssystem für sauerstoffempfindliche medikamenten
NZ716267A (en) 2013-07-23 2017-05-26 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
WO2015089321A2 (en) 2013-12-11 2015-06-18 The General Hospital Corporation Use of mullerian inhibiting substance (mis) proteins for contraception and ovarian reserve preservation
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
AU2018345844B2 (en) 2017-10-06 2024-03-07 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
KR102168204B1 (ko) 2018-11-30 2020-10-20 동국제약 주식회사 서방형 리포좀 제제의 제조방법
US20220273568A1 (en) * 2019-07-12 2022-09-01 Pacira Pharmaceuticals, Inc. Multivesicular liposome formulations of dexmedetomidine
US20220313686A1 (en) * 2019-08-12 2022-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical compositions comprising a combination of opioid antagonists
EP4087540A4 (de) * 2020-01-06 2024-01-10 Pacira Pharmaceuticals, Inc. Behandlung von schmerzen in verbindung mit einem kaiserschnitt mit zusammensetzung aus liposomalen anästhetika mit verzögerter freisetzung
WO2021141963A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
WO2021141959A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
WO2022150708A1 (en) 2021-01-11 2022-07-14 Pacira Pharmaceuticals, Inc. Treatment of hip pain with sustained-release liposomal anesthetic compositions
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
KR102701064B1 (ko) 2021-03-04 2024-08-30 포항공과대학교 산학협력단 부피바카인 리포좀 기반의 리포좀 약물전달체 제조방법 및 이에 의해 제조된 서방형 제제
WO2022197899A2 (en) 2021-03-19 2022-09-22 Pacira Pharmaceuticals, Inc. Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions
CN114949220B (zh) * 2022-01-30 2023-09-22 浙江大学 一种靶向损伤节段背根神经节的pH响应镇痛药及其应用
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35192A (en) * 1862-05-06 Improved nutmeg-grater
CH588887A5 (de) * 1974-07-19 1977-06-15 Battelle Memorial Institute
US4897308A (en) * 1975-06-30 1990-01-30 L'oreal Compositions comprising aqueous dispersions of lipid spheres
US4078052A (en) * 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
JPS55153713A (en) * 1979-05-02 1980-11-29 Kureha Chem Ind Co Ltd Pharmaceutical preparation of ribosome containing active substance
US4452025A (en) 1979-07-18 1984-06-05 Lew Hyok S Self-interlocking grille
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4578384A (en) 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4696258A (en) 1984-04-04 1987-09-29 The Magrath Company Method and substance for the detection of cows in estrus
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
FR2585246A1 (fr) 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
JPH0645396B2 (ja) 1985-09-04 1994-06-15 ザ・コカ−コ−ラ・カンパニ− 接続装置
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
US4788055A (en) 1985-12-09 1988-11-29 Ciba-Geigy Corporation Resinate sustained release dextromethorphan composition
US5244678A (en) * 1986-01-14 1993-09-14 Ire-Celltarg S.A. Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes
FR2592791A1 (fr) * 1986-01-14 1987-07-17 Ire Celltarg Sa Composition pharmaceutique, contenant un anesthesique local et/ou un analgesique central encapsule dans des liposomes
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613689D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US4816264A (en) 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
JP2666345B2 (ja) * 1987-04-16 1997-10-22 武田薬品工業株式会社 リポソーム製剤およびその製造法
US5261903A (en) * 1988-04-11 1993-11-16 M.D. Inc. Composite anesthetic article and method of use
EP0376999A1 (de) * 1988-04-27 1990-07-11 Baker Cummins Pharmaceuticals, Inc. Verfahren zur umkehrung der nebenwirkungen epiduraler analgetika
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US4996047A (en) 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
CA2002492A1 (en) 1988-11-11 1990-05-11 Sandra T. A. Malkowska Pharmaceutical ion exchange resin composition
US4921853A (en) * 1988-11-14 1990-05-01 Michigan State University Method for producing analgesia in mammals
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
SE8904298D0 (sv) 1989-12-21 1989-12-21 Astra Ab New compounds
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
USRE35192E (en) 1990-11-13 1996-03-26 Phoenix Surgical Products, Inc. Post-surgical anesthesia at a continuous and progressively decreasing administration rate
CH683149A5 (fr) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
SG50624A1 (en) * 1991-12-30 1998-07-20 Neurex Corp Methods of producing analgesia and enhancing opiate analgesia
EP0630234B1 (de) * 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Acth enthaltende mikrokugeln mit gesteuerter abgabe
WO1993020802A1 (en) * 1992-04-09 1993-10-28 Northwestern University Acoustically reflective liposomes and methods to make and use the same
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
ES2188612T3 (es) * 1993-04-22 2003-07-01 Skyepharma Inc Liposomas multivesiculares de ciclodextrina para encapsular compuestos farmacologicos y metodos para su uso.
JP3002702B2 (ja) * 1993-11-16 2000-01-24 スカイファーム インコーポレーテッド 活性物質の制御放出を有する小胞
US5451408A (en) * 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
EP1336409B1 (de) * 1995-06-27 2007-04-11 Eisai R&D Management Co., Ltd. Zusammensetzungen zur Erzielung von Analgesie und zur Hemmung der Progression neuropathischer Schmerzerkrankungen
JP4138874B2 (ja) * 1995-07-03 2008-08-27 スウェイジロック カンパニー ばね負荷形ベロー調整器
IL165365A0 (en) 2004-11-24 2006-01-15 Q Core Ltd Finger-type peristaltic pump
JP4478127B2 (ja) * 2006-07-04 2010-06-09 サカエ理研工業株式会社 車両用ドアハンドル装置
KR101989059B1 (ko) 2012-08-22 2019-06-14 삼성디스플레이 주식회사 캐스케이드형 화합물 및 이를 포함한 유기 발광 소자

Also Published As

Publication number Publication date
CN1085944C (zh) 2002-06-05
EP2036542B1 (de) 2016-04-20
US6428529B1 (en) 2002-08-06
JP2010043104A (ja) 2010-02-25
JP2010031030A (ja) 2010-02-12
WO1997003652A1 (en) 1997-02-06
EP2036542A1 (de) 2009-03-18
AU699177B2 (en) 1998-11-26
AU6491196A (en) 1997-02-18
NO980146D0 (no) 1998-01-13
NO980146L (no) 1998-03-13
JP4592119B2 (ja) 2010-12-01
EP0839027A4 (de) 2000-12-06
KR100593722B1 (ko) 2007-04-25
NZ312963A (en) 1999-06-29
CN1195286A (zh) 1998-10-07
CA2226870C (en) 2005-05-17
RU2215522C2 (ru) 2003-11-10
CA2226870A1 (en) 1997-02-06
NO326261B1 (no) 2008-10-27
US20020065506A1 (en) 2002-05-30
EP0839027A1 (de) 1998-05-06
BR9609717A (pt) 1999-12-21
US5931809A (en) 1999-08-03
JPH11508900A (ja) 1999-08-03
MX9800391A (es) 1998-09-30
KR20060012027A (ko) 2006-02-06
KR19990028906A (ko) 1999-04-15
JP2008143911A (ja) 2008-06-26

Similar Documents

Publication Publication Date Title
HK1014881A1 (en) Epidural administration of therapeutic compounds with sustained rate of release
ZA962248B (en) Nanususpensions for intravenous administration
AU5263496A (en) Targeted catheter drug administration
GB2303064B (en) Medicament for nasal administration
EP0800364A4 (de) Transdermale verabreichung von apomorphin
AU1683995A (en) Intravenous administration of psoralen
IL125111A0 (en) Medical intravenous administration line connector
EP0859604A4 (de) Verminderung physiologischer gegenreaktionen, die durch intravenös verabreichte nanopartikel-formulierungen ausgelöst werden
EP0761173A3 (de) Nadel zum Verabreichen therapeutischer Lösungen in den Subarachnoidalraum
AU4778893A (en) System of drug delivery to the lymphatic tissues
ZA928011B (en) Transdermal administration of melatonin.
GB9200417D0 (en) Cytotoxic drug therapy
HUP0001263A3 (en) Methods of therapeutic administration of anti-cd4ol compounds
AU2939897A (en) Administration of histamine for therapeutic purposes
PL325329A1 (en) Optically pure derivative of phenylpyrimidine as analgesic agent
GB9700737D0 (en) Administration of drugs
HK1015681A1 (en) Rate-controlled transdermal administration of risperidone
GB9524942D0 (en) Drug therapy
GB9523066D0 (en) Compounds and their therapeutic use
GB9501294D0 (en) Long-term administration of drugs
GB9503322D0 (en) Medicament administration dummy
GB9418414D0 (en) Long-term administration of drugs
ZA953839B (en) The administration of magnesium
SI0859595T1 (en) Therapeutic preparation for the transdermal administration of active substances
IL126778A0 (en) Administration of histamine for therapeutic purposes

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20160711