HK1013065A1 - Pyrimidinedione, pyrimidinetrione, triazinedione, derivatives as alpha-1-adrenergic receptor antagonists - Google Patents
Pyrimidinedione, pyrimidinetrione, triazinedione, derivatives as alpha-1-adrenergic receptor antagonistsInfo
- Publication number
- HK1013065A1 HK1013065A1 HK98114167A HK98114167A HK1013065A1 HK 1013065 A1 HK1013065 A1 HK 1013065A1 HK 98114167 A HK98114167 A HK 98114167A HK 98114167 A HK98114167 A HK 98114167A HK 1013065 A1 HK1013065 A1 HK 1013065A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- triazinedione
- pyrimidinetrione
- pyrimidinedione
- alpha
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48918395A | 1995-06-09 | 1995-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1013065A1 true HK1013065A1 (en) | 1999-08-13 |
Family
ID=23942748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98114167A HK1013065A1 (en) | 1995-06-09 | 1998-12-21 | Pyrimidinedione, pyrimidinetrione, triazinedione, derivatives as alpha-1-adrenergic receptor antagonists |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP0748800B1 (ru) |
JP (1) | JP2721147B2 (ru) |
KR (1) | KR100446877B1 (ru) |
CN (1) | CN1118459C (ru) |
AR (1) | AR003428A1 (ru) |
AT (1) | ATE201016T1 (ru) |
AU (1) | AU710754B2 (ru) |
BR (1) | BR9602705A (ru) |
CA (1) | CA2178548A1 (ru) |
CO (1) | CO4700472A1 (ru) |
CZ (1) | CZ290004B6 (ru) |
DE (1) | DE69612698T2 (ru) |
DK (1) | DK0748800T3 (ru) |
ES (1) | ES2157366T3 (ru) |
GR (1) | GR3036307T3 (ru) |
HK (1) | HK1013065A1 (ru) |
HU (1) | HU223594B1 (ru) |
IL (1) | IL118519A (ru) |
MA (1) | MA23899A1 (ru) |
MY (1) | MY113499A (ru) |
NO (1) | NO309424B1 (ru) |
NZ (1) | NZ286720A (ru) |
PE (1) | PE46497A1 (ru) |
PL (1) | PL188061B1 (ru) |
PT (1) | PT748800E (ru) |
RU (1) | RU2175322C2 (ru) |
SA (1) | SA96170263B1 (ru) |
SG (1) | SG45486A1 (ru) |
TR (1) | TR970073A2 (ru) |
TW (1) | TW340846B (ru) |
UY (1) | UY24257A1 (ru) |
ZA (1) | ZA964561B (ru) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
KR100795326B1 (ko) | 1997-10-31 | 2008-01-21 | 아스비오파마 가부시키가이샤 | 아릴피페리디노프로판올 및 아릴피페라지노프로판올유도체의 제조에 유용한 화합물의 제조방법 |
US6083950A (en) * | 1997-11-13 | 2000-07-04 | Ranbaxy Laboratories Limited | 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers |
DE69931100T2 (de) * | 1998-03-30 | 2007-04-19 | F. Hoffmann-La Roche Ag | Verfahren zu Fabrikation von Alpha 1l-Adrenorezeptor Antagonisten |
AU1979799A (en) * | 1998-07-21 | 2000-02-14 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers |
WO2000005205A1 (en) * | 1998-07-21 | 2000-02-03 | Ranbaxy Laboratories Limited | Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers |
WO2000029386A1 (en) | 1998-11-12 | 2000-05-25 | Merck & Co., Inc. | Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists |
US6358959B1 (en) | 1999-01-26 | 2002-03-19 | Merck & Co., Inc. | Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists |
US6387909B1 (en) | 1999-07-30 | 2002-05-14 | Recordati S.A. Chemical And Pharmaceutical Company | Thienopyranecarboxamide derivatives |
US6306861B1 (en) | 1999-07-30 | 2001-10-23 | Recordati S.A. Chemical And Pharmaceutical Company | Thienopyrancecarboxamide derivatives |
GB2355264A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355456A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355457A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists |
GB2355263A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists |
US6365591B1 (en) | 1999-10-18 | 2002-04-02 | Recordati, S.A., Chemical And Pharmacueticals Company | Isoxazolecarboxamide derivatives |
US6403594B1 (en) | 1999-10-18 | 2002-06-11 | Recordati, S.A. Chemical And Pharmaceutical Company | Benzopyran derivatives |
ATE548357T1 (de) * | 2000-01-25 | 2012-03-15 | Neurocrine Biosciences Inc | Gonadotropin freisetzende hormon rezeptor antagonisten und ihre verwandten verfahren |
HUP0400545A3 (en) * | 2000-11-30 | 2007-05-02 | Ranbaxy Lab Ltd | 1,4-disubstituted piperazine derivatives useful as uro-selectives alpha1-adrenoceptor blockers, and pharmaceutical compositions containing them |
EP1414808A1 (en) | 2001-08-02 | 2004-05-06 | Neurocrine Biosciences, Inc. | 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists |
DE10311065A1 (de) | 2003-03-13 | 2004-09-23 | Abbott Gmbh & Co. Kg | Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung |
CN1894234A (zh) | 2003-03-25 | 2007-01-10 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
KR20060041309A (ko) | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | 4-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
EP1699777B1 (en) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
GB0400290D0 (en) | 2004-01-08 | 2004-02-11 | Medivir Ab | dUTPase inhibitors |
CN102134231B (zh) | 2004-03-15 | 2020-08-04 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
EP1655288A1 (en) * | 2004-11-05 | 2006-05-10 | Institut Pasteur | Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents |
AU2005320217B2 (en) | 2004-12-20 | 2011-11-10 | Eisai R & D Management Co., Ltd. | Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine |
EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1889827B1 (en) * | 2005-05-25 | 2010-08-25 | Eisai R&D Management Co., Ltd. | Process for producing [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine |
ME02005B (me) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
DE102008030091B4 (de) * | 2008-06-25 | 2011-03-03 | Resprotect Gmbh | Uracilderivate und deren Verwendung |
US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
RU2449994C1 (ru) * | 2011-03-10 | 2012-05-10 | Светлана Алексеевна Мещерякова | 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность |
CN103596431B (zh) * | 2011-03-18 | 2016-06-22 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂 |
GB201318886D0 (en) * | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
PL3430010T3 (pl) | 2016-03-17 | 2020-11-16 | F. Hoffmann-La Roche Ag | Pochodna 5-etylo-4-metylopirazolo-3-karboksyamidu wykazująca aktywność jako agonista taar |
AU2020376386A1 (en) * | 2019-10-28 | 2022-03-24 | Nippon Soda Co., Ltd. | 2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent |
EP4344545A1 (en) * | 2021-04-28 | 2024-04-03 | Nippon Soda Co., Ltd. | Agricultural and horticultural fungicidal composition |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2727469A1 (de) * | 1977-06-18 | 1978-12-21 | Hoechst Ag | Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
JPH02184667A (ja) * | 1989-01-11 | 1990-07-19 | Meiji Seika Kaisha Ltd | N,n’―ジ置換ピペラジル誘導体及びそれを有効成分とする排尿障害改善剤 |
JPH0344379A (ja) * | 1989-07-13 | 1991-02-26 | Yamasa Shoyu Co Ltd | N↑3―ピペラジノウラシル誘導体 |
JP2814600B2 (ja) * | 1989-08-31 | 1998-10-22 | 正幸 石川 | 排尿障害治療剤 |
EP0558245A1 (en) * | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors |
FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
-
1996
- 1996-05-28 DE DE69612698T patent/DE69612698T2/de not_active Expired - Fee Related
- 1996-05-28 ES ES96108493T patent/ES2157366T3/es not_active Expired - Lifetime
- 1996-05-28 EP EP96108493A patent/EP0748800B1/en not_active Expired - Lifetime
- 1996-05-28 AT AT96108493T patent/ATE201016T1/de not_active IP Right Cessation
- 1996-05-28 DK DK96108493T patent/DK0748800T3/da active
- 1996-05-28 PT PT96108493T patent/PT748800E/pt unknown
- 1996-05-31 IL IL11851996A patent/IL118519A/xx not_active IP Right Cessation
- 1996-06-03 AU AU54690/96A patent/AU710754B2/en not_active Ceased
- 1996-06-03 ZA ZA964561A patent/ZA964561B/xx unknown
- 1996-06-04 NZ NZ286720A patent/NZ286720A/en unknown
- 1996-06-05 PL PL96314635A patent/PL188061B1/pl not_active IP Right Cessation
- 1996-06-05 HU HU9601529A patent/HU223594B1/hu not_active IP Right Cessation
- 1996-06-06 AR ARP960103000A patent/AR003428A1/es active IP Right Grant
- 1996-06-06 TR TR96/00475A patent/TR970073A2/xx unknown
- 1996-06-06 PE PE1996000428A patent/PE46497A1/es not_active Application Discontinuation
- 1996-06-06 MA MA24270A patent/MA23899A1/fr unknown
- 1996-06-07 JP JP8145236A patent/JP2721147B2/ja not_active Expired - Fee Related
- 1996-06-07 RU RU96111418/04A patent/RU2175322C2/ru not_active IP Right Cessation
- 1996-06-07 CN CN96110490A patent/CN1118459C/zh not_active Expired - Fee Related
- 1996-06-07 CO CO96029677A patent/CO4700472A1/es unknown
- 1996-06-07 BR BR9602705A patent/BR9602705A/pt not_active IP Right Cessation
- 1996-06-07 NO NO962412A patent/NO309424B1/no unknown
- 1996-06-07 UY UY24257A patent/UY24257A1/es not_active IP Right Cessation
- 1996-06-07 MY MYPI96002314A patent/MY113499A/en unknown
- 1996-06-07 SG SG1996010018A patent/SG45486A1/en unknown
- 1996-06-07 CA CA002178548A patent/CA2178548A1/en not_active Abandoned
- 1996-06-08 KR KR1019960020447A patent/KR100446877B1/ko not_active IP Right Cessation
- 1996-06-10 CZ CZ19961696A patent/CZ290004B6/cs not_active IP Right Cessation
- 1996-07-11 TW TW085108416A patent/TW340846B/zh active
- 1996-08-26 SA SA96170263A patent/SA96170263B1/ar unknown
-
1998
- 1998-12-21 HK HK98114167A patent/HK1013065A1/xx not_active IP Right Cessation
-
2001
- 2001-07-31 GR GR20010401157T patent/GR3036307T3/el not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GR3036307T3 (en) | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | |
ZA986968B (en) | 4-Aminopyrrole (3,2-D) pyrimidines as neuropeptide Y receptor antagonists. | |
IL123581A0 (en) | Pyrimidine derivatives as 5HT2c- receptor antagonists | |
ZA991413B (en) | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists. | |
AU5640299A (en) | 4-quinolinemethanol derivatives as purine receptor antagonists.(ii) | |
HK1019149A1 (en) | Indole derivatives useful as endothelin receptor antagonists | |
ZA969775B (en) | Endothelin receptor antagonists. | |
AU5640199A (en) | 4-quinolinemethanol derivatives as purine receptor antagonists (i) | |
ZA9811490B (en) | Herbicidal 3-(benzazol-4-yl)pyrimidinedione derivatives. | |
NZ315846A (en) | Endothelin receptor antagonists, in particular, substituted pyrazol-4-yl-substituted-prop-2-enoic acid derivatives | |
AU4980999A (en) | A3 adenosine receptor antagonists | |
HU9602054D0 (en) | Endothelin receptor antagonists | |
EP0854721A4 (en) | ENDOTHELIN RECEPTOR ANTAGONISTS | |
ZA966552B (en) | Endothelin receptor antagonists. | |
EG24597A (en) | Form vi 5,6-dichloro -2- (isopropylamino)1-1(b-1-ribofuranosyl)1h-benzimidaxole | |
AU4930696A (en) | Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists | |
EP0841926A4 (en) | ENDOTHELIN RECEPTOR ANTAGONISTS | |
AU6826698A (en) | Endothelin receptor antagonists | |
AU1150999A (en) | Indole derivative useful as endothelin receptor antagonist | |
HUP0004341A3 (en) | Novel heterocyclically substituted alpha-hydroxycarboxilic acid derivatives, method for producing the same and their use as endothelin receptor antagonists | |
ZA986551B (en) | Endothelin receptor antagonists. | |
EP0868180A4 (en) | ENDOTHELINM RECEPTOR ANTOGONISTS | |
SI0856001T1 (en) | Pyrimidine derivatives as 5ht2c receptor antagonists | |
ZA9610873B (en) | Integrin receptor antagonists. | |
ZA964195B (en) | Integrin receptor antagonists. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20070528 |