HK1011609A1 - Pharmaceutical compositions containing hiv protease inhibitors - Google Patents

Pharmaceutical compositions containing hiv protease inhibitors

Info

Publication number
HK1011609A1
HK1011609A1 HK98112594A HK98112594A HK1011609A1 HK 1011609 A1 HK1011609 A1 HK 1011609A1 HK 98112594 A HK98112594 A HK 98112594A HK 98112594 A HK98112594 A HK 98112594A HK 1011609 A1 HK1011609 A1 HK 1011609A1
Authority
HK
Hong Kong
Prior art keywords
hiv protease
pharmaceutical compositions
compositions containing
protease inhibitors
containing hiv
Prior art date
Application number
HK98112594A
Other languages
English (en)
Inventor
Laman Al-Razzak
Kennan C Marsh
Lourdes P Manning
Dilip Kaul
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of HK1011609A1 publication Critical patent/HK1011609A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK98112594A 1994-01-28 1998-11-30 Pharmaceutical compositions containing hiv protease inhibitors HK1011609A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18902194A 1994-01-28 1994-01-28
US28323994A 1994-07-29 1994-07-29
PCT/US1995/000232 WO1995020384A1 (fr) 1994-01-28 1995-01-03 Compositions pharmaceutiques contenant des inhibiteurs de protease du vih

Publications (1)

Publication Number Publication Date
HK1011609A1 true HK1011609A1 (en) 1999-07-16

Family

ID=26884695

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98112594A HK1011609A1 (en) 1994-01-28 1998-11-30 Pharmaceutical compositions containing hiv protease inhibitors

Country Status (14)

Country Link
US (1) US5484801A (fr)
EP (1) EP0732923B1 (fr)
JP (1) JP4353542B2 (fr)
KR (1) KR100360963B1 (fr)
AT (1) ATE210441T1 (fr)
AU (1) AU700942B2 (fr)
CA (1) CA2178632C (fr)
DE (1) DE69524567T2 (fr)
DK (1) DK0732923T3 (fr)
ES (1) ES2169121T3 (fr)
HK (1) HK1011609A1 (fr)
IL (1) IL111991A (fr)
PT (1) PT732923E (fr)
WO (1) WO1995020384A1 (fr)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
EP0769936A1 (fr) * 1994-07-22 1997-05-02 G.D. Searle & Co. Systeme d'apport de medicaments auto-emulsifiant
US5705524A (en) * 1994-11-04 1998-01-06 Gilead Sciences, Inc. Thiepane compounds
US6034118A (en) * 1994-11-04 2000-03-07 Gilead Sciences, Inc. Thiepane compounds
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
EP0861085B1 (fr) 1995-11-13 2005-07-20 Vitaleech Bioscience N.V. Isolats antiviraux obtenus a partir de sangsues
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US6730679B1 (en) 1996-03-22 2004-05-04 Smithkline Beecham Corporation Pharmaceutical formulations
AU3146997A (en) * 1996-06-03 1998-01-05 Merck & Co., Inc. Pediatric formulation for hiv protease inhibitors
GEP20012471B (en) 1996-10-18 2001-06-25 Vertex Pharma Inhibitors of Serine Proteases, Particularly Hepatitis C Virus NS3 Protease
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6894171B1 (en) * 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US6218438B1 (en) * 1998-11-18 2001-04-17 Supratek Pharma, Inc. Copolymer compositions for treating viral infections
JP2002531515A (ja) 1998-12-11 2002-09-24 ファーマソリューションズ・インコーポレイテッド 水に難溶性の薬剤のための自己乳化組成物
BE1012622A3 (fr) * 1999-04-21 2001-01-09 Solvay Procede pour la separation d'enantiomeres et reactif enantiopur.
US6057289A (en) * 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system
US7141593B1 (en) * 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
EP1733725B2 (fr) † 1999-06-04 2012-08-08 Abbott Laboratories Solution pharmaceutique comprenant ritonavir, un solvant (acide gras à chaîne longue) et de l'eau
US6589962B1 (en) 1999-07-20 2003-07-08 Merck & Co., Inc. Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof
AU6109500A (en) * 1999-07-20 2001-02-05 Merck & Co., Inc. Alpha-hydroxy-gamma-(((carbocyclic-or heterocyclic-substituted)amino)carbonyl)alkanamide derivatives and uses thereof
DE60028754T2 (de) 1999-11-12 2007-05-31 Abbott Laboratories, Abbott Park Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
DE60036961T2 (de) 1999-11-24 2008-08-28 Merck & Co., Inc. Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmer
GB0000313D0 (en) 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
SK287143B6 (sk) 2000-01-19 2010-01-07 Abbott Laboratories Farmaceutické kompozície obsahujúce zlúčeniny inhibujúce HIV proteázu
US7138538B2 (en) * 2000-04-14 2006-11-21 Solvay (Societe Anonyme) Process for the separation of enantiomers and enantiopure reagent
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
AU2001288695A1 (en) * 2000-09-05 2002-03-22 Abbott Laboratories Flavoring systems for pharmaceutical compositions and methods of making such compositions
US6911214B2 (en) 2000-09-05 2005-06-28 Abbott Laboratories Flavoring systems for pharmaceutical compositions and methods of making such compositions
EE200300201A (et) * 2000-10-31 2003-08-15 Boehringer Ingelheim Pharmaceuticals, Inc. Püranoonsete proteaasi inhibiitorite iseemulgeeruva kompositsiooni oraalne doos
WO2002051414A1 (fr) * 2000-12-22 2002-07-04 Takeda Chemical Industries, Ltd. Compositions médicinales s'administrant par voie orale
US20040116522A1 (en) * 2001-03-30 2004-06-17 Yutaka Yamagata Medicinal solutions
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US20030191121A1 (en) * 2001-08-09 2003-10-09 Miller Ross A. Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
US20040067216A1 (en) * 2002-02-22 2004-04-08 Karki Shyam B. Hiv protease inhibitors supported on cation exchange resins for oral administration
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
PL376900A1 (pl) * 2002-12-16 2006-01-09 Boehringer Ingelheim International Gmbh Zastosowanie kombinacji zawierającej nienukleozydowy inhibitor odwrotnej transkryptazy (NNRTI) i inhibitor cytochromu P450, taki jak inhibitor proteazy
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
TWI359147B (en) 2003-09-05 2012-03-01 Vertex Pharma Inhibitors of serine proteases, particularly hcv n
EP1670415A4 (fr) * 2003-09-12 2007-12-05 Vertex Pharma Modele animal permettant d'etudier l'activite des proteases et les atteintes hepatiques
CA2541634A1 (fr) * 2003-10-10 2005-04-28 Vertex Pharmaceuticals Incorporated Inhibiteurs de serine proteases, en particulier la ns3-ns4a protease du hcv
EP1944042A1 (fr) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Combinaisons pour le traitement HCV
KR20060120166A (ko) * 2003-10-27 2006-11-24 버텍스 파마슈티칼스 인코포레이티드 Ｈｃｖ ｎｓ３－ｎｓ４ａ 단백질분해효소 저항성 돌연변이
CA2554999A1 (fr) 2004-02-04 2005-08-25 Vertex Pharmaceuticals Incorporated Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a
CN101072575A (zh) * 2004-10-01 2007-11-14 威特克斯医药股份有限公司 Hcv ns3－ns4a蛋白酶抑制
MY141025A (en) 2004-10-29 2010-02-25 Vertex Pharma Dose forms
WO2006090270A1 (fr) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Sel d'addition acide de 2-isopropyl-4-(((n-methyl)amino)methyl)thiazole et utilisation de ce dernier dans la preparation de ritonavir
EP1919898B1 (fr) * 2005-07-29 2011-01-26 Tibotec Pharmaceuticals Inhibiteurs macrocycliques du virus de l'hépatite c
US8183277B2 (en) 2005-07-29 2012-05-22 Tibotec Pharmaceuticals Ltd. Macrocylic inhibitors of hepatitis C virus
PE20070210A1 (es) 2005-07-29 2007-04-16 Tibotec Pharm Ltd Compuestos macrociclicos como inhibidores del virus de hepatitis c
JO2768B1 (en) 2005-07-29 2014-03-15 تيبوتيك فارماسيوتيكالز ليمتد Large cyclic inhibitors of hepatitis C virus
AR055105A1 (es) * 2005-07-29 2007-08-08 Tibotec Pharm Ltd Inhibidores macrociclicos del virus de la hepatitis c
BRPI0614637A2 (pt) * 2005-07-29 2011-04-12 Tibotec Pharm Ltd inibidores macrocìclicos do vìrus da hepatite c
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1919899B1 (fr) * 2005-07-29 2011-01-19 Tibotec Pharmaceuticals Inhibiteurs macrocycliques du virus de l'hépatite c
EP2256113A1 (fr) * 2005-08-02 2010-12-01 Vertex Pharmaceuticals Incorporated Inhibiteurs de sérine protéases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
EP1951748B1 (fr) 2005-11-11 2013-07-24 Vertex Pharmaceuticals, Inc. Variantes du virus de l'hépatite c
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
CA2643688A1 (fr) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-cristaux et compositions pharmaceutiques les comprenant
WO2007109080A2 (fr) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Inhibiteurs de protéase de l'hépatite c deutérés
TWI406660B (zh) * 2006-11-17 2013-09-01 Tibotec Pharm Ltd Ｃ型肝炎病毒之巨環抑制劑
RU2481340C2 (ru) * 2007-02-08 2013-05-10 Тиботек Фармасьютикалз Лтд. Пиримидин-замещенные макроциклические ингибиторы hcv
CA2679426A1 (fr) * 2007-02-27 2008-09-04 Luc Farmer Inhibiteurs de serine proteases
AR065498A1 (es) * 2007-02-27 2009-06-10 Vertex Pharma Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden
CN102872461A (zh) 2007-05-04 2013-01-16 弗特克斯药品有限公司 用于治疗hcv感染的组合治疗
MX2010002407A (es) * 2007-08-30 2010-03-26 Vertex Pharma Cocristales y composiciones farmaceuticas que los comprenden.
JP2010540517A (ja) * 2007-09-25 2010-12-24 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖプロテアーゼ阻害剤
AP3010A (en) * 2007-10-29 2014-10-31 Cipla Ltd Novel antiretroviral combination
GT200800303A (es) * 2007-12-24 2009-09-18 Combinacion anti-retroviral
AR072428A1 (es) * 2008-07-01 2010-08-25 Medivir Ab Derivados de pirimidin nucleotidos inhibidores de polimerasas del virus de la hepatitis c (vhc), composiciones farmaceuticas que los contienen y metodo para prepararlos.
JP2012517478A (ja) 2009-02-12 2012-08-02 バーテックス ファーマシューティカルズ インコーポレイテッド ペグ化インターフェロン、リバビリンおよびテラプレビルを含む、ｈｃｖ組合せ治療剤
KR101471238B1 (ko) 2009-04-25 2014-12-12 에프. 호프만-라 로슈 아게 약물동력학을 개선하는 방법
EP2435037B1 (fr) 2009-05-27 2014-11-12 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
AU2011210795A1 (en) 2010-01-29 2012-08-02 Vertex Pharmaceuticals Incorporated Therapies for treating Hepatitis C virus infection
WO2012010942A2 (fr) 2010-07-22 2012-01-26 Lupin Limited Nouvelle(s) composition(s) pharmaceutique(s) d'inhibiteur(s) de la protéase du vih
EP2632895B1 (fr) 2010-10-28 2018-10-03 Merck Canada Inc. Inhibiteurs de la protéase du vih
WO2012109646A1 (fr) 2011-02-11 2012-08-16 Vertex Pharmaceuticals Incorporated Traitement du vhc chez des patients infectés par le vih
US9096556B2 (en) 2011-05-27 2015-08-04 Hetero Research Foundation Amorphous ritonavir co-precipitated
US9133157B2 (en) 2011-10-26 2015-09-15 Merck Canada Inc. HIV protease inhibitors
EP2895482B1 (fr) 2012-09-11 2016-10-19 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
WO2015013835A1 (fr) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih
UA117375C2 (uk) 2013-09-04 2018-07-25 Медівір Аб Інгібітори полімерази hcv
WO2015056213A1 (fr) 2013-10-17 2015-04-23 Medivir Ab Inhibiteurs de la polymérase du vhc
US9737545B2 (en) 2013-12-19 2017-08-22 Merck Sharp & Dohme Corp. HIV protease inhibitors
US9834526B2 (en) 2013-12-19 2017-12-05 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP3113780B1 (fr) 2014-03-06 2019-08-14 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
US10138255B2 (en) 2014-03-10 2018-11-27 Merck Sharp & Dohme Corp. Piperazine derivatives as HIV protease inhibitors
WO2016069955A1 (fr) 2014-10-29 2016-05-06 Wisconsin Alumni Research Foundation Inhibiteurs de protéase de vih à base d'acide borique

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342922A (en) * 1989-03-08 1994-08-30 Washington University Inhibitors of retroviral protease
US5086165A (en) * 1989-03-08 1992-02-04 Washington University Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
US5256677A (en) * 1989-05-23 1993-10-26 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5164300A (en) * 1989-12-28 1992-11-17 Washington University Method for determining activity of retroviral protease
CA2086414A1 (fr) * 1990-07-06 1992-01-07 Geoffrey B. Dreyer Inhibiteurs des proteases retrovirales
US5171662A (en) * 1990-09-13 1992-12-15 The Upjohn Company Method of detecting HIV protease activity
US5183826A (en) * 1990-09-25 1993-02-02 Merck & Co., Inc. Antiviral agent
IE913840A1 (en) * 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
WO1992015319A1 (fr) * 1991-03-08 1992-09-17 Smithkline Beecham Corporation Agents inhibiteurs de protease de l'hiv
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5250563A (en) * 1991-09-25 1993-10-05 Merck & Co., Inc. Inhibitors of HIV protease
US5296604A (en) * 1992-05-15 1994-03-22 Miles Inc. Proline derivatives and compositions for their use as inhibitors of HIV protease
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease

Also Published As

Publication number Publication date
WO1995020384A1 (fr) 1995-08-03
IL111991A0 (en) 1995-03-15
IL111991A (en) 2000-07-26
US5484801A (en) 1996-01-16
ATE210441T1 (de) 2001-12-15
DK0732923T3 (da) 2002-04-08
DE69524567T2 (de) 2002-09-05
PT732923E (pt) 2002-05-31
ES2169121T3 (es) 2002-07-01
CA2178632C (fr) 2006-04-11
KR100360963B1 (ko) 2003-02-11
CA2178632A1 (fr) 1995-08-03
EP0732923B1 (fr) 2001-12-12
AU700942B2 (en) 1999-01-14
JP4353542B2 (ja) 2009-10-28
AU1524895A (en) 1995-08-15
DE69524567D1 (de) 2002-01-24
EP0732923A1 (fr) 1996-09-25

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