HK1008980A1 - Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders - Google Patents
Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disordersInfo
- Publication number
- HK1008980A1 HK1008980A1 HK98109748A HK98109748A HK1008980A1 HK 1008980 A1 HK1008980 A1 HK 1008980A1 HK 98109748 A HK98109748 A HK 98109748A HK 98109748 A HK98109748 A HK 98109748A HK 1008980 A1 HK1008980 A1 HK 1008980A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- receptor
- treatment
- neurological disorders
- calcium channels
- operated calcium
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/485,038 US6071970A (en) | 1993-02-08 | 1995-06-07 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
PCT/US1996/010201 WO1996040097A1 (fr) | 1995-06-07 | 1996-06-07 | Composes actifs au niveau d'un nouveau site de canaux calciques actives par recepteur, utiles dans le traitement de troubles neurologiques |
Publications (1)
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HK1008980A1 true HK1008980A1 (en) | 1999-05-21 |
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Family Applications (1)
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HK98109748A HK1008980A1 (en) | 1995-06-07 | 1998-08-06 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders |
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US (2) | US6071970A (fr) |
EP (1) | EP0831799B1 (fr) |
JP (1) | JPH11506469A (fr) |
KR (1) | KR100430022B1 (fr) |
CN (1) | CN1153568C (fr) |
AT (1) | ATE238782T1 (fr) |
AU (1) | AU716122B2 (fr) |
BR (1) | BR9609019A (fr) |
CA (1) | CA2223978A1 (fr) |
DE (1) | DE69627852T2 (fr) |
DK (1) | DK0831799T3 (fr) |
ES (1) | ES2197945T3 (fr) |
HK (1) | HK1008980A1 (fr) |
NZ (1) | NZ310344A (fr) |
PL (1) | PL185492B1 (fr) |
PT (1) | PT831799E (fr) |
RU (1) | RU2246300C2 (fr) |
WO (1) | WO1996040097A1 (fr) |
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ATE312347T1 (de) * | 1991-08-23 | 2005-12-15 | Nps Pharma Inc | Screening-verfahren für kalzium-rezeptor aktive verbindungen |
US5281624A (en) * | 1991-09-27 | 1994-01-25 | Eli Lilly And Company | N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof |
DE4239816A1 (de) * | 1992-11-26 | 1994-06-01 | Inst Bioanalytik Ggmbh | Arzneimittel zur Behandlung des zentralen Nervensystems |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
ES2156162T3 (es) * | 1994-02-08 | 2001-06-16 | Nps Pharma Inc | Compuestos activos en un nuevo sitio sobre canales del calcio accionados por un receptor, utiles para el tratamiento de trastornos y enfermedades neurologicas. |
AU3414295A (en) * | 1994-08-19 | 1996-03-14 | Nps Pharmaceuticals, Inc. | Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases |
-
1995
- 1995-06-07 US US08/485,038 patent/US6071970A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 DE DE69627852T patent/DE69627852T2/de not_active Expired - Fee Related
- 1996-06-07 AU AU61125/96A patent/AU716122B2/en not_active Ceased
- 1996-06-07 BR BR9609019A patent/BR9609019A/pt not_active Application Discontinuation
- 1996-06-07 PT PT96918477T patent/PT831799E/pt unknown
- 1996-06-07 KR KR1019970709069A patent/KR100430022B1/ko not_active IP Right Cessation
- 1996-06-07 WO PCT/US1996/010201 patent/WO1996040097A1/fr active IP Right Grant
- 1996-06-07 PL PL96323871A patent/PL185492B1/pl not_active IP Right Cessation
- 1996-06-07 JP JP9502238A patent/JPH11506469A/ja not_active Ceased
- 1996-06-07 EP EP96918477A patent/EP0831799B1/fr not_active Expired - Lifetime
- 1996-06-07 RU RU98100454/15A patent/RU2246300C2/ru not_active IP Right Cessation
- 1996-06-07 NZ NZ310344A patent/NZ310344A/en unknown
- 1996-06-07 DK DK96918477T patent/DK0831799T3/da active
- 1996-06-07 AT AT96918477T patent/ATE238782T1/de not_active IP Right Cessation
- 1996-06-07 CA CA002223978A patent/CA2223978A1/fr not_active Abandoned
- 1996-06-07 ES ES96918477T patent/ES2197945T3/es not_active Expired - Lifetime
- 1996-06-07 CN CNB961960426A patent/CN1153568C/zh not_active Expired - Fee Related
-
1998
- 1998-08-06 HK HK98109748A patent/HK1008980A1/xx not_active IP Right Cessation
-
1999
- 1999-02-18 US US09/252,433 patent/US6051610A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PL185492B1 (pl) | 2003-05-30 |
ATE238782T1 (de) | 2003-05-15 |
ES2197945T3 (es) | 2004-01-16 |
KR100430022B1 (ko) | 2004-07-16 |
JPH11506469A (ja) | 1999-06-08 |
CN1153568C (zh) | 2004-06-16 |
RU2246300C2 (ru) | 2005-02-20 |
AU716122B2 (en) | 2000-02-17 |
DE69627852D1 (de) | 2003-06-05 |
US6051610A (en) | 2000-04-18 |
KR19990022588A (ko) | 1999-03-25 |
DK0831799T3 (da) | 2003-08-11 |
EP0831799B1 (fr) | 2003-05-02 |
PL323871A1 (en) | 1998-04-27 |
CN1192679A (zh) | 1998-09-09 |
WO1996040097A1 (fr) | 1996-12-19 |
DE69627852T2 (de) | 2004-02-26 |
NZ310344A (en) | 2001-03-30 |
PT831799E (pt) | 2003-09-30 |
EP0831799A1 (fr) | 1998-04-01 |
AU6112596A (en) | 1996-12-30 |
CA2223978A1 (fr) | 1996-12-19 |
US6071970A (en) | 2000-06-06 |
BR9609019A (pt) | 1999-07-06 |
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Legal Events
Date | Code | Title | Description |
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PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20080607 |