HK1006183A1 - Expression and secretion vectors for hirudine by way of transformed yeasts - Google Patents

Expression and secretion vectors for hirudine by way of transformed yeasts Download PDF

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Publication number
HK1006183A1
HK1006183A1 HK98105246A HK98105246A HK1006183A1 HK 1006183 A1 HK1006183 A1 HK 1006183A1 HK 98105246 A HK98105246 A HK 98105246A HK 98105246 A HK98105246 A HK 98105246A HK 1006183 A1 HK1006183 A1 HK 1006183A1
Authority
HK
Hong Kong
Prior art keywords
hirudin
yeast
gene
sequence
process according
Prior art date
Application number
HK98105246A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1006183B (en
Inventor
Loison Gerard
Tolstoshev Paul
Lemoine Yves
Lecocq Jean-Pierre
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HK1006183A1 publication Critical patent/HK1006183A1/xx
Publication of HK1006183B publication Critical patent/HK1006183B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Instructional Devices (AREA)
  • Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
HK98105246.4A 1985-05-02 1998-06-12 Expression and secretion vectors for hirudine by way of transformed yeasts HK1006183B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8506672A FR2593518B1 (fr) 1985-05-02 1985-05-02 Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
FR8506672 1985-05-02

Publications (2)

Publication Number Publication Date
HK1006183A1 true HK1006183A1 (en) 1999-02-12
HK1006183B HK1006183B (en) 1999-02-12

Family

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Also Published As

Publication number Publication date
EP0200655A1 (fr) 1986-11-05
DE3650306T2 (de) 1995-10-12
WO1986006406A1 (fr) 1986-11-06
CA1341501C (fr) 2006-03-14
CZ321786A3 (en) 1997-07-16
JPS62502661A (ja) 1987-10-15
NO865336L (no) 1987-03-02
MC1785A1 (fr) 1987-09-02
AU600667B2 (en) 1990-08-23
IE67136B1 (en) 1996-03-06
FR2593518B1 (fr) 1989-09-08
PT82490A (fr) 1986-05-01
CZ282928B6 (cs) 1997-11-12
ZA863261B (en) 1986-12-30
IE861183L (en) 1986-11-02
DK634386D0 (da) 1986-12-30
FI104635B (fi) 2000-03-15
RU1774950C (ru) 1992-11-07
KR870700234A (ko) 1987-05-30
FI865303L (fi) 1986-12-23
ES8703930A1 (es) 1987-03-16
JPH09103295A (ja) 1997-04-22
AU5778786A (en) 1986-11-18
FR2601383B2 (fr) 1989-12-22
PT82490B (pt) 1988-03-03
ES555121A0 (es) 1987-03-16
FR2601383A2 (fr) 1988-01-15
EP0200655B1 (fr) 1995-04-26
JP2779930B2 (ja) 1998-07-23
DK634386A (da) 1986-12-30
DK174837B1 (da) 2003-12-15
HUT42131A (en) 1987-06-29
BG49717A3 (bg) 1992-01-15
PL155074B1 (en) 1991-10-31
HU202919B (en) 1991-04-29
ATE121778T1 (de) 1995-05-15
FR2593518A1 (fr) 1987-07-31
FI865303A0 (fi) 1986-12-23
NO302375B1 (no) 1998-02-23
JP2580141B2 (ja) 1997-02-12
DE3650306D1 (de) 1995-06-01

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PE Patent expired

Effective date: 20060501